Putative zinc finger protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IPZ9_LEIDO

TriTrypDb:

LdBPK_354020.1 , LdCL_350045300 , LDHU3_35.5220

Length:

706

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IPZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IPZ9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0008270	zinc ion binding	6	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046914	transition metal ion binding	5	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.635
CLV_C14_Caspase3-7	614	618	PF00656	0.623
CLV_NRD_NRD_1	156	158	PF00675	0.614
CLV_NRD_NRD_1	309	311	PF00675	0.374
CLV_NRD_NRD_1	682	684	PF00675	0.643
CLV_NRD_NRD_1	7	9	PF00675	0.477
CLV_NRD_NRD_1	95	97	PF00675	0.599
CLV_PCSK_KEX2_1	156	158	PF00082	0.624
CLV_PCSK_KEX2_1	309	311	PF00082	0.374
CLV_PCSK_KEX2_1	373	375	PF00082	0.509
CLV_PCSK_KEX2_1	684	686	PF00082	0.646
CLV_PCSK_KEX2_1	7	9	PF00082	0.408
CLV_PCSK_KEX2_1	95	97	PF00082	0.620
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.509
CLV_PCSK_PC1ET2_1	684	686	PF00082	0.646
CLV_PCSK_SKI1_1	449	453	PF00082	0.477
CLV_PCSK_SKI1_1	49	53	PF00082	0.397
DEG_SPOP_SBC_1	191	195	PF00917	0.603
DEG_SPOP_SBC_1	264	268	PF00917	0.661
DEG_SPOP_SBC_1	463	467	PF00917	0.542
DOC_CKS1_1	283	288	PF01111	0.480
DOC_CKS1_1	347	352	PF01111	0.478
DOC_CKS1_1	368	373	PF01111	0.462
DOC_CKS1_1	414	419	PF01111	0.442
DOC_MAPK_gen_1	156	164	PF00069	0.618
DOC_MAPK_gen_1	309	315	PF00069	0.378
DOC_MAPK_gen_1	335	344	PF00069	0.372
DOC_PP2B_LxvP_1	141	144	PF13499	0.628
DOC_PP2B_LxvP_1	279	282	PF13499	0.637
DOC_PP2B_LxvP_1	305	308	PF13499	0.563
DOC_PP2B_LxvP_1	513	516	PF13499	0.469
DOC_PP2B_LxvP_1	662	665	PF13499	0.672
DOC_PP4_FxxP_1	322	325	PF00568	0.368
DOC_SPAK_OSR1_1	321	325	PF12202	0.444
DOC_USP7_MATH_1	146	150	PF00917	0.616
DOC_USP7_MATH_1	155	159	PF00917	0.623
DOC_USP7_MATH_1	215	219	PF00917	0.656
DOC_USP7_MATH_1	222	226	PF00917	0.668
DOC_USP7_MATH_1	245	249	PF00917	0.662
DOC_USP7_MATH_1	255	259	PF00917	0.569
DOC_USP7_MATH_1	265	269	PF00917	0.499
DOC_USP7_MATH_1	461	465	PF00917	0.533
DOC_USP7_MATH_1	627	631	PF00917	0.688
DOC_USP7_MATH_1	633	637	PF00917	0.718
DOC_USP7_MATH_1	666	670	PF00917	0.658
DOC_USP7_UBL2_3	39	43	PF12436	0.410
DOC_WW_Pin1_4	113	118	PF00397	0.748
DOC_WW_Pin1_4	151	156	PF00397	0.663
DOC_WW_Pin1_4	195	200	PF00397	0.680
DOC_WW_Pin1_4	268	273	PF00397	0.733
DOC_WW_Pin1_4	282	287	PF00397	0.595
DOC_WW_Pin1_4	346	351	PF00397	0.486
