HU-CCDC81_euk_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4496), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IPX9_LEIDO

TriTrypDb:

LdBPK_366690.1 , LdCL_360075200 , LDHU3_36.8900

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IPX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IPX9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.697
CLV_C14_Caspase3-7	487	491	PF00656	0.560
CLV_NRD_NRD_1	187	189	PF00675	0.436
CLV_NRD_NRD_1	272	274	PF00675	0.524
CLV_NRD_NRD_1	286	288	PF00675	0.507
CLV_NRD_NRD_1	294	296	PF00675	0.485
CLV_NRD_NRD_1	329	331	PF00675	0.700
CLV_NRD_NRD_1	416	418	PF00675	0.651
CLV_NRD_NRD_1	438	440	PF00675	0.591
CLV_NRD_NRD_1	46	48	PF00675	0.374
CLV_NRD_NRD_1	509	511	PF00675	0.721
CLV_NRD_NRD_1	81	83	PF00675	0.395
CLV_PCSK_KEX2_1	204	206	PF00082	0.598
CLV_PCSK_KEX2_1	271	273	PF00082	0.523
CLV_PCSK_KEX2_1	286	288	PF00082	0.515
CLV_PCSK_KEX2_1	294	296	PF00082	0.490
CLV_PCSK_KEX2_1	329	331	PF00082	0.700
CLV_PCSK_KEX2_1	438	440	PF00082	0.591
CLV_PCSK_KEX2_1	46	48	PF00082	0.374
CLV_PCSK_KEX2_1	511	513	PF00082	0.634
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.619
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.634
CLV_PCSK_PC7_1	434	440	PF00082	0.595
CLV_PCSK_PC7_1	507	513	PF00082	0.639
CLV_PCSK_SKI1_1	137	141	PF00082	0.321
CLV_PCSK_SKI1_1	248	252	PF00082	0.587
CLV_PCSK_SKI1_1	26	30	PF00082	0.434
CLV_PCSK_SKI1_1	46	50	PF00082	0.224
DEG_Nend_Nbox_1	1	3	PF02207	0.505
DEG_SPOP_SBC_1	206	210	PF00917	0.530
DOC_ANK_TNKS_1	106	113	PF00023	0.572
DOC_CYCLIN_RxL_1	148	156	PF00134	0.358
DOC_CYCLIN_RxL_1	43	53	PF00134	0.370
DOC_MAPK_gen_1	149	157	PF00069	0.403
DOC_MAPK_gen_1	166	172	PF00069	0.209
DOC_MAPK_gen_1	80	90	PF00069	0.460
DOC_MAPK_MEF2A_6	149	157	PF00069	0.471
DOC_MAPK_MEF2A_6	166	174	PF00069	0.277
DOC_MAPK_MEF2A_6	36	43	PF00069	0.355
DOC_MAPK_RevD_3	153	167	PF00069	0.411
DOC_PP1_RVXF_1	80	87	PF00149	0.369
DOC_PP2B_LxvP_1	155	158	PF13499	0.321
DOC_PP2B_LxvP_1	333	336	PF13499	0.576
DOC_PP4_FxxP_1	432	435	PF00568	0.603
DOC_USP7_MATH_1	213	217	PF00917	0.608
DOC_USP7_MATH_1	222	226	PF00917	0.567
DOC_USP7_MATH_1	254	258	PF00917	0.565
DOC_USP7_MATH_1	274	278	PF00917	0.382
DOC_USP7_MATH_1	336	340	PF00917	0.600
DOC_USP7_MATH_1	359	363	PF00917	0.641
DOC_USP7_MATH_2	455	461	PF00917	0.716
DOC_WW_Pin1_4	232	237	PF00397	0.544
DOC_WW_Pin1_4	252	257	PF00397	0.571
DOC_WW_Pin1_4	469	474	PF00397	0.728
