WWE domain-containing protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IQI6_LEIDO

TriTrypDb:

LdBPK_281330.1 , LdCL_280017900 , LDHU3_28.1680

Length:

467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote/Amastigote: 211

Expansion

Sequence features

A0A3Q8IQI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IQI6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	257	261	PF00656	0.550
CLV_C14_Caspase3-7	453	457	PF00656	0.627
CLV_NRD_NRD_1	214	216	PF00675	0.618
CLV_NRD_NRD_1	328	330	PF00675	0.402
CLV_NRD_NRD_1	397	399	PF00675	0.444
CLV_NRD_NRD_1	405	407	PF00675	0.549
CLV_NRD_NRD_1	464	466	PF00675	0.643
CLV_PCSK_KEX2_1	397	399	PF00082	0.444
CLV_PCSK_KEX2_1	407	409	PF00082	0.545
CLV_PCSK_KEX2_1	462	464	PF00082	0.659
CLV_PCSK_PC1ET2_1	407	409	PF00082	0.488
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.635
CLV_PCSK_SKI1_1	116	120	PF00082	0.575
CLV_PCSK_SKI1_1	19	23	PF00082	0.394
CLV_PCSK_SKI1_1	243	247	PF00082	0.585
CLV_PCSK_SKI1_1	407	411	PF00082	0.609
DEG_APCC_DBOX_1	51	59	PF00400	0.413
DEG_COP1_1	187	197	PF00400	0.650
DEG_SCF_SKP2-CKS1_1	454	461	PF00560	0.567
DEG_SPOP_SBC_1	442	446	PF00917	0.661
DOC_CYCLIN_yCln2_LP_2	134	140	PF00134	0.513
DOC_MAPK_gen_1	16	24	PF00069	0.406
DOC_MAPK_gen_1	329	335	PF00069	0.446
DOC_MAPK_MEF2A_6	16	24	PF00069	0.406
DOC_MAPK_MEF2A_6	243	250	PF00069	0.573
DOC_PP2B_LxvP_1	160	163	PF13499	0.453
DOC_PP2B_LxvP_1	192	195	PF13499	0.621
DOC_PP4_FxxP_1	359	362	PF00568	0.456
DOC_USP7_MATH_1	120	124	PF00917	0.568
DOC_USP7_MATH_1	193	197	PF00917	0.682
DOC_USP7_MATH_1	234	238	PF00917	0.650
DOC_USP7_MATH_1	288	292	PF00917	0.642
DOC_USP7_MATH_1	438	442	PF00917	0.615
DOC_USP7_MATH_1	91	95	PF00917	0.573
DOC_USP7_UBL2_3	361	365	PF12436	0.460
DOC_USP7_UBL2_3	388	392	PF12436	0.649
DOC_USP7_UBL2_3	407	411	PF12436	0.424
DOC_WW_Pin1_4	259	264	PF00397	0.697
DOC_WW_Pin1_4	414	419	PF00397	0.661
DOC_WW_Pin1_4	455	460	PF00397	0.619
DOC_WW_Pin1_4	78	83	PF00397	0.621
LIG_14-3-3_CanoR_1	186	194	PF00244	0.564
LIG_14-3-3_CanoR_1	19	25	PF00244	0.409
LIG_BIR_II_1	1	5	PF00653	0.563
LIG_BIR_III_4	363	367	PF00653	0.466
LIG_BRCT_BRCA1_1	355	359	PF00533	0.513
LIG_BRCT_BRCA1_2	355	361	PF00533	0.524
LIG_CSL_BTD_1	58	61	PF09270	0.400
LIG_CtBP_PxDLS_1	157	161	PF00389	0.515
LIG_FHA_1	127	133	PF00498	0.559
LIG_FHA_1	162	168	PF00498	0.512
LIG_FHA_1	25	31	PF00498	0.421
LIG_FHA_1	366	372	PF00498	0.394
LIG_FHA_1	4	10	PF00498	0.491
LIG_FHA_2	185	191	PF00498	0.584
LIG_FHA_2	451	457	PF00498	0.552
LIG_HCF-1_HBM_1	28	31	PF13415	0.415
LIG_Integrin_isoDGR_2	222	224	PF01839	0.595
LIG_LIR_Apic_2	356	362	PF02991	0.572
LIG_LIR_Nem_3	391	396	PF02991	0.459
LIG_PCNA_yPIPBox_3	329	339	PF02747	0.420
LIG_PTB_Apo_2	69	76	PF02174	0.479
LIG_SH2_STAT3	65	68	PF00017	0.384
LIG_SH2_STAT5	31	34	PF00017	0.400
LIG_SH2_STAT5	367	370	PF00017	0.416
LIG_SH3_3	127	133	PF00018	0.455
LIG_SH3_3	151	157	PF00018	0.552
LIG_SH3_3	55	61	PF00018	0.497
LIG_SH3_4	361	368	PF00018	0.441
