LeishMANIAdb
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Ras-like small GTPase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ras-like small GTPase, putative
Gene product:
ras-like small GTPases, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IQV2_LEIDO
TriTrypDb:
LdBPK_361900.1 , LdCL_360024500 , LDHU3_36.2470
Length:
873

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6
GO:0005886 plasma membrane 3 1

Expansion

Sequence features

A0A3Q8IQV2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IQV2

Function

Biological processes
Term Name Level Count
GO:0007165 signal transduction 2 6
GO:0009987 cellular process 1 6
GO:0050789 regulation of biological process 2 6
GO:0050794 regulation of cellular process 3 6
GO:0065007 biological regulation 1 6
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 6
GO:0003824 catalytic activity 1 6
GO:0003924 GTPase activity 7 6
GO:0005488 binding 1 6
GO:0005525 GTP binding 5 6
GO:0016462 pyrophosphatase activity 5 6
GO:0016787 hydrolase activity 2 6
GO:0016817 hydrolase activity, acting on acid anhydrides 3 6
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 6
GO:0017076 purine nucleotide binding 4 6
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 6
GO:0019001 guanyl nucleotide binding 5 6
GO:0032553 ribonucleotide binding 3 6
GO:0032555 purine ribonucleotide binding 4 6
GO:0032561 guanyl ribonucleotide binding 5 6
GO:0035639 purine ribonucleoside triphosphate binding 4 6
GO:0036094 small molecule binding 2 6
GO:0043167 ion binding 2 6
GO:0043168 anion binding 3 6
GO:0097159 organic cyclic compound binding 2 6
GO:0097367 carbohydrate derivative binding 2 6
GO:1901265 nucleoside phosphate binding 3 6
GO:1901363 heterocyclic compound binding 2 6
GO:0019003 GDP binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 232 236 PF00656 0.694
CLV_C14_Caspase3-7 237 241 PF00656 0.703
CLV_C14_Caspase3-7 316 320 PF00656 0.665
CLV_C14_Caspase3-7 54 58 PF00656 0.530
CLV_NRD_NRD_1 105 107 PF00675 0.530
CLV_NRD_NRD_1 206 208 PF00675 0.634
CLV_NRD_NRD_1 216 218 PF00675 0.568
CLV_NRD_NRD_1 524 526 PF00675 0.727
CLV_NRD_NRD_1 673 675 PF00675 0.732
CLV_NRD_NRD_1 696 698 PF00675 0.718
CLV_NRD_NRD_1 722 724 PF00675 0.670
CLV_NRD_NRD_1 844 846 PF00675 0.693
CLV_PCSK_FUR_1 525 529 PF00082 0.712
CLV_PCSK_KEX2_1 206 208 PF00082 0.635
CLV_PCSK_KEX2_1 216 218 PF00082 0.670
CLV_PCSK_KEX2_1 524 526 PF00082 0.727
CLV_PCSK_KEX2_1 527 529 PF00082 0.692
CLV_PCSK_KEX2_1 722 724 PF00082 0.670
