Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IQC4_LEIDO

TriTrypDb:

LdBPK_280270.1 , LdCL_280009800 , LDHU3_28.0610

Length:

227

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3Q8IQC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IQC4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	207	209	PF00675	0.468
CLV_NRD_NRD_1	79	81	PF00675	0.731
CLV_PCSK_KEX2_1	79	81	PF00082	0.665
DEG_Nend_UBRbox_1	1	4	PF02207	0.513
DEG_SCF_FBW7_1	182	189	PF00400	0.740
DEG_SPOP_SBC_1	186	190	PF00917	0.774
DEG_SPOP_SBC_1	74	78	PF00917	0.522
DEG_SPOP_SBC_1	90	94	PF00917	0.522
DOC_USP7_MATH_1	11	15	PF00917	0.518
DOC_USP7_MATH_1	186	190	PF00917	0.746
DOC_USP7_MATH_1	219	223	PF00917	0.713
DOC_USP7_MATH_1	74	78	PF00917	0.591
DOC_USP7_UBL2_3	16	20	PF12436	0.445
DOC_WW_Pin1_4	182	187	PF00397	0.770
DOC_WW_Pin1_4	221	226	PF00397	0.722
DOC_WW_Pin1_4	9	14	PF00397	0.560
LIG_14-3-3_CanoR_1	4	10	PF00244	0.522
LIG_14-3-3_CanoR_1	54	62	PF00244	0.450
LIG_14-3-3_CanoR_1	91	98	PF00244	0.552
LIG_FHA_1	104	110	PF00498	0.591
LIG_FHA_1	128	134	PF00498	0.419
LIG_FHA_1	172	178	PF00498	0.809
LIG_FHA_1	92	98	PF00498	0.516
LIG_GBD_Chelix_1	118	126	PF00786	0.563
LIG_LIR_Nem_3	135	141	PF02991	0.397
LIG_MYND_1	13	17	PF01753	0.430
LIG_NRBOX	117	123	PF00104	0.288
LIG_Pex14_1	124	128	PF04695	0.411
LIG_PTB_Apo_2	96	103	PF02174	0.455
LIG_SH2_GRB2like	25	28	PF00017	0.481
LIG_SH2_STAT5	141	144	PF00017	0.717
LIG_SH3_3	7	13	PF00018	0.499
LIG_SH3_4	16	23	PF00018	0.426
LIG_SUMO_SIM_anti_2	114	120	PF11976	0.424
LIG_SUMO_SIM_par_1	129	135	PF11976	0.436
MOD_CDK_SPxxK_3	9	16	PF00069	0.482
MOD_CK1_1	114	120	PF00069	0.424
MOD_CK1_1	149	155	PF00069	0.740
MOD_CK1_1	171	177	PF00069	0.733
MOD_CK1_1	187	193	PF00069	0.623
MOD_CK1_1	207	213	PF00069	0.725
MOD_CK1_1	26	32	PF00069	0.487
MOD_CK1_1	64	70	PF00069	0.521
MOD_CK1_1	86	92	PF00069	0.566
MOD_GlcNHglycan	109	112	PF01048	0.662
MOD_GlcNHglycan	148	151	PF01048	0.513
MOD_GlcNHglycan	182	185	PF01048	0.514
MOD_GlcNHglycan	56	59	PF01048	0.684
MOD_GlcNHglycan	66	69	PF01048	0.732
MOD_GSK3_1	103	110	PF00069	0.424
MOD_GSK3_1	127	134	PF00069	0.400
MOD_GSK3_1	142	149	PF00069	0.704
MOD_GSK3_1	180	187	PF00069	0.740
MOD_GSK3_1	217	224	PF00069	0.717
MOD_GSK3_1	23	30	PF00069	0.552
MOD_GSK3_1	5	12	PF00069	0.538
MOD_GSK3_1	50	57	PF00069	0.486
MOD_GSK3_1	85	92	PF00069	0.582
MOD_N-GLC_1	100	105	PF02516	0.706
MOD_N-GLC_1	114	119	PF02516	0.581
MOD_N-GLC_1	26	31	PF02516	0.691
MOD_N-GLC_1	37	42	PF02516	0.701
MOD_N-GLC_1	49	54	PF02516	0.691
MOD_N-GLC_1	64	69	PF02516	0.590
MOD_N-GLC_2	140	142	PF02516	0.497
MOD_NEK2_1	102	107	PF00069	0.461
MOD_NEK2_1	127	132	PF00069	0.394
MOD_NEK2_1	170	175	PF00069	0.748
MOD_NEK2_1	192	197	PF00069	0.681
MOD_NEK2_1	204	209	PF00069	0.621
MOD_NEK2_1	83	88	PF00069	0.536
MOD_PIKK_1	171	177	PF00454	0.672
MOD_PKA_2	207	213	PF00069	0.753
MOD_PKA_2	90	96	PF00069	0.512
MOD_PKB_1	2	10	PF00069	0.462
MOD_Plk_1	114	120	PF00069	0.376
MOD_Plk_1	37	43	PF00069	0.497
MOD_Plk_1	83	89	PF00069	0.468
MOD_Plk_4	114	120	PF00069	0.449
MOD_ProDKin_1	182	188	PF00069	0.767
MOD_ProDKin_1	221	227	PF00069	0.726
MOD_ProDKin_1	9	15	PF00069	0.560
TRG_DiLeu_BaLyEn_6	188	193	PF01217	0.712
TRG_ER_diArg_1	1	4	PF00400	0.508
TRG_ER_FFAT_2	84	93	PF00635	0.549
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.662

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Z6	Leptomonas seymouri	43%	100%
A4HG88	Leishmania braziliensis	53%	98%
E9AHH3	Leishmania infantum	99%	100%
E9AZK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q8M2	Leishmania major	82%	100%