LIG_14-3-3_CanoR_1	115	119	PF00244	0.321
LIG_14-3-3_CanoR_1	130	139	PF00244	0.321
LIG_14-3-3_CanoR_1	229	233	PF00244	0.675
LIG_14-3-3_CanoR_1	271	280	PF00244	0.504
LIG_14-3-3_CanoR_1	368	377	PF00244	0.703
LIG_14-3-3_CanoR_1	438	442	PF00244	0.590
LIG_14-3-3_CanoR_1	497	506	PF00244	0.647
LIG_14-3-3_CanoR_1	5	14	PF00244	0.409
LIG_BRCT_BRCA1_1	210	214	PF00533	0.609
LIG_FHA_1	222	228	PF00498	0.684
LIG_FHA_1	7	13	PF00498	0.368
LIG_FHA_1	79	85	PF00498	0.377
LIG_FHA_1	98	104	PF00498	0.448
LIG_FHA_2	237	243	PF00498	0.697
LIG_FHA_2	346	352	PF00498	0.602
LIG_FHA_2	438	444	PF00498	0.606
LIG_FHA_2	485	491	PF00498	0.615
LIG_IBAR_NPY_1	77	79	PF08397	0.496
LIG_LIR_Apic_2	429	435	PF02991	0.594
LIG_LIR_Apic_2	449	455	PF02991	0.458
LIG_LIR_Gen_1	111	121	PF02991	0.428
LIG_LIR_Gen_1	138	147	PF02991	0.321
LIG_LIR_Gen_1	197	206	PF02991	0.549
LIG_LIR_Gen_1	341	352	PF02991	0.630
LIG_LIR_Gen_1	35	45	PF02991	0.354
LIG_LIR_Gen_1	65	73	PF02991	0.395
LIG_LIR_Nem_3	111	116	PF02991	0.529
LIG_LIR_Nem_3	138	143	PF02991	0.321
LIG_LIR_Nem_3	197	202	PF02991	0.532
LIG_LIR_Nem_3	341	347	PF02991	0.628
LIG_LIR_Nem_3	35	41	PF02991	0.358
LIG_LIR_Nem_3	65	71	PF02991	0.389
LIG_Pex14_1	64	68	PF04695	0.382
LIG_Pex14_2	60	64	PF04695	0.340
LIG_SH2_CRK	344	348	PF00017	0.614
LIG_SH2_CRK	452	456	PF00017	0.612
LIG_SH2_GRB2like	92	95	PF00017	0.471
LIG_SH2_NCK_1	315	319	PF00017	0.680
LIG_SH2_NCK_1	344	348	PF00017	0.726
LIG_SH2_NCK_1	452	456	PF00017	0.612
LIG_SH2_PTP2	113	116	PF00017	0.343
LIG_SH2_PTP2	68	71	PF00017	0.387
LIG_SH2_SRC	305	308	PF00017	0.552
LIG_SH2_SRC	315	318	PF00017	0.519
LIG_SH2_STAP1	315	319	PF00017	0.642
LIG_SH2_STAP1	92	96	PF00017	0.376
LIG_SH2_STAT5	113	116	PF00017	0.351
LIG_SH2_STAT5	142	145	PF00017	0.321
LIG_SH2_STAT5	68	71	PF00017	0.387
LIG_SH3_3	328	334	PF00018	0.719
LIG_SH3_3	403	409	PF00018	0.693
LIG_SUMO_SIM_anti_2	390	395	PF11976	0.642
LIG_SUMO_SIM_par_1	392	401	PF11976	0.732
LIG_TRAF2_1	265	268	PF00917	0.495
LIG_UBA3_1	30	36	PF00899	0.384
MOD_CDK_SPxxK_3	252	259	PF00069	0.564
MOD_CK1_1	212	218	PF00069	0.600
MOD_CK1_1	220	226	PF00069	0.580
MOD_CK1_1	228	234	PF00069	0.627
MOD_CK1_1	24	30	PF00069	0.458
MOD_CK1_1	339	345	PF00069	0.617
MOD_CK1_1	372	378	PF00069	0.738
MOD_CK1_1	437	443	PF00069	0.589
MOD_CK1_1	465	471	PF00069	0.630
MOD_CK1_1	472	478	PF00069	0.584
MOD_CK1_1	482	488	PF00069	0.601
MOD_CK2_1	29	35	PF00069	0.378
MOD_CK2_1	437	443	PF00069	0.611
