Intu_longin_1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IR86_LEIDO

TriTrypDb:

LdBPK_363410.1 , LdCL_360040900 , LDHU3_36.4670

Length:

515

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IR86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IR86

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0016192	vesicle-mediated transport	4	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	386	390	PF00656	0.634
CLV_MEL_PAP_1	61	67	PF00089	0.293
CLV_NRD_NRD_1	138	140	PF00675	0.663
CLV_NRD_NRD_1	71	73	PF00675	0.395
CLV_NRD_NRD_1	75	77	PF00675	0.382
CLV_PCSK_KEX2_1	71	73	PF00082	0.331
CLV_PCSK_SKI1_1	168	172	PF00082	0.447
CLV_PCSK_SKI1_1	177	181	PF00082	0.377
CLV_PCSK_SKI1_1	247	251	PF00082	0.642
CLV_PCSK_SKI1_1	372	376	PF00082	0.712
CLV_PCSK_SKI1_1	509	513	PF00082	0.518
CLV_Separin_Metazoa	244	248	PF03568	0.730
DEG_SPOP_SBC_1	458	462	PF00917	0.578
DOC_ANK_TNKS_1	435	442	PF00023	0.591
DOC_CKS1_1	152	157	PF01111	0.711
DOC_CYCLIN_yCln2_LP_2	409	415	PF00134	0.591
DOC_MAPK_FxFP_2	37	40	PF00069	0.411
DOC_MAPK_gen_1	76	84	PF00069	0.325
DOC_MAPK_MEF2A_6	232	239	PF00069	0.612
DOC_PP1_RVXF_1	245	252	PF00149	0.552
DOC_PP2B_LxvP_1	130	133	PF13499	0.558
DOC_PP2B_LxvP_1	307	310	PF13499	0.481
DOC_PP2B_LxvP_1	409	412	PF13499	0.592
DOC_PP2B_LxvP_1	455	458	PF13499	0.655
DOC_PP2B_LxvP_1	512	515	PF13499	0.646
DOC_PP4_FxxP_1	222	225	PF00568	0.656
DOC_PP4_FxxP_1	279	282	PF00568	0.530
DOC_PP4_FxxP_1	37	40	PF00568	0.411
DOC_SPAK_OSR1_1	64	68	PF12202	0.293
DOC_USP7_MATH_1	160	164	PF00917	0.655
DOC_USP7_MATH_1	166	170	PF00917	0.482
DOC_USP7_MATH_1	205	209	PF00917	0.606
DOC_USP7_MATH_1	218	222	PF00917	0.600
DOC_USP7_MATH_1	312	316	PF00917	0.495
DOC_USP7_MATH_1	414	418	PF00917	0.713
DOC_USP7_MATH_1	57	61	PF00917	0.325
DOC_USP7_UBL2_3	406	410	PF12436	0.644
DOC_WW_Pin1_4	151	156	PF00397	0.721
DOC_WW_Pin1_4	354	359	PF00397	0.584
DOC_WW_Pin1_4	430	435	PF00397	0.705
DOC_WW_Pin1_4	83	88	PF00397	0.321
LIG_14-3-3_CanoR_1	177	182	PF00244	0.487
LIG_14-3-3_CanoR_1	227	235	PF00244	0.672
LIG_14-3-3_CanoR_1	365	375	PF00244	0.629
LIG_14-3-3_CanoR_1	471	476	PF00244	0.484
LIG_14-3-3_CanoR_1	76	85	PF00244	0.335
LIG_APCC_ABBA_1	341	346	PF00400	0.537
LIG_deltaCOP1_diTrp_1	467	476	PF00928	0.480
LIG_EH1_1	504	512	PF00400	0.522
LIG_eIF4E_1	505	511	PF01652	0.614
LIG_FHA_1	105	111	PF00498	0.325
LIG_FHA_1	346	352	PF00498	0.629
LIG_FHA_1	461	467	PF00498	0.581
LIG_FHA_2	114	120	PF00498	0.253
LIG_FHA_2	3	9	PF00498	0.655
LIG_FHA_2	381	387	PF00498	0.562
LIG_FHA_2	426	432	PF00498	0.578
LIG_GBD_Chelix_1	297	305	PF00786	0.548
LIG_LIR_Apic_2	219	225	PF02991	0.637
LIG_LIR_Gen_1	116	124	PF02991	0.234
LIG_LIR_Gen_1	389	400	PF02991	0.481
LIG_LIR_Gen_1	470	479	PF02991	0.462
LIG_LIR_Nem_3	116	121	PF02991	0.234
LIG_LIR_Nem_3	300	306	PF02991	0.542
LIG_LIR_Nem_3	433	438	PF02991	0.574
LIG_LIR_Nem_3	470	475	PF02991	0.476
LIG_NRBOX	116	122	PF00104	0.321
LIG_REV1ctd_RIR_1	172	181	PF16727	0.406
LIG_SH2_CRK	19	23	PF00017	0.411
LIG_SH2_CRK	308	312	PF00017	0.485
LIG_SH2_NCK_1	308	312	PF00017	0.485
LIG_SH2_SRC	308	311	PF00017	0.485
LIG_SH2_STAP1	451	455	PF00017	0.466
LIG_SH2_STAT3	505	508	PF00017	0.605
LIG_SH2_STAT5	19	22	PF00017	0.416
