EF-hand_domain_pair/EF-hand_domain_containing_pro tein_putative/Pfam:PF13833/Pfam:PF13405/Pfam:PF13499

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EF-hand domain pair, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IRB5_LEIDO

TriTrypDb:

LdBPK_363780.1 , LdCL_360044800 , LDHU3_36.5100

Length:

103

Annotations

Annotations by Jardim et al.

Metal Binding, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IRB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IRB5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005509	calcium ion binding	5	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	77	79	PF00675	0.322
CLV_PCSK_KEX2_1	55	57	PF00082	0.246
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.246
CLV_PCSK_SKI1_1	13	17	PF00082	0.567
CLV_Separin_Metazoa	75	79	PF03568	0.391
DEG_Nend_UBRbox_3	1	3	PF02207	0.584
DOC_MAPK_gen_1	55	61	PF00069	0.355
LIG_14-3-3_CanoR_1	13	18	PF00244	0.529
LIG_CtBP_PxDLS_1	65	71	PF00389	0.355
LIG_FHA_1	46	52	PF00498	0.329
LIG_FHA_2	14	20	PF00498	0.553
LIG_FHA_2	81	87	PF00498	0.349
LIG_LIR_Gen_1	16	24	PF02991	0.595
LIG_LIR_Gen_1	36	43	PF02991	0.281
LIG_LIR_Gen_1	87	98	PF02991	0.287
LIG_LIR_Nem_3	16	20	PF02991	0.594
LIG_LIR_Nem_3	36	41	PF02991	0.281
LIG_LIR_Nem_3	87	93	PF02991	0.289
LIG_Rb_pABgroove_1	32	40	PF01858	0.297
LIG_SH2_NCK_1	17	21	PF00017	0.616
LIG_SH2_SRC	17	20	PF00017	0.614
LIG_SH2_STAP1	90	94	PF00017	0.410
LIG_SUMO_SIM_anti_2	50	55	PF11976	0.391
LIG_SUMO_SIM_par_1	46	52	PF11976	0.397
LIG_TRAF2_1	89	92	PF00917	0.347
LIG_TYR_ITIM	15	20	PF00017	0.615
MOD_CK2_1	13	19	PF00069	0.524
MOD_CK2_1	66	72	PF00069	0.279
MOD_CK2_1	80	86	PF00069	0.279
MOD_GlcNHglycan	44	48	PF01048	0.352
MOD_GSK3_1	43	50	PF00069	0.391
MOD_GSK3_1	80	87	PF00069	0.368
MOD_NEK2_1	1	6	PF00069	0.551
MOD_NEK2_1	96	101	PF00069	0.424
MOD_Plk_1	84	90	PF00069	0.346
MOD_Plk_2-3	86	92	PF00069	0.347
MOD_Plk_4	1	7	PF00069	0.592
TRG_DiLeu_BaEn_3	91	97	PF01217	0.355
TRG_ENDOCYTIC_2	17	20	PF00928	0.614
TRG_ENDOCYTIC_2	58	61	PF00928	0.354
TRG_ENDOCYTIC_2	90	93	PF00928	0.301
TRG_Pf-PMV_PEXEL_1	13	18	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.306

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCM5	Leptomonas seymouri	71%	100%
A0A0S4J6C4	Bodo saltans	47%	100%
A0A1X0P443	Trypanosomatidae	58%	100%
A0A3R7N819	Trypanosoma rangeli	57%	100%
A4HPM9	Leishmania braziliensis	83%	100%
A4ID37	Leishmania infantum	100%	100%
D0A8I9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9ATE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q156	Leishmania major	99%	100%