Membrane-bound acid phosphatase 2, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

membrane-bound acid phosphatase 2, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IR23_LEIDO

TriTrypDb:

LdBPK_362720.1 , LdCL_360033600 , LDHU3_36.3750

Length:

571

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 65

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 43, no: 4
NetGPI	no	yes: 0, no: 47

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	35
GO:0110165	cellular anatomical entity	1	35

Expansion

Sequence features

A0A3Q8IR23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IR23

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016311	dephosphorylation	5	5
GO:0044237	cellular metabolic process	2	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0003993	acid phosphatase activity	6	3
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0016791	phosphatase activity	5	8
GO:0042578	phosphoric ester hydrolase activity	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	484	488	PF00656	0.601
CLV_C14_Caspase3-7	497	501	PF00656	0.368
CLV_NRD_NRD_1	537	539	PF00675	0.411
CLV_PCSK_KEX2_1	251	253	PF00082	0.567
CLV_PCSK_KEX2_1	397	399	PF00082	0.563
CLV_PCSK_KEX2_1	535	537	PF00082	0.405
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.391
CLV_PCSK_PC1ET2_1	397	399	PF00082	0.545
CLV_PCSK_PC1ET2_1	535	537	PF00082	0.458
CLV_PCSK_SKI1_1	137	141	PF00082	0.508
CLV_PCSK_SKI1_1	177	181	PF00082	0.544
CLV_PCSK_SKI1_1	222	226	PF00082	0.517
CLV_PCSK_SKI1_1	251	255	PF00082	0.515
CLV_PCSK_SKI1_1	398	402	PF00082	0.605
CLV_PCSK_SKI1_1	565	569	PF00082	0.578
DOC_CDC14_PxL_1	237	245	PF14671	0.383
DOC_CKS1_1	431	436	PF01111	0.329
DOC_CYCLIN_RxL_1	217	226	PF00134	0.357
DOC_MAPK_gen_1	249	258	PF00069	0.303
DOC_MAPK_gen_1	535	544	PF00069	0.647
DOC_MAPK_MEF2A_6	537	546	PF00069	0.682
DOC_PP1_RVXF_1	396	403	PF00149	0.406
DOC_PP1_RVXF_1	4	10	PF00149	0.673
DOC_PP4_FxxP_1	108	111	PF00568	0.297
DOC_PP4_MxPP_1	326	329	PF00568	0.354
DOC_USP7_MATH_1	141	145	PF00917	0.312
DOC_USP7_MATH_1	510	514	PF00917	0.393
DOC_USP7_UBL2_3	397	401	PF12436	0.243
DOC_WW_Pin1_4	102	107	PF00397	0.332
DOC_WW_Pin1_4	319	324	PF00397	0.275
DOC_WW_Pin1_4	356	361	PF00397	0.354
DOC_WW_Pin1_4	430	435	PF00397	0.401
DOC_WW_Pin1_4	69	74	PF00397	0.395
LIG_14-3-3_CanoR_1	121	129	PF00244	0.308
LIG_14-3-3_CanoR_1	252	257	PF00244	0.264
LIG_14-3-3_CanoR_1	444	453	PF00244	0.315
LIG_14-3-3_CanoR_1	545	551	PF00244	0.691
LIG_14-3-3_CanoR_1	6	16	PF00244	0.425
LIG_14-3-3_CanoR_1	95	100	PF00244	0.347
LIG_APCC_ABBA_1	390	395	PF00400	0.335
LIG_BIR_II_1	1	5	PF00653	0.641
LIG_BIR_III_4	378	382	PF00653	0.430
LIG_BIR_III_4	407	411	PF00653	0.366
LIG_BRCT_BRCA1_1	104	108	PF00533	0.342
LIG_deltaCOP1_diTrp_1	365	372	PF00928	0.308
LIG_FHA_1	121	127	PF00498	0.316
LIG_FHA_1	155	161	PF00498	0.278
LIG_FHA_1	186	192	PF00498	0.280
LIG_FHA_1	252	258	PF00498	0.340
LIG_FHA_1	296	302	PF00498	0.282
LIG_FHA_1	434	440	PF00498	0.478
