Short-chain dehydrogenase, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IQZ6_LEIDO

TriTrypDb:

LdBPK_362470.1 , LdCL_360030400 , LDHU3_36.3290

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IQZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IQZ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	336	340	PF00656	0.648
CLV_NRD_NRD_1	192	194	PF00675	0.370
CLV_NRD_NRD_1	266	268	PF00675	0.444
CLV_NRD_NRD_1	44	46	PF00675	0.361
CLV_PCSK_FUR_1	264	268	PF00082	0.460
CLV_PCSK_KEX2_1	141	143	PF00082	0.370
CLV_PCSK_KEX2_1	192	194	PF00082	0.358
CLV_PCSK_KEX2_1	266	268	PF00082	0.485
CLV_PCSK_KEX2_1	347	349	PF00082	0.425
CLV_PCSK_KEX2_1	44	46	PF00082	0.370
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.369
CLV_PCSK_PC1ET2_1	347	349	PF00082	0.433
CLV_PCSK_SKI1_1	119	123	PF00082	0.268
CLV_PCSK_SKI1_1	167	171	PF00082	0.289
DEG_APCC_DBOX_1	166	174	PF00400	0.475
DEG_APCC_DBOX_1	272	280	PF00400	0.566
DEG_Nend_Nbox_1	1	3	PF02207	0.347
DEG_SCF_FBW7_1	309	315	PF00400	0.717
DOC_CKS1_1	309	314	PF01111	0.750
DOC_CKS1_1	401	406	PF01111	0.518
DOC_CYCLIN_yClb5_NLxxxL_5	154	163	PF00134	0.539
DOC_CYCLIN_yCln2_LP_2	124	130	PF00134	0.511
DOC_CYCLIN_yCln2_LP_2	159	165	PF00134	0.539
DOC_MAPK_gen_1	270	279	PF00069	0.597
DOC_MAPK_gen_1	44	50	PF00069	0.576
DOC_MAPK_gen_1	76	86	PF00069	0.514
DOC_MAPK_MEF2A_6	167	174	PF00069	0.569
DOC_MAPK_NFAT4_5	167	175	PF00069	0.569
DOC_PP1_RVXF_1	393	400	PF00149	0.458
DOC_PP1_RVXF_1	54	61	PF00149	0.519
DOC_USP7_MATH_1	147	151	PF00917	0.502
DOC_USP7_MATH_1	176	180	PF00917	0.513
DOC_USP7_MATH_1	260	264	PF00917	0.728
DOC_USP7_MATH_1	312	316	PF00917	0.750
DOC_USP7_MATH_1	95	99	PF00917	0.691
DOC_WW_Pin1_4	158	163	PF00397	0.569
DOC_WW_Pin1_4	294	299	PF00397	0.680
DOC_WW_Pin1_4	305	310	PF00397	0.696
DOC_WW_Pin1_4	315	320	PF00397	0.689
DOC_WW_Pin1_4	400	405	PF00397	0.474
LIG_14-3-3_CanoR_1	273	277	PF00244	0.539
LIG_14-3-3_CanoR_1	330	337	PF00244	0.695
LIG_Actin_WH2_2	63	78	PF00022	0.622
LIG_BRCT_BRCA1_1	100	104	PF00533	0.526
LIG_DCNL_PONY_1	1	4	PF03556	0.379
LIG_FHA_1	155	161	PF00498	0.521
LIG_FHA_1	272	278	PF00498	0.565
LIG_FHA_1	30	36	PF00498	0.499
LIG_FHA_1	340	346	PF00498	0.648
LIG_FHA_1	376	382	PF00498	0.417
LIG_FHA_2	334	340	PF00498	0.684
LIG_Integrin_RGD_1	193	195	PF01839	0.313
LIG_LIR_Apic_2	281	287	PF02991	0.689
LIG_LIR_Gen_1	101	111	PF02991	0.569
LIG_LIR_Gen_1	195	203	PF02991	0.526
LIG_LIR_Gen_1	61	70	PF02991	0.574
LIG_LIR_Nem_3	19	23	PF02991	0.490
LIG_LIR_Nem_3	195	199	PF02991	0.526
LIG_LIR_Nem_3	221	226	PF02991	0.468
LIG_LIR_Nem_3	61	65	PF02991	0.578
LIG_LYPXL_S_1	381	385	PF13949	0.463
LIG_LYPXL_yS_3	382	385	PF13949	0.463
LIG_PTB_Apo_2	212	219	PF02174	0.416
LIG_PTB_Phospho_1	212	218	PF10480	0.416
LIG_SH2_CRK	196	200	PF00017	0.539
LIG_SH2_CRK	284	288	PF00017	0.686
LIG_SH2_CRK	62	66	PF00017	0.596
LIG_SH2_GRB2like	243	246	PF00017	0.529
LIG_SH2_STAP1	196	200	PF00017	0.539
LIG_SH2_STAP1	209	213	PF00017	0.539
LIG_SH2_STAP1	341	345	PF00017	0.634
LIG_SH2_STAP1	372	376	PF00017	0.497
LIG_SH2_STAT5	209	212	PF00017	0.529
LIG_SH2_STAT5	341	344	PF00017	0.616
LIG_SH2_STAT5	370	373	PF00017	0.592
LIG_SH3_3	295	301	PF00018	0.756
LIG_SH3_3	306	312	PF00018	0.717
