Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IR30_LEIDO

TriTrypDb:

LdBPK_290370.1 , LdCL_290008500 , LDHU3_29.0500

Length:

174

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IR30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IR30

PDB structure(s): 7aih_Ay , 7ane_Ay

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.474
CLV_NRD_NRD_1	29	31	PF00675	0.518
CLV_NRD_NRD_1	38	40	PF00675	0.550
CLV_PCSK_KEX2_1	133	135	PF00082	0.474
CLV_PCSK_KEX2_1	38	40	PF00082	0.550
CLV_PCSK_SKI1_1	137	141	PF00082	0.616
CLV_PCSK_SKI1_1	6	10	PF00082	0.588
DEG_APCC_DBOX_1	5	13	PF00400	0.609
DEG_Nend_Nbox_1	1	3	PF02207	0.592
DOC_CYCLIN_RxL_1	3	13	PF00134	0.585
DOC_PP1_RVXF_1	82	88	PF00149	0.473
DOC_USP7_MATH_1	20	24	PF00917	0.539
DOC_WW_Pin1_4	141	146	PF00397	0.459
DOC_WW_Pin1_4	168	173	PF00397	0.478
LIG_14-3-3_CanoR_1	137	142	PF00244	0.511
LIG_14-3-3_CanoR_1	3	9	PF00244	0.697
LIG_14-3-3_CanoR_1	38	44	PF00244	0.660
LIG_DCNL_PONY_1	1	4	PF03556	0.712
LIG_deltaCOP1_diTrp_1	108	113	PF00928	0.437
LIG_deltaCOP1_diTrp_1	165	174	PF00928	0.498
LIG_deltaCOP1_diTrp_1	49	53	PF00928	0.501
LIG_FHA_1	17	23	PF00498	0.647
LIG_FHA_2	126	132	PF00498	0.586
LIG_FHA_2	138	144	PF00498	0.518
LIG_LIR_Apic_2	144	150	PF02991	0.572
LIG_LIR_Gen_1	108	118	PF02991	0.472
LIG_LIR_Nem_3	108	113	PF02991	0.434
LIG_SH2_STAT5	102	105	PF00017	0.518
LIG_SH2_STAT5	52	55	PF00017	0.601
LIG_SH3_3	157	163	PF00018	0.558
LIG_SH3_3	166	172	PF00018	0.393
LIG_UBA3_1	26	34	PF00899	0.517
LIG_ULM_U2AF65_1	30	36	PF00076	0.523
MOD_CDK_SPK_2	168	173	PF00069	0.491
MOD_CK2_1	125	131	PF00069	0.548
MOD_CK2_1	137	143	PF00069	0.492
MOD_GlcNHglycan	22	25	PF01048	0.527
MOD_GSK3_1	10	17	PF00069	0.582
MOD_GSK3_1	137	144	PF00069	0.569
MOD_N-GLC_1	15	20	PF02516	0.560
MOD_PKA_1	30	36	PF00069	0.542
MOD_PKA_1	38	44	PF00069	0.568
MOD_PKA_2	37	43	PF00069	0.551
MOD_PKB_1	28	36	PF00069	0.540
MOD_Plk_1	10	16	PF00069	0.607
MOD_ProDKin_1	141	147	PF00069	0.461
MOD_ProDKin_1	168	174	PF00069	0.483
MOD_SUMO_for_1	156	159	PF00179	0.559
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.557
TRG_ER_diArg_1	133	135	PF00400	0.493
TRG_ER_diArg_1	27	30	PF00400	0.536
TRG_ER_diArg_1	84	87	PF00400	0.422
TRG_NLS_MonoExtC_3	29	34	PF00514	0.518
TRG_NLS_MonoExtN_4	28	35	PF00514	0.521
TRG_Pf-PMV_PEXEL_1	6	11	PF00026	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F9	Leptomonas seymouri	86%	100%
A0A0S4KP62	Bodo saltans	59%	100%
A0A1X0P0Z3	Trypanosomatidae	63%	100%
A0A422NUJ5	Trypanosoma rangeli	75%	100%
A4HH37	Leishmania braziliensis	94%	100%
A4I488	Leishmania infantum	100%	100%
C9ZKP2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9ADN7	Leishmania major	98%	100%
E9AM43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%