Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IPV2_LEIDO

TriTrypDb:

LdBPK_353540.1 , LdCL_350040400 , LDHU3_35.4640

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IPV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IPV2

PDB structure(s): 7ane_q

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.548
CLV_C14_Caspase3-7	207	211	PF00656	0.354
CLV_C14_Caspase3-7	246	250	PF00656	0.687
CLV_C14_Caspase3-7	337	341	PF00656	0.621
CLV_NRD_NRD_1	102	104	PF00675	0.545
CLV_NRD_NRD_1	26	28	PF00675	0.489
CLV_NRD_NRD_1	268	270	PF00675	0.680
CLV_NRD_NRD_1	286	288	PF00675	0.399
CLV_NRD_NRD_1	302	304	PF00675	0.593
CLV_NRD_NRD_1	324	326	PF00675	0.632
CLV_NRD_NRD_1	57	59	PF00675	0.418
CLV_NRD_NRD_1	9	11	PF00675	0.514
CLV_NRD_NRD_1	99	101	PF00675	0.551
CLV_PCSK_FUR_1	100	104	PF00082	0.635
CLV_PCSK_KEX2_1	101	103	PF00082	0.481
CLV_PCSK_KEX2_1	26	28	PF00082	0.590
CLV_PCSK_KEX2_1	286	288	PF00082	0.548
CLV_PCSK_KEX2_1	302	304	PF00082	0.593
CLV_PCSK_KEX2_1	323	325	PF00082	0.635
CLV_PCSK_KEX2_1	362	364	PF00082	0.671
CLV_PCSK_KEX2_1	62	64	PF00082	0.425
CLV_PCSK_KEX2_1	9	11	PF00082	0.521
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.475
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.669
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.675
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.438
CLV_PCSK_PC7_1	282	288	PF00082	0.544
CLV_PCSK_PC7_1	58	64	PF00082	0.419
CLV_PCSK_SKI1_1	112	116	PF00082	0.480
CLV_PCSK_SKI1_1	129	133	PF00082	0.361
CLV_PCSK_SKI1_1	26	30	PF00082	0.454
CLV_PCSK_SKI1_1	298	302	PF00082	0.629
CLV_PCSK_SKI1_1	349	353	PF00082	0.627
DOC_CKS1_1	31	36	PF01111	0.428
DOC_CYCLIN_RxL_1	112	125	PF00134	0.458
DOC_MAPK_gen_1	116	122	PF00069	0.455
DOC_PP4_FxxP_1	301	304	PF00568	0.651
DOC_PP4_FxxP_1	31	34	PF00568	0.434
DOC_USP7_MATH_1	19	23	PF00917	0.497
DOC_USP7_MATH_1	245	249	PF00917	0.663
DOC_USP7_UBL2_3	294	298	PF12436	0.615
DOC_USP7_UBL2_3	345	349	PF12436	0.723
DOC_WW_Pin1_4	30	35	PF00397	0.446
DOC_WW_Pin1_4	309	314	PF00397	0.755
DOC_WW_Pin1_4	317	322	PF00397	0.484
DOC_WW_Pin1_4	385	390	PF00397	0.676
LIG_14-3-3_CanoR_1	137	145	PF00244	0.406
LIG_14-3-3_CanoR_1	400	407	PF00244	0.615
LIG_FHA_1	27	33	PF00498	0.455
LIG_FHA_1	401	407	PF00498	0.669
LIG_FHA_2	212	218	PF00498	0.659
LIG_FHA_2	276	282	PF00498	0.525
LIG_LIR_Apic_2	214	219	PF02991	0.633
LIG_LIR_Apic_2	29	34	PF02991	0.435
LIG_LIR_Apic_2	299	304	PF02991	0.687
LIG_LIR_Gen_1	51	61	PF02991	0.418
LIG_LIR_Nem_3	44	49	PF02991	0.416
LIG_LIR_Nem_3	51	57	PF02991	0.420
LIG_MYND_3	183	187	PF01753	0.499
LIG_MYND_3	379	383	PF01753	0.677
LIG_PDZ_Class_3	421	426	PF00595	0.661
LIG_Pex14_1	65	69	PF04695	0.409
LIG_SH2_CRK	16	20	PF00017	0.473
LIG_SH2_GRB2like	15	18	PF00017	0.484
LIG_SH2_NCK_1	135	139	PF00017	0.401
LIG_SH2_NCK_1	16	20	PF00017	0.458
LIG_SH2_NCK_1	216	220	PF00017	0.669
LIG_SH2_STAT3	150	153	PF00017	0.486
LIG_SH2_STAT3	61	64	PF00017	0.422
LIG_SH2_STAT5	150	153	PF00017	0.452
LIG_SH2_STAT5	167	170	PF00017	0.447
LIG_SH2_STAT5	289	292	PF00017	0.522
LIG_SH2_STAT5	76	79	PF00017	0.409
LIG_TRAF2_1	155	158	PF00917	0.589
LIG_TRAF2_1	235	238	PF00917	0.597
LIG_TRAF2_1	274	277	PF00917	0.617
LIG_TRAF2_1	278	281	PF00917	0.634
LIG_TRAF2_1	334	337	PF00917	0.614
LIG_WRC_WIRS_1	66	71	PF05994	0.410
MOD_CDK_SPxK_1	30	36	PF00069	0.440
MOD_CDK_SPxK_1	317	323	PF00069	0.692
MOD_CDK_SPxxK_3	317	324	PF00069	0.688
MOD_CK1_1	152	158	PF00069	0.490
MOD_CK1_1	381	387	PF00069	0.671
MOD_CK2_1	152	158	PF00069	0.596
MOD_CK2_1	17	23	PF00069	0.529
MOD_CK2_1	211	217	PF00069	0.614
MOD_CK2_1	232	238	PF00069	0.624
MOD_CK2_1	271	277	PF00069	0.633
MOD_Cter_Amidation	24	27	PF01082	0.506
MOD_GlcNHglycan	234	237	PF01048	0.552
MOD_GlcNHglycan	262	265	PF01048	0.706
MOD_GlcNHglycan	314	317	PF01048	0.673
MOD_GlcNHglycan	4	7	PF01048	0.724
MOD_GlcNHglycan	84	87	PF01048	0.538
MOD_GSK3_1	195	202	PF00069	0.572
MOD_GSK3_1	245	252	PF00069	0.564
MOD_GSK3_1	26	33	PF00069	0.446
MOD_GSK3_1	271	278	PF00069	0.549
MOD_GSK3_1	292	299	PF00069	0.588
MOD_GSK3_1	312	319	PF00069	0.697
MOD_GSK3_1	381	388	PF00069	0.667
MOD_LATS_1	24	30	PF00433	0.483
MOD_N-GLC_1	80	85	PF02516	0.418
MOD_NEK2_1	1	6	PF00069	0.614
MOD_NEK2_1	232	237	PF00069	0.539
MOD_NEK2_2	211	216	PF00069	0.629
MOD_NEK2_2	296	301	PF00069	0.631
MOD_NEK2_2	65	70	PF00069	0.411
MOD_PIKK_1	102	108	PF00454	0.574
MOD_PIKK_1	149	155	PF00454	0.509
MOD_PKA_1	102	108	PF00069	0.574
MOD_PKA_1	26	32	PF00069	0.465
MOD_PKA_1	324	330	PF00069	0.701
MOD_PKA_2	102	108	PF00069	0.574
MOD_PKA_2	136	142	PF00069	0.405
MOD_PKA_2	2	8	PF00069	0.547
MOD_PKA_2	26	32	PF00069	0.570
MOD_PKA_2	324	330	PF00069	0.701
MOD_PKB_1	100	108	PF00069	0.637
MOD_Plk_1	353	359	PF00069	0.691
MOD_Plk_4	211	217	PF00069	0.633
MOD_Plk_4	296	302	PF00069	0.658
MOD_ProDKin_1	30	36	PF00069	0.440
MOD_ProDKin_1	309	315	PF00069	0.758
MOD_ProDKin_1	317	323	PF00069	0.482
MOD_ProDKin_1	385	391	PF00069	0.672
MOD_SUMO_for_1	351	354	PF00179	0.732
MOD_SUMO_rev_2	220	230	PF00179	0.663
TRG_ENDOCYTIC_2	15	18	PF00928	0.468
TRG_ER_diArg_1	100	103	PF00400	0.628
TRG_ER_diArg_1	241	244	PF00400	0.702
TRG_ER_diArg_1	26	28	PF00400	0.586
TRG_ER_diArg_1	301	303	PF00400	0.679
TRG_ER_diArg_1	370	373	PF00400	0.625
TRG_NLS_Bipartite_1	100	120	PF00514	0.487
TRG_NLS_MonoCore_2	322	327	PF00514	0.681
TRG_NLS_MonoExtC_3	115	121	PF00514	0.462
TRG_NLS_MonoExtC_3	324	330	PF00514	0.604
TRG_NLS_MonoExtN_4	321	327	PF00514	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P6	Leptomonas seymouri	78%	100%
A0A0S4IKL5	Bodo saltans	51%	91%
A0A1X0P5A6	Trypanosomatidae	61%	96%
A0A3R7NKQ1	Trypanosoma rangeli	62%	97%
A4HN18	Leishmania braziliensis	93%	100%
A4IBN9	Leishmania infantum	100%	100%
C9ZYZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	97%
E9AFH3	Leishmania major	97%	100%
E9B6M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BY99	Trypanosoma cruzi	61%	96%