Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IQE0_LEIDO

TriTrypDb:

LdBPK_280710.1 , LdCL_280011700 , LDHU3_28.0880

Length:

507

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IQE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IQE0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	252	256	PF00656	0.502
CLV_NRD_NRD_1	354	356	PF00675	0.605
CLV_NRD_NRD_1	43	45	PF00675	0.409
CLV_NRD_NRD_1	490	492	PF00675	0.396
CLV_NRD_NRD_1	66	68	PF00675	0.363
CLV_PCSK_KEX2_1	289	291	PF00082	0.416
CLV_PCSK_KEX2_1	43	45	PF00082	0.409
CLV_PCSK_KEX2_1	490	492	PF00082	0.363
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.416
CLV_PCSK_SKI1_1	149	153	PF00082	0.300
CLV_PCSK_SKI1_1	347	351	PF00082	0.609
CLV_PCSK_SKI1_1	403	407	PF00082	0.362
CLV_PCSK_SKI1_1	44	48	PF00082	0.299
CLV_PCSK_SKI1_1	70	74	PF00082	0.303
DEG_SCF_FBW7_1	437	443	PF00400	0.516
DOC_CKS1_1	437	442	PF01111	0.525
DOC_CYCLIN_RxL_1	41	51	PF00134	0.294
DOC_CYCLIN_yCln2_LP_2	478	484	PF00134	0.341
DOC_MAPK_MEF2A_6	474	482	PF00069	0.353
DOC_MAPK_RevD_3	476	491	PF00069	0.344
DOC_PP1_RVXF_1	483	490	PF00149	0.423
DOC_PP2B_LxvP_1	382	385	PF13499	0.375
DOC_PP2B_LxvP_1	478	481	PF13499	0.348
DOC_PP4_FxxP_1	442	445	PF00568	0.432
DOC_PP4_FxxP_1	73	76	PF00568	0.324
DOC_USP7_MATH_1	250	254	PF00917	0.481
DOC_USP7_MATH_1	432	436	PF00917	0.530
DOC_USP7_MATH_1	57	61	PF00917	0.437
DOC_USP7_MATH_1	83	87	PF00917	0.289
DOC_WW_Pin1_4	131	136	PF00397	0.436
DOC_WW_Pin1_4	171	176	PF00397	0.414
DOC_WW_Pin1_4	2	7	PF00397	0.544
DOC_WW_Pin1_4	388	393	PF00397	0.434
DOC_WW_Pin1_4	433	438	PF00397	0.574
DOC_WW_Pin1_4	88	93	PF00397	0.298
LIG_14-3-3_CanoR_1	10	16	PF00244	0.519
LIG_14-3-3_CanoR_1	123	132	PF00244	0.423
LIG_14-3-3_CanoR_1	147	152	PF00244	0.318
LIG_14-3-3_CanoR_1	229	239	PF00244	0.410
LIG_14-3-3_CanoR_1	249	258	PF00244	0.356
LIG_14-3-3_CanoR_1	290	296	PF00244	0.414
LIG_14-3-3_CanoR_1	427	432	PF00244	0.480
LIG_14-3-3_CanoR_1	43	47	PF00244	0.325
LIG_14-3-3_CanoR_1	56	66	PF00244	0.390
LIG_Actin_WH2_2	306	324	PF00022	0.344
LIG_Actin_WH2_2	394	409	PF00022	0.344
LIG_BIR_II_1	1	5	PF00653	0.552
LIG_CaM_IQ_9	415	430	PF13499	0.359
LIG_eIF4E_1	410	416	PF01652	0.292
LIG_FHA_1	100	106	PF00498	0.314
LIG_FHA_1	328	334	PF00498	0.361
LIG_FHA_1	411	417	PF00498	0.371
LIG_FHA_1	89	95	PF00498	0.299
LIG_FHA_2	105	111	PF00498	0.314
LIG_FHA_2	389	395	PF00498	0.448
LIG_FHA_2	419	425	PF00498	0.515
LIG_GBD_Chelix_1	317	325	PF00786	0.353
LIG_LIR_Apic_2	439	445	PF02991	0.475
LIG_LIR_Gen_1	161	168	PF02991	0.405
LIG_LIR_Gen_1	25	35	PF02991	0.291
LIG_LIR_Gen_1	51	57	PF02991	0.340
LIG_LIR_Nem_3	109	115	PF02991	0.310
LIG_LIR_Nem_3	161	166	PF02991	0.400
LIG_LIR_Nem_3	200	205	PF02991	0.359
LIG_LIR_Nem_3	25	31	PF02991	0.290
LIG_LIR_Nem_3	276	281	PF02991	0.393
LIG_LIR_Nem_3	394	398	PF02991	0.524
LIG_LIR_Nem_3	493	499	PF02991	0.416
LIG_LIR_Nem_3	502	506	PF02991	0.505
LIG_LIR_Nem_3	51	55	PF02991	0.329
LIG_LYPXL_yS_3	112	115	PF13949	0.301
LIG_Pex14_2	28	32	PF04695	0.268
LIG_PTB_Apo_2	280	287	PF02174	0.411
LIG_PTB_Apo_2	46	53	PF02174	0.308
LIG_REV1ctd_RIR_1	276	286	PF16727	0.352
LIG_SH2_STAP1	258	262	PF00017	0.467
LIG_SH2_STAP1	410	414	PF00017	0.317
LIG_SH2_STAT3	185	188	PF00017	0.447
LIG_SH2_STAT5	205	208	PF00017	0.322
LIG_SH2_STAT5	246	249	PF00017	0.352
LIG_SH2_STAT5	285	288	PF00017	0.342
LIG_SH2_STAT5	39	42	PF00017	0.268
LIG_SH2_STAT5	499	502	PF00017	0.416
LIG_SH3_1	498	504	PF00018	0.453
LIG_SH3_3	129	135	PF00018	0.408
LIG_SH3_3	268	274	PF00018	0.401
LIG_SH3_3	328	334	PF00018	0.322
LIG_SH3_3	434	440	PF00018	0.645
LIG_SH3_3	498	504	PF00018	0.488
LIG_TRFH_1	205	209	PF08558	0.328
LIG_TRFH_1	442	446	PF08558	0.379
LIG_WRC_WIRS_1	105	110	PF05994	0.312
MOD_CDK_SPK_2	88	93	PF00069	0.302
MOD_CK1_1	134	140	PF00069	0.365
MOD_CK1_1	14	20	PF00069	0.454
MOD_CK1_1	171	177	PF00069	0.429
MOD_CK1_1	2	8	PF00069	0.543
MOD_CK1_1	380	386	PF00069	0.469
MOD_CK1_1	436	442	PF00069	0.538
MOD_CK2_1	104	110	PF00069	0.312
MOD_CK2_1	122	128	PF00069	0.501
MOD_CK2_1	14	20	PF00069	0.475
MOD_CK2_1	166	172	PF00069	0.444
MOD_CK2_1	388	394	PF00069	0.461
MOD_GlcNHglycan	1	4	PF01048	0.545
MOD_GlcNHglycan	252	255	PF01048	0.563
MOD_GlcNHglycan	268	271	PF01048	0.319
MOD_GlcNHglycan	379	382	PF01048	0.364
MOD_GlcNHglycan	465	468	PF01048	0.360
MOD_GlcNHglycan	469	472	PF01048	0.331
MOD_GlcNHglycan	60	63	PF01048	0.459
MOD_GlcNHglycan	85	88	PF01048	0.279
MOD_GSK3_1	123	130	PF00069	0.440
MOD_GSK3_1	167	174	PF00069	0.390
MOD_GSK3_1	2	9	PF00069	0.543
MOD_GSK3_1	245	252	PF00069	0.440
MOD_GSK3_1	262	269	PF00069	0.468
MOD_GSK3_1	406	413	PF00069	0.305
MOD_GSK3_1	432	439	PF00069	0.511
MOD_GSK3_1	463	470	PF00069	0.424
MOD_GSK3_1	83	90	PF00069	0.287
MOD_N-GLC_1	48	53	PF02516	0.320
MOD_N-GLC_1	57	62	PF02516	0.426
MOD_NEK2_1	166	171	PF00069	0.443
MOD_NEK2_1	197	202	PF00069	0.354
MOD_PIKK_1	158	164	PF00454	0.335
MOD_PIKK_1	184	190	PF00454	0.417
MOD_PIKK_1	372	378	PF00454	0.360
MOD_PKA_2	122	128	PF00069	0.405
MOD_PKA_2	250	256	PF00069	0.650
MOD_PKA_2	406	412	PF00069	0.319
MOD_PKA_2	42	48	PF00069	0.339
MOD_PKB_1	147	155	PF00069	0.290
MOD_Plk_1	254	260	PF00069	0.508
MOD_Plk_1	327	333	PF00069	0.336
MOD_Plk_1	410	416	PF00069	0.320
MOD_Plk_1	48	54	PF00069	0.321
MOD_Plk_2-3	306	312	PF00069	0.466
MOD_Plk_4	197	203	PF00069	0.460
MOD_Plk_4	410	416	PF00069	0.320
MOD_ProDKin_1	131	137	PF00069	0.426
MOD_ProDKin_1	171	177	PF00069	0.422
MOD_ProDKin_1	2	8	PF00069	0.543
MOD_ProDKin_1	388	394	PF00069	0.426
MOD_ProDKin_1	433	439	PF00069	0.570
MOD_ProDKin_1	88	94	PF00069	0.296
MOD_SUMO_rev_2	351	358	PF00179	0.581
TRG_DiLeu_BaEn_1	411	416	PF01217	0.293
TRG_ENDOCYTIC_2	112	115	PF00928	0.301
TRG_ENDOCYTIC_2	285	288	PF00928	0.371
TRG_ER_diArg_1	320	323	PF00400	0.328
TRG_ER_diArg_1	341	344	PF00400	0.585
TRG_ER_diArg_1	489	491	PF00400	0.446
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	423	428	PF00026	0.377
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.299

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA55	Leptomonas seymouri	49%	100%
A4HGA7	Leishmania braziliensis	77%	100%
A4I3E1	Leishmania infantum	99%	100%
E9AZM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q8K3	Leishmania major	89%	100%