LIG_SUMO_SIM_anti_2	53	59	PF11976	0.373
LIG_SUMO_SIM_par_1	126	131	PF11976	0.502
LIG_SUMO_SIM_par_1	136	141	PF11976	0.493
LIG_SUMO_SIM_par_1	190	196	PF11976	0.651
LIG_SUMO_SIM_par_1	20	25	PF11976	0.401
LIG_TRAF2_1	211	214	PF00917	0.592
MOD_CDK_SPxK_1	455	461	PF00069	0.567
MOD_CDK_SPxxK_3	455	462	PF00069	0.605
MOD_CDK_SPxxK_3	78	85	PF00069	0.620
MOD_CK1_1	218	224	PF00069	0.685
MOD_CK1_1	259	265	PF00069	0.700
MOD_CK1_1	274	280	PF00069	0.784
MOD_CK1_1	417	423	PF00069	0.594
MOD_CK1_1	428	434	PF00069	0.624
MOD_CK1_1	441	447	PF00069	0.596
MOD_CK1_1	448	454	PF00069	0.495
MOD_CK1_1	455	461	PF00069	0.619
MOD_CK1_1	94	100	PF00069	0.574
MOD_CK2_1	184	190	PF00069	0.622
MOD_CK2_1	208	214	PF00069	0.680
MOD_CK2_1	288	294	PF00069	0.670
MOD_CK2_1	383	389	PF00069	0.415
MOD_CK2_1	423	429	PF00069	0.634
MOD_CK2_1	433	439	PF00069	0.637
MOD_GlcNHglycan	109	112	PF01048	0.521
MOD_GlcNHglycan	122	125	PF01048	0.569
MOD_GlcNHglycan	236	239	PF01048	0.746
MOD_GlcNHglycan	283	286	PF01048	0.580
MOD_GlcNHglycan	290	293	PF01048	0.642
MOD_GlcNHglycan	3	6	PF01048	0.578
MOD_GlcNHglycan	355	358	PF01048	0.507
MOD_GlcNHglycan	40	43	PF01048	0.460
MOD_GlcNHglycan	439	443	PF01048	0.779
MOD_GlcNHglycan	95	99	PF01048	0.560
MOD_GSK3_1	116	123	PF00069	0.586
MOD_GSK3_1	177	184	PF00069	0.676
MOD_GSK3_1	20	27	PF00069	0.587
MOD_GSK3_1	218	225	PF00069	0.666
MOD_GSK3_1	414	421	PF00069	0.566
MOD_GSK3_1	438	445	PF00069	0.602
MOD_GSK3_1	448	455	PF00069	0.730
MOD_N-GLC_1	234	239	PF02516	0.632
MOD_N-GLC_1	449	454	PF02516	0.622
MOD_NEK2_1	1	6	PF00069	0.544
MOD_NEK2_1	109	114	PF00069	0.551
MOD_NEK2_1	138	143	PF00069	0.556
MOD_NEK2_1	258	263	PF00069	0.556
MOD_NEK2_1	76	81	PF00069	0.603
MOD_NEK2_2	163	168	PF00069	0.385
MOD_PIKK_1	138	144	PF00454	0.560
MOD_PIKK_1	271	277	PF00454	0.690
MOD_PKA_1	215	221	PF00069	0.644
MOD_PKA_2	107	113	PF00069	0.459
MOD_PKA_2	185	191	PF00069	0.564
MOD_PKA_2	218	224	PF00069	0.630
MOD_PKA_2	396	402	PF00069	0.470
MOD_Plk_1	344	350	PF00069	0.483
MOD_Plk_1	438	444	PF00069	0.606
MOD_Plk_2-3	208	214	PF00069	0.640
MOD_Plk_2-3	425	431	PF00069	0.641
MOD_Plk_4	71	77	PF00069	0.477
MOD_Plk_4	97	103	PF00069	0.572
MOD_ProDKin_1	259	265	PF00069	0.700
MOD_ProDKin_1	414	420	PF00069	0.670
MOD_ProDKin_1	455	461	PF00069	0.622
MOD_ProDKin_1	78	84	PF00069	0.618
MOD_SUMO_rev_2	208	218	PF00179	0.647
MOD_SUMO_rev_2	313	323	PF00179	0.517
TRG_ER_diArg_1	396	398	PF00400	0.421
TRG_ER_diArg_1	463	465	PF00400	0.666
TRG_NLS_Bipartite_1	397	411	PF00514	0.447
TRG_NLS_MonoCore_2	460	465	PF00514	0.633
TRG_NLS_MonoExtC_3	406	411	PF00514	0.478
TRG_NLS_MonoExtC_3	460	465	PF00514	0.633
TRG_NLS_MonoExtN_4	406	411	PF00514	0.478
TRG_NLS_MonoExtN_4	459	466	PF00514	0.630
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J3	Leptomonas seymouri	55%	97%
A4HGG9	Leishmania braziliensis	72%	100%
A4I3K1	Leishmania infantum	100%	100%
E9AZU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q8E4	Leishmania major	87%	100%