HIT zinc finger/Zinc finger C-x8-C-x5-C-x3-H type (And similar), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IQB2_LEIDO

TriTrypDb:

LdBPK_280440.1 , LdCL_280007900 , LDHU3_28.0390

Length:

633

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0070761	pre-snoRNP complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3Q8IQB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IQB2

Function

Biological processes
Term	Name	Level	Count
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000470	maturation of LSU-rRNA	9	1
GO:0000491	small nucleolar ribonucleoprotein complex assembly	7	1
GO:0000492	box C/D snoRNP assembly	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006403	RNA localization	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0033036	macromolecule localization	2	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048254	snoRNA localization	4	1
GO:0051179	localization	1	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	30	34	PF00656	0.756
CLV_C14_Caspase3-7	328	332	PF00656	0.774
CLV_NRD_NRD_1	122	124	PF00675	0.361
CLV_NRD_NRD_1	170	172	PF00675	0.461
CLV_NRD_NRD_1	205	207	PF00675	0.501
CLV_NRD_NRD_1	217	219	PF00675	0.490
CLV_NRD_NRD_1	228	230	PF00675	0.428
CLV_NRD_NRD_1	286	288	PF00675	0.605
CLV_NRD_NRD_1	378	380	PF00675	0.564
CLV_NRD_NRD_1	456	458	PF00675	0.532
CLV_NRD_NRD_1	507	509	PF00675	0.609
CLV_NRD_NRD_1	527	529	PF00675	0.558
CLV_NRD_NRD_1	580	582	PF00675	0.493
CLV_PCSK_KEX2_1	122	124	PF00082	0.361
CLV_PCSK_KEX2_1	170	172	PF00082	0.461
CLV_PCSK_KEX2_1	204	206	PF00082	0.461
CLV_PCSK_KEX2_1	219	221	PF00082	0.407
CLV_PCSK_KEX2_1	286	288	PF00082	0.617
CLV_PCSK_KEX2_1	378	380	PF00082	0.564
CLV_PCSK_KEX2_1	456	458	PF00082	0.535
CLV_PCSK_KEX2_1	509	511	PF00082	0.606
CLV_PCSK_KEX2_1	527	529	PF00082	0.558
CLV_PCSK_KEX2_1	582	584	PF00082	0.520
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.532
CLV_PCSK_PC1ET2_1	509	511	PF00082	0.645
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.520
CLV_PCSK_PC7_1	200	206	PF00082	0.521
CLV_PCSK_PC7_1	523	529	PF00082	0.583
CLV_PCSK_PC7_1	578	584	PF00082	0.601
CLV_PCSK_SKI1_1	301	305	PF00082	0.775
CLV_PCSK_SKI1_1	441	445	PF00082	0.514
CLV_PCSK_SKI1_1	456	460	PF00082	0.392
CLV_PCSK_SKI1_1	527	531	PF00082	0.467
CLV_PCSK_SKI1_1	554	558	PF00082	0.396
DEG_APCC_DBOX_1	261	269	PF00400	0.400
DEG_SCF_FBW7_1	316	321	PF00400	0.602
DEG_SCF_FBW7_2	89	96	PF00400	0.652
DOC_CKS1_1	406	411	PF01111	0.509
DOC_CYCLIN_yCln2_LP_2	192	198	PF00134	0.446
DOC_CYCLIN_yCln2_LP_2	383	389	PF00134	0.752
DOC_MAPK_gen_1	122	130	PF00069	0.536
DOC_MAPK_MEF2A_6	123	132	PF00069	0.551
DOC_MAPK_MEF2A_6	143	151	PF00069	0.297
DOC_MAPK_MEF2A_6	393	401	PF00069	0.631
DOC_PP1_RVXF_1	454	461	PF00149	0.391
DOC_PP2B_LxvP_1	192	195	PF13499	0.455
DOC_PP2B_LxvP_1	383	386	PF13499	0.760
DOC_PP2B_LxvP_1	399	402	PF13499	0.540
DOC_PP4_FxxP_1	625	628	PF00568	0.727
DOC_USP7_MATH_1	15	19	PF00917	0.766
DOC_USP7_MATH_1	181	185	PF00917	0.676
