DUF4470 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IQJ6_LEIDO

TriTrypDb:

LdBPK_360870.1 , LdCL_360013700 , LDHU3_36.1140

Length:

459

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IQJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IQJ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.312
CLV_C14_Caspase3-7	240	244	PF00656	0.376
CLV_C14_Caspase3-7	276	280	PF00656	0.320
CLV_NRD_NRD_1	157	159	PF00675	0.548
CLV_NRD_NRD_1	230	232	PF00675	0.527
CLV_NRD_NRD_1	3	5	PF00675	0.411
CLV_NRD_NRD_1	54	56	PF00675	0.568
CLV_PCSK_FUR_1	440	444	PF00082	0.553
CLV_PCSK_KEX2_1	230	232	PF00082	0.527
CLV_PCSK_KEX2_1	3	5	PF00082	0.411
CLV_PCSK_KEX2_1	442	444	PF00082	0.672
CLV_PCSK_KEX2_1	54	56	PF00082	0.596
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.673
CLV_PCSK_SKI1_1	139	143	PF00082	0.487
CLV_PCSK_SKI1_1	159	163	PF00082	0.410
CLV_PCSK_SKI1_1	213	217	PF00082	0.542
CLV_PCSK_SKI1_1	230	234	PF00082	0.438
CLV_PCSK_SKI1_1	353	357	PF00082	0.585
CLV_PCSK_SKI1_1	430	434	PF00082	0.538
CLV_PCSK_SKI1_1	442	446	PF00082	0.701
CLV_PCSK_SKI1_1	55	59	PF00082	0.563
CLV_PCSK_SKI1_1	94	98	PF00082	0.537
DEG_APCC_DBOX_1	54	62	PF00400	0.396
DEG_APCC_DBOX_1	93	101	PF00400	0.320
DOC_CDC14_PxL_1	175	183	PF14671	0.292
DOC_CYCLIN_RxL_1	208	221	PF00134	0.331
DOC_CYCLIN_RxL_1	52	62	PF00134	0.380
DOC_CYCLIN_yCln2_LP_2	83	89	PF00134	0.385
DOC_MAPK_gen_1	155	163	PF00069	0.331
DOC_MAPK_MEF2A_6	189	196	PF00069	0.281
DOC_PP1_RVXF_1	157	164	PF00149	0.319
DOC_PP2B_LxvP_1	123	126	PF13499	0.367
DOC_PP2B_LxvP_1	76	79	PF13499	0.390
DOC_PP4_FxxP_1	162	165	PF00568	0.262
DOC_PP4_FxxP_1	447	450	PF00568	0.449
DOC_USP7_MATH_1	177	181	PF00917	0.325
DOC_USP7_MATH_1	211	215	PF00917	0.263
DOC_USP7_MATH_1	26	30	PF00917	0.397
DOC_USP7_MATH_1	312	316	PF00917	0.418
DOC_USP7_UBL2_3	271	275	PF12436	0.330
LIG_14-3-3_CanoR_1	213	218	PF00244	0.360
LIG_BIR_III_4	279	283	PF00653	0.302
LIG_BIR_III_4	44	48	PF00653	0.357
LIG_FHA_1	219	225	PF00498	0.428
LIG_FHA_1	257	263	PF00498	0.300
LIG_FHA_1	346	352	PF00498	0.405
LIG_FHA_1	354	360	PF00498	0.355
LIG_FHA_1	393	399	PF00498	0.305
LIG_FHA_1	429	435	PF00498	0.389
LIG_FHA_1	71	77	PF00498	0.420
LIG_FHA_2	238	244	PF00498	0.395
LIG_GBD_Chelix_1	111	119	PF00786	0.516
LIG_GBD_Chelix_1	398	406	PF00786	0.571
LIG_IBAR_NPY_1	204	206	PF08397	0.372
LIG_LIR_Apic_2	445	450	PF02991	0.394
LIG_LIR_Gen_1	166	176	PF02991	0.263
LIG_LIR_Gen_1	422	429	PF02991	0.390
LIG_LIR_Gen_1	60	71	PF02991	0.481
LIG_LIR_Nem_3	166	171	PF02991	0.267
LIG_LIR_Nem_3	17	22	PF02991	0.569
LIG_LIR_Nem_3	193	199	PF02991	0.300
LIG_LIR_Nem_3	254	260	PF02991	0.321
LIG_LIR_Nem_3	327	333	PF02991	0.286
LIG_LIR_Nem_3	339	344	PF02991	0.308
LIG_LIR_Nem_3	422	426	PF02991	0.415
LIG_LIR_Nem_3	60	66	PF02991	0.396
LIG_LIR_Nem_3	81	87	PF02991	0.355
LIG_LYPXL_yS_3	178	181	PF13949	0.294
LIG_PCNA_PIPBox_1	374	383	PF02747	0.289
LIG_Pex14_2	19	23	PF04695	0.431
LIG_SH2_CRK	206	210	PF00017	0.299
LIG_SH2_CRK	295	299	PF00017	0.354
LIG_SH2_SRC	416	419	PF00017	0.376
LIG_SH2_STAP1	206	210	PF00017	0.317
LIG_SH2_STAT5	110	113	PF00017	0.299
LIG_SH2_STAT5	184	187	PF00017	0.281
LIG_SH2_STAT5	35	38	PF00017	0.456
LIG_SH2_STAT5	381	384	PF00017	0.306
LIG_SUMO_SIM_anti_2	190	196	PF11976	0.319
LIG_SUMO_SIM_anti_2	364	370	PF11976	0.417
LIG_SUMO_SIM_par_1	258	264	PF11976	0.286
LIG_SUMO_SIM_par_1	364	370	PF11976	0.373
LIG_UBA3_1	402	410	PF00899	0.301
LIG_UBA3_1	425	433	PF00899	0.382
LIG_UBA3_1	83	91	PF00899	0.363
LIG_WRC_WIRS_1	217	222	PF05994	0.347
MOD_CK1_1	389	395	PF00069	0.400
MOD_CK1_1	419	425	PF00069	0.316
MOD_CK2_1	177	183	PF00069	0.379
MOD_CK2_1	337	343	PF00069	0.422
MOD_Cter_Amidation	316	319	PF01082	0.585
MOD_GlcNHglycan	455	458	PF01048	0.788
MOD_GSK3_1	147	154	PF00069	0.406
MOD_GSK3_1	246	253	PF00069	0.351
MOD_GSK3_1	256	263	PF00069	0.317
MOD_N-GLC_2	291	293	PF02516	0.469
MOD_NEK2_1	149	154	PF00069	0.397
MOD_NEK2_1	218	223	PF00069	0.302
MOD_NEK2_1	260	265	PF00069	0.282
MOD_NEK2_1	337	342	PF00069	0.364
MOD_NEK2_1	354	359	PF00069	0.202
MOD_PIKK_1	218	224	PF00454	0.306
MOD_PIKK_1	8	14	PF00454	0.671
MOD_PKA_1	442	448	PF00069	0.469
MOD_PKA_2	199	205	PF00069	0.357
MOD_PKA_2	442	448	PF00069	0.441
MOD_Plk_1	119	125	PF00069	0.343
MOD_Plk_1	142	148	PF00069	0.369
MOD_Plk_1	386	392	PF00069	0.375
MOD_Plk_2-3	72	78	PF00069	0.452
MOD_Plk_4	213	219	PF00069	0.362
MOD_Plk_4	237	243	PF00069	0.382
MOD_Plk_4	256	262	PF00069	0.216
MOD_Plk_4	354	360	PF00069	0.336
TRG_DiLeu_BaEn_2	325	331	PF01217	0.299
TRG_DiLeu_BaEn_4	326	332	PF01217	0.308
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.376
TRG_ENDOCYTIC_2	178	181	PF00928	0.294
TRG_ENDOCYTIC_2	206	209	PF00928	0.301
TRG_ENDOCYTIC_2	295	298	PF00928	0.350
TRG_ENDOCYTIC_2	371	374	PF00928	0.283
TRG_ENDOCYTIC_2	423	426	PF00928	0.399
TRG_ER_diArg_1	2	4	PF00400	0.621
TRG_ER_diArg_1	230	232	PF00400	0.327
TRG_ER_diArg_1	53	55	PF00400	0.400
TRG_ER_FFAT_1	339	350	PF00635	0.359
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	303	307	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM88	Leptomonas seymouri	85%	100%
A0A0S4JVF0	Bodo saltans	58%	100%
A0A1X0P8C7	Trypanosomatidae	71%	100%
A0A3R7MNS3	Trypanosoma rangeli	71%	100%
A4HNU1	Leishmania braziliensis	90%	100%
A4ICQ3	Leishmania infantum	100%	100%
D0A2Q6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9ASK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q1Z5	Leishmania major	98%	100%