Elks delta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IQ67_LEIDO

TriTrypDb:

LdBPK_367300.1 , LdCL_360085600 , LDHU3_36.9680

Length:

368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IQ67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IQ67

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.549
CLV_NRD_NRD_1	200	202	PF00675	0.451
CLV_NRD_NRD_1	205	207	PF00675	0.519
CLV_NRD_NRD_1	249	251	PF00675	0.560
CLV_NRD_NRD_1	304	306	PF00675	0.530
CLV_NRD_NRD_1	31	33	PF00675	0.552
CLV_NRD_NRD_1	332	334	PF00675	0.463
CLV_PCSK_KEX2_1	130	132	PF00082	0.476
CLV_PCSK_KEX2_1	200	202	PF00082	0.441
CLV_PCSK_KEX2_1	304	306	PF00082	0.480
CLV_PCSK_KEX2_1	33	35	PF00082	0.570
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.553
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.479
CLV_PCSK_SKI1_1	119	123	PF00082	0.572
CLV_PCSK_SKI1_1	130	134	PF00082	0.467
CLV_PCSK_SKI1_1	207	211	PF00082	0.578
CLV_PCSK_SKI1_1	222	226	PF00082	0.396
CLV_PCSK_SKI1_1	334	338	PF00082	0.460
CLV_PCSK_SKI1_1	351	355	PF00082	0.298
CLV_PCSK_SKI1_1	72	76	PF00082	0.557
DEG_APCC_DBOX_1	12	20	PF00400	0.510
DEG_APCC_KENBOX_2	347	351	PF00400	0.535
DOC_MAPK_gen_1	175	183	PF00069	0.534
DOC_MAPK_gen_1	328	338	PF00069	0.401
DOC_MAPK_RevD_3	109	125	PF00069	0.414
DOC_MAPK_RevD_3	135	151	PF00069	0.584
DOC_PP1_RVXF_1	332	339	PF00149	0.510
DOC_USP7_MATH_1	50	54	PF00917	0.498
LIG_14-3-3_CanoR_1	131	135	PF00244	0.450
LIG_14-3-3_CanoR_1	136	141	PF00244	0.423
LIG_14-3-3_CanoR_1	211	216	PF00244	0.559
LIG_APCC_ABBA_1	213	218	PF00400	0.408
LIG_FHA_1	178	184	PF00498	0.519
LIG_FHA_1	208	214	PF00498	0.524
LIG_FHA_1	277	283	PF00498	0.676
LIG_FHA_1	309	315	PF00498	0.406
LIG_FHA_2	167	173	PF00498	0.564
LIG_FHA_2	50	56	PF00498	0.594
LIG_LIR_Gen_1	193	202	PF02991	0.339
LIG_LIR_Nem_3	193	197	PF02991	0.525
LIG_NRBOX	143	149	PF00104	0.589
LIG_PCNA_yPIPBox_3	244	256	PF02747	0.490
LIG_SH2_SRC	153	156	PF00017	0.388
LIG_SH2_SRC	216	219	PF00017	0.469
LIG_SH2_STAT3	93	96	PF00017	0.586
LIG_SH2_STAT5	261	264	PF00017	0.543
LIG_SH2_STAT5	307	310	PF00017	0.499
LIG_SH2_STAT5	48	51	PF00017	0.453
LIG_SH2_STAT5	93	96	PF00017	0.504
LIG_SH3_3	149	155	PF00018	0.650
LIG_TRAF2_1	100	103	PF00917	0.442
LIG_TRAF2_1	169	172	PF00917	0.516
LIG_TRAF2_1	52	55	PF00917	0.467
LIG_TRAF2_1	8	11	PF00917	0.471
LIG_UBA3_1	140	149	PF00899	0.566
LIG_WRC_WIRS_1	191	196	PF05994	0.340
MOD_CK1_1	82	88	PF00069	0.663
MOD_CK2_1	153	159	PF00069	0.605
MOD_CK2_1	166	172	PF00069	0.347
MOD_CK2_1	182	188	PF00069	0.552
MOD_CK2_1	272	278	PF00069	0.694
MOD_CK2_1	314	320	PF00069	0.432
MOD_CK2_1	49	55	PF00069	0.475
MOD_CK2_1	5	11	PF00069	0.496
MOD_CK2_1	85	91	PF00069	0.592
MOD_GlcNHglycan	154	158	PF01048	0.681
MOD_GlcNHglycan	264	267	PF01048	0.545
MOD_GlcNHglycan	274	277	PF01048	0.570
MOD_GSK3_1	207	214	PF00069	0.477
MOD_GSK3_1	256	263	PF00069	0.469
MOD_GSK3_1	272	279	PF00069	0.647
MOD_GSK3_1	356	363	PF00069	0.407
MOD_GSK3_1	50	57	PF00069	0.534
MOD_GSK3_1	75	82	PF00069	0.581
MOD_N-GLC_1	211	216	PF02516	0.508
MOD_NEK2_1	166	171	PF00069	0.570
MOD_NEK2_1	19	24	PF00069	0.438
MOD_NEK2_1	256	261	PF00069	0.442
MOD_NEK2_1	280	285	PF00069	0.602
MOD_NEK2_1	324	329	PF00069	0.509
MOD_NEK2_1	356	361	PF00069	0.397
MOD_NEK2_1	49	54	PF00069	0.559
MOD_PIKK_1	50	56	PF00454	0.593
MOD_PIKK_1	77	83	PF00454	0.645
MOD_PIKK_1	92	98	PF00454	0.582
MOD_PKA_1	130	136	PF00069	0.503
MOD_PKA_2	130	136	PF00069	0.463
MOD_PKA_2	269	275	PF00069	0.683
MOD_PKA_2	327	333	PF00069	0.525
MOD_PKB_1	175	183	PF00069	0.509
MOD_PKB_1	32	40	PF00069	0.557
MOD_Plk_1	177	183	PF00069	0.497
MOD_Plk_1	19	25	PF00069	0.417
MOD_Plk_1	211	217	PF00069	0.466
MOD_Plk_1	319	325	PF00069	0.470
MOD_Plk_1	340	346	PF00069	0.524
MOD_Plk_2-3	190	196	PF00069	0.414
MOD_Plk_4	136	142	PF00069	0.487
MOD_Plk_4	143	149	PF00069	0.551
MOD_Plk_4	19	25	PF00069	0.470
MOD_Plk_4	190	196	PF00069	0.414
MOD_Plk_4	211	217	PF00069	0.467
MOD_Plk_4	319	325	PF00069	0.552
MOD_Plk_4	82	88	PF00069	0.697
MOD_SUMO_for_1	309	312	PF00179	0.470
MOD_SUMO_rev_2	101	107	PF00179	0.562
MOD_SUMO_rev_2	120	126	PF00179	0.630
MOD_SUMO_rev_2	254	262	PF00179	0.450
MOD_SUMO_rev_2	347	356	PF00179	0.532
TRG_DiLeu_BaEn_1	234	239	PF01217	0.536
TRG_DiLeu_BaEn_2	189	195	PF01217	0.340
TRG_ER_diArg_1	200	202	PF00400	0.518
TRG_ER_diArg_1	304	306	PF00400	0.545
TRG_NES_CRM1_1	15	28	PF08389	0.557
TRG_NES_CRM1_1	203	218	PF08389	0.525
TRG_NLS_MonoExtC_3	148	154	PF00514	0.381
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAJ8	Leptomonas seymouri	68%	100%
A0A0S4KNY7	Bodo saltans	24%	95%
A0A1X0NLT9	Trypanosomatidae	33%	98%
A0A422NVX8	Trypanosoma rangeli	32%	98%
A4HQL8	Leishmania braziliensis	76%	100%
A4ICD6	Leishmania infantum	99%	100%
D0A3S1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	98%
E9AUD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q057	Leishmania major	92%	100%
V5BD37	Trypanosoma cruzi	31%	99%