LeishMANIAdb
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Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Lipase_3 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IQ50_LEIDO
TriTrypDb:
LdBPK_271990.1 * , LdCL_270027200 , LDHU3_27.3060
Length:
852

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A0A3Q8IQ50
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IQ50

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 250 254 PF00656 0.423
CLV_C14_Caspase3-7 34 38 PF00656 0.784
CLV_C14_Caspase3-7 461 465 PF00656 0.834
CLV_C14_Caspase3-7 814 818 PF00656 0.584
CLV_NRD_NRD_1 289 291 PF00675 0.705
CLV_NRD_NRD_1 355 357 PF00675 0.658
CLV_NRD_NRD_1 499 501 PF00675 0.621
CLV_NRD_NRD_1 603 605 PF00675 0.626
CLV_NRD_NRD_1 666 668 PF00675 0.632
CLV_NRD_NRD_1 711 713 PF00675 0.588
CLV_NRD_NRD_1 720 722 PF00675 0.566
CLV_PCSK_FUR_1 664 668 PF00082 0.629
CLV_PCSK_KEX2_1 289 291 PF00082 0.705
CLV_PCSK_KEX2_1 355 357 PF00082 0.658
CLV_PCSK_KEX2_1 498 500 PF00082 0.631
CLV_PCSK_KEX2_1 603 605 PF00082 0.626
CLV_PCSK_KEX2_1 666 668 PF00082 0.632
CLV_PCSK_KEX2_1 704 706 PF00082 0.640
CLV_PCSK_KEX2_1 710 712 PF00082 0.574
CLV_PCSK_KEX2_1 722 724 PF00082 0.407
CLV_PCSK_KEX2_1 93 95 PF00082 0.599
CLV_PCSK_PC1ET2_1 704 706 PF00082 0.640
CLV_PCSK_PC1ET2_1 710 712 PF00082 0.574
CLV_PCSK_PC1ET2_1 722 724 PF00082 0.407
CLV_PCSK_PC1ET2_1 93 95 PF00082 0.599
CLV_PCSK_PC7_1 89 95 PF00082 0.595
CLV_PCSK_SKI1_1 101 105 PF00082 0.618
CLV_PCSK_SKI1_1 289 293 PF00082 0.502
CLV_PCSK_SKI1_1 480 484 PF00082 0.518
CLV_PCSK_SKI1_1 769 773 PF00082 0.664
CLV_PCSK_SKI1_1 799 803 PF00082 0.788
CLV_PCSK_SKI1_1 837 841 PF00082 0.700
DEG_APCC_DBOX_1 288 296 PF00400 0.302
DEG_APCC_DBOX_1 798 806 PF00400 0.588
DEG_SPOP_SBC_1 457 461 PF00917 0.801
DEG_SPOP_SBC_1 519 523 PF00917 0.742
DEG_SPOP_SBC_1 83 87 PF00917 0.698
DOC_CYCLIN_RxL_1 721 734 PF00134 0.760
DOC_MAPK_DCC_7 606 616 PF00069 0.714
DOC_MAPK_gen_1 166 175 PF00069 0.710
DOC_MAPK_gen_1 196 205 PF00069 0.703
DOC_MAPK_gen_1 319 329 PF00069 0.635
DOC_MAPK_gen_1 721 730 PF00069 0.770
DOC_MAPK_HePTP_8 205 217 PF00069 0.635
DOC_MAPK_MEF2A_6 135 143 PF00069 0.680
DOC_MAPK_MEF2A_6 208 217 PF00069 0.529
DOC_MAPK_MEF2A_6 322 331 PF00069 0.635
DOC_MAPK_RevD_3 79 94 PF00069 0.706
DOC_PP1_RVXF_1 724 731 PF00149 0.762
DOC_PP2B_LxvP_1 139 142 PF13499 0.783
DOC_PP2B_LxvP_1 582 585 PF13499 0.806
DOC_PP2B_LxvP_1 677 680 PF13499 0.713
DOC_PP4_FxxP_1 772 775 PF00568 0.503
DOC_SPAK_OSR1_1 208 212 PF12202 0.529
DOC_USP7_MATH_1 152 156 PF00917 0.775
DOC_USP7_MATH_1 320 324 PF00917 0.714
DOC_USP7_MATH_1 445 449 PF00917 0.763
DOC_USP7_MATH_1 494 498 PF00917 0.738
DOC_USP7_MATH_1 515 519 PF00917 0.820
DOC_USP7_MATH_1 67 71 PF00917 0.710
DOC_USP7_MATH_1 694 698 PF00917 0.723
DOC_USP7_MATH_1 72 76 PF00917 0.747
DOC_USP7_MATH_1 784 788 PF00917 0.568
DOC_USP7_MATH_1 809 813 PF00917 0.592
DOC_USP7_MATH_1 83 87 PF00917 0.648
DOC_USP7_UBL2_3 722 726 PF12436 0.760
DOC_WW_Pin1_4 563 568 PF00397 0.853
DOC_WW_Pin1_4 670 675 PF00397 0.843
DOC_WW_Pin1_4 788 793 PF00397 0.553
DOC_WW_Pin1_4 805 810 PF00397 0.432
DOC_WW_Pin1_4 831 836 PF00397 0.522
DOC_WW_Pin1_4 84 89 PF00397 0.808
LIG_14-3-3_CanoR_1 101 110 PF00244 0.814
LIG_14-3-3_CanoR_1 168 174 PF00244 0.718
LIG_14-3-3_CanoR_1 181 185 PF00244 0.578
LIG_14-3-3_CanoR_1 257 263 PF00244 0.479
LIG_14-3-3_CanoR_1 355 363 PF00244 0.495
LIG_14-3-3_CanoR_1 404 411 PF00244 0.735
LIG_14-3-3_CanoR_1 417 427 PF00244 0.611
LIG_14-3-3_CanoR_1 451 455 PF00244 0.814
LIG_14-3-3_CanoR_1 480 488 PF00244 0.728
LIG_14-3-3_CanoR_1 517 526 PF00244 0.742
LIG_14-3-3_CanoR_1 647 655 PF00244 0.812
LIG_14-3-3_CanoR_1 813 820 PF00244 0.511
LIG_14-3-3_CanoR_1 837 845 PF00244 0.503
LIG_APCC_ABBA_1 192 197 PF00400 0.703
LIG_APCC_ABBA_1 327 332 PF00400 0.467
LIG_BIR_III_4 443 447 PF00653 0.791
LIG_BRCT_BRCA1_1 283 287 PF00533 0.485
LIG_Clathr_ClatBox_1 328 332 PF01394 0.529
LIG_Clathr_ClatBox_1 829 833 PF01394 0.575
LIG_EH1_1 208 216 PF00400 0.529
LIG_FHA_1 229 235 PF00498 0.567
LIG_FHA_1 274 280 PF00498 0.358
LIG_FHA_1 295 301 PF00498 0.519
LIG_FHA_1 341 347 PF00498 0.504
LIG_FHA_1 349 355 PF00498 0.393
LIG_FHA_1 435 441 PF00498 0.764
LIG_FHA_1 458 464 PF00498 0.852
LIG_FHA_1 481 487 PF00498 0.766
LIG_FHA_1 751 757 PF00498 0.585
LIG_FHA_2 102 108 PF00498 0.711
LIG_FHA_2 143 149 PF00498 0.790
LIG_FHA_2 586 592 PF00498 0.802
LIG_FHA_2 739 745 PF00498 0.529
LIG_FHA_2 838 844 PF00498 0.624
LIG_Integrin_RGD_1 500 502 PF01839 0.550
LIG_Integrin_RGD_1 64 66 PF01839 0.536
LIG_LIR_Gen_1 197 206 PF02991 0.698
LIG_LIR_Gen_1 218 226 PF02991 0.525
LIG_LIR_Gen_1 230 240 PF02991 0.336
LIG_LIR_Gen_1 241 249 PF02991 0.363
LIG_LIR_Gen_1 268 275 PF02991 0.494
LIG_LIR_Nem_3 183 187 PF02991 0.678
LIG_LIR_Nem_3 190 195 PF02991 0.678
LIG_LIR_Nem_3 197 203 PF02991 0.595
LIG_LIR_Nem_3 218 222 PF02991 0.525
LIG_LIR_Nem_3 230 236 PF02991 0.318
LIG_LIR_Nem_3 240 245 PF02991 0.349
LIG_LIR_Nem_3 268 272 PF02991 0.491
LIG_LIR_Nem_3 580 584 PF02991 0.812
LIG_LIR_Nem_3 591 597 PF02991 0.716
LIG_LIR_Nem_3 761 767 PF02991 0.406
LIG_Pex14_2 287 291 PF04695 0.494
LIG_Pex14_2 727 731 PF04695 0.807
LIG_PTB_Apo_2 729 736 PF02174 0.755
LIG_PTB_Phospho_1 729 735 PF10480 0.757
LIG_REV1ctd_RIR_1 246 256 PF16727 0.500
LIG_REV1ctd_RIR_1 728 737 PF16727 0.800
LIG_SH2_CRK 200 204 PF00017 0.697
LIG_SH2_GRB2like 780 783 PF00017 0.512
LIG_SH2_NCK_1 200 204 PF00017 0.697
LIG_SH2_STAP1 350 354 PF00017 0.461
LIG_SH2_STAP1 735 739 PF00017 0.590
LIG_SH2_STAT3 195 198 PF00017 0.708
LIG_SH2_STAT5 350 353 PF00017 0.462
LIG_SH2_STAT5 379 382 PF00017 0.467
LIG_SH2_STAT5 399 402 PF00017 0.350
LIG_SH2_STAT5 427 430 PF00017 0.719
LIG_SH2_STAT5 739 742 PF00017 0.529
LIG_SH2_STAT5 804 807 PF00017 0.592
LIG_SH3_1 606 612 PF00018 0.711
LIG_SH3_3 172 178 PF00018 0.695
LIG_SH3_3 488 494 PF00018 0.850
LIG_SH3_3 523 529 PF00018 0.808
LIG_SH3_3 606 612 PF00018 0.711
LIG_SUMO_SIM_anti_2 826 834 PF11976 0.566
LIG_SUMO_SIM_par_1 212 218 PF11976 0.488
LIG_SUMO_SIM_par_1 342 348 PF11976 0.479
LIG_SxIP_EBH_1 151 165 PF03271 0.651
LIG_TRAF2_1 146 149 PF00917 0.790
LIG_TRAF2_1 787 790 PF00917 0.556
LIG_WRC_WIRS_1 216 221 PF05994 0.488
LIG_WRC_WIRS_1 764 769 PF05994 0.641
MOD_CDC14_SPxK_1 834 837 PF00782 0.605
MOD_CDK_SPK_2 84 89 PF00069 0.771
MOD_CDK_SPxK_1 831 837 PF00069 0.612
MOD_CK1_1 241 247 PF00069 0.486
MOD_CK1_1 261 267 PF00069 0.407
MOD_CK1_1 434 440 PF00069 0.745
MOD_CK1_1 47 53 PF00069 0.631
MOD_CK1_1 518 524 PF00069 0.680
MOD_CK1_1 610 616 PF00069 0.850
MOD_CK1_1 643 649 PF00069 0.708
MOD_CK1_1 697 703 PF00069 0.705
MOD_CK1_1 8 14 PF00069 0.769
MOD_CK1_1 808 814 PF00069 0.711
MOD_CK2_1 101 107 PF00069 0.640
MOD_CK2_1 142 148 PF00069 0.743
MOD_CK2_1 503 509 PF00069 0.659
MOD_CK2_1 595 601 PF00069 0.641
MOD_CK2_1 738 744 PF00069 0.445
MOD_CK2_1 784 790 PF00069 0.711
MOD_CMANNOS 266 269 PF00535 0.556
MOD_GlcNHglycan 101 104 PF01048 0.663
MOD_GlcNHglycan 109 113 PF01048 0.533
MOD_GlcNHglycan 119 122 PF01048 0.513
MOD_GlcNHglycan 154 157 PF01048 0.706
MOD_GlcNHglycan 2 5 PF01048 0.754
MOD_GlcNHglycan 21 24 PF01048 0.530
MOD_GlcNHglycan 263 266 PF01048 0.568
MOD_GlcNHglycan 283 286 PF01048 0.326
MOD_GlcNHglycan 322 325 PF01048 0.633
MOD_GlcNHglycan 420 423 PF01048 0.608
MOD_GlcNHglycan 480 483 PF01048 0.754
MOD_GlcNHglycan 544 547 PF01048 0.771
MOD_GlcNHglycan 649 652 PF01048 0.645
MOD_GlcNHglycan 686 689 PF01048 0.861
MOD_GlcNHglycan 7 10 PF01048 0.729
MOD_GlcNHglycan 847 850 PF01048 0.773
MOD_GlcNHglycan 90 93 PF01048 0.770
MOD_GSK3_1 101 108 PF00069 0.589
MOD_GSK3_1 17 24 PF00069 0.743
MOD_GSK3_1 228 235 PF00069 0.554
MOD_GSK3_1 33 40 PF00069 0.596
MOD_GSK3_1 431 438 PF00069 0.680
MOD_GSK3_1 445 452 PF00069 0.621
MOD_GSK3_1 466 473 PF00069 0.769
MOD_GSK3_1 474 481 PF00069 0.663
MOD_GSK3_1 515 522 PF00069 0.786
MOD_GSK3_1 555 562 PF00069 0.836
MOD_GSK3_1 595 602 PF00069 0.783
MOD_GSK3_1 633 640 PF00069 0.758
MOD_GSK3_1 643 650 PF00069 0.598
MOD_GSK3_1 675 682 PF00069 0.800
MOD_GSK3_1 694 701 PF00069 0.786
MOD_GSK3_1 734 741 PF00069 0.481
MOD_GSK3_1 784 791 PF00069 0.707