DOC_WW_Pin1_4	367	372	PF00397	0.437
DOC_WW_Pin1_4	413	418	PF00397	0.391
LIG_14-3-3_CanoR_1	156	164	PF00244	0.628
LIG_14-3-3_CanoR_1	17	21	PF00244	0.454
LIG_14-3-3_CanoR_1	246	252	PF00244	0.682
LIG_14-3-3_CanoR_1	303	308	PF00244	0.438
LIG_14-3-3_CanoR_1	314	320	PF00244	0.350
LIG_14-3-3_CanoR_1	398	405	PF00244	0.400
LIG_14-3-3_CanoR_1	455	462	PF00244	0.475
LIG_14-3-3_CanoR_1	521	528	PF00244	0.472
LIG_14-3-3_CanoR_1	581	588	PF00244	0.414
LIG_14-3-3_CanoR_1	75	84	PF00244	0.482
LIG_Actin_WH2_2	298	316	PF00022	0.371
LIG_Actin_WH2_2	44	61	PF00022	0.414
LIG_Actin_WH2_2	566	583	PF00022	0.387
LIG_BIR_III_2	89	93	PF00653	0.516
LIG_BRCT_BRCA1_1	229	233	PF00533	0.649
LIG_EVH1_1	662	666	PF00568	0.621
LIG_FHA_1	103	109	PF00498	0.621
LIG_FHA_1	148	154	PF00498	0.795
LIG_FHA_1	163	169	PF00498	0.590
LIG_FHA_1	278	284	PF00498	0.692
LIG_FHA_1	391	397	PF00498	0.395
LIG_FHA_1	414	420	PF00498	0.437
LIG_FHA_2	29	35	PF00498	0.486
LIG_FHA_2	353	359	PF00498	0.413
LIG_FHA_2	601	607	PF00498	0.511
LIG_FHA_2	697	703	PF00498	0.673
LIG_GBD_Chelix_1	37	45	PF00786	0.401
LIG_LIR_Apic_2	413	417	PF02991	0.401
LIG_LIR_Gen_1	258	265	PF02991	0.711
LIG_LIR_Gen_1	481	487	PF02991	0.388
LIG_LIR_Gen_1	561	571	PF02991	0.384
LIG_LIR_Nem_3	22	26	PF02991	0.405
LIG_LIR_Nem_3	258	262	PF02991	0.713
LIG_LIR_Nem_3	3	9	PF02991	0.411
LIG_LIR_Nem_3	385	390	PF02991	0.392
LIG_LIR_Nem_3	481	485	PF02991	0.422
LIG_LIR_Nem_3	561	567	PF02991	0.374
LIG_LIR_Nem_3	569	573	PF02991	0.435
LIG_NRBOX	47	53	PF00104	0.389
LIG_PDZ_Class_2	701	706	PF00595	0.638
LIG_Pex14_2	233	237	PF04695	0.581
LIG_Pex14_2	311	315	PF04695	0.375
LIG_PTB_Apo_2	408	415	PF02174	0.415
LIG_PTB_Phospho_1	408	414	PF10480	0.413
LIG_REV1ctd_RIR_1	299	307	PF16727	0.365
LIG_SH2_CRK	259	263	PF00017	0.639
LIG_SH2_CRK	340	344	PF00017	0.560
LIG_SH2_CRK	414	418	PF00017	0.448
LIG_SH2_CRK	482	486	PF00017	0.385
LIG_SH2_GRB2like	362	365	PF00017	0.378
LIG_SH2_GRB2like	542	545	PF00017	0.469
LIG_SH2_NCK_1	259	263	PF00017	0.639
LIG_SH2_SRC	328	331	PF00017	0.385
LIG_SH2_SRC	53	56	PF00017	0.514
LIG_SH2_STAP1	482	486	PF00017	0.415
LIG_SH2_STAT5	328	331	PF00017	0.464
LIG_SH2_STAT5	36	39	PF00017	0.422
LIG_SH2_STAT5	362	365	PF00017	0.378
LIG_SH2_STAT5	387	390	PF00017	0.432
LIG_SH2_STAT5	394	397	PF00017	0.397
LIG_SH2_STAT5	566	569	PF00017	0.419
LIG_SH2_STAT5	579	582	PF00017	0.402
LIG_SH3_2	347	352	PF14604	0.408
LIG_SH3_3	186	192	PF00018	0.788
LIG_SH3_3	259	265	PF00018	0.663
LIG_SH3_3	269	275	PF00018	0.587
LIG_SH3_3	344	350	PF00018	0.417
LIG_SH3_3	365	371	PF00018	0.429
LIG_SH3_3	626	632	PF00018	0.658
LIG_SH3_3	651	657	PF00018	0.654
LIG_SH3_3	660	666	PF00018	0.581
LIG_SUMO_SIM_par_1	149	154	PF11976	0.642
LIG_SUMO_SIM_par_1	388	393	PF11976	0.360
LIG_TRAF2_1	427	430	PF00917	0.389
LIG_TRAF2_1	692	695	PF00917	0.700
LIG_TRAF2_2	325	330	PF00917	0.470
LIG_WRC_WIRS_1	567	572	PF05994	0.440
MOD_CDC14_SPxK_1	154	157	PF00782	0.610
MOD_CDK_SPK_2	151	156	PF00069	0.619
MOD_CDK_SPxK_1	151	157	PF00069	0.619
MOD_CDK_SPxK_1	346	352	PF00069	0.488
MOD_CDK_SPxK_1	367	373	PF00069	0.451
MOD_CDK_SPxxK_3	367	374	PF00069	0.458
MOD_CK1_1	149	155	PF00069	0.733
MOD_CK1_1	177	183	PF00069	0.622
MOD_CK1_1	198	204	PF00069	0.817
MOD_CK1_1	225	231	PF00069	0.719
MOD_CK1_1	25	31	PF00069	0.448
MOD_CK1_1	266	272	PF00069	0.619
MOD_CK1_1	277	283	PF00069	0.560
MOD_CK1_1	397	403	PF00069	0.456
MOD_CK1_1	454	460	PF00069	0.585
MOD_CK1_1	464	470	PF00069	0.414
MOD_CK1_1	520	526	PF00069	0.374
MOD_CK1_1	600	606	PF00069	0.597
MOD_CK1_1	638	644	PF00069	0.650
MOD_CK1_1	649	655	PF00069	0.603
MOD_CK1_1	98	104	PF00069	0.743
MOD_CK2_1	16	22	PF00069	0.492
MOD_CK2_1	352	358	PF00069	0.423
MOD_CK2_1	424	430	PF00069	0.386
MOD_CK2_1	613	619	PF00069	0.684
MOD_CK2_1	637	643	PF00069	0.673
MOD_CK2_1	689	695	PF00069	0.714
MOD_Cter_Amidation	67	70	PF01082	0.475
MOD_GlcNHglycan	101	104	PF01048	0.586
MOD_GlcNHglycan	120	123	PF01048	0.648
MOD_GlcNHglycan	133	136	PF01048	0.638
MOD_GlcNHglycan	176	179	PF01048	0.701
MOD_GlcNHglycan	224	227	PF01048	0.630
MOD_GlcNHglycan	229	232	PF01048	0.646
MOD_GlcNHglycan	268	271	PF01048	0.601
MOD_GlcNHglycan	296	299	PF01048	0.516
MOD_GlcNHglycan	457	460	PF01048	0.655
MOD_GlcNHglycan	466	469	PF01048	0.399
MOD_GlcNHglycan	582	585	PF01048	0.395
MOD_GlcNHglycan	629	632	PF01048	0.624
MOD_GlcNHglycan	637	640	PF01048	0.595
MOD_GlcNHglycan	654	657	PF01048	0.712
MOD_GlcNHglycan	66	69	PF01048	0.443
MOD_GSK3_1	111	118	PF00069	0.492
MOD_GSK3_1	147	154	PF00069	0.790
MOD_GSK3_1	191	198	PF00069	0.753
MOD_GSK3_1	199	206	PF00069	0.629
MOD_GSK3_1	227	234	PF00069	0.737
MOD_GSK3_1	264	271	PF00069	0.670
MOD_GSK3_1	277	284	PF00069	0.588
MOD_GSK3_1	390	397	PF00069	0.366
MOD_GSK3_1	451	458	PF00069	0.475
MOD_GSK3_1	462	469	PF00069	0.444
MOD_GSK3_1	534	541	PF00069	0.325
MOD_GSK3_1	558	565	PF00069	0.365
MOD_GSK3_1	633	640	PF00069	0.729
MOD_GSK3_1	642	649	PF00069	0.560
MOD_GSK3_1	95	102	PF00069	0.753
MOD_N-GLC_1	294	299	PF02516	0.465
MOD_NEK2_1	111	116	PF00069	0.703
MOD_NEK2_1	294	299	PF00069	0.401
MOD_NEK2_1	315	320	PF00069	0.458
MOD_NEK2_1	390	395	PF00069	0.394
MOD_NEK2_1	435	440	PF00069	0.381
MOD_NEK2_1	451	456	PF00069	0.552
MOD_NEK2_1	462	467	PF00069	0.531
MOD_NEK2_1	470	475	PF00069	0.376
MOD_NEK2_1	533	538	PF00069	0.304
MOD_NEK2_1	580	585	PF00069	0.382
MOD_NEK2_1	642	647	PF00069	0.706
MOD_PIKK_1	506	512	PF00454	0.304
MOD_PK_1	303	309	PF00069	0.442
MOD_PK_1	59	65	PF00069	0.524
MOD_PKA_1	156	162	PF00069	0.713
MOD_PKA_1	95	101	PF00069	0.642
MOD_PKA_2	125	131	PF00069	0.620
MOD_PKA_2	155	161	PF00069	0.682
MOD_PKA_2	16	22	PF00069	0.492
MOD_PKA_2	245	251	PF00069	0.619
MOD_PKA_2	397	403	PF00069	0.534
MOD_PKA_2	454	460	PF00069	0.469
MOD_PKA_2	517	523	PF00069	0.374
MOD_PKA_2	580	586	PF00069	0.388
MOD_PKA_2	696	702	PF00069	0.697
MOD_PKA_2	95	101	PF00069	0.645
MOD_Plk_1	390	396	PF00069	0.390
MOD_Plk_1	59	65	PF00069	0.524
MOD_Plk_1	649	655	PF00069	0.683
MOD_Plk_2-3	613	619	PF00069	0.638
MOD_Plk_2-3	690	696	PF00069	0.681
MOD_Plk_4	171	177	PF00069	0.614
MOD_Plk_4	185	191	PF00069	0.725
MOD_Plk_4	22	28	PF00069	0.520
MOD_Plk_4	274	280	PF00069	0.638
MOD_Plk_4	315	321	PF00069	0.469
MOD_Plk_4	383	389	PF00069	0.378
MOD_Plk_4	466	472	PF00069	0.398
MOD_Plk_4	538	544	PF00069	0.350
MOD_Plk_4	558	564	PF00069	0.330
MOD_Plk_4	59	65	PF00069	0.576
MOD_ProDKin_1	113	119	PF00069	0.606
MOD_ProDKin_1	151	157	PF00069	0.663
MOD_ProDKin_1	195	201	PF00069	0.682
MOD_ProDKin_1	268	274	PF00069	0.733
MOD_ProDKin_1	282	288	PF00069	0.585
MOD_ProDKin_1	346	352	PF00069	0.488
MOD_ProDKin_1	367	373	PF00069	0.451
MOD_ProDKin_1	413	419	PF00069	0.384
MOD_SUMO_rev_2	19	26	PF00179	0.535
TRG_DiLeu_BaEn_1	171	176	PF01217	0.601
TRG_DiLeu_BaEn_1	47	52	PF01217	0.382
TRG_DiLeu_BaEn_4	490	496	PF01217	0.482
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.469
TRG_ENDOCYTIC_2	259	262	PF00928	0.640
TRG_ENDOCYTIC_2	387	390	PF00928	0.433
TRG_ENDOCYTIC_2	482	485	PF00928	0.427
TRG_ENDOCYTIC_2	579	582	PF00928	0.396
TRG_ER_diArg_1	155	157	PF00400	0.612
TRG_ER_diArg_1	308	310	PF00400	0.385
TRG_ER_diArg_1	6	8	PF00400	0.479
TRG_ER_diArg_1	682	685	PF00400	0.615
TRG_ER_diArg_1	94	96	PF00400	0.596
TRG_NLS_MonoExtC_3	682	687	PF00514	0.676
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	49	54	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0M6	Leptomonas seymouri	52%	97%
A4IBT5	Leishmania infantum	99%	100%
E9AFM2	Leishmania major	91%	100%
E9B6S5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%