Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IQ96_LEIDO

TriTrypDb:

LdBPK_280130.1 , LdCL_280006200 , LDHU3_28.0160

Length:

182

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15

Expansion

Sequence features

A0A3Q8IQ96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IQ96

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	173	175	PF00675	0.455
CLV_PCSK_KEX2_1	173	175	PF00082	0.475
DOC_CKS1_1	34	39	PF01111	0.285
DOC_MAPK_gen_1	76	86	PF00069	0.450
DOC_MAPK_MEF2A_6	79	88	PF00069	0.459
DOC_USP7_MATH_1	156	160	PF00917	0.659
DOC_WW_Pin1_4	33	38	PF00397	0.398
LIG_14-3-3_CanoR_1	111	115	PF00244	0.254
LIG_14-3-3_CanoR_1	173	179	PF00244	0.702
LIG_14-3-3_CanoR_1	5	9	PF00244	0.579
LIG_Actin_WH2_2	95	113	PF00022	0.366
LIG_EH1_1	15	23	PF00400	0.330
LIG_FHA_1	122	128	PF00498	0.365
LIG_FHA_1	162	168	PF00498	0.577
LIG_FHA_1	72	78	PF00498	0.587
LIG_GBD_Chelix_1	85	93	PF00786	0.428
LIG_LIR_Gen_1	100	110	PF02991	0.398
LIG_LIR_Gen_1	132	142	PF02991	0.388
LIG_LIR_Gen_1	42	50	PF02991	0.278
LIG_LIR_Nem_3	100	106	PF02991	0.335
LIG_LIR_Nem_3	132	137	PF02991	0.364
LIG_LIR_Nem_3	23	27	PF02991	0.394
LIG_LIR_Nem_3	42	47	PF02991	0.291
LIG_NRBOX	76	82	PF00104	0.580
LIG_PCNA_PIPBox_1	138	147	PF02747	0.605
LIG_PDZ_Class_3	177	182	PF00595	0.625
LIG_Pex14_2	131	135	PF04695	0.363
LIG_Pex14_2	144	148	PF04695	0.616
LIG_SH2_CRK	137	141	PF00017	0.461
LIG_SH2_CRK	15	19	PF00017	0.445
LIG_SH2_STAP1	65	69	PF00017	0.513
LIG_SH2_STAT5	27	30	PF00017	0.378
LIG_SH2_STAT5	44	47	PF00017	0.323
LIG_SH3_3	3	9	PF00018	0.466
LIG_SUMO_SIM_par_1	17	23	PF11976	0.335
LIG_SUMO_SIM_par_1	94	100	PF11976	0.323
LIG_TYR_ITIM	13	18	PF00017	0.417
LIG_WRC_WIRS_1	103	108	PF05994	0.461
LIG_WRC_WIRS_1	21	26	PF05994	0.442
MOD_CDK_SPK_2	33	38	PF00069	0.258
MOD_GSK3_1	110	117	PF00069	0.321
MOD_NEK2_1	114	119	PF00069	0.304
MOD_NEK2_1	121	126	PF00069	0.288
MOD_NEK2_1	4	9	PF00069	0.527
MOD_NEK2_1	63	68	PF00069	0.470
MOD_NEK2_1	88	93	PF00069	0.384
MOD_PIKK_1	172	178	PF00454	0.669
MOD_PKA_2	110	116	PF00069	0.264
MOD_PKA_2	172	178	PF00069	0.584
MOD_PKA_2	4	10	PF00069	0.532
MOD_Plk_4	114	120	PF00069	0.282
MOD_Plk_4	130	136	PF00069	0.238
MOD_ProDKin_1	33	39	PF00069	0.398
TRG_DiLeu_BaEn_2	98	104	PF01217	0.375
TRG_DiLeu_BaLyEn_6	76	81	PF01217	0.554
TRG_ENDOCYTIC_2	137	140	PF00928	0.421
TRG_ENDOCYTIC_2	15	18	PF00928	0.445
TRG_ENDOCYTIC_2	27	30	PF00928	0.517
TRG_ENDOCYTIC_2	44	47	PF00928	0.310
TRG_ER_diArg_1	172	174	PF00400	0.669
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILT5	Leptomonas seymouri	59%	100%
A0A0N1PC80	Leptomonas seymouri	24%	99%
A0A0S4IY98	Bodo saltans	35%	100%
A0A0S4KLI9	Bodo saltans	23%	76%
A0A1X0NX01	Trypanosomatidae	39%	99%
A0A1X0NXC4	Trypanosomatidae	30%	100%
A0A3R7JVT6	Trypanosoma rangeli	37%	99%
A4HBK6	Leishmania braziliensis	27%	100%
A4HG55	Leishmania braziliensis	69%	100%
A4I386	Leishmania infantum	99%	100%
E9AZH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q8Q7	Leishmania major	91%	100%
V5B3X7	Trypanosoma cruzi	26%	73%
V5BC06	Trypanosoma cruzi	30%	99%