Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IQL8_LEIDO

TriTrypDb:

LdBPK_281670.1 , LdCL_280021400 , LDHU3_28.2140

Length:

860

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IQL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IQL8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.603
CLV_C14_Caspase3-7	730	734	PF00656	0.575
CLV_MEL_PAP_1	159	165	PF00089	0.573
CLV_NRD_NRD_1	130	132	PF00675	0.571
CLV_NRD_NRD_1	201	203	PF00675	0.568
CLV_NRD_NRD_1	233	235	PF00675	0.604
CLV_NRD_NRD_1	362	364	PF00675	0.555
CLV_NRD_NRD_1	492	494	PF00675	0.530
CLV_NRD_NRD_1	512	514	PF00675	0.359
CLV_NRD_NRD_1	717	719	PF00675	0.603
CLV_PCSK_KEX2_1	130	132	PF00082	0.571
CLV_PCSK_KEX2_1	201	203	PF00082	0.568
CLV_PCSK_KEX2_1	233	235	PF00082	0.611
CLV_PCSK_KEX2_1	362	364	PF00082	0.555
CLV_PCSK_KEX2_1	492	494	PF00082	0.530
CLV_PCSK_KEX2_1	512	514	PF00082	0.359
CLV_PCSK_KEX2_1	674	676	PF00082	0.568
CLV_PCSK_KEX2_1	716	718	PF00082	0.605
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.571
CLV_PCSK_PC1ET2_1	674	676	PF00082	0.568
CLV_PCSK_PC7_1	126	132	PF00082	0.599
CLV_PCSK_PC7_1	197	203	PF00082	0.568
CLV_PCSK_SKI1_1	135	139	PF00082	0.571
CLV_PCSK_SKI1_1	363	367	PF00082	0.542
CLV_PCSK_SKI1_1	512	516	PF00082	0.414
CLV_PCSK_SKI1_1	674	678	PF00082	0.576
CLV_PCSK_SKI1_1	721	725	PF00082	0.601
DEG_APCC_DBOX_1	512	520	PF00400	0.418
DEG_COP1_1	817	826	PF00400	0.592
DEG_SCF_FBW7_1	159	164	PF00400	0.620
DEG_SCF_FBW7_1	792	799	PF00400	0.549
DEG_SPOP_SBC_1	225	229	PF00917	0.603
DEG_SPOP_SBC_1	806	810	PF00917	0.597
DEG_SPOP_SBC_1	832	836	PF00917	0.605
DOC_CYCLIN_RxL_1	472	482	PF00134	0.330
DOC_MAPK_gen_1	716	725	PF00069	0.580
DOC_MIT_MIM_1	402	410	PF04212	0.401
DOC_PP1_RVXF_1	265	272	PF00149	0.555
DOC_PP1_RVXF_1	426	432	PF00149	0.508
DOC_PP1_RVXF_1	719	726	PF00149	0.601
DOC_PP4_FxxP_1	271	274	PF00568	0.579
DOC_USP7_MATH_1	106	110	PF00917	0.585
DOC_USP7_MATH_1	161	165	PF00917	0.584
DOC_USP7_MATH_1	169	173	PF00917	0.519
DOC_USP7_MATH_1	225	229	PF00917	0.592
DOC_USP7_MATH_1	278	282	PF00917	0.620
DOC_USP7_MATH_1	357	361	PF00917	0.634
DOC_USP7_MATH_1	386	390	PF00917	0.533
DOC_USP7_MATH_1	581	585	PF00917	0.563
DOC_USP7_MATH_1	60	64	PF00917	0.536
DOC_USP7_MATH_1	806	810	PF00917	0.610
DOC_USP7_MATH_1	832	836	PF00917	0.590