MOD_Cter_Amidation	508	511	PF01082	0.643
MOD_GlcNHglycan	132	135	PF01048	0.358
MOD_GlcNHglycan	211	214	PF01048	0.608
MOD_GlcNHglycan	215	218	PF01048	0.635
MOD_GlcNHglycan	256	259	PF01048	0.701
MOD_GlcNHglycan	276	279	PF01048	0.373
MOD_GlcNHglycan	336	339	PF01048	0.610
MOD_GlcNHglycan	371	374	PF01048	0.699
MOD_GlcNHglycan	443	447	PF01048	0.658
MOD_GlcNHglycan	464	467	PF01048	0.650
MOD_GlcNHglycan	479	482	PF01048	0.640
MOD_GlcNHglycan	51	55	PF01048	0.537
MOD_GSK3_1	205	212	PF00069	0.538
MOD_GSK3_1	213	220	PF00069	0.611
MOD_GSK3_1	221	228	PF00069	0.684
MOD_GSK3_1	232	239	PF00069	0.767
MOD_GSK3_1	371	378	PF00069	0.716
MOD_GSK3_1	430	437	PF00069	0.597
MOD_GSK3_1	465	472	PF00069	0.650
MOD_GSK3_1	479	486	PF00069	0.716
MOD_N-GLC_1	21	26	PF02516	0.566
MOD_NEK2_1	1	6	PF00069	0.500
MOD_NEK2_1	153	158	PF00069	0.326
MOD_NEK2_1	450	455	PF00069	0.598
MOD_NEK2_1	50	55	PF00069	0.515
MOD_NEK2_2	161	166	PF00069	0.411
MOD_PIKK_1	450	456	PF00454	0.603
MOD_PKA_1	272	278	PF00069	0.499
MOD_PKA_2	114	120	PF00069	0.317
MOD_PKA_2	220	226	PF00069	0.594
MOD_PKA_2	228	234	PF00069	0.608
MOD_PKA_2	272	278	PF00069	0.507
MOD_PKA_2	352	358	PF00069	0.738
MOD_PKA_2	437	443	PF00069	0.589
MOD_PKB_1	510	518	PF00069	0.656
MOD_Plk_1	24	30	PF00069	0.458
MOD_Plk_4	24	30	PF00069	0.458
MOD_Plk_4	339	345	PF00069	0.617
MOD_Plk_4	522	528	PF00069	0.600
MOD_ProDKin_1	232	238	PF00069	0.546
MOD_ProDKin_1	252	258	PF00069	0.570
MOD_ProDKin_1	469	475	PF00069	0.728
MOD_SUMO_rev_2	242	249	PF00179	0.581
TRG_DiLeu_BaEn_1	66	71	PF01217	0.370
TRG_DiLeu_BaEn_4	66	72	PF01217	0.377
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.353
TRG_ENDOCYTIC_2	113	116	PF00928	0.343
TRG_ENDOCYTIC_2	199	202	PF00928	0.537
TRG_ENDOCYTIC_2	344	347	PF00928	0.636
TRG_ENDOCYTIC_2	68	71	PF00928	0.387
TRG_ER_diArg_1	149	152	PF00400	0.299
TRG_ER_diArg_1	271	273	PF00400	0.622
TRG_ER_diArg_1	285	287	PF00400	0.452
TRG_ER_diArg_1	294	296	PF00400	0.512
TRG_ER_diArg_1	328	330	PF00400	0.699
TRG_ER_diArg_1	46	48	PF00400	0.374
TRG_ER_diArg_1	510	513	PF00400	0.636
TRG_Pf-PMV_PEXEL_1	286	290	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	424	428	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I476	Leptomonas seymouri	56%	94%
A4HQG1	Leishmania braziliensis	76%	100%
A4IC97	Leishmania infantum	99%	100%
E9AU77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q0B7	Leishmania major	92%	100%