Putative DUF1126 protein/EF-hand domain pair, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Repeat of unknown function (DUF1126)/EF-hand domain pair, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IPU3_LEIDO

TriTrypDb:

LdBPK_270720.1 , LdCL_270013800 , LDHU3_27.1120

Length:

756

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005819	spindle	5	1
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0072686	mitotic spindle	6	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IPU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IPU3

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0000281	mitotic cytokinesis	4	1
GO:0000910	cytokinesis	3	1
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0007051	spindle organization	3	1
GO:0007052	mitotic spindle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0048870	cell motility	2	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0061640	cytoskeleton-dependent cytokinesis	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1902850	microtubule cytoskeleton organization involved in mitosis	4	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005509	calcium ion binding	5	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0043014	alpha-tubulin binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	723	729	PF00089	0.496
CLV_NRD_NRD_1	115	117	PF00675	0.255
CLV_NRD_NRD_1	251	253	PF00675	0.334
CLV_NRD_NRD_1	29	31	PF00675	0.542
CLV_NRD_NRD_1	34	36	PF00675	0.538
CLV_NRD_NRD_1	396	398	PF00675	0.572
CLV_NRD_NRD_1	416	418	PF00675	0.461
CLV_NRD_NRD_1	441	443	PF00675	0.255
CLV_NRD_NRD_1	478	480	PF00675	0.307
CLV_NRD_NRD_1	532	534	PF00675	0.405
CLV_NRD_NRD_1	646	648	PF00675	0.652
CLV_NRD_NRD_1	669	671	PF00675	0.405
CLV_NRD_NRD_1	699	701	PF00675	0.450
CLV_PCSK_KEX2_1	148	150	PF00082	0.255
CLV_PCSK_KEX2_1	29	31	PF00082	0.542
CLV_PCSK_KEX2_1	34	36	PF00082	0.538
CLV_PCSK_KEX2_1	396	398	PF00082	0.572
CLV_PCSK_KEX2_1	416	418	PF00082	0.485
CLV_PCSK_KEX2_1	441	443	PF00082	0.255
CLV_PCSK_KEX2_1	478	480	PF00082	0.255
CLV_PCSK_KEX2_1	669	671	PF00082	0.381
CLV_PCSK_KEX2_1	699	701	PF00082	0.539
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.255
CLV_PCSK_PC7_1	30	36	PF00082	0.647
CLV_PCSK_PC7_1	474	480	PF00082	0.255
CLV_PCSK_SKI1_1	117	121	PF00082	0.238
CLV_PCSK_SKI1_1	188	192	PF00082	0.444
CLV_PCSK_SKI1_1	245	249	PF00082	0.346
CLV_PCSK_SKI1_1	252	256	PF00082	0.314
CLV_PCSK_SKI1_1	271	275	PF00082	0.152
CLV_PCSK_SKI1_1	308	312	PF00082	0.229
CLV_PCSK_SKI1_1	354	358	PF00082	0.247
CLV_PCSK_SKI1_1	442	446	PF00082	0.252
CLV_PCSK_SKI1_1	495	499	PF00082	0.303
CLV_PCSK_SKI1_1	55	59	PF00082	0.646
CLV_PCSK_SKI1_1	657	661	PF00082	0.499
CLV_PCSK_SKI1_1	670	674	PF00082	0.418
CLV_PCSK_SKI1_1	717	721	PF00082	0.471
CLV_Separin_Metazoa	26	30	PF03568	0.546
DEG_SIAH_1	198	206	PF03145	0.597
DOC_ANK_TNKS_1	604	611	PF00023	0.487
DOC_CDC14_PxL_1	15	23	PF14671	0.663
DOC_CYCLIN_RxL_1	185	193	PF00134	0.640
DOC_CYCLIN_RxL_1	568	579	PF00134	0.381
DOC_CYCLIN_RxL_1	664	676	PF00134	0.407
DOC_CYCLIN_RxL_1	695	708	PF00134	0.513
DOC_MAPK_FxFP_2	141	144	PF00069	0.452
DOC_MAPK_gen_1	114	122	PF00069	0.457
DOC_MAPK_gen_1	242	250	PF00069	0.452
DOC_MAPK_gen_1	34	42	PF00069	0.650
DOC_MAPK_gen_1	439	449	PF00069	0.461
DOC_MAPK_MEF2A_6	114	122	PF00069	0.507
DOC_MAPK_MEF2A_6	441	449	PF00069	0.502
DOC_PP4_FxxP_1	13	16	PF00568	0.536
DOC_PP4_FxxP_1	141	144	PF00568	0.452
DOC_PP4_FxxP_1	389	392	PF00568	0.627
DOC_USP7_MATH_1	450	454	PF00917	0.525
DOC_USP7_MATH_1	608	612	PF00917	0.587
DOC_USP7_MATH_1	631	635	PF00917	0.677
DOC_USP7_MATH_1	653	657	PF00917	0.471
DOC_USP7_MATH_1	684	688	PF00917	0.541
DOC_USP7_MATH_1	725	729	PF00917	0.529
DOC_USP7_MATH_1	748	752	PF00917	0.536
DOC_USP7_UBL2_3	435	439	PF12436	0.557
DOC_USP7_UBL2_3	530	534	PF12436	0.540
DOC_WW_Pin1_4	155	160	PF00397	0.455
DOC_WW_Pin1_4	227	232	PF00397	0.559
DOC_WW_Pin1_4	234	239	PF00397	0.509
DOC_WW_Pin1_4	382	387	PF00397	0.575
LIG_14-3-3_CanoR_1	419	425	PF00244	0.395
LIG_14-3-3_CanoR_1	657	666	PF00244	0.314
LIG_14-3-3_CanoR_1	726	730	PF00244	0.430
LIG_AP2alpha_2	184	186	PF02296	0.558
LIG_AP2alpha_2	298	300	PF02296	0.455
LIG_BIR_II_1	1	5	PF00653	0.560
LIG_BIR_III_2	182	186	PF00653	0.567
LIG_BRCT_BRCA1_1	169	173	PF00533	0.475
LIG_BRCT_BRCA1_1	283	287	PF00533	0.502
LIG_BRCT_BRCA1_1	315	319	PF00533	0.495
LIG_BRCT_BRCA1_1	325	329	PF00533	0.434
LIG_BRCT_BRCA1_1	499	503	PF00533	0.534
LIG_BRCT_BRCA1_1	690	694	PF00533	0.479
LIG_eIF4E_1	683	689	PF01652	0.535
LIG_FHA_1	110	116	PF00498	0.495
LIG_FHA_1	126	132	PF00498	0.408
LIG_FHA_1	175	181	PF00498	0.455
LIG_FHA_1	185	191	PF00498	0.527
LIG_FHA_1	262	268	PF00498	0.457
LIG_FHA_1	541	547	PF00498	0.446
LIG_FHA_1	658	664	PF00498	0.317
LIG_FHA_1	89	95	PF00498	0.356
LIG_FHA_2	258	264	PF00498	0.534
LIG_FHA_2	326	332	PF00498	0.462
LIG_FHA_2	337	343	PF00498	0.441
LIG_FHA_2	393	399	PF00498	0.620
LIG_FHA_2	401	407	PF00498	0.381
LIG_FHA_2	576	582	PF00498	0.419
LIG_LIR_Apic_2	12	16	PF02991	0.541
LIG_LIR_Apic_2	139	144	PF02991	0.452
LIG_LIR_Gen_1	206	217	PF02991	0.506
LIG_LIR_Gen_1	244	255	PF02991	0.447
LIG_LIR_Gen_1	270	280	PF02991	0.503
LIG_LIR_Gen_1	500	510	PF02991	0.509
LIG_LIR_Gen_1	564	573	PF02991	0.284
LIG_LIR_Gen_1	598	607	PF02991	0.467
LIG_LIR_Gen_1	619	628	PF02991	0.424
LIG_LIR_Gen_1	660	666	PF02991	0.448
LIG_LIR_Gen_1	676	684	PF02991	0.377
LIG_LIR_Gen_1	728	736	PF02991	0.488
LIG_LIR_Nem_3	177	181	PF02991	0.511
LIG_LIR_Nem_3	244	250	PF02991	0.447
LIG_LIR_Nem_3	270	276	PF02991	0.459
LIG_LIR_Nem_3	298	303	PF02991	0.444
LIG_LIR_Nem_3	360	364	PF02991	0.453
LIG_LIR_Nem_3	376	381	PF02991	0.391
LIG_LIR_Nem_3	455	460	PF02991	0.485
LIG_LIR_Nem_3	500	506	PF02991	0.509
LIG_LIR_Nem_3	564	569	PF02991	0.284
LIG_LIR_Nem_3	594	599	PF02991	0.308
LIG_LIR_Nem_3	619	623	PF02991	0.417
LIG_LIR_Nem_3	660	665	PF02991	0.442
LIG_LIR_Nem_3	676	680	PF02991	0.287
LIG_LIR_Nem_3	728	732	PF02991	0.493
LIG_Pex14_1	620	624	PF04695	0.542
LIG_Pex14_2	673	677	PF04695	0.443
LIG_SH2_CRK	378	382	PF00017	0.482
LIG_SH2_NCK_1	378	382	PF00017	0.394
LIG_SH2_NCK_1	599	603	PF00017	0.419
LIG_SH2_SRC	378	381	PF00017	0.362
LIG_SH2_SRC	599	602	PF00017	0.419
LIG_SH2_SRC	624	627	PF00017	0.594
LIG_SH2_STAP1	599	603	PF00017	0.308
LIG_SH2_STAP1	729	733	PF00017	0.480
LIG_SH2_STAP1	742	746	PF00017	0.529
LIG_SH2_STAT3	352	355	PF00017	0.558
LIG_SH2_STAT5	100	103	PF00017	0.468
LIG_SH2_STAT5	123	126	PF00017	0.534
LIG_SH2_STAT5	209	212	PF00017	0.531
LIG_SH2_STAT5	278	281	PF00017	0.461
LIG_SH2_STAT5	338	341	PF00017	0.455
LIG_SH2_STAT5	364	367	PF00017	0.552
LIG_SH2_STAT5	448	451	PF00017	0.502
LIG_SH2_STAT5	484	487	PF00017	0.470
LIG_SH2_STAT5	491	494	PF00017	0.466
LIG_SH2_STAT5	588	591	PF00017	0.308
LIG_SH2_STAT5	596	599	PF00017	0.308
LIG_SH3_3	128	134	PF00018	0.534
LIG_SH3_3	13	19	PF00018	0.529
LIG_SH3_3	149	155	PF00018	0.507
LIG_SH3_3	385	391	PF00018	0.479
LIG_SH3_3	719	725	PF00018	0.441
LIG_SUMO_SIM_anti_2	581	587	PF11976	0.327
LIG_TRAF2_1	578	581	PF00917	0.308
LIG_TRAF2_1	598	601	PF00917	0.122
LIG_TRAF2_1	708	711	PF00917	0.507
LIG_TRAF2_1	728	731	PF00917	0.292
LIG_TYR_ITIM	597	602	PF00017	0.406
LIG_TYR_ITSM	374	381	PF00017	0.434
LIG_UBA3_1	582	591	PF00899	0.319
MOD_CK1_1	281	287	PF00069	0.502
MOD_CK1_1	323	329	PF00069	0.530
MOD_CK1_1	400	406	PF00069	0.587
MOD_CK1_1	541	547	PF00069	0.423
MOD_CK1_1	595	601	PF00069	0.308
MOD_CK1_1	705	711	PF00069	0.513
MOD_CK2_1	105	111	PF00069	0.457
MOD_CK2_1	127	133	PF00069	0.455
MOD_CK2_1	19	25	PF00069	0.526
MOD_CK2_1	325	331	PF00069	0.485
MOD_CK2_1	392	398	PF00069	0.609
MOD_CK2_1	400	406	PF00069	0.374
MOD_CK2_1	452	458	PF00069	0.485
MOD_CK2_1	575	581	PF00069	0.308
MOD_CK2_1	595	601	PF00069	0.122
MOD_CK2_1	705	711	PF00069	0.432
MOD_CK2_1	725	731	PF00069	0.342
MOD_GlcNHglycan	107	110	PF01048	0.312
MOD_GlcNHglycan	137	141	PF01048	0.255
MOD_GlcNHglycan	294	297	PF01048	0.255
MOD_GlcNHglycan	313	316	PF01048	0.335
MOD_GlcNHglycan	463	466	PF01048	0.268
MOD_GlcNHglycan	557	560	PF01048	0.397
MOD_GlcNHglycan	609	613	PF01048	0.607
MOD_GSK3_1	105	112	PF00069	0.533
MOD_GSK3_1	125	132	PF00069	0.389
MOD_GSK3_1	203	210	PF00069	0.523
MOD_GSK3_1	222	229	PF00069	0.401
MOD_GSK3_1	257	264	PF00069	0.534
MOD_GSK3_1	319	326	PF00069	0.470
MOD_GSK3_1	332	339	PF00069	0.396
MOD_GSK3_1	505	512	PF00069	0.455
MOD_GSK3_1	55	62	PF00069	0.662
MOD_GSK3_1	608	615	PF00069	0.589
MOD_GSK3_1	653	660	PF00069	0.460
MOD_GSK3_1	684	691	PF00069	0.503
MOD_GSK3_1	738	745	PF00069	0.529
MOD_GSK3_1	748	755	PF00069	0.568
MOD_N-GLC_1	555	560	PF02516	0.400
MOD_N-GLC_1	592	597	PF02516	0.316
MOD_N-GLC_1	616	621	PF02516	0.504
MOD_N-GLC_1	736	741	PF02516	0.409
MOD_NEK2_1	1	6	PF00069	0.569
MOD_NEK2_1	267	272	PF00069	0.497
MOD_NEK2_1	319	324	PF00069	0.515
MOD_NEK2_1	373	378	PF00069	0.474
MOD_NEK2_1	420	425	PF00069	0.518
MOD_NEK2_1	538	543	PF00069	0.416
MOD_NEK2_1	702	707	PF00069	0.478
MOD_NEK2_1	736	741	PF00069	0.427
MOD_NEK2_2	169	174	PF00069	0.405
MOD_NEK2_2	325	330	PF00069	0.485
MOD_NEK2_2	65	70	PF00069	0.733
MOD_PIKK_1	1	7	PF00454	0.574
MOD_PKA_2	241	247	PF00069	0.438
MOD_PKA_2	461	467	PF00069	0.468
MOD_PKA_2	646	652	PF00069	0.626
MOD_PKA_2	725	731	PF00069	0.431
MOD_Plk_1	257	263	PF00069	0.534
MOD_Plk_1	319	325	PF00069	0.534
MOD_Plk_1	400	406	PF00069	0.587
MOD_Plk_1	450	456	PF00069	0.455
MOD_Plk_1	509	515	PF00069	0.538
MOD_Plk_1	53	59	PF00069	0.640
MOD_Plk_1	592	598	PF00069	0.297
MOD_Plk_1	616	622	PF00069	0.502
MOD_Plk_1	702	708	PF00069	0.496
MOD_Plk_2-3	616	622	PF00069	0.488
MOD_Plk_2-3	703	709	PF00069	0.480
MOD_Plk_4	169	175	PF00069	0.534
MOD_Plk_4	231	237	PF00069	0.632
MOD_Plk_4	263	269	PF00069	0.501
MOD_Plk_4	272	278	PF00069	0.446
MOD_Plk_4	332	338	PF00069	0.468
MOD_Plk_4	420	426	PF00069	0.534
MOD_Plk_4	452	458	PF00069	0.531
MOD_Plk_4	565	571	PF00069	0.362
MOD_Plk_4	581	587	PF00069	0.209
MOD_Plk_4	592	598	PF00069	0.308
MOD_Plk_4	631	637	PF00069	0.633
MOD_Plk_4	684	690	PF00069	0.426
MOD_ProDKin_1	155	161	PF00069	0.455
MOD_ProDKin_1	227	233	PF00069	0.559
MOD_ProDKin_1	234	240	PF00069	0.501
MOD_ProDKin_1	382	388	PF00069	0.584
MOD_SUMO_rev_2	249	255	PF00179	0.534
MOD_SUMO_rev_2	432	440	PF00179	0.558
MOD_SUMO_rev_2	634	642	PF00179	0.559
MOD_SUMO_rev_2	643	649	PF00179	0.508
MOD_SUMO_rev_2	687	696	PF00179	0.431
TRG_DiLeu_BaEn_1	731	736	PF01217	0.479