MOD_GSK3_1 805 812 PF00069 0.706
MOD_GSK3_1 821 828 PF00069 0.544
MOD_GSK3_1 833 840 PF00069 0.700
MOD_GSK3_1 84 91 PF00069 0.741
MOD_N-GLC_1 238 243 PF02516 0.576
MOD_N-GLC_1 273 278 PF02516 0.560
MOD_N-GLC_1 432 437 PF02516 0.659
MOD_N-GLC_1 465 470 PF02516 0.744
MOD_N-GLC_1 519 524 PF02516 0.680
MOD_N-GLC_1 633 638 PF02516 0.752
MOD_N-GLC_1 845 850 PF02516 0.774
MOD_NEK2_1 169 174 PF00069 0.670
MOD_NEK2_1 215 220 PF00069 0.525
MOD_NEK2_1 247 252 PF00069 0.573
MOD_NEK2_1 255 260 PF00069 0.540
MOD_NEK2_1 333 338 PF00069 0.529
MOD_NEK2_1 349 354 PF00069 0.310
MOD_NEK2_1 431 436 PF00069 0.647
MOD_NEK2_1 577 582 PF00069 0.795
MOD_OFUCOSY 353 358 PF10250 0.585
MOD_PIKK_1 458 464 PF00454 0.771
MOD_PIKK_1 774 780 PF00454 0.651
MOD_PK_1 470 476 PF00069 0.772
MOD_PKA_1 93 99 PF00069 0.759
MOD_PKA_2 105 111 PF00069 0.580
MOD_PKA_2 180 186 PF00069 0.662
MOD_PKA_2 318 324 PF00069 0.643
MOD_PKA_2 354 360 PF00069 0.596
MOD_PKA_2 403 409 PF00069 0.663
MOD_PKA_2 416 422 PF00069 0.494
MOD_PKA_2 450 456 PF00069 0.773
MOD_PKA_2 457 463 PF00069 0.748
MOD_PKA_2 466 472 PF00069 0.603
MOD_PKA_2 50 56 PF00069 0.645
MOD_PKA_2 88 94 PF00069 0.755
MOD_PKB_1 813 821 PF00069 0.674
MOD_Plk_1 108 114 PF00069 0.619
MOD_Plk_1 238 244 PF00069 0.567
MOD_Plk_1 519 525 PF00069 0.783
MOD_Plk_1 640 646 PF00069 0.843
MOD_Plk_1 65 71 PF00069 0.760
MOD_Plk_1 675 681 PF00069 0.845
MOD_Plk_1 695 701 PF00069 0.770
MOD_Plk_1 72 78 PF00069 0.660
MOD_Plk_1 825 831 PF00069 0.760
MOD_Plk_4 169 175 PF00069 0.671
MOD_Plk_4 238 244 PF00069 0.567
MOD_Plk_4 340 346 PF00069 0.467
MOD_Plk_4 395 401 PF00069 0.426
MOD_Plk_4 470 476 PF00069 0.731
MOD_Plk_4 577 583 PF00069 0.777
MOD_Plk_4 640 646 PF00069 0.843
MOD_Plk_4 825 831 PF00069 0.719
MOD_ProDKin_1 563 569 PF00069 0.837
MOD_ProDKin_1 670 676 PF00069 0.821
MOD_ProDKin_1 788 794 PF00069 0.701
MOD_ProDKin_1 805 811 PF00069 0.527
MOD_ProDKin_1 831 837 PF00069 0.653
MOD_ProDKin_1 84 90 PF00069 0.774
TRG_DiLeu_BaEn_1 744 749 PF01217 0.467
TRG_DiLeu_BaLyEn_6 139 144 PF01217 0.740
TRG_ENDOCYTIC_2 200 203 PF00928 0.624
TRG_ENDOCYTIC_2 764 767 PF00928 0.557
TRG_ER_diArg_1 165 168 PF00400 0.635
TRG_ER_diArg_1 288 290 PF00400 0.616
TRG_ER_diArg_1 354 356 PF00400 0.552
TRG_ER_diArg_1 415 418 PF00400 0.713
TRG_ER_diArg_1 498 500 PF00400 0.701
TRG_ER_diArg_1 603 605 PF00400 0.790
TRG_ER_diArg_1 664 667 PF00400 0.801
TRG_NLS_Bipartite_1 704 725 PF00514 0.673
TRG_Pf-PMV_PEXEL_1 705 709 PF00026 0.624

Homologs

Protein Taxonomy Sequence identity Coverage
A4HFY4 Leishmania braziliensis 63% 96%
A4I2X7 Leishmania infantum 100% 100%
E9ADI7 Leishmania major 91% 100%
E9AZB3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS