Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IR44_LEIDO

TriTrypDb:

LdBPK_290530.1 , LdCL_290010100 , LDHU3_29.0760

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IR44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IR44

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.647
CLV_C14_Caspase3-7	74	78	PF00656	0.712
CLV_NRD_NRD_1	184	186	PF00675	0.724
CLV_NRD_NRD_1	62	64	PF00675	0.744
CLV_NRD_NRD_1	66	68	PF00675	0.711
CLV_PCSK_KEX2_1	184	186	PF00082	0.724
CLV_PCSK_KEX2_1	62	64	PF00082	0.744
CLV_PCSK_SKI1_1	226	230	PF00082	0.774
DEG_Nend_UBRbox_3	1	3	PF02207	0.836
DEG_SPOP_SBC_1	217	221	PF00917	0.783
DOC_CDC14_PxL_1	137	145	PF14671	0.743
DOC_CDC14_PxL_1	30	38	PF14671	0.789
DOC_CKS1_1	199	204	PF01111	0.624
DOC_CYCLIN_RxL_1	223	232	PF00134	0.773
DOC_CYCLIN_yCln2_LP_2	111	117	PF00134	0.736
DOC_PP2B_LxvP_1	111	114	PF13499	0.744
DOC_USP7_MATH_1	167	171	PF00917	0.799
DOC_USP7_MATH_1	18	22	PF00917	0.772
DOC_USP7_MATH_1	212	216	PF00917	0.783
DOC_USP7_MATH_1	217	221	PF00917	0.720
DOC_WW_Pin1_4	198	203	PF00397	0.640
LIG_14-3-3_CanoR_1	44	48	PF00244	0.656
LIG_14-3-3_CanoR_1	71	79	PF00244	0.654
LIG_BIR_III_2	24	28	PF00653	0.648
LIG_BIR_III_4	75	79	PF00653	0.595
LIG_BRCT_BRCA1_1	220	224	PF00533	0.767
LIG_Clathr_ClatBox_1	116	120	PF01394	0.725
LIG_Clathr_ClatBox_1	85	89	PF01394	0.650
LIG_eIF4E_1	145	151	PF01652	0.754
LIG_EVH1_1	208	212	PF00568	0.670
LIG_EVH1_2	34	38	PF00568	0.785
LIG_FHA_1	177	183	PF00498	0.779
LIG_FHA_1	220	226	PF00498	0.681
LIG_FHA_1	92	98	PF00498	0.770
LIG_LIR_Gen_1	15	25	PF02991	0.724
LIG_LIR_Gen_1	204	213	PF02991	0.665
LIG_LIR_Nem_3	15	20	PF02991	0.734
LIG_LIR_Nem_3	204	208	PF02991	0.662
LIG_LIR_Nem_3	32	36	PF02991	0.582
LIG_LYPXL_yS_3	33	36	PF13949	0.794
LIG_SH2_SRC	155	158	PF00017	0.668
LIG_SH2_STAT5	155	158	PF00017	0.652
LIG_SH2_STAT5	163	166	PF00017	0.565
LIG_SH3_3	161	167	PF00018	0.764
LIG_SH3_3	180	186	PF00018	0.758
LIG_SH3_3	188	194	PF00018	0.674
LIG_SH3_3	196	202	PF00018	0.726
LIG_SH3_3	206	212	PF00018	0.637
LIG_SH3_3	76	82	PF00018	0.604
LIG_SUMO_SIM_par_1	89	98	PF11976	0.713
LIG_TYR_ITIM	31	36	PF00017	0.791
LIG_UBA3_1	115	124	PF00899	0.616
LIG_WRC_WIRS_1	13	18	PF05994	0.539
MOD_CK1_1	12	18	PF00069	0.655
MOD_CK1_1	219	225	PF00069	0.731
MOD_CK1_1	43	49	PF00069	0.704
MOD_CK1_1	93	99	PF00069	0.652
MOD_CK2_1	171	177	PF00069	0.822
MOD_Cter_Amidation	60	63	PF01082	0.696
MOD_Cter_Amidation	65	68	PF01082	0.661
MOD_GlcNHglycan	158	161	PF01048	0.720
MOD_GlcNHglycan	174	177	PF01048	0.639
MOD_GSK3_1	167	174	PF00069	0.768
MOD_GSK3_1	212	219	PF00069	0.800
MOD_GSK3_1	39	46	PF00069	0.628
MOD_GSK3_1	66	73	PF00069	0.841
MOD_GSK3_1	8	15	PF00069	0.612
MOD_GSK3_1	89	96	PF00069	0.688
MOD_NEK2_1	218	223	PF00069	0.715
MOD_PIKK_1	66	72	PF00454	0.842
MOD_PKA_2	43	49	PF00069	0.654
MOD_PKA_2	66	72	PF00069	0.757
MOD_Plk_1	18	24	PF00069	0.773
MOD_Plk_1	40	46	PF00069	0.703
MOD_Plk_1	90	96	PF00069	0.742
MOD_Plk_4	9	15	PF00069	0.721
MOD_ProDKin_1	198	204	PF00069	0.637
TRG_DiLeu_BaEn_1	146	151	PF01217	0.706
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.738
TRG_ENDOCYTIC_2	33	36	PF00928	0.753
TRG_ER_diArg_1	183	185	PF00400	0.729

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HH53	Leishmania braziliensis	65%	95%
A4I4A4	Leishmania infantum	98%	100%
E9ADQ3	Leishmania major	85%	97%
E9AM27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%