DNA damage-binding protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

bardet-biedl syndrome 7 protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IR58_LEIDO

TriTrypDb:

LdBPK_290740.1 , LdCL_290012100 , LDHU3_29.1010

Length:

855

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	1
GO:0020018	ciliary pocket membrane	6	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0032991	protein-containing complex	1	1
GO:0034464	BBSome	2	1
GO:0035869	ciliary transition zone	2	1
GO:0036064	ciliary basal body	3	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3Q8IR58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IR58

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006826	iron ion transport	8	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030001	metal ion transport	6	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0033036	macromolecule localization	2	1
GO:0033572	transferrin transport	5	1
GO:0044782	cilium organization	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0060271	cilium assembly	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070925	organelle assembly	5	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.459
CLV_C14_Caspase3-7	620	624	PF00656	0.603
CLV_NRD_NRD_1	108	110	PF00675	0.395
CLV_NRD_NRD_1	13	15	PF00675	0.473
CLV_NRD_NRD_1	148	150	PF00675	0.584
CLV_NRD_NRD_1	245	247	PF00675	0.453
CLV_NRD_NRD_1	403	405	PF00675	0.581
CLV_NRD_NRD_1	688	690	PF00675	0.559
CLV_PCSK_KEX2_1	13	15	PF00082	0.503
CLV_PCSK_KEX2_1	504	506	PF00082	0.460
CLV_PCSK_KEX2_1	57	59	PF00082	0.558
CLV_PCSK_KEX2_1	644	646	PF00082	0.402
CLV_PCSK_KEX2_1	688	690	PF00082	0.559
CLV_PCSK_KEX2_1	738	740	PF00082	0.530
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.523
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.496
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.558
CLV_PCSK_PC1ET2_1	644	646	PF00082	0.407
CLV_PCSK_PC1ET2_1	738	740	PF00082	0.530
CLV_PCSK_SKI1_1	112	116	PF00082	0.412
CLV_PCSK_SKI1_1	15	19	PF00082	0.451
CLV_PCSK_SKI1_1	223	227	PF00082	0.480
CLV_PCSK_SKI1_1	554	558	PF00082	0.503
CLV_PCSK_SKI1_1	602	606	PF00082	0.472
CLV_PCSK_SKI1_1	629	633	PF00082	0.406
CLV_PCSK_SKI1_1	84	88	PF00082	0.492
DEG_APCC_DBOX_1	579	587	PF00400	0.428
DEG_Nend_UBRbox_1	1	4	PF02207	0.614
DEG_ODPH_VHL_1	156	168	PF01847	0.489
DEG_SPOP_SBC_1	473	477	PF00917	0.730
DEG_SPOP_SBC_1	487	491	PF00917	0.529
DEG_SPOP_SBC_1	801	805	PF00917	0.577
DOC_CDC14_PxL_1	397	405	PF14671	0.628
DOC_CDC14_PxL_1	706	714	PF14671	0.485
DOC_CKS1_1	130	135	PF01111	0.361
DOC_CKS1_1	65	70	PF01111	0.473
DOC_CYCLIN_RxL_1	219	229	PF00134	0.494
DOC_MAPK_DCC_7	2	12	PF00069	0.532
DOC_MAPK_gen_1	35	43	PF00069	0.407
DOC_MAPK_gen_1	393	402	PF00069	0.415
DOC_MAPK_gen_1	57	65	PF00069	0.494
