Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IPS4_LEIDO

TriTrypDb:

LdBPK_366060.1 , LdCL_360068000 , LDHU3_36.7990

Length:

445

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IPS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IPS4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.574
CLV_C14_Caspase3-7	333	337	PF00656	0.471
CLV_C14_Caspase3-7	392	396	PF00656	0.578
CLV_NRD_NRD_1	169	171	PF00675	0.538
CLV_NRD_NRD_1	274	276	PF00675	0.484
CLV_NRD_NRD_1	386	388	PF00675	0.664
CLV_PCSK_FUR_1	384	388	PF00082	0.660
CLV_PCSK_KEX2_1	274	276	PF00082	0.470
CLV_PCSK_KEX2_1	282	284	PF00082	0.505
CLV_PCSK_KEX2_1	386	388	PF00082	0.662
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.614
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.626
CLV_PCSK_PC7_1	384	390	PF00082	0.702
CLV_PCSK_SKI1_1	267	271	PF00082	0.482
CLV_PCSK_SKI1_1	305	309	PF00082	0.450
CLV_PCSK_SKI1_1	311	315	PF00082	0.494
DEG_APCC_DBOX_1	177	185	PF00400	0.509
DEG_APCC_DBOX_1	266	274	PF00400	0.530
DEG_Nend_Nbox_1	1	3	PF02207	0.463
DEG_SCF_FBW7_2	35	42	PF00400	0.538
DEG_SPOP_SBC_1	200	204	PF00917	0.641
DOC_CYCLIN_RxL_1	264	271	PF00134	0.467
DOC_MAPK_gen_1	142	149	PF00069	0.527
DOC_MAPK_gen_1	314	323	PF00069	0.490
DOC_MAPK_MEF2A_6	316	325	PF00069	0.460
DOC_PP2B_LxvP_1	227	230	PF13499	0.543
DOC_PP2B_LxvP_1	261	264	PF13499	0.532
DOC_PP2B_LxvP_1	345	348	PF13499	0.505
DOC_USP7_MATH_1	431	435	PF00917	0.361
DOC_USP7_MATH_1	51	55	PF00917	0.609
DOC_USP7_UBL2_3	377	381	PF12436	0.713
DOC_WW_Pin1_4	127	132	PF00397	0.639
DOC_WW_Pin1_4	134	139	PF00397	0.560
DOC_WW_Pin1_4	201	206	PF00397	0.700
DOC_WW_Pin1_4	33	38	PF00397	0.671
LIG_14-3-3_CanoR_1	146	155	PF00244	0.540
LIG_14-3-3_CanoR_1	186	194	PF00244	0.357
LIG_14-3-3_CanoR_1	258	264	PF00244	0.427
LIG_14-3-3_CanoR_1	296	304	PF00244	0.420
LIG_14-3-3_CanoR_1	316	322	PF00244	0.282
LIG_14-3-3_CanoR_1	92	96	PF00244	0.538
LIG_Actin_WH2_2	406	424	PF00022	0.463
LIG_FHA_1	222	228	PF00498	0.684
LIG_FHA_1	70	76	PF00498	0.456
LIG_FHA_2	238	244	PF00498	0.679
LIG_FHA_2	403	409	PF00498	0.583
LIG_FHA_2	72	78	PF00498	0.557
LIG_LIR_Gen_1	299	308	PF02991	0.448
LIG_LIR_Nem_3	188	193	PF02991	0.555
LIG_LIR_Nem_3	299	304	PF02991	0.440
LIG_LIR_Nem_3	66	71	PF02991	0.493
LIG_LYPXL_SIV_4	300	308	PF13949	0.461
LIG_NBox_RRM_1	331	341	PF00076	0.443
LIG_NRBOX	265	271	PF00104	0.530
LIG_NRBOX	340	346	PF00104	0.476
LIG_PCNA_yPIPBox_3	425	439	PF02747	0.350
LIG_SH2_CRK	17	21	PF00017	0.600
LIG_SH2_PTP2	193	196	PF00017	0.388
LIG_SH2_STAP1	190	194	PF00017	0.530
LIG_SH2_STAT5	148	151	PF00017	0.551
LIG_SH2_STAT5	193	196	PF00017	0.561
LIG_SH2_STAT5	2	5	PF00017	0.530
LIG_SUMO_SIM_anti_2	121	126	PF11976	0.525
