Choline/ethanolamine kinase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ethanolamine kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IPY5_LEIDO

TriTrypDb:

LdBPK_271330.1 , LdCL_270020100 , LDHU3_27.2060

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IPY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IPY5

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0044237	cellular metabolic process	2	7
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006646	phosphatidylethanolamine biosynthetic process	6	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006656	phosphatidylcholine biosynthetic process	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008610	lipid biosynthetic process	4	1
GO:0008654	phospholipid biosynthetic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0019637	organophosphate metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046337	phosphatidylethanolamine metabolic process	6	1
GO:0046470	phosphatidylcholine metabolic process	4	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004103	choline kinase activity	5	5
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	5
GO:0004305	ethanolamine kinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.576
CLV_NRD_NRD_1	482	484	PF00675	0.292
CLV_NRD_NRD_1	535	537	PF00675	0.375
CLV_PCSK_KEX2_1	261	263	PF00082	0.476
CLV_PCSK_KEX2_1	434	436	PF00082	0.319
CLV_PCSK_KEX2_1	495	497	PF00082	0.292
CLV_PCSK_KEX2_1	535	537	PF00082	0.488
CLV_PCSK_KEX2_1	59	61	PF00082	0.556
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.476
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.274
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.292
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.556
CLV_PCSK_SKI1_1	130	134	PF00082	0.719
CLV_PCSK_SKI1_1	356	360	PF00082	0.323
CLV_PCSK_SKI1_1	496	500	PF00082	0.292
CLV_PCSK_SKI1_1	51	55	PF00082	0.478
CLV_PCSK_SKI1_1	539	543	PF00082	0.399
CLV_PCSK_SKI1_1	567	571	PF00082	0.413
CLV_PCSK_SKI1_1	587	591	PF00082	0.228
CLV_PCSK_SKI1_1	77	81	PF00082	0.681
DOC_AGCK_PIF_2	319	324	PF00069	0.576
DOC_CDC14_PxL_1	507	515	PF14671	0.476
DOC_CKS1_1	109	114	PF01111	0.778
DOC_CYCLIN_RxL_1	48	56	PF00134	0.394
DOC_CYCLIN_RxL_1	584	596	PF00134	0.378
DOC_MAPK_gen_1	481	491	PF00069	0.498
DOC_MAPK_MEF2A_6	16	25	PF00069	0.386
DOC_PP1_RVXF_1	485	492	PF00149	0.492
DOC_PP1_RVXF_1	565	572	PF00149	0.410
DOC_PP2B_LxvP_1	220	223	PF13499	0.719
DOC_PP2B_LxvP_1	308	311	PF13499	0.492
DOC_PP4_FxxP_1	123	126	PF00568	0.700
DOC_USP7_MATH_1	197	201	PF00917	0.632
DOC_USP7_MATH_1	280	284	PF00917	0.552
DOC_USP7_MATH_1	386	390	PF00917	0.474
DOC_USP7_MATH_1	525	529	PF00917	0.504
DOC_USP7_MATH_1	547	551	PF00917	0.612
DOC_USP7_MATH_1	633	637	PF00917	0.529
DOC_USP7_MATH_1	89	93	PF00917	0.622
DOC_USP7_UBL2_3	373	377	PF12436	0.553
DOC_USP7_UBL2_3	55	59	PF12436	0.540
DOC_WW_Pin1_4	108	113	PF00397	0.660
DOC_WW_Pin1_4	190	195	PF00397	0.674
DOC_WW_Pin1_4	199	204	PF00397	0.631
DOC_WW_Pin1_4	239	244	PF00397	0.634
DOC_WW_Pin1_4	247	252	PF00397	0.598
DOC_WW_Pin1_4	548	553	PF00397	0.581
DOC_WW_Pin1_4	66	71	PF00397	0.691