DOC_USP7_UBL2_3	16	20	PF12436	0.570
DOC_USP7_UBL2_3	848	852	PF12436	0.550
DOC_WW_Pin1_4	102	107	PF00397	0.594
DOC_WW_Pin1_4	157	162	PF00397	0.557
DOC_WW_Pin1_4	167	172	PF00397	0.574
DOC_WW_Pin1_4	214	219	PF00397	0.568
DOC_WW_Pin1_4	232	237	PF00397	0.600
DOC_WW_Pin1_4	250	255	PF00397	0.541
DOC_WW_Pin1_4	332	337	PF00397	0.614
DOC_WW_Pin1_4	369	374	PF00397	0.572
DOC_WW_Pin1_4	491	496	PF00397	0.583
DOC_WW_Pin1_4	605	610	PF00397	0.567
DOC_WW_Pin1_4	63	68	PF00397	0.577
DOC_WW_Pin1_4	656	661	PF00397	0.786
DOC_WW_Pin1_4	666	671	PF00397	0.597
DOC_WW_Pin1_4	705	710	PF00397	0.585
DOC_WW_Pin1_4	754	759	PF00397	0.514
DOC_WW_Pin1_4	792	797	PF00397	0.598
DOC_WW_Pin1_4	8	13	PF00397	0.595
DOC_WW_Pin1_4	822	827	PF00397	0.599
DOC_WW_Pin1_4	93	98	PF00397	0.644
LIG_14-3-3_CanoR_1	197	201	PF00244	0.579
LIG_14-3-3_CanoR_1	202	207	PF00244	0.587
LIG_14-3-3_CanoR_1	223	231	PF00244	0.620
LIG_14-3-3_CanoR_1	283	292	PF00244	0.578
LIG_14-3-3_CanoR_1	493	502	PF00244	0.578
LIG_14-3-3_CanoR_1	513	522	PF00244	0.298
LIG_14-3-3_CanoR_1	582	586	PF00244	0.485
LIG_14-3-3_CanoR_1	716	725	PF00244	0.588
LIG_14-3-3_CanoR_1	735	745	PF00244	0.537
LIG_Actin_WH2_2	193	209	PF00022	0.518
LIG_BIR_III_2	667	671	PF00653	0.541
LIG_BIR_III_2	733	737	PF00653	0.569
LIG_BRCT_BRCA1_1	459	463	PF00533	0.330
LIG_BRCT_BRCA1_1	65	69	PF00533	0.532
LIG_DLG_GKlike_1	202	210	PF00625	0.587
LIG_FHA_1	158	164	PF00498	0.592
LIG_FHA_1	191	197	PF00498	0.638
LIG_FHA_1	344	350	PF00498	0.602
LIG_FHA_1	37	43	PF00498	0.634
LIG_FHA_1	412	418	PF00498	0.454
LIG_FHA_1	439	445	PF00498	0.544
LIG_FHA_1	503	509	PF00498	0.502
LIG_FHA_1	51	57	PF00498	0.525
LIG_FHA_1	606	612	PF00498	0.628
LIG_FHA_1	722	728	PF00498	0.595
LIG_FHA_1	742	748	PF00498	0.388
LIG_FHA_1	793	799	PF00498	0.630
LIG_FHA_1	832	838	PF00498	0.642
LIG_LIR_Apic_2	255	260	PF02991	0.549
LIG_LIR_Apic_2	268	274	PF02991	0.564
LIG_LIR_Apic_2	66	71	PF02991	0.537
LIG_LIR_Gen_1	391	401	PF02991	0.392
LIG_LIR_Gen_1	464	474	PF02991	0.397
LIG_LIR_Gen_1	757	765	PF02991	0.444
LIG_LIR_Gen_1	843	853	PF02991	0.583
LIG_LIR_Nem_3	326	332	PF02991	0.547
LIG_LIR_Nem_3	391	396	PF02991	0.451
LIG_LIR_Nem_3	464	470	PF02991	0.517
LIG_LIR_Nem_3	66	72	PF02991	0.516
LIG_LIR_Nem_3	757	762	PF02991	0.452
LIG_LIR_Nem_3	843	849	PF02991	0.589
LIG_LYPXL_yS_3	133	136	PF13949	0.580
