Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IPT0_LEIDO

TriTrypDb:

LdBPK_270560.1 , LdCL_270012100 , LDHU3_27.0920

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IPT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IPT0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	315	319	PF00656	0.624
CLV_NRD_NRD_1	191	193	PF00675	0.632
CLV_NRD_NRD_1	256	258	PF00675	0.539
CLV_NRD_NRD_1	287	289	PF00675	0.497
CLV_NRD_NRD_1	63	65	PF00675	0.635
CLV_NRD_NRD_1	83	85	PF00675	0.652
CLV_PCSK_KEX2_1	191	193	PF00082	0.633
CLV_PCSK_KEX2_1	203	205	PF00082	0.551
CLV_PCSK_KEX2_1	256	258	PF00082	0.539
CLV_PCSK_KEX2_1	287	289	PF00082	0.497
CLV_PCSK_KEX2_1	63	65	PF00082	0.633
CLV_PCSK_KEX2_1	83	85	PF00082	0.677
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.585
CLV_PCSK_PC7_1	252	258	PF00082	0.504
CLV_PCSK_PC7_1	79	85	PF00082	0.711
CLV_PCSK_SKI1_1	149	153	PF00082	0.633
CLV_PCSK_SKI1_1	345	349	PF00082	0.568
CLV_PCSK_SKI1_1	370	374	PF00082	0.538
DEG_COP1_1	214	223	PF00400	0.443
DEG_Nend_UBRbox_1	1	4	PF02207	0.746
DOC_ANK_TNKS_1	360	367	PF00023	0.489
DOC_CKS1_1	72	77	PF01111	0.695
DOC_CYCLIN_RxL_1	367	378	PF00134	0.493
DOC_MAPK_gen_1	231	238	PF00069	0.468
DOC_MAPK_gen_1	63	72	PF00069	0.692
DOC_MAPK_MEF2A_6	208	217	PF00069	0.544
DOC_MAPK_MEF2A_6	231	238	PF00069	0.537
DOC_MAPK_RevD_3	70	84	PF00069	0.695
DOC_PP1_RVXF_1	190	197	PF00149	0.644
DOC_PP1_RVXF_1	368	375	PF00149	0.463
DOC_PP2B_LxvP_1	217	220	PF13499	0.523
DOC_PP4_FxxP_1	266	269	PF00568	0.607
DOC_USP7_MATH_1	120	124	PF00917	0.722
DOC_USP7_MATH_1	218	222	PF00917	0.580
DOC_USP7_MATH_1	298	302	PF00917	0.544
DOC_USP7_MATH_1	42	46	PF00917	0.727
DOC_USP7_MATH_1	94	98	PF00917	0.641
DOC_WW_Pin1_4	108	113	PF00397	0.648
DOC_WW_Pin1_4	318	323	PF00397	0.594
DOC_WW_Pin1_4	384	389	PF00397	0.521
DOC_WW_Pin1_4	71	76	PF00397	0.623
LIG_14-3-3_CanoR_1	170	174	PF00244	0.697
LIG_14-3-3_CanoR_1	191	195	PF00244	0.622
LIG_14-3-3_CanoR_1	261	265	PF00244	0.602
LIG_14-3-3_CanoR_1	48	54	PF00244	0.688
LIG_14-3-3_CanoR_1	67	73	PF00244	0.660
LIG_BRCT_BRCA1_1	262	266	PF00533	0.625
LIG_BRCT_BRCA1_1	49	53	PF00533	0.576
LIG_CaM_NSCaTE_8	99	106	PF13499	0.536
LIG_deltaCOP1_diTrp_1	195	200	PF00928	0.621
LIG_deltaCOP1_diTrp_1	390	398	PF00928	0.540
LIG_FHA_1	150	156	PF00498	0.566
LIG_FHA_1	367	373	PF00498	0.481
LIG_FHA_1	375	381	PF00498	0.371
LIG_FHA_1	384	390	PF00498	0.378
LIG_FHA_1	424	430	PF00498	0.643
LIG_FHA_2	162	168	PF00498	0.609
LIG_FHA_2	242	248	PF00498	0.647
LIG_FHA_2	329	335	PF00498	0.581
LIG_FHA_2	406	412	PF00498	0.667
LIG_FHA_2	88	94	PF00498	0.678
LIG_LIR_Apic_2	263	269	PF02991	0.610
LIG_LIR_Gen_1	29	40	PF02991	0.685
LIG_LIR_Gen_1	74	82	PF02991	0.672
LIG_LIR_Gen_1	97	108	PF02991	0.498
LIG_LIR_Nem_3	193	199	PF02991	0.626
LIG_LIR_Nem_3	29	35	PF02991	0.649
LIG_LIR_Nem_3	390	395	PF02991	0.481
LIG_LIR_Nem_3	426	430	PF02991	0.638
LIG_LIR_Nem_3	74	80	PF02991	0.667
LIG_LIR_Nem_3	97	103	PF02991	0.445
LIG_NRBOX	371	377	PF00104	0.505
LIG_Pex14_1	100	104	PF04695	0.493
LIG_SH2_STAP1	104	108	PF00017	0.609
LIG_SH2_STAT5	142	145	PF00017	0.488
LIG_SH2_STAT5	189	192	PF00017	0.642
LIG_SH2_STAT5	397	400	PF00017	0.602
LIG_SH3_2	117	122	PF14604	0.716
LIG_SH3_3	111	117	PF00018	0.669
LIG_SH3_3	151	157	PF00018	0.500
LIG_SH3_3	163	169	PF00018	0.588
LIG_SH3_3	191	197	PF00018	0.617
LIG_SH3_3	359	365	PF00018	0.683
LIG_SH3_3	69	75	PF00018	0.628
LIG_SUMO_SIM_par_1	211	216	PF11976	0.493
LIG_TRAF2_1	331	334	PF00917	0.569
LIG_WRC_WIRS_1	371	376	PF05994	0.535
MOD_CK1_1	321	327	PF00069	0.573
MOD_CK1_1	34	40	PF00069	0.631
MOD_CK1_1	355	361	PF00069	0.677
MOD_CK2_1	161	167	PF00069	0.601
MOD_CK2_1	328	334	PF00069	0.567
MOD_CK2_1	384	390	PF00069	0.531
MOD_CK2_1	405	411	PF00069	0.665
MOD_CK2_1	434	440	PF00069	0.684
MOD_CK2_1	87	93	PF00069	0.544
MOD_GlcNHglycan	176	179	PF01048	0.754
MOD_GlcNHglycan	220	223	PF01048	0.568
MOD_GlcNHglycan	26	29	PF01048	0.557
MOD_GlcNHglycan	300	303	PF01048	0.443
MOD_GlcNHglycan	37	40	PF01048	0.560
MOD_GSK3_1	120	127	PF00069	0.662
MOD_GSK3_1	26	33	PF00069	0.502
MOD_GSK3_1	260	267	PF00069	0.604
MOD_GSK3_1	34	41	PF00069	0.621
MOD_GSK3_1	366	373	PF00069	0.508
MOD_GSK3_1	443	450	PF00069	0.646
MOD_NEK2_1	213	218	PF00069	0.495
MOD_NEK2_1	234	239	PF00069	0.486
MOD_NEK2_1	260	265	PF00069	0.522
MOD_NEK2_1	303	308	PF00069	0.415
MOD_NEK2_1	31	36	PF00069	0.543
MOD_NEK2_1	311	316	PF00069	0.453
MOD_NEK2_1	339	344	PF00069	0.601
MOD_NEK2_1	374	379	PF00069	0.407
MOD_NEK2_1	383	388	PF00069	0.456
MOD_NEK2_1	413	418	PF00069	0.536
MOD_NEK2_1	445	450	PF00069	0.736
MOD_PIKK_1	149	155	PF00454	0.615
MOD_PIKK_1	321	327	PF00454	0.591
MOD_PIKK_1	339	345	PF00454	0.600
MOD_PIKK_1	443	449	PF00454	0.773
MOD_PKA_2	169	175	PF00069	0.636
MOD_PKA_2	190	196	PF00069	0.617
MOD_PKA_2	260	266	PF00069	0.582
MOD_PKA_2	47	53	PF00069	0.711
MOD_Plk_1	149	155	PF00069	0.587
MOD_Plk_1	213	219	PF00069	0.473
MOD_Plk_1	241	247	PF00069	0.597
MOD_Plk_1	312	318	PF00069	0.591
MOD_Plk_2-3	405	411	PF00069	0.665
MOD_Plk_4	195	201	PF00069	0.623
MOD_Plk_4	26	32	PF00069	0.515
MOD_Plk_4	370	376	PF00069	0.452
MOD_Plk_4	429	435	PF00069	0.649
MOD_Plk_4	95	101	PF00069	0.611
MOD_ProDKin_1	108	114	PF00069	0.657
MOD_ProDKin_1	318	324	PF00069	0.589
MOD_ProDKin_1	384	390	PF00069	0.531
MOD_ProDKin_1	71	77	PF00069	0.617
TRG_DiLeu_BaEn_1	367	372	PF01217	0.405
TRG_DiLeu_BaEn_4	440	446	PF01217	0.587
TRG_ER_diArg_1	1	4	PF00400	0.713
TRG_ER_diArg_1	286	288	PF00400	0.529
TRG_NES_CRM1_1	138	150	PF08389	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU3	Leptomonas seymouri	39%	100%
A0A0S4JRJ3	Bodo saltans	25%	100%
A0A3R7KFH1	Trypanosoma rangeli	28%	100%
D0A5R9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AD48	Leishmania major	90%	100%
E9AHE2	Leishmania infantum	99%	100%
E9AYX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BIJ6	Trypanosoma cruzi	27%	100%