Mitochondrial fission process protein 1

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 6

Species:

Leishmania donovani

UniProt:

A0A3Q8IQ29_LEIDO

TriTrypDb:

LdBPK_354340.1 , LdCL_350048500 , LDHU3_35.5750

Length:

169

Annotations

Annotations by Jardim et al.

Mitochondrial protein, outer mitochondrial membrane proteome 6 (POMP6) Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000331	contractile vacuole	6	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0005773	vacuole	5	1
GO:0016020	membrane	2	2
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	2

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IQ29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IQ29

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	129	131	PF00675	0.447
CLV_NRD_NRD_1	161	163	PF00675	0.501
CLV_NRD_NRD_1	63	65	PF00675	0.438
CLV_NRD_NRD_1	67	69	PF00675	0.444
CLV_PCSK_FUR_1	159	163	PF00082	0.594
CLV_PCSK_KEX2_1	129	131	PF00082	0.447
CLV_PCSK_KEX2_1	159	161	PF00082	0.489
CLV_PCSK_KEX2_1	67	69	PF00082	0.452
CLV_PCSK_SKI1_1	130	134	PF00082	0.479
DEG_Nend_UBRbox_2	1	3	PF02207	0.484
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.563
DOC_MAPK_gen_1	78	86	PF00069	0.532
DOC_MAPK_MEF2A_6	14	22	PF00069	0.482
DOC_MAPK_MEF2A_6	30	38	PF00069	0.473
DOC_PP2B_LxvP_1	18	21	PF13499	0.506
DOC_USP7_MATH_1	102	106	PF00917	0.633
LIG_FHA_1	135	141	PF00498	0.547
LIG_FHA_2	95	101	PF00498	0.437
LIG_LIR_Apic_2	45	51	PF02991	0.450
LIG_PCNA_yPIPBox_3	78	89	PF02747	0.560
LIG_Pex14_2	62	66	PF04695	0.437
LIG_RPA_C_Fungi	124	136	PF08784	0.454
LIG_SH2_STAP1	25	29	PF00017	0.514
LIG_SH2_STAT3	107	110	PF00017	0.595
LIG_SH2_STAT5	107	110	PF00017	0.519
LIG_SH2_STAT5	28	31	PF00017	0.532
LIG_SH3_3	18	24	PF00018	0.508
LIG_SH3_3	51	57	PF00018	0.538
LIG_TRAF2_1	98	101	PF00917	0.590
MOD_CK2_1	94	100	PF00069	0.504
MOD_GlcNHglycan	113	116	PF01048	0.459
MOD_GlcNHglycan	8	11	PF01048	0.541
MOD_GSK3_1	102	109	PF00069	0.517
MOD_NEK2_1	94	99	PF00069	0.509
MOD_PIKK_1	106	112	PF00454	0.614
MOD_PKA_2	110	116	PF00069	0.483
MOD_Plk_4	24	30	PF00069	0.453
MOD_Plk_4	57	63	PF00069	0.492
TRG_ER_diArg_1	158	161	PF00400	0.480
TRG_ER_diArg_1	66	68	PF00400	0.479
TRG_NLS_MonoExtC_3	63	68	PF00514	0.367
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD34	Leptomonas seymouri	80%	100%
A0A1X0P529	Trypanosomatidae	48%	100%
A0A422NU90	Trypanosoma rangeli	46%	100%
A4HN96	Leishmania braziliensis	91%	100%
A4IBW7	Leishmania infantum	100%	100%
C9ZYP2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AFQ4	Leishmania major	96%	100%
E9B6V7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%