LIG_MLH1_MIPbox_1	65	69	PF16413	0.513
LIG_MYND_1	792	796	PF01753	0.525
LIG_SH2_CRK	257	261	PF00017	0.544
LIG_SH2_CRK	846	850	PF00017	0.587
LIG_SH2_NCK_1	257	261	PF00017	0.544
LIG_SH2_SRC	257	260	PF00017	0.599
LIG_SH2_STAT5	264	267	PF00017	0.603
LIG_SH2_STAT5	467	470	PF00017	0.384
LIG_SH2_STAT5	678	681	PF00017	0.578
LIG_SH2_STAT5	68	71	PF00017	0.561
LIG_SH2_STAT5	703	706	PF00017	0.619
LIG_SH3_2	121	126	PF14604	0.621
LIG_SH3_2	670	675	PF14604	0.574
LIG_SH3_3	117	123	PF00018	0.652
LIG_SH3_3	253	259	PF00018	0.608
LIG_SH3_3	3	9	PF00018	0.578
LIG_SH3_3	555	561	PF00018	0.496
LIG_SH3_3	655	661	PF00018	0.621
LIG_SH3_3	667	673	PF00018	0.604
LIG_SH3_3	76	82	PF00018	0.583
LIG_SH3_3	818	824	PF00018	0.585
LIG_SUMO_SIM_anti_2	744	749	PF11976	0.492
LIG_SUMO_SIM_par_1	52	58	PF11976	0.575
LIG_SUMO_SIM_par_1	520	526	PF11976	0.404
LIG_SUMO_SIM_par_1	742	749	PF11976	0.500
LIG_TRAF2_1	523	526	PF00917	0.425
LIG_TRAF2_1	768	771	PF00917	0.429
LIG_TRFH_1	725	729	PF08558	0.588
LIG_UBA3_1	747	755	PF00899	0.501
LIG_WRC_WIRS_1	471	476	PF05994	0.377
LIG_WW_3	579	583	PF00397	0.484
MOD_CDC14_SPxK_1	96	99	PF00782	0.559
MOD_CDK_SPK_2	157	162	PF00069	0.557
MOD_CDK_SPK_2	792	797	PF00069	0.567
MOD_CDK_SPK_2	822	827	PF00069	0.592
MOD_CDK_SPxK_1	93	99	PF00069	0.565
MOD_CK1_1	10	16	PF00069	0.703
MOD_CK1_1	157	163	PF00069	0.557
MOD_CK1_1	172	178	PF00069	0.681
MOD_CK1_1	205	211	PF00069	0.618
MOD_CK1_1	216	222	PF00069	0.621
MOD_CK1_1	286	292	PF00069	0.619
MOD_CK1_1	315	321	PF00069	0.566
MOD_CK1_1	36	42	PF00069	0.639
MOD_CK1_1	389	395	PF00069	0.462
MOD_CK1_1	47	53	PF00069	0.542
MOD_CK1_1	494	500	PF00069	0.573
MOD_CK1_1	590	596	PF00069	0.567
MOD_CK1_1	599	605	PF00069	0.598
MOD_CK1_1	61	67	PF00069	0.516
MOD_CK1_1	618	624	PF00069	0.483
MOD_CK1_1	635	641	PF00069	0.598
MOD_CK1_1	648	654	PF00069	0.582
MOD_CK1_1	707	713	PF00069	0.671
MOD_CK1_1	739	745	PF00069	0.518
MOD_CK1_1	825	831	PF00069	0.616
MOD_CK1_1	844	850	PF00069	0.472
MOD_CK2_1	102	108	PF00069	0.736
MOD_CK2_1	315	321	PF00069	0.532
MOD_CK2_1	344	350	PF00069	0.596
MOD_CK2_1	35	41	PF00069	0.642
MOD_CK2_1	764	770	PF00069	0.432
MOD_GlcNHglycan	237	240	PF01048	0.799
MOD_GlcNHglycan	280	283	PF01048	0.609
MOD_GlcNHglycan	286	289	PF01048	0.581
MOD_GlcNHglycan	295	298	PF01048	0.514
MOD_GlcNHglycan	314	317	PF01048	0.495