CLV_PCSK_KEX2_1 837 839 PF00082 0.738
CLV_PCSK_KEX2_1 844 846 PF00082 0.614
CLV_PCSK_PC1ET2_1 527 529 PF00082 0.724
CLV_PCSK_PC1ET2_1 837 839 PF00082 0.725
CLV_PCSK_SKI1_1 107 111 PF00082 0.530
CLV_PCSK_SKI1_1 123 127 PF00082 0.265
CLV_PCSK_SKI1_1 245 249 PF00082 0.723
CLV_PCSK_SKI1_1 328 332 PF00082 0.418
CLV_PCSK_SKI1_1 71 75 PF00082 0.369
CLV_PCSK_SKI1_1 845 849 PF00082 0.707
DEG_APCC_DBOX_1 105 113 PF00400 0.479
DEG_APCC_DBOX_1 308 316 PF00400 0.656
DEG_SPOP_SBC_1 272 276 PF00917 0.620
DEG_SPOP_SBC_1 353 357 PF00917 0.705
DEG_SPOP_SBC_1 807 811 PF00917 0.701
DOC_CKS1_1 775 780 PF01111 0.657
DOC_CYCLIN_yClb1_LxF_4 69 74 PF00134 0.530
DOC_MAPK_gen_1 104 112 PF00069 0.530
DOC_MAPK_gen_1 591 600 PF00069 0.606
DOC_MAPK_gen_1 672 679 PF00069 0.733
DOC_MAPK_MEF2A_6 328 337 PF00069 0.635
DOC_MAPK_MEF2A_6 93 100 PF00069 0.530
DOC_MAPK_NFAT4_5 328 336 PF00069 0.631
DOC_PP1_RVXF_1 69 75 PF00149 0.530
DOC_PP2B_LxvP_1 300 303 PF13499 0.754
DOC_PP2B_LxvP_1 395 398 PF13499 0.684
DOC_PP2B_LxvP_1 598 601 PF13499 0.607
DOC_PP2B_PxIxI_1 17 23 PF00149 0.593
DOC_PP4_FxxP_1 424 427 PF00568 0.714
DOC_USP7_MATH_1 192 196 PF00917 0.661
DOC_USP7_MATH_1 272 276 PF00917 0.617
DOC_USP7_MATH_1 304 308 PF00917 0.660
DOC_USP7_MATH_1 353 357 PF00917 0.831
DOC_USP7_MATH_1 358 362 PF00917 0.781
DOC_USP7_MATH_1 367 371 PF00917 0.642
DOC_USP7_MATH_1 373 377 PF00917 0.514
DOC_USP7_MATH_1 387 391 PF00917 0.563
DOC_USP7_MATH_1 406 410 PF00917 0.500
DOC_USP7_MATH_1 45 49 PF00917 0.530
DOC_USP7_MATH_1 567 571 PF00917 0.728
DOC_USP7_MATH_1 730 734 PF00917 0.823
DOC_USP7_MATH_1 742 746 PF00917 0.667
DOC_USP7_MATH_1 807 811 PF00917 0.777
DOC_USP7_MATH_1 816 820 PF00917 0.749
DOC_USP7_UBL2_3 545 549 PF12436 0.749
DOC_USP7_UBL2_3 622 626 PF12436 0.617
DOC_USP7_UBL2_3 833 837 PF12436 0.711
DOC_WW_Pin1_4 215 220 PF00397 0.698
DOC_WW_Pin1_4 259 264 PF00397 0.786
DOC_WW_Pin1_4 268 273 PF00397 0.691
DOC_WW_Pin1_4 349 354 PF00397 0.825
DOC_WW_Pin1_4 444 449 PF00397 0.713
DOC_WW_Pin1_4 463 468 PF00397 0.583
DOC_WW_Pin1_4 760 765 PF00397 0.666
DOC_WW_Pin1_4 770 775 PF00397 0.706
LIG_14-3-3_CanoR_1 104 110 PF00244 0.530
LIG_14-3-3_CanoR_1 130 138 PF00244 0.503
LIG_14-3-3_CanoR_1 194 199 PF00244 0.584
LIG_14-3-3_CanoR_1 328 334 PF00244 0.536
LIG_14-3-3_CanoR_1 419 425 PF00244 0.707
LIG_14-3-3_CanoR_1 454 459 PF00244 0.634
LIG_14-3-3_CanoR_1 525 534 PF00244 0.720
LIG_14-3-3_CanoR_1 697 701 PF00244 0.746
LIG_14-3-3_CanoR_1 71 81 PF00244 0.491
LIG_14-3-3_CanoR_1 736 743 PF00244 0.728