DOC_MAPK_gen_1	644	650	PF00069	0.436
DOC_MAPK_HePTP_8	402	414	PF00069	0.593
DOC_MAPK_MEF2A_6	160	168	PF00069	0.447
DOC_MAPK_MEF2A_6	405	414	PF00069	0.570
DOC_MAPK_MEF2A_6	501	510	PF00069	0.552
DOC_MAPK_MEF2A_6	57	65	PF00069	0.532
DOC_PP1_RVXF_1	148	155	PF00149	0.479
DOC_PP1_RVXF_1	221	227	PF00149	0.495
DOC_PP2B_LxvP_1	818	821	PF13499	0.556
DOC_PP4_FxxP_1	155	158	PF00568	0.513
DOC_PP4_FxxP_1	65	68	PF00568	0.443
DOC_USP7_MATH_1	439	443	PF00917	0.427
DOC_USP7_MATH_1	486	490	PF00917	0.606
DOC_USP7_MATH_1	633	637	PF00917	0.368
DOC_USP7_MATH_1	678	682	PF00917	0.515
DOC_USP7_MATH_1	800	804	PF00917	0.635
DOC_USP7_MATH_1	806	810	PF00917	0.574
DOC_USP7_MATH_1	838	842	PF00917	0.732
DOC_WW_Pin1_4	129	134	PF00397	0.371
DOC_WW_Pin1_4	422	427	PF00397	0.435
DOC_WW_Pin1_4	474	479	PF00397	0.750
DOC_WW_Pin1_4	494	499	PF00397	0.393
DOC_WW_Pin1_4	64	69	PF00397	0.457
LIG_14-3-3_CanoR_1	124	129	PF00244	0.459
LIG_14-3-3_CanoR_1	257	265	PF00244	0.466
LIG_14-3-3_CanoR_1	317	322	PF00244	0.460
LIG_14-3-3_CanoR_1	521	525	PF00244	0.544
LIG_Actin_WH2_2	181	198	PF00022	0.454
LIG_BRCT_BRCA1_1	261	265	PF00533	0.533
LIG_BRCT_BRCA1_1	414	418	PF00533	0.443
LIG_EH1_1	218	226	PF00400	0.386
LIG_FHA_1	120	126	PF00498	0.400
LIG_FHA_1	130	136	PF00498	0.347
LIG_FHA_1	212	218	PF00498	0.407
LIG_FHA_1	282	288	PF00498	0.408
LIG_FHA_1	392	398	PF00498	0.457
LIG_FHA_1	464	470	PF00498	0.545
LIG_FHA_1	482	488	PF00498	0.571
LIG_FHA_1	530	536	PF00498	0.435
LIG_FHA_1	571	577	PF00498	0.371
LIG_FHA_1	613	619	PF00498	0.459
LIG_FHA_1	802	808	PF00498	0.685
LIG_FHA_2	143	149	PF00498	0.476
LIG_FHA_2	297	303	PF00498	0.477
LIG_FHA_2	377	383	PF00498	0.576
LIG_FHA_2	423	429	PF00498	0.491
LIG_FHA_2	702	708	PF00498	0.592
LIG_FHA_2	788	794	PF00498	0.613
LIG_Integrin_RGD_1	355	357	PF01839	0.483
LIG_LIR_Gen_1	131	142	PF02991	0.424
LIG_LIR_Gen_1	215	226	PF02991	0.361
LIG_LIR_Gen_1	262	270	PF02991	0.537
LIG_LIR_Gen_1	747	756	PF02991	0.532
LIG_LIR_LC3C_4	434	437	PF02991	0.506
LIG_LIR_Nem_3	131	137	PF02991	0.461
LIG_LIR_Nem_3	215	221	PF02991	0.369
LIG_LIR_Nem_3	262	268	PF02991	0.531
LIG_LIR_Nem_3	47	53	PF02991	0.472
LIG_LIR_Nem_3	747	751	PF02991	0.474
LIG_LYPXL_S_1	676	680	PF13949	0.495
LIG_LYPXL_yS_3	677	680	PF13949	0.502
LIG_PCNA_yPIPBox_3	191	202	PF02747	0.468
LIG_Pex14_2	605	609	PF04695	0.437
LIG_SH2_CRK	218	222	PF00017	0.460
LIG_SH2_NCK_1	546	550	PF00017	0.388
LIG_SH2_PTP2	167	170	PF00017	0.453
LIG_SH2_PTP2	537	540	PF00017	0.502
LIG_SH2_PTP2	815	818	PF00017	0.640
LIG_SH2_SRC	280	283	PF00017	0.423
LIG_SH2_STAP1	525	529	PF00017	0.576
LIG_SH2_STAT3	227	230	PF00017	0.448
LIG_SH2_STAT3	525	528	PF00017	0.531
LIG_SH2_STAT5	167	170	PF00017	0.478
LIG_SH2_STAT5	184	187	PF00017	0.307
LIG_SH2_STAT5	537	540	PF00017	0.502