LIG_SH3_3	377	383	PF00018	0.432
LIG_SUMO_SIM_anti_2	161	167	PF11976	0.569
LIG_SUMO_SIM_par_1	170	175	PF11976	0.569
LIG_SUMO_SIM_par_1	198	204	PF11976	0.513
LIG_SUMO_SIM_par_1	31	36	PF11976	0.508
LIG_TYR_ITIM	380	385	PF00017	0.443
LIG_WRC_WIRS_1	17	22	PF05994	0.392
MOD_CK1_1	16	22	PF00069	0.373
MOD_CK1_1	177	183	PF00069	0.384
MOD_CK1_1	246	252	PF00069	0.699
MOD_CK1_1	29	35	PF00069	0.442
MOD_CK1_1	292	298	PF00069	0.635
MOD_CK1_1	308	314	PF00069	0.709
MOD_CK1_1	315	321	PF00069	0.760
MOD_CK1_1	326	332	PF00069	0.611
MOD_CK1_1	333	339	PF00069	0.576
MOD_CK1_1	98	104	PF00069	0.503
MOD_CK2_1	228	234	PF00069	0.463
MOD_CMANNOS	12	15	PF00535	0.322
MOD_Cter_Amidation	42	45	PF01082	0.458
MOD_DYRK1A_RPxSP_1	305	309	PF00069	0.706
MOD_GlcNHglycan	100	103	PF01048	0.526
MOD_GlcNHglycan	148	152	PF01048	0.452
MOD_GlcNHglycan	174	177	PF01048	0.347
MOD_GlcNHglycan	203	206	PF01048	0.386
MOD_GlcNHglycan	211	214	PF01048	0.284
MOD_GlcNHglycan	246	249	PF01048	0.672
MOD_GlcNHglycan	28	31	PF01048	0.529
MOD_GlcNHglycan	314	317	PF01048	0.754
MOD_GlcNHglycan	373	376	PF01048	0.410
MOD_GSK3_1	154	161	PF00069	0.424
MOD_GSK3_1	172	179	PF00069	0.229
MOD_GSK3_1	246	253	PF00069	0.695
MOD_GSK3_1	285	292	PF00069	0.552
MOD_GSK3_1	29	36	PF00069	0.393
MOD_GSK3_1	307	314	PF00069	0.770
MOD_GSK3_1	326	333	PF00069	0.605
MOD_GSK3_1	371	378	PF00069	0.405
MOD_N-GLC_1	177	182	PF02516	0.448
MOD_N-GLC_1	207	212	PF02516	0.419
MOD_N-GLC_1	244	249	PF02516	0.682
MOD_NEK2_1	154	159	PF00069	0.461
MOD_NEK2_1	172	177	PF00069	0.236
MOD_NEK2_1	228	233	PF00069	0.380
MOD_NEK2_1	244	249	PF00069	0.517
MOD_NEK2_1	293	298	PF00069	0.629
MOD_NEK2_2	95	100	PF00069	0.594
MOD_PIKK_1	218	224	PF00454	0.357
MOD_PIKK_1	339	345	PF00454	0.557
MOD_PKA_2	272	278	PF00069	0.422
MOD_PKA_2	337	343	PF00069	0.559
MOD_PKB_1	24	32	PF00069	0.547
MOD_Plk_1	207	213	PF00069	0.386
MOD_Plk_2-3	80	86	PF00069	0.503
MOD_Plk_4	16	22	PF00069	0.343
MOD_Plk_4	198	204	PF00069	0.386
MOD_Plk_4	272	278	PF00069	0.397
MOD_Plk_4	285	291	PF00069	0.540
MOD_Plk_4	29	35	PF00069	0.356
MOD_ProDKin_1	158	164	PF00069	0.463
MOD_ProDKin_1	294	300	PF00069	0.622
MOD_ProDKin_1	305	311	PF00069	0.642
MOD_ProDKin_1	315	321	PF00069	0.631
MOD_ProDKin_1	400	406	PF00069	0.616
MOD_SUMO_rev_2	249	258	PF00179	0.760
TRG_DiLeu_BaLyEn_6	168	173	PF01217	0.372
TRG_DiLeu_BaLyEn_6	380	385	PF01217	0.365
TRG_DiLeu_BaLyEn_6	392	397	PF01217	0.473
TRG_ENDOCYTIC_2	196	199	PF00928	0.422
TRG_ENDOCYTIC_2	382	385	PF00928	0.419
TRG_ENDOCYTIC_2	62	65	PF00928	0.503
TRG_ER_diArg_1	23	26	PF00400	0.434
TRG_ER_diArg_1	264	267	PF00400	0.601
TRG_ER_diArg_1	44	46	PF00400	0.423
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7B0	Leptomonas seymouri	50%	100%
A0A1X0P7L9	Trypanosomatidae	29%	100%
A1L1W4	Danio rerio	22%	100%
A4HPA2	Leishmania braziliensis	75%	99%
A4IDK8	Leishmania infantum	99%	100%
D0A3A6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AT11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q1I7	Leishmania major	93%	100%
Q5XGF7	Xenopus tropicalis	22%	100%
Q7TQA3	Mus musculus	23%	100%
Q80ZF7	Rattus norvegicus	23%	100%
Q8HZT6	Bos taurus	23%	100%
Q8IZV5	Homo sapiens	23%	100%
V5DCK9	Trypanosoma cruzi	27%	100%