LIG_SH2_STAT5	304	307	PF00017	0.458
LIG_SH2_STAT5	38	41	PF00017	0.275
LIG_SH2_STAT5	445	448	PF00017	0.546
LIG_SH2_STAT5	478	481	PF00017	0.438
LIG_SH3_3	149	155	PF00018	0.668
LIG_SH3_3	15	21	PF00018	0.308
LIG_SH3_3	6	12	PF00018	0.581
LIG_TYR_ITIM	301	306	PF00017	0.548
LIG_WRC_WIRS_1	171	176	PF05994	0.404
MOD_CDK_SPxK_1	430	436	PF00069	0.627
MOD_CK1_1	123	129	PF00069	0.569
MOD_CK1_1	150	156	PF00069	0.669
MOD_CK1_1	162	168	PF00069	0.505
MOD_CK1_1	459	465	PF00069	0.516
MOD_CK2_1	113	119	PF00069	0.301
MOD_CK2_1	227	233	PF00069	0.669
MOD_CK2_1	356	362	PF00069	0.586
MOD_CK2_1	380	386	PF00069	0.568
MOD_CK2_1	425	431	PF00069	0.571
MOD_CK2_1	461	467	PF00069	0.605
MOD_CK2_1	83	89	PF00069	0.462
MOD_CMANNOS	469	472	PF00535	0.475
MOD_Cter_Amidation	137	140	PF01082	0.663
MOD_DYRK1A_RPxSP_1	354	358	PF00069	0.614
MOD_GlcNHglycan	122	125	PF01048	0.543
MOD_GlcNHglycan	168	171	PF01048	0.373
MOD_GlcNHglycan	202	205	PF01048	0.692
MOD_GlcNHglycan	207	210	PF01048	0.649
MOD_GlcNHglycan	216	219	PF01048	0.514
MOD_GlcNHglycan	416	419	PF01048	0.617
MOD_GlcNHglycan	93	96	PF01048	0.325
MOD_GSK3_1	142	149	PF00069	0.642
MOD_GSK3_1	150	157	PF00069	0.648
MOD_GSK3_1	162	169	PF00069	0.394
MOD_GSK3_1	177	184	PF00069	0.409
MOD_GSK3_1	214	221	PF00069	0.610
MOD_GSK3_1	456	463	PF00069	0.630
MOD_GSK3_1	467	474	PF00069	0.442
MOD_GSK3_1	67	74	PF00069	0.330
MOD_LATS_1	363	369	PF00433	0.574
MOD_NEK2_1	1	6	PF00069	0.684
MOD_NEK2_1	111	116	PF00069	0.183
MOD_NEK2_1	128	133	PF00069	0.467
MOD_NEK2_1	181	186	PF00069	0.493
MOD_NEK2_1	200	205	PF00069	0.623
MOD_NEK2_1	288	293	PF00069	0.582
MOD_NEK2_1	425	430	PF00069	0.571
MOD_NEK2_1	449	454	PF00069	0.558
MOD_NEK2_1	91	96	PF00069	0.329
MOD_NEK2_2	170	175	PF00069	0.495
MOD_NEK2_2	270	275	PF00069	0.600
MOD_NEK2_2	391	396	PF00069	0.535
MOD_NEK2_2	405	410	PF00069	0.589
MOD_PKA_1	71	77	PF00069	0.331
MOD_PKA_2	270	276	PF00069	0.597
MOD_PKA_2	425	431	PF00069	0.571
MOD_PKA_2	71	77	PF00069	0.370
MOD_PKA_2	78	84	PF00069	0.453
MOD_Plk_1	218	224	PF00069	0.539
MOD_Plk_4	113	119	PF00069	0.297
MOD_Plk_4	123	129	PF00069	0.458
MOD_Plk_4	177	183	PF00069	0.525
MOD_Plk_4	356	362	PF00069	0.543
MOD_Plk_4	425	431	PF00069	0.576
MOD_Plk_4	461	467	PF00069	0.566
MOD_Plk_4	471	477	PF00069	0.414
MOD_ProDKin_1	151	157	PF00069	0.719
MOD_ProDKin_1	354	360	PF00069	0.578
MOD_ProDKin_1	430	436	PF00069	0.712
MOD_ProDKin_1	83	89	PF00069	0.321
MOD_SUMO_rev_2	384	390	PF00179	0.551
TRG_DiLeu_BaEn_1	370	375	PF01217	0.494
TRG_DiLeu_BaEn_1	506	511	PF01217	0.612
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.297
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.507
TRG_DiLeu_LyEn_5	506	511	PF01217	0.545
TRG_ENDOCYTIC_2	19	22	PF00928	0.411
TRG_ENDOCYTIC_2	303	306	PF00928	0.453
TRG_ENDOCYTIC_2	308	311	PF00928	0.507
TRG_ENDOCYTIC_2	404	407	PF00928	0.646
TRG_ENDOCYTIC_2	478	481	PF00928	0.438
TRG_ER_diArg_1	423	426	PF00400	0.551
TRG_Pf-PMV_PEXEL_1	501	506	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW11	Leptomonas seymouri	43%	100%
A4HPJ2	Leishmania braziliensis	77%	100%
A4ID71	Leishmania infantum	100%	100%
E9ATA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q193	Leishmania major	92%	100%