LIG_SH2_STAT5	736	739	PF00017	0.384
LIG_SH2_STAT5	750	753	PF00017	0.401
LIG_SH2_STAT5	815	818	PF00017	0.689
LIG_SH2_STAT5	98	101	PF00017	0.488
LIG_SH3_3	250	256	PF00018	0.553
LIG_SUMO_SIM_anti_2	566	573	PF11976	0.511
LIG_SUMO_SIM_par_1	410	415	PF11976	0.500
LIG_SUMO_SIM_par_1	566	573	PF11976	0.400
LIG_SUMO_SIM_par_1	612	617	PF11976	0.474
LIG_SUMO_SIM_par_1	636	642	PF11976	0.335
LIG_TRAF2_1	313	316	PF00917	0.314
LIG_TRAF2_1	719	722	PF00917	0.516
LIG_TRAF2_1	731	734	PF00917	0.520
LIG_TRAF2_1	790	793	PF00917	0.657
LIG_TRFH_1	154	158	PF08558	0.492
LIG_TYR_ITIM	216	221	PF00017	0.452
LIG_TYR_ITIM	535	540	PF00017	0.505
LIG_WRC_WIRS_1	337	342	PF05994	0.367
LIG_WRC_WIRS_1	571	576	PF05994	0.316
LIG_WRC_WIRS_1	745	750	PF05994	0.502
MOD_CDK_SPxxK_3	494	501	PF00069	0.532
MOD_CK1_1	34	40	PF00069	0.517
MOD_CK1_1	477	483	PF00069	0.742
MOD_CK1_1	489	495	PF00069	0.442
MOD_CK1_1	555	561	PF00069	0.515
MOD_CK1_1	607	613	PF00069	0.439
MOD_CK1_1	636	642	PF00069	0.373
MOD_CK1_1	681	687	PF00069	0.522
MOD_CK1_1	849	855	PF00069	0.718
MOD_CK2_1	142	148	PF00069	0.465
MOD_CK2_1	310	316	PF00069	0.450
MOD_CK2_1	376	382	PF00069	0.564
MOD_CK2_1	422	428	PF00069	0.512
MOD_CK2_1	656	662	PF00069	0.489
MOD_CK2_1	716	722	PF00069	0.474
MOD_CK2_1	74	80	PF00069	0.649
MOD_CK2_1	787	793	PF00069	0.616
MOD_Cter_Amidation	55	58	PF01082	0.526
MOD_GlcNHglycan	170	173	PF01048	0.432
MOD_GlcNHglycan	2	5	PF01048	0.727
MOD_GlcNHglycan	21	24	PF01048	0.308
MOD_GlcNHglycan	230	233	PF01048	0.385
MOD_GlcNHglycan	340	343	PF01048	0.360
MOD_GlcNHglycan	414	417	PF01048	0.555
MOD_GlcNHglycan	437	440	PF01048	0.505
MOD_GlcNHglycan	481	484	PF01048	0.718
MOD_GlcNHglycan	525	528	PF01048	0.529
MOD_GlcNHglycan	557	560	PF01048	0.538
MOD_GlcNHglycan	609	612	PF01048	0.312
MOD_GlcNHglycan	718	721	PF01048	0.537
MOD_GlcNHglycan	76	79	PF01048	0.665
MOD_GlcNHglycan	849	852	PF01048	0.532
MOD_GSK3_1	15	22	PF00069	0.392
MOD_GSK3_1	226	233	PF00069	0.382
MOD_GSK3_1	290	297	PF00069	0.501
MOD_GSK3_1	391	398	PF00069	0.543
MOD_GSK3_1	418	425	PF00069	0.438
MOD_GSK3_1	431	438	PF00069	0.476
MOD_GSK3_1	452	459	PF00069	0.479
MOD_GSK3_1	472	479	PF00069	0.421
MOD_GSK3_1	488	495	PF00069	0.402
MOD_GSK3_1	516	523	PF00069	0.458
MOD_GSK3_1	548	555	PF00069	0.544
MOD_GSK3_1	603	610	PF00069	0.345
MOD_GSK3_1	67	74	PF00069	0.563
MOD_GSK3_1	678	685	PF00069	0.504
MOD_GSK3_1	767	774	PF00069	0.469
MOD_GSK3_1	802	809	PF00069	0.652
MOD_GSK3_1	838	845	PF00069	0.711
MOD_GSK3_1	847	854	PF00069	0.568
MOD_N-GLC_1	119	124	PF02516	0.405
MOD_N-GLC_1	241	246	PF02516	0.333
MOD_N-GLC_1	656	661	PF02516	0.504
MOD_NEK2_1	141	146	PF00069	0.371
MOD_NEK2_1	226	231	PF00069	0.480
MOD_NEK2_1	292	297	PF00069	0.521
MOD_NEK2_1	336	341	PF00069	0.366
MOD_NEK2_1	412	417	PF00069	0.489
MOD_NEK2_1	418	423	PF00069	0.409
