LeishMANIAdb
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Zinc knuckle family protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Zinc knuckle family protein
Gene product:
universal minicircle sequence binding protein, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IQS7_LEIDO
TriTrypDb:
LdBPK_361720.1 , LdCL_360022700 , LDHU3_36.2280
Length:
271

Annotations

Annotations by Jardim et al.

Kinetoplastid proteins, universal minicircle sequence binding (UMSBP) HEXBP

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IQS7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IQS7

Function

Biological processes
Term Name Level Count
GO:0006417 regulation of translation 6 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0009891 positive regulation of biosynthetic process 5 1
GO:0009893 positive regulation of metabolic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0010557 positive regulation of macromolecule biosynthetic process 6 1
GO:0010604 positive regulation of macromolecule metabolic process 5 1
GO:0010608 post-transcriptional regulation of gene expression 6 1
GO:0010628 positive regulation of gene expression 6 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031325 positive regulation of cellular metabolic process 5 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0031328 positive regulation of cellular biosynthetic process 6 1
GO:0034248 regulation of amide metabolic process 5 1
GO:0034250 positive regulation of amide metabolic process 6 1
GO:0045727 positive regulation of translation 7 1
GO:0048518 positive regulation of biological process 3 1
GO:0048522 positive regulation of cellular process 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051173 positive regulation of nitrogen compound metabolic process 5 1
GO:0051246 regulation of protein metabolic process 5 1
GO:0051247 positive regulation of protein metabolic process 6 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
GO:2000112 obsolete regulation of cellular macromolecule biosynthetic process 6 1
GO:2000765 regulation of cytoplasmic translation 7 1
GO:2000767 positive regulation of cytoplasmic translation 8 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 11
GO:0005488 binding 1 11
GO:0008270 zinc ion binding 6 11
GO:0043167 ion binding 2 11
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11
GO:0046914 transition metal ion binding 5 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11
GO:0003723 RNA binding 4 1
GO:0003727 single-stranded RNA binding 5 1
GO:0003729 mRNA binding 5 1
GO:0045182 translation regulator activity 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 36 40 PF00656 0.389
CLV_NRD_NRD_1 195 197 PF00675 0.285
CLV_PCSK_KEX2_1 126 128 PF00082 0.630
CLV_PCSK_KEX2_1 8 10 PF00082 0.627
CLV_PCSK_PC1ET2_1 126 128 PF00082 0.630
CLV_PCSK_PC1ET2_1 8 10 PF00082 0.623
DOC_USP7_MATH_1 240 244 PF00917 0.597
DOC_USP7_MATH_2 59 65 PF00917 0.564
LIG_BIR_II_1 1 5 PF00653 0.654
LIG_FHA_1 2 8 PF00498 0.641
LIG_SH3_3 4 10 PF00018 0.649
MOD_CK1_1 14 20 PF00069 0.460
MOD_CK1_1 213 219 PF00069 0.480
MOD_GlcNHglycan 129 132 PF01048 0.540
MOD_GlcNHglycan 162 165 PF01048 0.590
MOD_GlcNHglycan 190 193 PF01048 0.526
MOD_GlcNHglycan 203 206 PF01048 0.365
MOD_GlcNHglycan 212 215 PF01048 0.442
MOD_GlcNHglycan 218 221 PF01048 0.329
MOD_GlcNHglycan 63 66 PF01048 0.555
MOD_GlcNHglycan 87 90 PF01048 0.568
MOD_GSK3_1 112 119 PF00069 0.599
MOD_GSK3_1 201 208 PF00069 0.410
MOD_GSK3_1 216 223 PF00069 0.403
MOD_GSK3_1 240 247 PF00069 0.670
MOD_GSK3_1 9 16 PF00069 0.586
MOD_N-GLC_1 216 221 PF02516 0.369
MOD_NEK2_2 138 143 PF00069 0.338
MOD_NEK2_2 166 171 PF00069 0.317
MOD_NEK2_2 220 225 PF00069 0.258
MOD_NEK2_2 251 256 PF00069 0.342
MOD_NEK2_2 68 73 PF00069 0.515
MOD_PIKK_1 112 118 PF00454 0.554
MOD_PKA_2 40 46 PF00069 0.510
MOD_PKB_1 9 17 PF00069 0.577
MOD_Plk_1 138 144 PF00069 0.338
MOD_Plk_1 166 172 PF00069 0.317
MOD_Plk_1 220 226 PF00069 0.274
MOD_Plk_1 251 257 PF00069 0.359
MOD_SUMO_rev_2 2 10 PF00179 0.637
TRG_NLS_MonoCore_2 7 12 PF00514 0.615
TRG_NLS_MonoExtC_3 7 13 PF00514 0.613

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P715 Leptomonas seymouri 68% 96%
A0A0S4JI86 Bodo saltans 30% 98%
A0A1X0P815 Trypanosomatidae 50% 100%
A0A1X0P8V4 Trypanosomatidae 34% 100%
A0A3R7K9Q9 Trypanosoma rangeli 35% 100%
A4HP28 Leishmania braziliensis 89% 100%
A4IDD5 Leishmania infantum 100% 100%
D0A309 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9AST3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E9AST6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
O65639 Arabidopsis thaliana 41% 91%
Q04832 Leishmania major 98% 100%
Q12476 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 79%
Q4Q1R0 Leishmania major 97% 100%
Q94C69 Arabidopsis thaliana 38% 90%
V5BJZ6 Trypanosoma cruzi 35% 100%
V5BU64 Trypanosoma cruzi 48% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS