Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IQ43_LEIDO

TriTrypDb:

LdBPK_366950.1 , LdCL_360082000 , LDHU3_36.9280

Length:

197

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0043226	organelle	2	11
GO:0043229	intracellular organelle	3	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A0A3Q8IQ43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IQ43

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.509
CLV_PCSK_KEX2_1	190	192	PF00082	0.652
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.652
CLV_PCSK_SKI1_1	57	61	PF00082	0.538
CLV_Separin_Metazoa	165	169	PF03568	0.507
DEG_APCC_DBOX_1	178	186	PF00400	0.493
DOC_CYCLIN_yCln2_LP_2	155	161	PF00134	0.572
DOC_MAPK_HePTP_8	147	159	PF00069	0.572
DOC_MAPK_MEF2A_6	150	159	PF00069	0.558
DOC_MAPK_MEF2A_6	65	74	PF00069	0.605
DOC_PP2B_LxvP_1	155	158	PF13499	0.558
DOC_USP7_MATH_1	18	22	PF00917	0.600
DOC_USP7_MATH_1	23	27	PF00917	0.641
DOC_WW_Pin1_4	159	164	PF00397	0.466
DOC_WW_Pin1_4	190	195	PF00397	0.686
LIG_14-3-3_CanoR_1	174	182	PF00244	0.481
LIG_14-3-3_CanoR_1	42	51	PF00244	0.625
LIG_14-3-3_CanoR_1	65	71	PF00244	0.627
LIG_BIR_II_1	1	5	PF00653	0.634
LIG_BRCT_BRCA1_1	77	81	PF00533	0.590
LIG_FHA_1	136	142	PF00498	0.628
LIG_FHA_1	184	190	PF00498	0.498
LIG_FHA_1	83	89	PF00498	0.582
LIG_FHA_2	58	64	PF00498	0.577
LIG_FHA_2	74	80	PF00498	0.614
LIG_LIR_Gen_1	105	114	PF02991	0.563
LIG_LIR_Gen_1	9	20	PF02991	0.623
LIG_LIR_Gen_1	90	99	PF02991	0.641
LIG_LIR_Nem_3	105	109	PF02991	0.499
LIG_LIR_Nem_3	148	152	PF02991	0.558
LIG_LIR_Nem_3	78	84	PF02991	0.574
LIG_LIR_Nem_3	9	15	PF02991	0.499
LIG_LIR_Nem_3	90	96	PF02991	0.569
LIG_NRBOX	109	115	PF00104	0.590
LIG_NRP_CendR_1	196	197	PF00754	0.754
LIG_PTB_Apo_2	143	150	PF02174	0.558
LIG_PTB_Phospho_1	143	149	PF10480	0.558
LIG_SH2_CRK	149	153	PF00017	0.572
LIG_SH2_CRK	175	179	PF00017	0.496
LIG_SH2_CRK	84	88	PF00017	0.574
LIG_SH2_STAP1	30	34	PF00017	0.469
LIG_SH2_STAP1	84	88	PF00017	0.574
LIG_SH2_STAT5	84	87	PF00017	0.572
LIG_SUMO_SIM_anti_2	153	158	PF11976	0.624
LIG_TRAF2_1	61	64	PF00917	0.617
LIG_TYR_ITIM	147	152	PF00017	0.572
LIG_UBA3_1	110	115	PF00899	0.572
MOD_CDC14_SPxK_1	193	196	PF00782	0.727
MOD_CDK_SPxK_1	190	196	PF00069	0.699
MOD_CDK_SPxxK_3	190	197	PF00069	0.712
MOD_CK1_1	47	53	PF00069	0.617
MOD_CK2_1	159	165	PF00069	0.491
MOD_CK2_1	3	9	PF00069	0.638
MOD_CK2_1	57	63	PF00069	0.608
MOD_GlcNHglycan	175	178	PF01048	0.490
MOD_GlcNHglycan	46	49	PF01048	0.570
MOD_GSK3_1	43	50	PF00069	0.654
MOD_N-GLC_2	118	120	PF02516	0.358
MOD_NEK2_1	109	114	PF00069	0.558
MOD_NEK2_1	82	87	PF00069	0.558
MOD_PIKK_1	3	9	PF00454	0.638
MOD_PK_1	150	156	PF00069	0.648
MOD_PKA_2	173	179	PF00069	0.476
MOD_Plk_2-3	73	79	PF00069	0.558
MOD_Plk_4	109	115	PF00069	0.592
MOD_Plk_4	150	156	PF00069	0.648
MOD_ProDKin_1	159	165	PF00069	0.471
MOD_ProDKin_1	190	196	PF00069	0.699
MOD_SUMO_rev_2	142	152	PF00179	0.558
TRG_DiLeu_BaEn_1	98	103	PF01217	0.568
TRG_DiLeu_BaEn_2	104	110	PF01217	0.648
TRG_DiLeu_BaEn_2	122	128	PF01217	0.572
TRG_ENDOCYTIC_2	149	152	PF00928	0.558
TRG_ENDOCYTIC_2	175	178	PF00928	0.492
TRG_ENDOCYTIC_2	84	87	PF00928	0.574
TRG_ER_diArg_1	178	181	PF00400	0.496
TRG_ER_diArg_1	94	97	PF00400	0.572
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7A5	Leptomonas seymouri	96%	100%
A0A0S4IMA0	Bodo saltans	56%	98%
A0A1X0NLJ6	Trypanosomatidae	71%	98%
A0A3R7NPT4	Trypanosoma rangeli	69%	98%
A4HQI7	Leishmania braziliensis	97%	100%
D0A3N5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	86%
E9AHZ6	Leishmania infantum	100%	100%
E9AUA0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4Q091	Leishmania major	100%	100%