bVLRF1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IQ93_LEIDO

TriTrypDb:

LdBPK_355380.1 , LdCL_350056100 , LDHU3_35.6700

Length:

512

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A0A3Q8IQ93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IQ93

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0030433	ubiquitin-dependent ERAD pathway	6	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0036503	ERAD pathway	5	1
GO:0042221	response to chemical	2	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0050896	response to stimulus	1	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901698	response to nitrogen compound	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.733
CLV_NRD_NRD_1	114	116	PF00675	0.702
CLV_NRD_NRD_1	383	385	PF00675	0.282
CLV_NRD_NRD_1	464	466	PF00675	0.349
CLV_PCSK_KEX2_1	114	116	PF00082	0.741
CLV_PCSK_KEX2_1	138	140	PF00082	0.801
CLV_PCSK_KEX2_1	70	72	PF00082	0.634
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.801
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.634
CLV_PCSK_SKI1_1	15	19	PF00082	0.533
CLV_PCSK_SKI1_1	209	213	PF00082	0.526
CLV_PCSK_SKI1_1	274	278	PF00082	0.607
CLV_PCSK_SKI1_1	345	349	PF00082	0.390
CLV_PCSK_SKI1_1	42	46	PF00082	0.547
CLV_PCSK_SKI1_1	421	425	PF00082	0.276
CLV_PCSK_SKI1_1	447	451	PF00082	0.281
CLV_Separin_Metazoa	492	496	PF03568	0.438
DEG_APCC_DBOX_1	41	49	PF00400	0.561
DEG_APCC_DBOX_1	501	509	PF00400	0.586
DEG_Nend_Nbox_1	1	3	PF02207	0.586
DEG_SCF_FBW7_1	17	24	PF00400	0.555
DEG_SPOP_SBC_1	190	194	PF00917	0.639
DEG_SPOP_SBC_1	284	288	PF00917	0.755
DOC_CKS1_1	18	23	PF01111	0.587
DOC_CKS1_1	203	208	PF01111	0.446
DOC_CYCLIN_RxL_1	9	20	PF00134	0.477
DOC_MAPK_DCC_7	465	473	PF00069	0.555
DOC_MAPK_gen_1	465	473	PF00069	0.547
DOC_MAPK_gen_1	474	483	PF00069	0.527
DOC_MAPK_RevD_3	453	466	PF00069	0.555
DOC_PP1_RVXF_1	207	213	PF00149	0.434
DOC_PP2B_LxvP_1	330	333	PF13499	0.613
DOC_USP7_MATH_1	110	114	PF00917	0.757
DOC_USP7_MATH_1	116	120	PF00917	0.793
DOC_USP7_MATH_1	258	262	PF00917	0.592
DOC_USP7_MATH_1	284	288	PF00917	0.755
DOC_USP7_MATH_1	298	302	PF00917	0.555
DOC_USP7_MATH_1	458	462	PF00917	0.585
DOC_USP7_MATH_1	46	50	PF00917	0.577
DOC_USP7_MATH_1	476	480	PF00917	0.361
DOC_USP7_UBL2_3	118	122	PF12436	0.713
DOC_USP7_UBL2_3	386	390	PF12436	0.482
DOC_WW_Pin1_4	165	170	PF00397	0.745
DOC_WW_Pin1_4	17	22	PF00397	0.550
DOC_WW_Pin1_4	202	207	PF00397	0.432