MOD_NEK2_1	520	525	PF00069	0.423
MOD_NEK2_1	603	608	PF00069	0.446
MOD_NEK2_1	609	614	PF00069	0.414
MOD_NEK2_1	656	661	PF00069	0.446
MOD_NEK2_1	665	670	PF00069	0.407
MOD_NEK2_1	679	684	PF00069	0.428
MOD_NEK2_1	744	749	PF00069	0.375
MOD_NEK2_1	802	807	PF00069	0.633
MOD_NEK2_2	8	13	PF00069	0.549
MOD_NEK2_2	806	811	PF00069	0.589
MOD_PIKK_1	226	232	PF00454	0.424
MOD_PIKK_1	355	361	PF00454	0.601
MOD_PIKK_1	376	382	PF00454	0.564
MOD_PIKK_1	477	483	PF00454	0.678
MOD_PIKK_1	683	689	PF00454	0.535
MOD_PK_1	294	300	PF00069	0.503
MOD_PK_1	317	323	PF00069	0.477
MOD_PK_1	51	57	PF00069	0.483
MOD_PK_1	548	554	PF00069	0.500
MOD_PKA_2	256	262	PF00069	0.562
MOD_PKA_2	500	506	PF00069	0.532
MOD_PKA_2	520	526	PF00069	0.501
MOD_PKA_2	607	613	PF00069	0.479
MOD_PKB_1	393	401	PF00069	0.624
MOD_Plk_1	439	445	PF00069	0.431
MOD_Plk_1	459	465	PF00069	0.232
MOD_Plk_1	552	558	PF00069	0.606
MOD_Plk_1	787	793	PF00069	0.559
MOD_Plk_4	212	218	PF00069	0.388
MOD_Plk_4	304	310	PF00069	0.405
MOD_Plk_4	431	437	PF00069	0.469
MOD_Plk_4	452	458	PF00069	0.487
MOD_Plk_4	520	526	PF00069	0.470
MOD_Plk_4	552	558	PF00069	0.619
MOD_Plk_4	609	615	PF00069	0.398
MOD_Plk_4	633	639	PF00069	0.387
MOD_Plk_4	665	671	PF00069	0.407
MOD_Plk_4	87	93	PF00069	0.381
MOD_Plk_4	99	105	PF00069	0.352
MOD_ProDKin_1	129	135	PF00069	0.366
MOD_ProDKin_1	422	428	PF00069	0.441
MOD_ProDKin_1	474	480	PF00069	0.749
MOD_ProDKin_1	494	500	PF00069	0.399
MOD_ProDKin_1	64	70	PF00069	0.468
MOD_SUMO_rev_2	147	152	PF00179	0.557
MOD_SUMO_rev_2	76	86	PF00179	0.660
TRG_DiLeu_BaEn_2	150	156	PF01217	0.543
TRG_DiLeu_BaEn_3	598	604	PF01217	0.493
TRG_DiLeu_BaEn_4	407	413	PF01217	0.556
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.481
TRG_DiLeu_BaLyEn_6	564	569	PF01217	0.512
TRG_ENDOCYTIC_2	218	221	PF00928	0.486
TRG_ENDOCYTIC_2	537	540	PF00928	0.443
TRG_ENDOCYTIC_2	546	549	PF00928	0.340
TRG_ENDOCYTIC_2	677	680	PF00928	0.502
TRG_ENDOCYTIC_2	745	748	PF00928	0.406
TRG_ENDOCYTIC_2	815	818	PF00928	0.640
TRG_ER_diArg_1	688	690	PF00400	0.559
TRG_NES_CRM1_1	585	599	PF08389	0.369
TRG_NLS_MonoExtC_3	108	113	PF00514	0.435
TRG_NLS_MonoExtN_4	32	39	PF00514	0.436
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	387	392	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	645	649	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7W9	Leptomonas seymouri	62%	100%
A0A1X0NZL6	Trypanosomatidae	36%	100%
A0A422NRV6	Trypanosoma rangeli	35%	100%
A4HH78	Leishmania braziliensis	81%	100%
A4I4C4	Leishmania infantum	100%	100%
C9ZL44	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ADS3	Leishmania major	94%	100%
E9AM07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q8IWZ6	Homo sapiens	23%	100%
Q8K2G4	Mus musculus	24%	100%
V5BKF4	Trypanosoma cruzi	34%	100%