LIG_14-3-3_CanoR_1	211	217	PF00244	0.620
LIG_14-3-3_CanoR_1	443	453	PF00244	0.576
LIG_APCC_ABBA_1	272	277	PF00400	0.425
LIG_BRCT_BRCA1_1	300	304	PF00533	0.492
LIG_FHA_1	111	117	PF00498	0.742
LIG_FHA_1	173	179	PF00498	0.595
LIG_FHA_1	200	206	PF00498	0.691
LIG_FHA_1	248	254	PF00498	0.746
LIG_FHA_1	266	272	PF00498	0.346
LIG_FHA_1	291	297	PF00498	0.494
LIG_FHA_1	413	419	PF00498	0.488
LIG_FHA_2	163	169	PF00498	0.710
LIG_FHA_2	394	400	PF00498	0.530
LIG_LIR_Apic_2	122	126	PF02991	0.699
LIG_LIR_Apic_2	326	332	PF02991	0.599
LIG_LIR_Gen_1	302	313	PF02991	0.492
LIG_LIR_Gen_1	330	341	PF02991	0.490
LIG_LIR_Gen_1	415	422	PF02991	0.492
LIG_LIR_Gen_1	557	566	PF02991	0.411
LIG_LIR_Gen_1	601	610	PF02991	0.521
LIG_LIR_Nem_3	270	275	PF02991	0.423
LIG_LIR_Nem_3	302	308	PF02991	0.492
LIG_LIR_Nem_3	317	322	PF02991	0.492
LIG_LIR_Nem_3	326	331	PF02991	0.492
LIG_LIR_Nem_3	374	379	PF02991	0.492
LIG_LIR_Nem_3	415	420	PF02991	0.492
LIG_LIR_Nem_3	497	501	PF02991	0.482
LIG_LIR_Nem_3	509	513	PF02991	0.511
LIG_LIR_Nem_3	514	520	PF02991	0.533
LIG_LIR_Nem_3	557	563	PF02991	0.431
LIG_LIR_Nem_3	601	606	PF02991	0.441
LIG_LIR_Nem_3	614	620	PF02991	0.317
LIG_LYPXL_yS_3	180	183	PF13949	0.630
LIG_LYPXL_yS_3	510	513	PF13949	0.476
LIG_NRBOX	49	55	PF00104	0.534
LIG_NRBOX	587	593	PF00104	0.370
LIG_PCNA_yPIPBox_3	16	24	PF02747	0.432
LIG_PDZ_Class_3	634	639	PF00595	0.568
LIG_Pex14_2	4	8	PF04695	0.494
LIG_PTAP_UEV_1	253	258	PF05743	0.527
LIG_PTB_Apo_2	266	273	PF02174	0.455
LIG_SH2_CRK	305	309	PF00017	0.492
LIG_SH2_CRK	329	333	PF00017	0.531
LIG_SH2_CRK	620	624	PF00017	0.292
LIG_SH2_NCK_1	329	333	PF00017	0.499
LIG_SH2_NCK_1	501	505	PF00017	0.492
LIG_SH2_SRC	313	316	PF00017	0.476
LIG_SH2_SRC	324	327	PF00017	0.476
LIG_SH2_SRC	409	412	PF00017	0.553
LIG_SH2_STAP1	517	521	PF00017	0.492
LIG_SH2_STAT3	106	109	PF00017	0.589
LIG_SH2_STAT5	313	316	PF00017	0.492
LIG_SH2_STAT5	324	327	PF00017	0.492
LIG_SH2_STAT5	329	332	PF00017	0.492
LIG_SH2_STAT5	409	412	PF00017	0.492
LIG_SH2_STAT5	462	465	PF00017	0.530
LIG_SH2_STAT5	493	496	PF00017	0.492
LIG_SH2_STAT5	520	523	PF00017	0.396
LIG_SH2_STAT5	628	631	PF00017	0.390
LIG_SH3_1	191	197	PF00018	0.629
LIG_SH3_3	191	197	PF00018	0.683
LIG_SH3_3	248	254	PF00018	0.705
LIG_SUMO_SIM_par_1	590	596	PF11976	0.356
LIG_TRAF2_1	212	215	PF00917	0.619
LIG_TYR_ITIM	178	183	PF00017	0.582
LIG_TYR_ITIM	303	308	PF00017	0.492
LIG_TYR_ITIM	320	325	PF00017	0.492
LIG_TYR_ITIM	618	623	PF00017	0.297
LIG_UBA3_1	410	416	PF00899	0.492
LIG_UBA3_1	452	460	PF00899	0.476
LIG_WRC_WIRS_1	163	168	PF05994	0.712
MOD_CK1_1	119	125	PF00069	0.755
MOD_CK1_1	149	155	PF00069	0.766
MOD_CK1_1	167	173	PF00069	0.568
MOD_CK1_1	209	215	PF00069	0.623
MOD_CK1_1	298	304	PF00069	0.492
MOD_CK1_1	389	395	PF00069	0.576
MOD_CK1_1	444	450	PF00069	0.576
MOD_CK1_1	550	556	PF00069	0.675
MOD_CK1_1	596	602	PF00069	0.345
MOD_CK1_1	66	72	PF00069	0.713
MOD_CK1_1	75	81	PF00069	0.631
MOD_CK2_1	162	168	PF00069	0.712
MOD_CK2_1	209	215	PF00069	0.620
MOD_CK2_1	39	45	PF00069	0.423
MOD_CK2_1	451	457	PF00069	0.478
MOD_CK2_1	569	575	PF00069	0.547
MOD_CMANNOS	600	603	PF00535	0.350
MOD_DYRK1A_RPxSP_1	247	251	PF00069	0.675
MOD_GlcNHglycan	156	159	PF01048	0.768
MOD_GlcNHglycan	254	257	PF01048	0.553
MOD_GlcNHglycan	263	266	PF01048	0.478
MOD_GlcNHglycan	277	283	PF01048	0.295
MOD_GlcNHglycan	335	339	PF01048	0.251
MOD_GlcNHglycan	41	44	PF01048	0.423
MOD_GlcNHglycan	446	449	PF01048	0.376
MOD_GlcNHglycan	473	476	PF01048	0.292
MOD_GlcNHglycan	527	530	PF01048	0.353
MOD_GlcNHglycan	610	613	PF01048	0.556
MOD_GlcNHglycan	91	94	PF01048	0.767
MOD_GSK3_1	115	122	PF00069	0.765
MOD_GSK3_1	142	149	PF00069	0.665
MOD_GSK3_1	154	161	PF00069	0.738
MOD_GSK3_1	162	169	PF00069	0.546
MOD_GSK3_1	205	212	PF00069	0.619
MOD_GSK3_1	222	229	PF00069	0.685
MOD_GSK3_1	23	30	PF00069	0.438
MOD_GSK3_1	261	268	PF00069	0.511
MOD_GSK3_1	386	393	PF00069	0.498
MOD_GSK3_1	434	441	PF00069	0.519
MOD_GSK3_1	516	523	PF00069	0.492
MOD_GSK3_1	550	557	PF00069	0.648
MOD_GSK3_1	62	69	PF00069	0.731
MOD_N-GLC_1	548	553	PF02516	0.548
MOD_NEK2_1	116	121	PF00069	0.626
MOD_NEK2_1	166	171	PF00069	0.771
MOD_NEK2_1	206	211	PF00069	0.679
MOD_NEK2_1	304	309	PF00069	0.492
MOD_NEK2_1	367	372	PF00069	0.500
MOD_NEK2_1	410	415	PF00069	0.492
MOD_NEK2_1	438	443	PF00069	0.489
MOD_NEK2_1	491	496	PF00069	0.555
MOD_NEK2_1	53	58	PF00069	0.445
MOD_NEK2_1	598	603	PF00069	0.434
MOD_NEK2_2	63	68	PF00069	0.733
MOD_OFUCOSY	67	73	PF10250	0.665
MOD_PIKK_1	116	122	PF00454	0.732
MOD_PIKK_1	142	148	PF00454	0.680
MOD_PIKK_1	367	373	PF00454	0.505
MOD_PIKK_1	420	426	PF00454	0.530
MOD_PIKK_1	72	78	PF00454	0.788
MOD_PKA_1	261	267	PF00069	0.502
MOD_PKA_1	434	440	PF00069	0.519
MOD_PKA_2	210	216	PF00069	0.619
MOD_PKA_2	261	267	PF00069	0.511
MOD_PKA_2	298	304	PF00069	0.492
MOD_PKA_2	352	358	PF00069	0.492
MOD_PKA_2	367	373	PF00069	0.492
MOD_PKA_2	404	410	PF00069	0.551
MOD_PKA_2	434	440	PF00069	0.576
MOD_Plk_1	398	404	PF00069	0.530
MOD_Plk_4	146	152	PF00069	0.686
MOD_Plk_4	27	33	PF00069	0.373
MOD_Plk_4	280	286	PF00069	0.345
MOD_Plk_4	304	310	PF00069	0.492
MOD_Plk_4	434	440	PF00069	0.592
MOD_Plk_4	451	457	PF00069	0.409
MOD_Plk_4	516	522	PF00069	0.492
MOD_ProDKin_1	108	114	PF00069	0.659
MOD_ProDKin_1	190	196	PF00069	0.672
MOD_ProDKin_1	199	205	PF00069	0.630
MOD_ProDKin_1	239	245	PF00069	0.629
MOD_ProDKin_1	247	253	PF00069	0.585
MOD_ProDKin_1	548	554	PF00069	0.585
MOD_ProDKin_1	66	72	PF00069	0.692
TRG_DiLeu_BaEn_1	406	411	PF01217	0.492
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.542
TRG_DiLeu_BaLyEn_6	362	367	PF01217	0.492
TRG_ENDOCYTIC_2	180	183	PF00928	0.630
TRG_ENDOCYTIC_2	305	308	PF00928	0.492
TRG_ENDOCYTIC_2	322	325	PF00928	0.492
TRG_ENDOCYTIC_2	328	331	PF00928	0.492
TRG_ENDOCYTIC_2	333	336	PF00928	0.492
TRG_ENDOCYTIC_2	375	378	PF00928	0.530
TRG_ENDOCYTIC_2	510	513	PF00928	0.492
TRG_ENDOCYTIC_2	560	563	PF00928	0.383
TRG_ENDOCYTIC_2	620	623	PF00928	0.350
TRG_ENDOCYTIC_2	628	631	PF00928	0.421
TRG_ER_diArg_1	534	536	PF00400	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C8	Leptomonas seymouri	59%	100%
A4HFS0	Leishmania braziliensis	74%	100%
A4I2U4	Leishmania infantum	100%	100%
E9ADC3	Leishmania major	92%	100%
E9AZ47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%