DOC_WW_Pin1_4	280	285	PF00397	0.775
DOC_WW_Pin1_4	466	471	PF00397	0.482
LIG_14-3-3_CanoR_1	22	26	PF00244	0.552
LIG_14-3-3_CanoR_1	345	354	PF00244	0.354
LIG_14-3-3_CanoR_1	447	457	PF00244	0.482
LIG_14-3-3_CanoR_1	480	490	PF00244	0.520
LIG_14-3-3_CanoR_1	502	506	PF00244	0.435
LIG_BRCT_BRCA1_1	298	302	PF00533	0.555
LIG_BRCT_BRCA1_1	336	340	PF00533	0.543
LIG_BRCT_BRCA1_1	85	89	PF00533	0.703
LIG_FHA_1	169	175	PF00498	0.624
LIG_FHA_1	211	217	PF00498	0.504
LIG_FHA_1	22	28	PF00498	0.580
LIG_FHA_1	327	333	PF00498	0.568
LIG_FHA_1	346	352	PF00498	0.430
LIG_FHA_1	9	15	PF00498	0.533
LIG_FHA_2	118	124	PF00498	0.776
LIG_FHA_2	138	144	PF00498	0.804
LIG_FHA_2	21	27	PF00498	0.613
LIG_FHA_2	236	242	PF00498	0.476
LIG_FHA_2	263	269	PF00498	0.633
LIG_FHA_2	284	290	PF00498	0.770
LIG_FHA_2	305	311	PF00498	0.595
LIG_FHA_2	487	493	PF00498	0.513
LIG_LIR_Apic_2	238	242	PF02991	0.388
LIG_LIR_Gen_1	170	180	PF02991	0.634
LIG_LIR_Gen_1	349	356	PF02991	0.364
LIG_LIR_Gen_1	400	408	PF02991	0.561
LIG_LIR_Gen_1	451	460	PF02991	0.513
LIG_LIR_Gen_1	489	497	PF02991	0.496
LIG_LIR_Nem_3	170	176	PF02991	0.652
LIG_LIR_Nem_3	228	233	PF02991	0.429
LIG_LIR_Nem_3	349	355	PF02991	0.374
LIG_LIR_Nem_3	400	404	PF02991	0.483
LIG_LIR_Nem_3	426	430	PF02991	0.513
LIG_LIR_Nem_3	435	439	PF02991	0.506
LIG_LIR_Nem_3	451	456	PF02991	0.375
LIG_LIR_Nem_3	489	493	PF02991	0.496
LIG_NRBOX	13	19	PF00104	0.482
LIG_PCNA_yPIPBox_3	198	211	PF02747	0.554
LIG_Pex14_2	85	89	PF04695	0.703
LIG_SH2_CRK	230	234	PF00017	0.428
LIG_SH2_CRK	401	405	PF00017	0.482
LIG_SH2_CRK	439	443	PF00017	0.560
LIG_SH2_NCK_1	316	320	PF00017	0.569
LIG_SH2_NCK_1	401	405	PF00017	0.562
LIG_SH2_NCK_1	439	443	PF00017	0.562
LIG_SH2_SRC	316	319	PF00017	0.455
LIG_SH2_STAP1	272	276	PF00017	0.655
LIG_SH2_STAT3	507	510	PF00017	0.507
LIG_SH2_STAT3	52	55	PF00017	0.566
LIG_SH2_STAT5	361	364	PF00017	0.482
LIG_SH2_STAT5	381	384	PF00017	0.350
LIG_SH2_STAT5	430	433	PF00017	0.482
LIG_SH2_STAT5	507	510	PF00017	0.414
LIG_SH2_STAT5	52	55	PF00017	0.464
LIG_SH3_3	143	149	PF00018	0.724
LIG_SH3_3	200	206	PF00018	0.507
LIG_TRAF2_1	322	325	PF00917	0.662
LIG_TRAF2_1	410	413	PF00917	0.562
LIG_TRAF2_1	489	492	PF00917	0.496
LIG_TRAF2_2	470	475	PF00917	0.585
LIG_TRFH_1	453	457	PF08558	0.562
MOD_CDK_SPK_2	17	22	PF00069	0.587
MOD_CDK_SPK_2	280	285	PF00069	0.713
MOD_CDK_SPxxK_3	165	172	PF00069	0.634
MOD_CDK_SPxxK_3	202	209	PF00069	0.440