TRG_DiLeu_BaEn_4	710	716	PF01217	0.483
TRG_DiLeu_LyEn_5	731	736	PF01217	0.512
TRG_ENDOCYTIC_2	209	212	PF00928	0.501
TRG_ENDOCYTIC_2	277	280	PF00928	0.460
TRG_ENDOCYTIC_2	378	381	PF00928	0.458
TRG_ENDOCYTIC_2	599	602	PF00928	0.308
TRG_ENDOCYTIC_2	729	732	PF00928	0.450
TRG_ER_diArg_1	212	215	PF00400	0.545
TRG_ER_diArg_1	28	30	PF00400	0.547
TRG_ER_diArg_1	306	309	PF00400	0.478
TRG_ER_diArg_1	415	417	PF00400	0.536
TRG_ER_diArg_1	440	442	PF00400	0.455
TRG_ER_diArg_1	477	479	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	188	193	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	397	401	PF00026	0.656

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5H4	Leptomonas seymouri	23%	90%
A0A0N1HZ98	Leptomonas seymouri	25%	98%
A0A0N1I3M2	Leptomonas seymouri	76%	99%
A0A0N1PBW1	Leptomonas seymouri	27%	100%
A0A0S4IJW8	Bodo saltans	26%	92%
A0A0S4IQM0	Bodo saltans	24%	100%
A0A0S4J8J7	Bodo saltans	29%	82%
A0A1X0NEV8	Trypanosomatidae	24%	95%
A0A1X0NLI2	Trypanosomatidae	27%	100%
A0A1X0NMQ3	Trypanosomatidae	25%	97%
A0A1X0P419	Trypanosomatidae	62%	99%
A0A3Q1N1R0	Bos taurus	30%	100%
A0A3Q8IDH4	Leishmania donovani	26%	100%
A0A3R7KM50	Trypanosoma rangeli	27%	95%
A0A3R7L048	Trypanosoma rangeli	59%	100%
A0A3S7XC76	Leishmania donovani	27%	100%
A0A422N0Z6	Trypanosoma rangeli	25%	97%
A0A422NK00	Trypanosoma rangeli	29%	100%
A4HE78	Leishmania braziliensis	26%	99%
A4HFK9	Leishmania braziliensis	87%	100%
A4HQF8	Leishmania braziliensis	26%	96%
A4I1J2	Leishmania infantum	26%	100%
A4IC94	Leishmania infantum	27%	97%
C9ZJX4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	94%
C9ZPE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	97%
D0A3K7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A5T5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E1BKH1	Bos taurus	29%	100%
E9AD64	Leishmania major	97%	100%
E9AHF6	Leishmania infantum	100%	100%
E9AI34	Leishmania braziliensis	23%	100%
E9AMI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AU74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	96%
E9AXM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	99%
E9AYY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q32TF8	Danio rerio	30%	100%
Q32TG3	Gallus gallus	28%	100%
Q4Q0C0	Leishmania major	27%	97%
Q4Q9U5	Leishmania major	25%	100%
Q4QI57	Leishmania major	24%	87%
Q5JST6	Homo sapiens	28%	100%
Q5JVL4	Homo sapiens	30%	100%
Q9D485	Mus musculus	29%	100%
Q9D9T8	Mus musculus	30%	100%
V5ASV2	Trypanosoma cruzi	26%	100%
V5D3X9	Trypanosoma cruzi	24%	97%
V5DA42	Trypanosoma cruzi	59%	100%