LIG_14-3-3_CanoR_1 772 778 PF00244 0.755
LIG_14-3-3_CanoR_1 808 816 PF00244 0.791
LIG_14-3-3_CanoR_1 844 854 PF00244 0.675
LIG_APCC_ABBAyCdc20_2 37 43 PF00400 0.530
LIG_BIR_II_1 1 5 PF00653 0.637
LIG_FHA_1 274 280 PF00498 0.819
LIG_FHA_1 295 301 PF00498 0.816
LIG_FHA_1 31 37 PF00498 0.530
LIG_FHA_1 330 336 PF00498 0.515
LIG_FHA_1 445 451 PF00498 0.618
LIG_FHA_1 563 569 PF00498 0.713
LIG_FHA_1 668 674 PF00498 0.803
LIG_FHA_1 848 854 PF00498 0.677
LIG_FHA_1 861 867 PF00498 0.546
LIG_FHA_2 132 138 PF00498 0.460
LIG_FHA_2 160 166 PF00498 0.701
LIG_FHA_2 246 252 PF00498 0.755
LIG_FHA_2 47 53 PF00498 0.489
LIG_FHA_2 58 64 PF00498 0.356
LIG_LIR_Apic_2 423 427 PF02991 0.717
LIG_LIR_Apic_2 773 778 PF02991 0.653
LIG_LIR_Gen_1 57 64 PF02991 0.530
LIG_LIR_Nem_3 135 141 PF02991 0.491
LIG_LIR_Nem_3 57 62 PF02991 0.530
LIG_LIR_Nem_3 67 73 PF02991 0.365
LIG_LIR_Nem_3 717 721 PF02991 0.716
LIG_SH2_CRK 70 74 PF00017 0.530
LIG_SH2_CRK 775 779 PF00017 0.656
LIG_SH2_NCK_1 59 63 PF00017 0.530
LIG_SH2_NCK_1 775 779 PF00017 0.656
LIG_SH2_SRC 39 42 PF00017 0.530
LIG_SH2_STAP1 51 55 PF00017 0.355
LIG_SH2_STAP1 536 540 PF00017 0.716
LIG_SH2_STAT3 458 461 PF00017 0.728
LIG_SH2_STAT5 180 183 PF00017 0.689
LIG_SH2_STAT5 39 42 PF00017 0.369
LIG_SH2_STAT5 415 418 PF00017 0.696
LIG_SH2_STAT5 458 461 PF00017 0.728
LIG_SH2_STAT5 59 62 PF00017 0.530
LIG_SH2_STAT5 64 67 PF00017 0.447
LIG_SH2_STAT5 90 93 PF00017 0.530
LIG_SH3_2 823 828 PF14604 0.788
LIG_SH3_3 257 263 PF00018 0.654
LIG_SH3_3 274 280 PF00018 0.519
LIG_SH3_3 630 636 PF00018 0.704
LIG_SH3_3 798 804 PF00018 0.730
LIG_SH3_3 820 826 PF00018 0.692
LIG_SH3_CIN85_PxpxPR_1 800 805 PF14604 0.644
LIG_SUMO_SIM_anti_2 95 102 PF11976 0.452
LIG_SUMO_SIM_par_1 21 27 PF11976 0.530
LIG_SUMO_SIM_par_1 660 666 PF11976 0.611
LIG_SUMO_SIM_par_1 95 102 PF11976 0.526
LIG_SxIP_EBH_1 419 431 PF03271 0.722
LIG_TRAF2_1 794 797 PF00917 0.739
LIG_WRC_WIRS_1 421 426 PF05994 0.681
MOD_CDK_SPK_2 215 220 PF00069 0.722
MOD_CDK_SPK_2 760 765 PF00069 0.623
MOD_CDK_SPxxK_3 444 451 PF00069 0.658
MOD_CK1_1 156 162 PF00069 0.582
MOD_CK1_1 197 203 PF00069 0.625
MOD_CK1_1 262 268 PF00069 0.711
MOD_CK1_1 271 277 PF00069 0.684
MOD_CK1_1 294 300 PF00069 0.742
MOD_CK1_1 356 362 PF00069 0.793
MOD_CK1_1 376 382 PF00069 0.509
MOD_CK1_1 408 414 PF00069 0.769
MOD_CK1_1 417 423 PF00069 0.687
MOD_CK1_1 444 450 PF00069 0.755
MOD_CK1_1 46 52 PF00069 0.483
MOD_CK1_1 465 471 PF00069 0.681
MOD_CK1_1 483 489 PF00069 0.605
MOD_CK1_1 496 502 PF00069 0.581
MOD_CK1_1 535 541 PF00069 0.786
MOD_CK1_1 580 586 PF00069 0.723
MOD_CK1_1 596 602 PF00069 0.583
MOD_CK1_1 628 634 PF00069 0.754
MOD_CK1_1 647 653 PF00069 0.560
MOD_CK1_1 746 752 PF00069 0.678
MOD_CK1_1 770 776 PF00069 0.814
MOD_CK1_1 79 85 PF00069 0.373
MOD_CK1_1 8 14 PF00069 0.688
MOD_CK1_1 821 827 PF00069 0.696
MOD_CK1_1 846 852 PF00069 0.644
MOD_CK2_1 160 166 PF00069 0.604
MOD_CK2_1 245 251 PF00069 0.719
MOD_CK2_1 358 364 PF00069 0.697
MOD_CK2_1 387 393 PF00069 0.607
MOD_CK2_1 46 52 PF00069 0.440
MOD_CK2_1 475 481 PF00069 0.775
MOD_CK2_1 567 573 PF00069 0.758
MOD_CK2_1 7 13 PF00069 0.733
MOD_CK2_1 79 85 PF00069 0.530
MOD_CK2_1 791 797 PF00069 0.805
MOD_CK2_1 816 822 PF00069 0.782
MOD_Cter_Amidation 525 528 PF01082 0.765
MOD_Cter_Amidation 546 549 PF01082 0.712
MOD_Cter_Amidation 835 838 PF01082 0.684
MOD_GlcNHglycan 101 104 PF01048 0.504
MOD_GlcNHglycan 12 16 PF01048 0.591
MOD_GlcNHglycan 176 179 PF01048 0.573
MOD_GlcNHglycan 283 286 PF01048 0.647
MOD_GlcNHglycan 297 300 PF01048 0.534
MOD_GlcNHglycan 347 350 PF01048 0.770
MOD_GlcNHglycan 356 359 PF01048 0.729
MOD_GlcNHglycan 369 372 PF01048 0.724
MOD_GlcNHglycan 378 381 PF01048 0.720
MOD_GlcNHglycan 408 411 PF01048 0.763
MOD_GlcNHglycan 436 439 PF01048 0.778
MOD_GlcNHglycan 467 470 PF01048 0.676
MOD_GlcNHglycan 485 488 PF01048 0.566
MOD_GlcNHglycan 579 582 PF01048 0.758
MOD_GlcNHglycan 604 607 PF01048 0.781
MOD_GlcNHglycan 630 633 PF01048 0.775
MOD_GlcNHglycan 647 650 PF01048 0.547
MOD_GlcNHglycan 728 731 PF01048 0.749
MOD_GlcNHglycan 732 735 PF01048 0.692
MOD_GlcNHglycan 738 741 PF01048 0.707
MOD_GlcNHglycan 78 81 PF01048 0.365
MOD_GlcNHglycan 793 796 PF01048 0.784
MOD_GlcNHglycan 810 813 PF01048 0.574
MOD_GlcNHglycan 845 848 PF01048 0.680
MOD_GSK3_1 152 159 PF00069 0.678
MOD_GSK3_1 246 253 PF00069 0.721
MOD_GSK3_1 268 275 PF00069 0.806
MOD_GSK3_1 290 297 PF00069 0.773
MOD_GSK3_1 3 10 PF00069 0.726
MOD_GSK3_1 341 348 PF00069 0.766
MOD_GSK3_1 349 356 PF00069 0.713
MOD_GSK3_1 442 449 PF00069 0.682
MOD_GSK3_1 450 457 PF00069 0.732
MOD_GSK3_1 459 466 PF00069 0.674
MOD_GSK3_1 46 53 PF00069 0.497
MOD_GSK3_1 492 499 PF00069 0.726
MOD_GSK3_1 535 542 PF00069 0.736
MOD_GSK3_1 558 565 PF00069 0.722
MOD_GSK3_1 596 603 PF00069 0.727
MOD_GSK3_1 640 647 PF00069 0.751
MOD_GSK3_1 663 670 PF00069 0.810
MOD_GSK3_1 696 703 PF00069 0.729
MOD_GSK3_1 710 717 PF00069 0.608
MOD_GSK3_1 72 79 PF00069 0.389
MOD_GSK3_1 726 733 PF00069 0.640
MOD_GSK3_1 742 749 PF00069 0.600
MOD_GSK3_1 770 777 PF00069 0.809