LIG_FHA_1	526	532	PF00498	0.469
LIG_FHA_1	547	553	PF00498	0.668
LIG_FHA_1	8	14	PF00498	0.520
LIG_FHA_2	150	156	PF00498	0.324
LIG_FHA_2	214	220	PF00498	0.317
LIG_FHA_2	221	227	PF00498	0.305
LIG_FHA_2	315	321	PF00498	0.315
LIG_FHA_2	360	366	PF00498	0.459
LIG_FHA_2	495	501	PF00498	0.570
LIG_LIR_Apic_2	105	111	PF02991	0.298
LIG_LIR_Gen_1	144	154	PF02991	0.334
LIG_LIR_Gen_1	165	173	PF02991	0.346
LIG_LIR_Gen_1	194	203	PF02991	0.356
LIG_LIR_Gen_1	244	253	PF02991	0.296
LIG_LIR_Nem_3	144	150	PF02991	0.292
LIG_LIR_Nem_3	165	171	PF02991	0.304
LIG_LIR_Nem_3	194	198	PF02991	0.351
LIG_LIR_Nem_3	244	250	PF02991	0.307
LIG_LIR_Nem_3	395	399	PF02991	0.305
LIG_LIR_Nem_3	78	82	PF02991	0.381
LIG_LYPXL_yS_3	240	243	PF13949	0.387
LIG_PDZ_Class_3	566	571	PF00595	0.781
LIG_Pex14_1	168	172	PF04695	0.341
LIG_Pex14_2	135	139	PF04695	0.370
LIG_Pex14_2	364	368	PF04695	0.429
LIG_Rb_pABgroove_1	219	227	PF01858	0.369
LIG_SH2_CRK	147	151	PF00017	0.345
LIG_SH2_CRK	431	435	PF00017	0.458
LIG_SH2_GRB2like	173	176	PF00017	0.354
LIG_SH2_PTP2	348	351	PF00017	0.361
LIG_SH2_SRC	206	209	PF00017	0.201
LIG_SH2_SRC	260	263	PF00017	0.356
LIG_SH2_STAP1	113	117	PF00017	0.295
LIG_SH2_STAP1	260	264	PF00017	0.308
LIG_SH2_STAT3	413	416	PF00017	0.241
LIG_SH2_STAT5	210	213	PF00017	0.335
LIG_SH2_STAT5	348	351	PF00017	0.302
LIG_SH2_STAT5	411	414	PF00017	0.330
LIG_SH2_STAT5	543	546	PF00017	0.632
LIG_SH2_STAT5	76	79	PF00017	0.306
LIG_SH3_3	100	106	PF00018	0.343
LIG_SH3_3	180	186	PF00018	0.318
LIG_SH3_3	422	428	PF00018	0.391
LIG_TRAF2_1	480	483	PF00917	0.381
LIG_TRAF2_2	356	361	PF00917	0.399
LIG_UBA3_1	224	232	PF00899	0.379
LIG_WRC_WIRS_1	514	519	PF05994	0.393
MOD_CDK_SPxxK_3	356	363	PF00069	0.392
MOD_CK1_1	101	107	PF00069	0.357
MOD_CK1_1	120	126	PF00069	0.327
MOD_CK1_1	359	365	PF00069	0.412
MOD_CK1_1	471	477	PF00069	0.436
MOD_CK1_1	513	519	PF00069	0.485
MOD_CK2_1	149	155	PF00069	0.348
MOD_CK2_1	209	215	PF00069	0.392
MOD_CK2_1	359	365	PF00069	0.418
MOD_CK2_1	545	551	PF00069	0.696
MOD_GlcNHglycan	130	133	PF01048	0.495
MOD_GlcNHglycan	304	307	PF01048	0.518
MOD_GlcNHglycan	447	450	PF01048	0.565
MOD_GlcNHglycan	482	487	PF01048	0.715
MOD_GlcNHglycan	504	507	PF01048	0.713
MOD_GlcNHglycan	57	60	PF01048	0.575
MOD_GSK3_1	149	156	PF00069	0.296
MOD_GSK3_1	209	216	PF00069	0.320
MOD_GSK3_1	302	309	PF00069	0.295
MOD_GSK3_1	494	501	PF00069	0.581
MOD_GSK3_1	63	70	PF00069	0.396
MOD_GSK3_1	91	98	PF00069	0.339
MOD_N-GLC_1	141	146	PF02516	0.507
MOD_N-GLC_1	264	269	PF02516	0.510
MOD_N-GLC_1	63	68	PF02516	0.591
MOD_N-GLC_2	389	391	PF02516	0.544
MOD_NEK2_1	160	165	PF00069	0.341
MOD_NEK2_1	171	176	PF00069	0.340
MOD_NEK2_1	302	307	PF00069	0.335
MOD_NEK2_1	445	450	PF00069	0.379
MOD_NEK2_1	498	503	PF00069	0.533
MOD_NEK2_1	7	12	PF00069	0.461
MOD_NEK2_1	91	96	PF00069	0.316
MOD_NEK2_2	220	225	PF00069	0.353
MOD_OFUCOSY	468	475	PF10250	0.629
MOD_PIKK_1	162	168	PF00454	0.366
MOD_PKA_1	251	257	PF00069	0.191
MOD_PKA_1	494	500	PF00069	0.398
MOD_PKA_2	120	126	PF00069	0.316