MOD_GlcNHglycan	336	339	PF01048	0.625
MOD_GlcNHglycan	388	391	PF01048	0.465
MOD_GlcNHglycan	49	52	PF01048	0.581
MOD_GlcNHglycan	496	499	PF01048	0.587
MOD_GlcNHglycan	60	63	PF01048	0.525
MOD_GlcNHglycan	604	607	PF01048	0.636
MOD_GlcNHglycan	621	624	PF01048	0.539
MOD_GlcNHglycan	653	656	PF01048	0.663
MOD_GlcNHglycan	738	741	PF01048	0.549
MOD_GlcNHglycan	766	769	PF01048	0.438
MOD_GlcNHglycan	809	812	PF01048	0.593
MOD_GlcNHglycan	830	833	PF01048	0.578
MOD_GlcNHglycan	857	860	PF01048	0.551
MOD_GSK3_1	102	109	PF00069	0.631
MOD_GSK3_1	157	164	PF00069	0.649
MOD_GSK3_1	167	174	PF00069	0.520
MOD_GSK3_1	191	198	PF00069	0.562
MOD_GSK3_1	201	208	PF00069	0.586
MOD_GSK3_1	283	290	PF00069	0.616
MOD_GSK3_1	36	43	PF00069	0.601
MOD_GSK3_1	436	443	PF00069	0.513
MOD_GSK3_1	46	53	PF00069	0.548
MOD_GSK3_1	462	469	PF00069	0.389
MOD_GSK3_1	592	599	PF00069	0.577
MOD_GSK3_1	615	622	PF00069	0.582
MOD_GSK3_1	63	70	PF00069	0.549
MOD_GSK3_1	645	652	PF00069	0.632
MOD_GSK3_1	699	706	PF00069	0.600
MOD_GSK3_1	708	715	PF00069	0.648
MOD_GSK3_1	760	767	PF00069	0.411
MOD_GSK3_1	792	799	PF00069	0.564
MOD_GSK3_1	8	15	PF00069	0.598
MOD_GSK3_1	801	808	PF00069	0.561
MOD_GSK3_1	828	835	PF00069	0.565
MOD_GSK3_1	836	843	PF00069	0.576
MOD_N-GLC_1	157	162	PF02516	0.589
MOD_N-GLC_1	283	288	PF02516	0.597
MOD_N-GLC_1	36	41	PF02516	0.627
MOD_N-GLC_1	615	620	PF02516	0.591
MOD_N-GLC_1	648	653	PF02516	0.627
MOD_N-GLC_1	693	698	PF02516	0.547
MOD_NEK2_1	1	6	PF00069	0.579
MOD_NEK2_1	111	116	PF00069	0.562
MOD_NEK2_1	176	181	PF00069	0.755
MOD_NEK2_1	19	24	PF00069	0.574
MOD_NEK2_1	190	195	PF00069	0.563
MOD_NEK2_1	196	201	PF00069	0.581
MOD_NEK2_1	206	211	PF00069	0.566
MOD_NEK2_1	307	312	PF00069	0.696
MOD_NEK2_1	396	401	PF00069	0.383
MOD_NEK2_1	438	443	PF00069	0.508
MOD_NEK2_1	462	467	PF00069	0.388
MOD_NEK2_1	515	520	PF00069	0.371
MOD_NEK2_1	575	580	PF00069	0.474
MOD_NEK2_1	592	597	PF00069	0.568
MOD_NEK2_1	610	615	PF00069	0.575
MOD_NEK2_1	617	622	PF00069	0.586
MOD_NEK2_1	764	769	PF00069	0.394
MOD_NEK2_2	192	197	PF00069	0.555
MOD_NEK2_2	446	451	PF00069	0.442
MOD_PIKK_1	135	141	PF00454	0.566
MOD_PIKK_1	462	468	PF00454	0.385
MOD_PIKK_1	710	716	PF00454	0.670
MOD_PKA_1	201	207	PF00069	0.561
MOD_PKA_1	7	13	PF00069	0.599
MOD_PKA_1	716	722	PF00069	0.595
MOD_PKA_2	161	167	PF00069	0.601