MOD_GSK3_1 843 850 PF00069 0.768
MOD_LATS_1 452 458 PF00433 0.669
MOD_N-GLC_1 294 299 PF02516 0.731
MOD_N-GLC_1 492 497 PF02516 0.720
MOD_N-GLC_1 726 731 PF02516 0.761
MOD_N-GLC_1 791 796 PF02516 0.784
MOD_N-GLC_2 267 269 PF02516 0.766
MOD_NEK2_1 229 234 PF00069 0.639
MOD_NEK2_1 313 318 PF00069 0.647
MOD_NEK2_1 450 455 PF00069 0.637
MOD_NEK2_1 5 10 PF00069 0.706
MOD_NEK2_1 55 60 PF00069 0.530
MOD_NEK2_1 558 563 PF00069 0.767
MOD_NEK2_1 574 579 PF00069 0.631
MOD_NEK2_1 743 748 PF00069 0.652
MOD_NEK2_1 99 104 PF00069 0.530
MOD_NEK2_2 329 334 PF00069 0.626
MOD_PIKK_1 197 203 PF00454 0.610
MOD_PIKK_1 516 522 PF00454 0.758
MOD_PIKK_1 64 70 PF00454 0.496
MOD_PIKK_1 663 669 PF00454 0.748
MOD_PIKK_1 816 822 PF00454 0.815
MOD_PIKK_1 860 866 PF00454 0.744
MOD_PK_1 194 200 PF00069 0.581
MOD_PKA_1 245 251 PF00069 0.719
MOD_PKA_2 105 111 PF00069 0.530
MOD_PKA_2 450 456 PF00069 0.766
MOD_PKA_2 46 52 PF00069 0.413
MOD_PKA_2 483 489 PF00069 0.647
MOD_PKA_2 693 699 PF00069 0.823
MOD_PKA_2 721 727 PF00069 0.738
MOD_PKA_2 807 813 PF00069 0.852
MOD_PKA_2 829 835 PF00069 0.679
MOD_PKA_2 843 849 PF00069 0.645
MOD_Plk_1 11 17 PF00069 0.601
MOD_Plk_1 3 9 PF00069 0.707
MOD_Plk_1 417 423 PF00069 0.691
MOD_Plk_1 496 502 PF00069 0.745
MOD_Plk_1 51 57 PF00069 0.452
MOD_Plk_2-3 186 192 PF00069 0.645
MOD_Plk_4 105 111 PF00069 0.530
MOD_Plk_4 31 37 PF00069 0.320
MOD_Plk_4 411 417 PF00069 0.657
MOD_Plk_4 420 426 PF00069 0.702
MOD_Plk_4 454 460 PF00069 0.675
MOD_Plk_4 51 57 PF00069 0.530
MOD_ProDKin_1 215 221 PF00069 0.689
MOD_ProDKin_1 259 265 PF00069 0.786
MOD_ProDKin_1 268 274 PF00069 0.690
MOD_ProDKin_1 349 355 PF00069 0.827
MOD_ProDKin_1 444 450 PF00069 0.714
MOD_ProDKin_1 463 469 PF00069 0.585
MOD_ProDKin_1 760 766 PF00069 0.665
MOD_ProDKin_1 770 776 PF00069 0.706
MOD_SUMO_for_1 785 788 PF00179 0.679
MOD_SUMO_rev_2 316 323 PF00179 0.658
MOD_SUMO_rev_2 503 509 PF00179 0.658
MOD_SUMO_rev_2 809 819 PF00179 0.691
TRG_DiLeu_BaEn_2 139 145 PF01217 0.530
TRG_DiLeu_BaLyEn_6 68 73 PF01217 0.530
TRG_ENDOCYTIC_2 59 62 PF00928 0.530
TRG_ENDOCYTIC_2 70 73 PF00928 0.348
TRG_ER_diArg_1 671 674 PF00400 0.731
TRG_ER_diArg_1 721 723 PF00400 0.673
TRG_Pf-PMV_PEXEL_1 512 516 PF00026 0.619

Homologs

Protein Taxonomy Sequence identity Coverage
A4HP46 Leishmania braziliensis 51% 100%
A4IDF3 Leishmania infantum 99% 100%
E9ASV4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 76% 100%
Q4Q1P2 Leishmania major 83% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS