Serine esterase (DUF676), putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative serine esterase (DUF676), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IQU6_LEIDO

TriTrypDb:

LdBPK_282630.1 , LdCL_280031400 , LDHU3_28.3560

Length:

487

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IQU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IQU6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	284	288	PF00656	0.505
CLV_C14_Caspase3-7	381	385	PF00656	0.554
CLV_MEL_PAP_1	270	276	PF00089	0.442
CLV_NRD_NRD_1	245	247	PF00675	0.371
CLV_NRD_NRD_1	272	274	PF00675	0.402
CLV_NRD_NRD_1	317	319	PF00675	0.373
CLV_NRD_NRD_1	388	390	PF00675	0.614
CLV_NRD_NRD_1	94	96	PF00675	0.473
CLV_PCSK_FUR_1	242	246	PF00082	0.431
CLV_PCSK_KEX2_1	200	202	PF00082	0.340
CLV_PCSK_KEX2_1	244	246	PF00082	0.347
CLV_PCSK_KEX2_1	272	274	PF00082	0.563
CLV_PCSK_KEX2_1	388	390	PF00082	0.589
CLV_PCSK_KEX2_1	94	96	PF00082	0.473
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.305
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.357
CLV_PCSK_SKI1_1	156	160	PF00082	0.328
CLV_PCSK_SKI1_1	201	205	PF00082	0.445
CLV_PCSK_SKI1_1	245	249	PF00082	0.348
CLV_PCSK_SKI1_1	431	435	PF00082	0.509
CLV_PCSK_SKI1_1	469	473	PF00082	0.556
CLV_PCSK_SKI1_1	47	51	PF00082	0.385
CLV_PCSK_SKI1_1	71	75	PF00082	0.482
DEG_APCC_DBOX_1	155	163	PF00400	0.328
DEG_APCC_DBOX_1	244	252	PF00400	0.467
DEG_Nend_UBRbox_2	1	3	PF02207	0.599
DEG_SPOP_SBC_1	259	263	PF00917	0.401
DOC_CKS1_1	187	192	PF01111	0.371
DOC_CKS1_1	67	72	PF01111	0.476
DOC_CYCLIN_yClb3_PxF_3	66	72	PF00134	0.375
DOC_CYCLIN_yClb5_NLxxxL_5	326	335	PF00134	0.371
DOC_MAPK_DCC_7	350	360	PF00069	0.405
DOC_MAPK_FxFP_2	416	419	PF00069	0.483
DOC_MAPK_gen_1	242	251	PF00069	0.440
DOC_MAPK_gen_1	94	104	PF00069	0.405
DOC_MAPK_MEF2A_6	223	231	PF00069	0.305
DOC_MAPK_MEF2A_6	242	251	PF00069	0.467
DOC_MAPK_MEF2A_6	95	104	PF00069	0.401
DOC_PP1_RVXF_1	138	144	PF00149	0.485
DOC_PP2B_LxvP_1	16	19	PF13499	0.484
DOC_PP4_FxxP_1	416	419	PF00568	0.483
DOC_PP4_FxxP_1	74	77	PF00568	0.496
DOC_USP7_MATH_1	259	263	PF00917	0.294
DOC_USP7_MATH_1	375	379	PF00917	0.663
DOC_USP7_MATH_1	402	406	PF00917	0.529
DOC_USP7_MATH_1	463	467	PF00917	0.642
DOC_USP7_MATH_1	481	485	PF00917	0.679
DOC_USP7_UBL2_3	47	51	PF12436	0.512
DOC_WW_Pin1_4	186	191	PF00397	0.365
DOC_WW_Pin1_4	329	334	PF00397	0.564
DOC_WW_Pin1_4	66	71	PF00397	0.650
LIG_14-3-3_CanoR_1	223	227	PF00244	0.401
LIG_14-3-3_CanoR_1	273	279	PF00244	0.424
LIG_14-3-3_CanoR_1	33	42	PF00244	0.396
LIG_Actin_WH2_2	143	158	PF00022	0.440
LIG_BRCT_BRCA1_1	260	264	PF00533	0.352
LIG_deltaCOP1_diTrp_1	178	184	PF00928	0.375
LIG_EH1_1	147	155	PF00400	0.347
LIG_eIF4E_1	428	434	PF01652	0.468
LIG_FHA_1	132	138	PF00498	0.554
LIG_FHA_1	187	193	PF00498	0.482
LIG_FHA_1	20	26	PF00498	0.508
LIG_FHA_1	200	206	PF00498	0.257
LIG_FHA_1	265	271	PF00498	0.455
LIG_FHA_2	279	285	PF00498	0.643
LIG_FHA_2	379	385	PF00498	0.502
LIG_GSK3_LRP6_1	66	71	PF00069	0.384
LIG_LIR_Gen_1	103	112	PF02991	0.458
LIG_LIR_Gen_1	167	176	PF02991	0.452
LIG_LIR_Gen_1	178	188	PF02991	0.364
LIG_LIR_Gen_1	441	451	PF02991	0.510
LIG_LIR_Gen_1	69	77	PF02991	0.435
LIG_LIR_Nem_3	103	108	PF02991	0.405
LIG_LIR_Nem_3	167	173	PF02991	0.484
LIG_LIR_Nem_3	178	184	PF02991	0.342
LIG_LIR_Nem_3	37	42	PF02991	0.526
LIG_LIR_Nem_3	420	425	PF02991	0.391
LIG_LIR_Nem_3	441	446	PF02991	0.503
LIG_LIR_Nem_3	69	75	PF02991	0.438
LIG_LYPXL_yS_3	418	421	PF13949	0.520
LIG_MYND_1	333	337	PF01753	0.528
LIG_SH2_CRK	105	109	PF00017	0.463
LIG_SH2_NCK_1	105	109	PF00017	0.357
LIG_SH2_SRC	105	108	PF00017	0.486
LIG_SH2_SRC	297	300	PF00017	0.462
LIG_SH2_STAP1	105	109	PF00017	0.357
LIG_SH2_STAP1	260	264	PF00017	0.442
LIG_SH2_STAT3	96	99	PF00017	0.399
LIG_SH2_STAT5	297	300	PF00017	0.633
LIG_SH2_STAT5	41	44	PF00017	0.404
LIG_SH2_STAT5	428	431	PF00017	0.465
LIG_SH2_STAT5	96	99	PF00017	0.459
LIG_SH3_3	441	447	PF00018	0.663
LIG_SH3_3	62	68	PF00018	0.527
LIG_SH3_3	70	76	PF00018	0.442
LIG_SH3_CIN85_PxpxPR_1	66	71	PF14604	0.492
LIG_TRAF2_1	281	284	PF00917	0.616
LIG_TYR_ITSM	101	108	PF00017	0.353
LIG_UBA3_1	162	169	PF00899	0.401
LIG_WW_3	18	22	PF00397	0.472
LIG_WW_3	75	79	PF00397	0.386
MOD_CDK_SPK_2	66	71	PF00069	0.514
MOD_CK1_1	10	16	PF00069	0.533
MOD_CK1_1	132	138	PF00069	0.652
MOD_CK1_1	199	205	PF00069	0.454
MOD_CK1_1	263	269	PF00069	0.341
MOD_CK1_1	277	283	PF00069	0.361
MOD_CK1_1	34	40	PF00069	0.398
MOD_CK1_1	378	384	PF00069	0.714
MOD_CK2_1	277	283	PF00069	0.564
MOD_CK2_1	314	320	PF00069	0.441
MOD_GlcNHglycan	12	15	PF01048	0.632
MOD_GlcNHglycan	131	134	PF01048	0.623
MOD_GlcNHglycan	143	146	PF01048	0.411
MOD_GlcNHglycan	373	376	PF01048	0.568
MOD_GlcNHglycan	464	468	PF01048	0.669
MOD_GlcNHglycan	483	486	PF01048	0.577
MOD_GSK3_1	259	266	PF00069	0.445
MOD_GSK3_1	274	281	PF00069	0.582
MOD_GSK3_1	371	378	PF00069	0.591
MOD_GSK3_1	438	445	PF00069	0.594
MOD_N-GLC_1	329	334	PF02516	0.474
MOD_N-GLC_1	55	60	PF02516	0.481
MOD_N-GLC_2	459	461	PF02516	0.543
MOD_NEK2_1	141	146	PF00069	0.401
MOD_NEK2_1	258	263	PF00069	0.379
MOD_NEK2_1	264	269	PF00069	0.448
MOD_NEK2_2	402	407	PF00069	0.472
MOD_PK_1	417	423	PF00069	0.403
MOD_PKA_2	222	228	PF00069	0.343
MOD_PKA_2	288	294	PF00069	0.532
MOD_PKA_2	370	376	PF00069	0.546
MOD_PKA_2	378	384	PF00069	0.648
MOD_Plk_1	116	122	PF00069	0.610
MOD_Plk_1	253	259	PF00069	0.467
MOD_Plk_4	100	106	PF00069	0.460
MOD_Plk_4	222	228	PF00069	0.401
MOD_Plk_4	253	259	PF00069	0.409
MOD_Plk_4	260	266	PF00069	0.389
MOD_Plk_4	417	423	PF00069	0.511
MOD_ProDKin_1	186	192	PF00069	0.365
MOD_ProDKin_1	329	335	PF00069	0.561
MOD_ProDKin_1	66	72	PF00069	0.640
TRG_ENDOCYTIC_2	105	108	PF00928	0.461
TRG_ENDOCYTIC_2	170	173	PF00928	0.423
TRG_ENDOCYTIC_2	418	421	PF00928	0.493
TRG_ER_diArg_1	245	247	PF00400	0.374
TRG_ER_diArg_1	271	273	PF00400	0.484
TRG_ER_diArg_1	365	368	PF00400	0.469
TRG_ER_diArg_1	388	390	PF00400	0.579
TRG_ER_diArg_1	94	96	PF00400	0.455
TRG_NLS_MonoExtN_4	242	248	PF00514	0.431
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3P6	Leptomonas seymouri	42%	100%
A0A1X0NR47	Trypanosomatidae	27%	100%
A0A1X0NX73	Trypanosomatidae	24%	100%
A0A3R7K6Z5	Trypanosoma rangeli	29%	100%
A4HGU8	Leishmania braziliensis	55%	100%
A4I3X6	Leishmania infantum	99%	100%
D0A944	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B066	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%