EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IRA6_LEIDO

TriTrypDb:

LdBPK_291260.1 , LdCL_290017700 , LDHU3_29.1740

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IRA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IRA6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005509	calcium ion binding	5	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.829
CLV_C14_Caspase3-7	24	28	PF00656	0.571
CLV_MEL_PAP_1	140	146	PF00089	0.741
CLV_NRD_NRD_1	160	162	PF00675	0.683
CLV_PCSK_FUR_1	158	162	PF00082	0.659
CLV_PCSK_KEX2_1	160	162	PF00082	0.710
CLV_PCSK_KEX2_1	207	209	PF00082	0.713
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.713
CLV_PCSK_SKI1_1	131	135	PF00082	0.673
CLV_PCSK_SKI1_1	287	291	PF00082	0.659
CLV_PCSK_SKI1_1	314	318	PF00082	0.549
DEG_Nend_Nbox_1	1	3	PF02207	0.772
DOC_AGCK_PIF_1	357	362	PF00069	0.511
DOC_CKS1_1	279	284	PF01111	0.697
DOC_MAPK_gen_1	31	38	PF00069	0.522
DOC_MAPK_gen_1	70	78	PF00069	0.612
DOC_PP2B_LxvP_1	333	336	PF13499	0.679
DOC_PP4_FxxP_1	134	137	PF00568	0.754
DOC_USP7_MATH_1	164	168	PF00917	0.755
DOC_USP7_MATH_1	187	191	PF00917	0.796
DOC_USP7_MATH_1	216	220	PF00917	0.753
DOC_USP7_MATH_2	46	52	PF00917	0.619
DOC_WW_Pin1_4	14	19	PF00397	0.612
DOC_WW_Pin1_4	212	217	PF00397	0.739
DOC_WW_Pin1_4	261	266	PF00397	0.651
DOC_WW_Pin1_4	278	283	PF00397	0.706
LIG_14-3-3_CanoR_1	158	168	PF00244	0.705
LIG_14-3-3_CanoR_1	188	192	PF00244	0.805
LIG_14-3-3_CanoR_1	314	320	PF00244	0.554
LIG_14-3-3_CanoR_1	324	330	PF00244	0.578
LIG_14-3-3_CanoR_1	33	37	PF00244	0.455
LIG_APCC_ABBA_1	193	198	PF00400	0.689
LIG_BRCT_BRCA1_1	189	193	PF00533	0.795
LIG_CaM_IQ_9	50	66	PF13499	0.658
LIG_Clathr_ClatBox_1	44	48	PF01394	0.519
LIG_deltaCOP1_diTrp_1	352	360	PF00928	0.527
LIG_FHA_1	171	177	PF00498	0.685
LIG_FHA_1	239	245	PF00498	0.726
LIG_FHA_1	33	39	PF00498	0.544
LIG_FHA_1	339	345	PF00498	0.623
LIG_FHA_1	63	69	PF00498	0.689
LIG_FHA_2	176	182	PF00498	0.763
LIG_FHA_2	279	285	PF00498	0.686
LIG_FHA_2	296	302	PF00498	0.622
LIG_LIR_Gen_1	148	157	PF02991	0.625
LIG_LIR_Gen_1	304	311	PF02991	0.519
LIG_LIR_Gen_1	337	347	PF02991	0.606
LIG_LIR_Gen_1	352	362	PF02991	0.401
LIG_LIR_Gen_1	39	47	PF02991	0.531
LIG_LIR_Nem_3	148	153	PF02991	0.627
LIG_LIR_Nem_3	190	196	PF02991	0.718
LIG_LIR_Nem_3	304	309	PF02991	0.518
LIG_LIR_Nem_3	320	325	PF02991	0.556
LIG_LIR_Nem_3	337	342	PF02991	0.530
LIG_LIR_Nem_3	352	357	PF02991	0.412
LIG_LIR_Nem_3	358	363	PF02991	0.443
LIG_LIR_Nem_3	39	44	PF02991	0.609
LIG_LIR_Nem_3	75	80	PF02991	0.734
LIG_PALB2_WD40_1	301	309	PF16756	0.560
LIG_PTAP_UEV_1	245	250	PF05743	0.702
LIG_PTB_Apo_2	249	256	PF02174	0.611
LIG_PTB_Phospho_1	249	255	PF10480	0.621
LIG_SH2_CRK	255	259	PF00017	0.569
LIG_SH2_CRK	41	45	PF00017	0.528
LIG_SH2_CRK	80	84	PF00017	0.642
LIG_SH2_GRB2like	80	83	PF00017	0.633
LIG_SH2_STAT5	267	270	PF00017	0.752
LIG_SH2_STAT5	362	365	PF00017	0.446
LIG_SH2_STAT5	80	83	PF00017	0.639
LIG_SH2_STAT5	95	98	PF00017	0.536
LIG_SH3_2	246	251	PF14604	0.769
LIG_SH3_3	186	192	PF00018	0.756
LIG_SH3_3	243	249	PF00018	0.730
LIG_SH3_3	40	46	PF00018	0.552
LIG_SUMO_SIM_par_1	315	321	PF11976	0.621
LIG_SUMO_SIM_par_1	340	345	PF11976	0.597
LIG_TRAF2_1	114	117	PF00917	0.735
LIG_TRAF2_1	298	301	PF00917	0.592
LIG_TRAF2_1	318	321	PF00917	0.296
LIG_UBA3_1	22	31	PF00899	0.508
MOD_CDK_SPK_2	212	217	PF00069	0.753
MOD_CDK_SPxxK_3	14	21	PF00069	0.546
MOD_CK1_1	106	112	PF00069	0.807
MOD_CK1_1	175	181	PF00069	0.808
MOD_CK1_1	215	221	PF00069	0.796
MOD_CK1_1	239	245	PF00069	0.730
MOD_CK2_1	145	151	PF00069	0.709
MOD_CK2_1	272	278	PF00069	0.782
MOD_CK2_1	295	301	PF00069	0.666
MOD_CK2_1	315	321	PF00069	0.291
MOD_Cter_Amidation	205	208	PF01082	0.690
MOD_GlcNHglycan	218	221	PF01048	0.771
MOD_GlcNHglycan	223	226	PF01048	0.726
MOD_GlcNHglycan	246	249	PF01048	0.704
MOD_GlcNHglycan	9	12	PF01048	0.702
MOD_GSK3_1	112	119	PF00069	0.794
MOD_GSK3_1	160	167	PF00069	0.721
MOD_GSK3_1	168	175	PF00069	0.767
MOD_GSK3_1	212	219	PF00069	0.832
MOD_GSK3_1	236	243	PF00069	0.779
MOD_GSK3_1	261	268	PF00069	0.662
MOD_GSK3_1	32	39	PF00069	0.617
MOD_GSK3_1	334	341	PF00069	0.663
MOD_N-GLC_1	169	174	PF02516	0.776
MOD_N-GLC_1	212	217	PF02516	0.820
MOD_N-GLC_1	290	295	PF02516	0.599
MOD_NEK2_1	127	132	PF00069	0.567
MOD_NEK2_1	168	173	PF00069	0.780
MOD_NEK2_1	290	295	PF00069	0.576
MOD_NEK2_1	36	41	PF00069	0.540
MOD_NEK2_2	145	150	PF00069	0.712
MOD_PIKK_1	268	274	PF00454	0.652
MOD_PKA_1	160	166	PF00069	0.703
MOD_PKA_2	106	112	PF00069	0.801
MOD_PKA_2	159	165	PF00069	0.759
MOD_PKA_2	187	193	PF00069	0.718
MOD_PKA_2	244	250	PF00069	0.664
MOD_PKA_2	32	38	PF00069	0.545
MOD_PKA_2	78	84	PF00069	0.679
MOD_PKB_1	158	166	PF00069	0.683
MOD_Plk_1	290	296	PF00069	0.642
MOD_Plk_2-3	112	118	PF00069	0.640
MOD_Plk_2-3	338	344	PF00069	0.642
MOD_Plk_4	145	151	PF00069	0.637
MOD_Plk_4	32	38	PF00069	0.537
MOD_Plk_4	48	54	PF00069	0.402
MOD_ProDKin_1	14	20	PF00069	0.605
MOD_ProDKin_1	212	218	PF00069	0.741
MOD_ProDKin_1	261	267	PF00069	0.654
MOD_ProDKin_1	278	284	PF00069	0.705
MOD_SUMO_rev_2	198	204	PF00179	0.755
TRG_DiLeu_BaEn_2	47	53	PF01217	0.546
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.610
TRG_ENDOCYTIC_2	150	153	PF00928	0.623
TRG_ENDOCYTIC_2	255	258	PF00928	0.568
TRG_ENDOCYTIC_2	339	342	PF00928	0.596
TRG_ENDOCYTIC_2	362	365	PF00928	0.502
TRG_ENDOCYTIC_2	41	44	PF00928	0.604
TRG_ER_diArg_1	157	160	PF00400	0.639

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7W0	Leptomonas seymouri	47%	100%
A0A1X0NZT2	Trypanosomatidae	29%	100%
A4HHC9	Leishmania braziliensis	73%	100%
A4I4H4	Leishmania infantum	100%	100%
E9ADX5	Leishmania major	95%	100%
E9ALV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	98%