MOD_PKA_2	196	202	PF00069	0.585
MOD_PKA_2	581	587	PF00069	0.490
MOD_PKA_2	638	644	PF00069	0.594
MOD_PKA_2	716	722	PF00069	0.595
MOD_PKA_2	736	742	PF00069	0.480
MOD_PKA_2	844	850	PF00069	0.573
MOD_Plk_1	36	42	PF00069	0.601
MOD_Plk_1	615	621	PF00069	0.626
MOD_Plk_2-3	321	327	PF00069	0.538
MOD_Plk_2-3	344	350	PF00069	0.647
MOD_Plk_4	106	112	PF00069	0.621
MOD_Plk_4	206	212	PF00069	0.570
MOD_Plk_4	287	293	PF00069	0.606
MOD_Plk_4	307	313	PF00069	0.462
MOD_Plk_4	396	402	PF00069	0.373
MOD_Plk_4	466	472	PF00069	0.377
MOD_Plk_4	587	593	PF00069	0.532
MOD_Plk_4	699	705	PF00069	0.614
MOD_Plk_4	760	766	PF00069	0.410
MOD_Plk_4	833	839	PF00069	0.604
MOD_ProDKin_1	102	108	PF00069	0.597
MOD_ProDKin_1	157	163	PF00069	0.559
MOD_ProDKin_1	167	173	PF00069	0.574
MOD_ProDKin_1	214	220	PF00069	0.570
MOD_ProDKin_1	232	238	PF00069	0.599
MOD_ProDKin_1	250	256	PF00069	0.538
MOD_ProDKin_1	332	338	PF00069	0.614
MOD_ProDKin_1	369	375	PF00069	0.573
MOD_ProDKin_1	491	497	PF00069	0.584
MOD_ProDKin_1	605	611	PF00069	0.567
MOD_ProDKin_1	63	69	PF00069	0.580
MOD_ProDKin_1	656	662	PF00069	0.787
MOD_ProDKin_1	666	672	PF00069	0.591
MOD_ProDKin_1	705	711	PF00069	0.587
MOD_ProDKin_1	754	760	PF00069	0.508
MOD_ProDKin_1	792	798	PF00069	0.598
MOD_ProDKin_1	8	14	PF00069	0.599
MOD_ProDKin_1	822	828	PF00069	0.599
MOD_ProDKin_1	93	99	PF00069	0.644
MOD_SUMO_for_1	483	486	PF00179	0.403
MOD_SUMO_rev_2	477	485	PF00179	0.395
TRG_DiLeu_BaEn_1	607	612	PF01217	0.630
TRG_ENDOCYTIC_2	133	136	PF00928	0.580
TRG_ENDOCYTIC_2	393	396	PF00928	0.441
TRG_ENDOCYTIC_2	467	470	PF00928	0.397
TRG_ENDOCYTIC_2	846	849	PF00928	0.588
TRG_ER_diArg_1	200	202	PF00400	0.566
TRG_ER_diArg_1	426	429	PF00400	0.482
TRG_ER_diArg_1	491	493	PF00400	0.521
TRG_ER_diArg_1	716	718	PF00400	0.822
TRG_ER_diArg_1	735	738	PF00400	0.500
TRG_NES_CRM1_1	771	784	PF08389	0.367
TRG_NLS_MonoExtC_3	129	134	PF00514	0.557
TRG_NLS_MonoExtN_4	673	678	PF00514	0.550
TRG_Pf-PMV_PEXEL_1	363	368	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	418	423	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHK2	Leptomonas seymouri	40%	100%
A4HGK7	Leishmania braziliensis	57%	98%
A4I3N3	Leishmania infantum	99%	100%
E9AZX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	98%
Q4Q8B1	Leishmania major	87%	100%