LIG_SUMO_SIM_par_1	152	159	PF11976	0.469
LIG_SUMO_SIM_par_1	2	8	PF11976	0.511
LIG_TRAF2_1	156	159	PF00917	0.560
LIG_TYR_ITIM	15	20	PF00017	0.587
MOD_CDC14_SPxK_1	130	133	PF00782	0.538
MOD_CDK_SPxK_1	127	133	PF00069	0.543
MOD_CK1_1	114	120	PF00069	0.809
MOD_CK1_1	201	207	PF00069	0.662
MOD_CK1_1	217	223	PF00069	0.542
MOD_CK1_1	350	356	PF00069	0.449
MOD_CK2_1	153	159	PF00069	0.437
MOD_CK2_1	2	8	PF00069	0.511
MOD_CK2_1	237	243	PF00069	0.662
MOD_CK2_1	296	302	PF00069	0.457
MOD_CK2_1	402	408	PF00069	0.614
MOD_Cter_Amidation	384	387	PF01082	0.658
MOD_GlcNHglycan	100	103	PF01048	0.604
MOD_GlcNHglycan	113	116	PF01048	0.816
MOD_GlcNHglycan	23	26	PF01048	0.722
MOD_GlcNHglycan	253	256	PF01048	0.450
MOD_GlcNHglycan	261	264	PF01048	0.470
MOD_GlcNHglycan	298	301	PF01048	0.543
MOD_GlcNHglycan	30	33	PF01048	0.739
MOD_GlcNHglycan	349	352	PF01048	0.369
MOD_GlcNHglycan	367	370	PF01048	0.568
MOD_GlcNHglycan	44	47	PF01048	0.628
MOD_GSK3_1	114	121	PF00069	0.639
MOD_GSK3_1	149	156	PF00069	0.511
MOD_GSK3_1	217	224	PF00069	0.690
MOD_GSK3_1	232	239	PF00069	0.605
MOD_GSK3_1	402	409	PF00069	0.657
MOD_N-GLC_1	232	237	PF02516	0.746
MOD_N-GLC_1	431	436	PF02516	0.363
MOD_NEK2_1	125	130	PF00069	0.706
MOD_NEK2_1	147	152	PF00069	0.546
MOD_NEK2_1	257	262	PF00069	0.460
MOD_NEK2_1	352	357	PF00069	0.547
MOD_NEK2_2	431	436	PF00069	0.587
MOD_PIKK_1	268	274	PF00454	0.560
MOD_PK_1	120	126	PF00069	0.526
MOD_PKA_1	170	176	PF00069	0.550
MOD_PKA_2	185	191	PF00069	0.544
MOD_PKA_2	257	263	PF00069	0.429
MOD_PKA_2	28	34	PF00069	0.773
MOD_PKA_2	91	97	PF00069	0.542
MOD_Plk_1	326	332	PF00069	0.526
MOD_Plk_1	403	409	PF00069	0.685
MOD_Plk_4	120	126	PF00069	0.539
MOD_Plk_4	2	8	PF00069	0.514
MOD_Plk_4	352	358	PF00069	0.497
MOD_ProDKin_1	127	133	PF00069	0.639
MOD_ProDKin_1	134	140	PF00069	0.557
MOD_ProDKin_1	201	207	PF00069	0.705
MOD_ProDKin_1	33	39	PF00069	0.667
MOD_SUMO_rev_2	368	376	PF00179	0.710
TRG_DiLeu_BaEn_1	419	424	PF01217	0.504
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.519
TRG_ENDOCYTIC_2	17	20	PF00928	0.597
TRG_ENDOCYTIC_2	193	196	PF00928	0.388
TRG_ENDOCYTIC_2	301	304	PF00928	0.402
TRG_ENDOCYTIC_2	68	71	PF00928	0.436
TRG_ER_diArg_1	143	146	PF00400	0.563
TRG_ER_diArg_1	273	275	PF00400	0.453
TRG_Pf-PMV_PEXEL_1	267	272	PF00026	0.604
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEF3	Leptomonas seymouri	45%	84%
A0A1X0NLI7	Trypanosomatidae	29%	100%
A0A3R7NLX1	Trypanosoma rangeli	28%	100%
A4HQ97	Leishmania braziliensis	70%	100%
D0A414	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AHY4	Leishmania infantum	100%	100%
E9AU15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q0I0	Leishmania major	89%	100%