MOD_CK1_1	167	173	PF00069	0.713
MOD_CK1_1	283	289	PF00069	0.765
MOD_CK1_1	400	406	PF00069	0.477
MOD_CK1_1	501	507	PF00069	0.510
MOD_CK2_1	1	7	PF00069	0.516
MOD_CK2_1	117	123	PF00069	0.796
MOD_CK2_1	152	158	PF00069	0.639
MOD_CK2_1	20	26	PF00069	0.414
MOD_CK2_1	235	241	PF00069	0.491
MOD_CK2_1	242	248	PF00069	0.503
MOD_CK2_1	298	304	PF00069	0.734
MOD_CK2_1	486	492	PF00069	0.496
MOD_Cter_Amidation	133	136	PF01082	0.785
MOD_Cter_Amidation	463	466	PF01082	0.355
MOD_GlcNHglycan	103	106	PF01048	0.747
MOD_GlcNHglycan	193	196	PF01048	0.589
MOD_GlcNHglycan	274	277	PF01048	0.745
MOD_GlcNHglycan	296	301	PF01048	0.782
MOD_GlcNHglycan	47	51	PF01048	0.502
MOD_GSK3_1	13	20	PF00069	0.547
MOD_GSK3_1	163	170	PF00069	0.700
MOD_GSK3_1	258	265	PF00069	0.565
MOD_GSK3_1	280	287	PF00069	0.730
MOD_GSK3_1	292	299	PF00069	0.691
MOD_GSK3_1	482	489	PF00069	0.496
MOD_NEK2_1	191	196	PF00069	0.622
MOD_PIKK_1	403	409	PF00454	0.473
MOD_PKA_1	117	123	PF00069	0.760
MOD_PKA_1	137	143	PF00069	0.768
MOD_PKA_2	21	27	PF00069	0.535
MOD_PKA_2	368	374	PF00069	0.526
MOD_PKA_2	476	482	PF00069	0.532
MOD_PKA_2	486	492	PF00069	0.482
MOD_PKA_2	501	507	PF00069	0.541
MOD_PKB_1	343	351	PF00069	0.494
MOD_Plk_1	304	310	PF00069	0.584
MOD_Plk_1	451	457	PF00069	0.513
MOD_Plk_2-3	304	310	PF00069	0.587
MOD_Plk_4	13	19	PF00069	0.504
MOD_Plk_4	298	304	PF00069	0.715
MOD_Plk_4	432	438	PF00069	0.585
MOD_Plk_4	501	507	PF00069	0.590
MOD_ProDKin_1	165	171	PF00069	0.732
MOD_ProDKin_1	17	23	PF00069	0.547
MOD_ProDKin_1	202	208	PF00069	0.423
MOD_ProDKin_1	280	286	PF00069	0.779
MOD_ProDKin_1	466	472	PF00069	0.482
MOD_SUMO_rev_2	4	11	PF00179	0.558
TRG_ENDOCYTIC_2	230	233	PF00928	0.450
TRG_ENDOCYTIC_2	401	404	PF00928	0.482
TRG_ER_diArg_1	114	116	PF00400	0.802
TRG_NLS_Bipartite_1	117	139	PF00514	0.770
TRG_NLS_MonoCore_2	134	139	PF00514	0.607
TRG_NLS_MonoExtC_3	134	139	PF00514	0.669
TRG_NLS_MonoExtN_4	133	140	PF00514	0.781
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.745

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGL8	Leptomonas seymouri	63%	99%
A0A1X0P4S2	Trypanosomatidae	41%	100%
A0A3S5IQY8	Trypanosoma rangeli	39%	99%
A4HNG8	Leishmania braziliensis	73%	100%
A4IC59	Leishmania infantum	99%	100%
C9ZYE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	99%
E9AFX9	Leishmania major	91%	100%
E9B732	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DQH4	Trypanosoma cruzi	42%	99%