Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IQR8_LEIDO

TriTrypDb:

LdBPK_361570.1 , LdCL_360021200 , LDHU3_36.2000

Length:

174

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IQR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IQR8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	88	92	PF00656	0.440
CLV_NRD_NRD_1	14	16	PF00675	0.700
CLV_NRD_NRD_1	38	40	PF00675	0.656
CLV_PCSK_KEX2_1	14	16	PF00082	0.682
CLV_PCSK_KEX2_1	38	40	PF00082	0.656
CLV_PCSK_KEX2_1	64	66	PF00082	0.737
CLV_PCSK_KEX2_1	77	79	PF00082	0.531
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.737
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.531
CLV_PCSK_SKI1_1	158	162	PF00082	0.547
CLV_PCSK_SKI1_1	78	82	PF00082	0.681
DEG_Nend_Nbox_1	1	3	PF02207	0.713
DOC_CKS1_1	72	77	PF01111	0.703
DOC_MAPK_gen_1	14	24	PF00069	0.605
DOC_MAPK_gen_1	148	157	PF00069	0.506
DOC_MAPK_MEF2A_6	14	22	PF00069	0.593
DOC_USP7_MATH_1	103	107	PF00917	0.491
DOC_USP7_MATH_1	41	45	PF00917	0.698
DOC_WW_Pin1_4	71	76	PF00397	0.753
LIG_DLG_GKlike_1	129	137	PF00625	0.536
LIG_FHA_1	121	127	PF00498	0.515
LIG_FHA_1	47	53	PF00498	0.555
LIG_FHA_2	140	146	PF00498	0.594
LIG_FHA_2	164	170	PF00498	0.495
LIG_FHA_2	79	85	PF00498	0.577
LIG_Rb_pABgroove_1	147	155	PF01858	0.537
LIG_SH2_STAP1	153	157	PF00017	0.597
LIG_SH2_STAT5	111	114	PF00017	0.537
LIG_SH2_STAT5	36	39	PF00017	0.711
LIG_SH3_3	26	32	PF00018	0.671
LIG_TRAF2_1	142	145	PF00917	0.525
LIG_WRC_WIRS_1	90	95	PF05994	0.480
MOD_CDK_SPxK_1	71	77	PF00069	0.601
MOD_CDK_SPxxK_3	71	78	PF00069	0.752
MOD_CK1_1	106	112	PF00069	0.523
MOD_CK1_1	44	50	PF00069	0.616
MOD_CK2_1	139	145	PF00069	0.622
MOD_CK2_1	163	169	PF00069	0.490
MOD_CK2_1	78	84	PF00069	0.608
MOD_CK2_1	89	95	PF00069	0.395
MOD_GSK3_1	103	110	PF00069	0.491
MOD_GSK3_1	40	47	PF00069	0.689
MOD_N-GLC_1	4	9	PF02516	0.640
MOD_NEK2_1	89	94	PF00069	0.452
MOD_OFUCOSY	3	9	PF10250	0.505
MOD_PIKK_1	120	126	PF00454	0.478
MOD_PKA_2	16	22	PF00069	0.599
MOD_PKA_2	44	50	PF00069	0.660
MOD_Plk_2-3	163	169	PF00069	0.490
MOD_Plk_4	107	113	PF00069	0.535
MOD_ProDKin_1	71	77	PF00069	0.756
MOD_SUMO_for_1	160	163	PF00179	0.607
MOD_SUMO_rev_2	132	142	PF00179	0.556
MOD_SUMO_rev_2	98	106	PF00179	0.590
TRG_DiLeu_BaEn_1	95	100	PF01217	0.478
TRG_ER_diArg_1	14	17	PF00400	0.707
TRG_ER_diArg_1	37	39	PF00400	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJJ7	Leptomonas seymouri	58%	100%
A4HP11	Leishmania braziliensis	69%	99%
A4IDC0	Leishmania infantum	99%	100%
E9ASS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q1S5	Leishmania major	88%	100%