DOC_USP7_MATH_1	318	322	PF00917	0.608
DOC_USP7_MATH_1	374	378	PF00917	0.716
DOC_USP7_MATH_1	488	492	PF00917	0.627
DOC_USP7_UBL2_3	134	138	PF12436	0.518
DOC_WW_Pin1_4	314	319	PF00397	0.606
DOC_WW_Pin1_4	405	410	PF00397	0.497
DOC_WW_Pin1_4	543	548	PF00397	0.545
DOC_WW_Pin1_4	590	595	PF00397	0.559
DOC_WW_Pin1_4	87	92	PF00397	0.783
LIG_14-3-3_CanoR_1	122	128	PF00244	0.514
LIG_14-3-3_CanoR_1	182	186	PF00244	0.586
LIG_14-3-3_CanoR_1	477	481	PF00244	0.582
LIG_14-3-3_CanoR_1	490	494	PF00244	0.399
LIG_14-3-3_CanoR_1	508	515	PF00244	0.590
LIG_14-3-3_CanoR_1	567	571	PF00244	0.401
LIG_14-3-3_CanoR_1	73	81	PF00244	0.643
LIG_14-3-3_CterR_2	629	633	PF00244	0.776
LIG_APCC_ABBA_1	130	135	PF00400	0.647
LIG_BIR_III_4	14	18	PF00653	0.555
LIG_EVH1_1	399	403	PF00568	0.602
LIG_FHA_1	222	228	PF00498	0.481
LIG_FHA_1	229	235	PF00498	0.413
LIG_FHA_1	345	351	PF00498	0.778
LIG_FHA_1	84	90	PF00498	0.724
LIG_FHA_2	315	321	PF00498	0.826
LIG_FHA_2	326	332	PF00498	0.476
LIG_FHA_2	338	344	PF00498	0.624
LIG_FHA_2	406	412	PF00498	0.630
LIG_FHA_2	448	454	PF00498	0.393
LIG_FHA_2	480	486	PF00498	0.450
LIG_FHA_2	544	550	PF00498	0.540
LIG_LIR_Gen_1	162	167	PF02991	0.455
LIG_LIR_Gen_1	425	433	PF02991	0.467
LIG_LIR_Gen_1	446	455	PF02991	0.442
LIG_LIR_Gen_1	555	563	PF02991	0.459
LIG_LIR_Nem_3	162	166	PF02991	0.457
LIG_LIR_Nem_3	425	430	PF02991	0.488
LIG_LIR_Nem_3	446	451	PF02991	0.471
LIG_LIR_Nem_3	462	467	PF02991	0.280
LIG_LIR_Nem_3	555	559	PF02991	0.423
LIG_Pex14_1	185	189	PF04695	0.544
LIG_Pex14_1	236	240	PF04695	0.387
LIG_Pex14_2	417	421	PF04695	0.574
LIG_Pex14_2	460	464	PF04695	0.355
LIG_SH2_CRK	115	119	PF00017	0.490
LIG_SH2_CRK	189	193	PF00017	0.595
LIG_SH2_CRK	448	452	PF00017	0.540
LIG_SH2_NCK_1	115	119	PF00017	0.490
LIG_SH2_NCK_1	288	292	PF00017	0.539
LIG_SH2_PTP2	427	430	PF00017	0.487
LIG_SH2_STAP1	395	399	PF00017	0.628
LIG_SH2_STAT5	115	118	PF00017	0.490
LIG_SH2_STAT5	271	274	PF00017	0.408
LIG_SH2_STAT5	294	297	PF00017	0.716
LIG_SH2_STAT5	427	430	PF00017	0.478
LIG_SH2_STAT5	442	445	PF00017	0.441
LIG_SH2_STAT5	61	64	PF00017	0.730
LIG_SH3_3	144	150	PF00018	0.448
LIG_SH3_3	359	365	PF00018	0.714
LIG_SH3_3	394	400	PF00018	0.588
LIG_SH3_3	403	409	PF00018	0.510
LIG_SUMO_SIM_anti_2	340	347	PF11976	0.604
LIG_TRFH_1	443	447	PF08558	0.481
MOD_CDC14_SPxK_1	593	596	PF00782	0.570
MOD_CDK_SPK_2	405	410	PF00069	0.475
MOD_CDK_SPxK_1	590	596	PF00069	0.565
MOD_CK1_1	101	107	PF00069	0.617
MOD_CK1_1	152	158	PF00069	0.473
MOD_CK1_1	27	33	PF00069	0.790
MOD_CK1_1	492	498	PF00069	0.649
MOD_CK1_1	72	78	PF00069	0.644
MOD_CK1_1	87	93	PF00069	0.674
MOD_CK2_1	374	380	PF00069	0.664
MOD_CK2_1	405	411	PF00069	0.492
MOD_CK2_1	428	434	PF00069	0.420
MOD_CK2_1	447	453	PF00069	0.401
MOD_CK2_1	508	514	PF00069	0.547
MOD_CK2_1	543	549	PF00069	0.532
MOD_CK2_1	79	85	PF00069	0.699
MOD_Cter_Amidation	120	123	PF01082	0.347
MOD_GlcNHglycan	243	246	PF01048	0.621
MOD_GlcNHglycan	28	32	PF01048	0.731
MOD_GlcNHglycan	297	300	PF01048	0.781
