LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IQ83_LEIDO
TriTrypDb:
LdBPK_272450.1 , LdCL_270032900 , LDHU3_27.3690
Length:
132

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3Q8IQ83
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IQ83

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 14 18 PF00656 0.802
CLV_NRD_NRD_1 129 131 PF00675 0.668
CLV_NRD_NRD_1 56 58 PF00675 0.603
CLV_NRD_NRD_1 81 83 PF00675 0.579
CLV_NRD_NRD_1 94 96 PF00675 0.637
CLV_PCSK_FUR_1 101 105 PF00082 0.753
CLV_PCSK_KEX2_1 103 105 PF00082 0.621
CLV_PCSK_KEX2_1 129 131 PF00082 0.657
CLV_PCSK_KEX2_1 4 6 PF00082 0.723
CLV_PCSK_KEX2_1 56 58 PF00082 0.601
CLV_PCSK_KEX2_1 94 96 PF00082 0.637
CLV_PCSK_PC1ET2_1 103 105 PF00082 0.655
CLV_PCSK_PC1ET2_1 4 6 PF00082 0.723
CLV_PCSK_SKI1_1 57 61 PF00082 0.588
CLV_PCSK_SKI1_1 86 90 PF00082 0.599
CLV_PCSK_SKI1_1 96 100 PF00082 0.644
DEG_APCC_DBOX_1 81 89 PF00400 0.604
DEG_SPOP_SBC_1 18 22 PF00917 0.797
DOC_MAPK_gen_1 56 66 PF00069 0.609
DOC_MAPK_gen_1 79 87 PF00069 0.680
DOC_MAPK_MEF2A_6 57 66 PF00069 0.605
DOC_USP7_MATH_1 29 33 PF00917 0.704
DOC_USP7_UBL2_3 99 103 PF12436 0.709
DOC_WW_Pin1_4 22 27 PF00397 0.655
DOC_WW_Pin1_4 33 38 PF00397 0.656
LIG_FHA_1 76 82 PF00498 0.621
LIG_Pex14_2 118 122 PF04695 0.737
LIG_SUMO_SIM_par_1 62 67 PF11976 0.609
LIG_TRAF2_1 74 77 PF00917 0.632
MOD_Cter_Amidation 127 130 PF01082 0.701
MOD_GlcNHglycan 31 34 PF01048 0.729
MOD_GSK3_1 18 25 PF00069 0.725
MOD_GSK3_1 29 36 PF00069 0.752
MOD_PKB_1 73 81 PF00069 0.674
MOD_ProDKin_1 22 28 PF00069 0.658
MOD_ProDKin_1 33 39 PF00069 0.653
TRG_DiLeu_BaEn_4 76 82 PF01217 0.625
TRG_ER_diArg_1 129 131 PF00400 0.710
TRG_NLS_MonoExtC_3 125 130 PF00514 0.646
TRG_NLS_MonoExtC_3 56 61 PF00514 0.657
TRG_NLS_MonoExtN_4 123 130 PF00514 0.635
TRG_NLS_MonoExtN_4 56 61 PF00514 0.657

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDY2 Leptomonas seymouri 78% 100%
A4I332 Leishmania infantum 99% 100%
C9ZJM3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 100%
E9ACX0 Leishmania major 89% 100%
E9AZF9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS