Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IQ44_LEIDO

TriTrypDb:

LdBPK_354550.1 , LdCL_350050600 , LDHU3_35.5990

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	4
GO:0005929	cilium	4	4
GO:0042995	cell projection	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0110165	cellular anatomical entity	1	4
GO:0120025	plasma membrane bounded cell projection	3	4

Expansion

Sequence features

A0A3Q8IQ44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IQ44

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.695
CLV_C14_Caspase3-7	20	24	PF00656	0.379
CLV_PCSK_SKI1_1	139	143	PF00082	0.371
DOC_CKS1_1	15	20	PF01111	0.434
DOC_USP7_MATH_1	24	28	PF00917	0.444
DOC_USP7_MATH_1	61	65	PF00917	0.527
DOC_WW_Pin1_4	116	121	PF00397	0.599
DOC_WW_Pin1_4	14	19	PF00397	0.567
DOC_WW_Pin1_4	4	9	PF00397	0.739
LIG_14-3-3_CanoR_1	107	117	PF00244	0.559
LIG_14-3-3_CanoR_1	118	127	PF00244	0.555
LIG_BIR_II_1	1	5	PF00653	0.700
LIG_FHA_1	127	133	PF00498	0.340
LIG_FHA_1	41	47	PF00498	0.393
LIG_FHA_1	54	60	PF00498	0.386
LIG_FHA_2	1	7	PF00498	0.518
LIG_FHA_2	66	72	PF00498	0.615
LIG_LIR_Apic_2	115	120	PF02991	0.512
LIG_LIR_Gen_1	140	149	PF02991	0.334
LIG_LIR_Gen_1	31	37	PF02991	0.295
LIG_LIR_Nem_3	121	127	PF02991	0.380
LIG_LIR_Nem_3	135	141	PF02991	0.363
LIG_LIR_Nem_3	31	36	PF02991	0.501
LIG_Pex14_2	33	37	PF04695	0.283
LIG_SH2_CRK	124	128	PF00017	0.533
LIG_SH2_PTP2	83	86	PF00017	0.282
LIG_SH2_STAT5	131	134	PF00017	0.312
LIG_SH2_STAT5	83	86	PF00017	0.387
LIG_SH3_3	12	18	PF00018	0.487
LIG_SUMO_SIM_anti_2	54	65	PF11976	0.469
LIG_TRAF2_1	112	115	PF00917	0.381
LIG_TRAF2_1	163	166	PF00917	0.579
LIG_TYR_ITSM	120	127	PF00017	0.387
LIG_WRC_WIRS_1	33	38	PF05994	0.395
MOD_CK1_1	10	16	PF00069	0.480
MOD_CK1_1	101	107	PF00069	0.481
MOD_CK1_1	119	125	PF00069	0.616
MOD_CK2_1	160	166	PF00069	0.551
MOD_CK2_1	59	65	PF00069	0.442
MOD_GlcNHglycan	110	113	PF01048	0.586
MOD_GlcNHglycan	12	15	PF01048	0.503
MOD_GlcNHglycan	26	29	PF01048	0.485
MOD_GSK3_1	10	17	PF00069	0.610
MOD_GSK3_1	181	188	PF00069	0.650
MOD_GSK3_1	61	68	PF00069	0.546
MOD_GSK3_1	94	101	PF00069	0.512
MOD_NEK2_1	108	113	PF00069	0.343
MOD_PIKK_1	35	41	PF00454	0.385
MOD_Plk_1	101	107	PF00069	0.439
MOD_Plk_1	53	59	PF00069	0.453
MOD_Plk_2-3	161	167	PF00069	0.511
MOD_Plk_4	101	107	PF00069	0.486
MOD_Plk_4	127	133	PF00069	0.386
MOD_Plk_4	17	23	PF00069	0.598
MOD_Plk_4	32	38	PF00069	0.401
MOD_ProDKin_1	116	122	PF00069	0.601
MOD_ProDKin_1	14	20	PF00069	0.561
MOD_ProDKin_1	4	10	PF00069	0.739
MOD_SUMO_rev_2	135	141	PF00179	0.370
MOD_SUMO_rev_2	20	27	PF00179	0.356
TRG_ENDOCYTIC_2	124	127	PF00928	0.541
TRG_ENDOCYTIC_2	138	141	PF00928	0.453
TRG_ENDOCYTIC_2	77	80	PF00928	0.316
TRG_ENDOCYTIC_2	83	86	PF00928	0.280

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICH3	Leptomonas seymouri	48%	98%
A0A0S4JM98	Bodo saltans	33%	100%
A0A1X0P624	Trypanosomatidae	32%	100%
A0A422P1B2	Trypanosoma rangeli	34%	100%
A4HNB6	Leishmania braziliensis	71%	100%
A4IBY8	Leishmania infantum	100%	100%
C9ZYL7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B6X7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%