MOD_PKA_2	251	257	PF00069	0.334
MOD_PKA_2	498	504	PF00069	0.548
MOD_PKA_2	544	550	PF00069	0.648
MOD_PKB_1	93	101	PF00069	0.383
MOD_Plk_1	141	147	PF00069	0.357
MOD_Plk_1	307	313	PF00069	0.300
MOD_Plk_2-3	415	421	PF00069	0.250
MOD_Plk_4	142	148	PF00069	0.325
MOD_Plk_4	252	258	PF00069	0.284
MOD_Plk_4	98	104	PF00069	0.322
MOD_ProDKin_1	102	108	PF00069	0.332
MOD_ProDKin_1	319	325	PF00069	0.275
MOD_ProDKin_1	356	362	PF00069	0.356
MOD_ProDKin_1	430	436	PF00069	0.403
MOD_ProDKin_1	69	75	PF00069	0.389
MOD_SUMO_rev_2	359	364	PF00179	0.272
MOD_SUMO_rev_2	487	497	PF00179	0.404
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.300
TRG_ENDOCYTIC_2	147	150	PF00928	0.321
TRG_ENDOCYTIC_2	240	243	PF00928	0.351
TRG_ENDOCYTIC_2	299	302	PF00928	0.352
TRG_ENDOCYTIC_2	348	351	PF00928	0.343
TRG_ENDOCYTIC_2	411	414	PF00928	0.339
TRG_ENDOCYTIC_2	543	546	PF00928	0.700
TRG_ER_diArg_1	536	538	PF00400	0.582
TRG_ER_diArg_1	92	95	PF00400	0.345
TRG_NES_CRM1_1	324	337	PF08389	0.369
TRG_NLS_MonoCore_2	534	539	PF00514	0.485
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y5	Leptomonas seymouri	63%	100%
A0A0N1I756	Leptomonas seymouri	40%	100%
A0A0N1PEH4	Leptomonas seymouri	38%	100%
A0A0S4IRF5	Bodo saltans	23%	85%
A0A0S4IV77	Bodo saltans	36%	100%
A0A0S4JEA9	Bodo saltans	27%	100%
A0A0S4JJK3	Bodo saltans	25%	100%
A0A0S4JW09	Bodo saltans	30%	100%
A0A1X0NNY4	Trypanosomatidae	34%	100%
A0A1X0NQL4	Trypanosomatidae	30%	100%
A0A1X0NY34	Trypanosomatidae	24%	100%
A0A1X0P7V5	Trypanosomatidae	46%	100%
A0A3R7KSH4	Trypanosoma rangeli	25%	100%
A0A3R7MEN7	Trypanosoma rangeli	42%	100%
A0A3R7MHJ7	Trypanosoma rangeli	30%	100%
A0A3S5H827	Leishmania donovani	38%	100%
A0A3S7WXU0	Leishmania donovani	51%	100%
A0A3S7X1W4	Leishmania donovani	46%	100%
A4HCZ0	Leishmania braziliensis	50%	100%
A4HGW8	Leishmania braziliensis	46%	100%
A4HPC1	Leishmania braziliensis	40%	100%
A4HPC5	Leishmania braziliensis	80%	100%
A4HQG6	Leishmania braziliensis	37%	100%
A4HQG9	Leishmania braziliensis	36%	100%
A4I0H5	Leishmania infantum	50%	100%
A4I3Z8	Leishmania infantum	47%	100%
A4ICA5	Leishmania infantum	36%	100%
A4ICG3	Leishmania infantum	38%	100%
A4ICG5	Leishmania infantum	100%	100%
D0A3E0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D0A947	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A948	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A9J5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AT34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AT36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AWD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9B088	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
Q4Q0A9	Leishmania major	27%	91%
Q4Q1G2	Leishmania major	94%	100%
Q4Q1G4	Leishmania major	39%	100%
Q4Q7Z7	Leishmania major	47%	100%
Q4QB35	Leishmania major	50%	100%
V5BCI2	Trypanosoma cruzi	26%	100%
V5BIM1	Trypanosoma cruzi	24%	100%
V5BK91	Trypanosoma cruzi	41%	100%
V5BL75	Trypanosoma cruzi	30%	100%