MOD_GlcNHglycan	320	323	PF01048	0.767
MOD_GlcNHglycan	333	336	PF01048	0.750
MOD_GlcNHglycan	383	386	PF01048	0.555
MOD_GlcNHglycan	64	67	PF01048	0.660
MOD_GlcNHglycan	76	79	PF01048	0.594
MOD_GSK3_1	249	256	PF00069	0.530
MOD_GSK3_1	295	302	PF00069	0.781
MOD_GSK3_1	314	321	PF00069	0.569
MOD_GSK3_1	344	351	PF00069	0.735
MOD_GSK3_1	35	42	PF00069	0.773
MOD_GSK3_1	488	495	PF00069	0.642
MOD_GSK3_1	79	86	PF00069	0.718
MOD_N-GLC_1	222	227	PF02516	0.457
MOD_N-GLC_1	35	40	PF02516	0.783
MOD_N-GLC_1	590	595	PF02516	0.520
MOD_NEK2_1	137	142	PF00069	0.595
MOD_NEK2_1	84	89	PF00069	0.761
MOD_OFUCOSY	120	125	PF10250	0.290
MOD_PIKK_1	96	102	PF00454	0.691
MOD_PKA_1	508	514	PF00069	0.632
MOD_PKA_2	121	127	PF00069	0.561
MOD_PKA_2	15	21	PF00069	0.770
MOD_PKA_2	181	187	PF00069	0.566
MOD_PKA_2	228	234	PF00069	0.450
MOD_PKA_2	289	295	PF00069	0.586
MOD_PKA_2	476	482	PF00069	0.547
MOD_PKA_2	489	495	PF00069	0.390
MOD_PKA_2	519	525	PF00069	0.519
MOD_PKA_2	566	572	PF00069	0.373
MOD_PKA_2	62	68	PF00069	0.713
MOD_PKA_2	72	78	PF00069	0.517
MOD_Plk_1	222	228	PF00069	0.455
MOD_Plk_1	249	255	PF00069	0.531
MOD_Plk_1	348	354	PF00069	0.674
MOD_Plk_1	69	75	PF00069	0.662
MOD_Plk_1	84	90	PF00069	0.498
MOD_Plk_4	123	129	PF00069	0.583
MOD_Plk_4	230	236	PF00069	0.450
MOD_ProDKin_1	314	320	PF00069	0.606
MOD_ProDKin_1	405	411	PF00069	0.486
MOD_ProDKin_1	543	549	PF00069	0.547
MOD_ProDKin_1	590	596	PF00069	0.565
MOD_ProDKin_1	87	93	PF00069	0.781
MOD_SUMO_rev_2	135	140	PF00179	0.596
MOD_SUMO_rev_2	222	231	PF00179	0.573
MOD_SUMO_rev_2	483	488	PF00179	0.583
TRG_DiLeu_BaEn_2	462	468	PF01217	0.464
TRG_DiLeu_BaEn_4	516	522	PF01217	0.571
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.535
TRG_DiLeu_BaLyEn_6	607	612	PF01217	0.555
TRG_ENDOCYTIC_2	163	166	PF00928	0.557
TRG_ENDOCYTIC_2	189	192	PF00928	0.608
TRG_ENDOCYTIC_2	395	398	PF00928	0.670
TRG_ENDOCYTIC_2	427	430	PF00928	0.501
TRG_ENDOCYTIC_2	442	445	PF00928	0.441
TRG_ENDOCYTIC_2	448	451	PF00928	0.430
TRG_ER_diArg_1	170	172	PF00400	0.449
TRG_ER_diArg_1	204	206	PF00400	0.540
TRG_ER_diArg_1	217	220	PF00400	0.564
TRG_ER_diArg_1	262	265	PF00400	0.429
TRG_ER_diArg_1	286	288	PF00400	0.617
TRG_ER_diArg_1	455	457	PF00400	0.525
TRG_ER_diArg_1	507	510	PF00400	0.604
TRG_ER_diArg_1	527	529	PF00400	0.558
TRG_ER_diArg_1	595	598	PF00400	0.704
TRG_ER_diArg_1	628	631	PF00400	0.743
TRG_NES_CRM1_1	449	463	PF08389	0.442
TRG_NLS_MonoExtC_3	580	585	PF00514	0.512
TRG_NLS_MonoExtN_4	578	585	PF00514	0.608
TRG_Pf-PMV_PEXEL_1	157	162	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	533	538	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0N9	Leptomonas seymouri	58%	100%
A0A422N6T6	Trypanosoma rangeli	46%	100%
A4HG71	Leishmania braziliensis	78%	100%
A4I3B4	Leishmania infantum	100%	100%
D0A7T3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AZJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q8P0	Leishmania major	91%	100%
V5BJ07	Trypanosoma cruzi	47%	100%