Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IPQ0_LEIDO

TriTrypDb:

LdBPK_365710.1 , LdCL_360064500 , LDHU3_36.7580

Length:

970

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IPQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IPQ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	377	381	PF00656	0.803
CLV_C14_Caspase3-7	389	393	PF00656	0.508
CLV_C14_Caspase3-7	516	520	PF00656	0.630
CLV_NRD_NRD_1	15	17	PF00675	0.456
CLV_NRD_NRD_1	183	185	PF00675	0.440
CLV_NRD_NRD_1	188	190	PF00675	0.455
CLV_NRD_NRD_1	196	198	PF00675	0.588
CLV_NRD_NRD_1	218	220	PF00675	0.639
CLV_NRD_NRD_1	278	280	PF00675	0.530
CLV_NRD_NRD_1	28	30	PF00675	0.496
CLV_NRD_NRD_1	351	353	PF00675	0.586
CLV_NRD_NRD_1	439	441	PF00675	0.780
CLV_NRD_NRD_1	442	444	PF00675	0.756
CLV_NRD_NRD_1	776	778	PF00675	0.546
CLV_NRD_NRD_1	80	82	PF00675	0.473
CLV_NRD_NRD_1	835	837	PF00675	0.653
CLV_NRD_NRD_1	842	844	PF00675	0.674
CLV_NRD_NRD_1	964	966	PF00675	0.616
CLV_PCSK_FUR_1	26	30	PF00082	0.615
CLV_PCSK_FUR_1	439	443	PF00082	0.787
CLV_PCSK_KEX2_1	15	17	PF00082	0.400
CLV_PCSK_KEX2_1	183	185	PF00082	0.440
CLV_PCSK_KEX2_1	195	197	PF00082	0.314
CLV_PCSK_KEX2_1	217	219	PF00082	0.637
CLV_PCSK_KEX2_1	28	30	PF00082	0.488
CLV_PCSK_KEX2_1	353	355	PF00082	0.607
CLV_PCSK_KEX2_1	439	441	PF00082	0.800
CLV_PCSK_KEX2_1	442	444	PF00082	0.742
CLV_PCSK_KEX2_1	5	7	PF00082	0.461
CLV_PCSK_KEX2_1	776	778	PF00082	0.541
CLV_PCSK_KEX2_1	80	82	PF00082	0.498
CLV_PCSK_KEX2_1	835	837	PF00082	0.659
CLV_PCSK_KEX2_1	964	966	PF00082	0.616
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.599
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.774
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.517
CLV_PCSK_SKI1_1	184	188	PF00082	0.591
CLV_PCSK_SKI1_1	250	254	PF00082	0.603
CLV_PCSK_SKI1_1	28	32	PF00082	0.623
CLV_PCSK_SKI1_1	308	312	PF00082	0.455
CLV_PCSK_SKI1_1	543	547	PF00082	0.503
CLV_PCSK_SKI1_1	605	609	PF00082	0.515
CLV_PCSK_SKI1_1	888	892	PF00082	0.666
CLV_Separin_Metazoa	696	700	PF03568	0.550
DEG_APCC_DBOX_1	307	315	PF00400	0.473
DEG_Nend_UBRbox_2	1	3	PF02207	0.563
DOC_ANK_TNKS_1	324	331	PF00023	0.585
DOC_ANK_TNKS_1	645	652	PF00023	0.645
DOC_CKS1_1	512	517	PF01111	0.719
DOC_CKS1_1	724	729	PF01111	0.390
DOC_CKS1_1	745	750	PF01111	0.692
DOC_CYCLIN_RxL_1	181	191	PF00134	0.548
DOC_CYCLIN_RxL_1	25	33	PF00134	0.578
DOC_MAPK_gen_1	622	631	PF00069	0.657
DOC_MAPK_gen_1	634	642	PF00069	0.574
DOC_MAPK_gen_1	80	88	PF00069	0.491
DOC_MAPK_gen_1	964	970	PF00069	0.645
DOC_MAPK_MEF2A_6	308	316	PF00069	0.491
DOC_MAPK_MEF2A_6	634	642	PF00069	0.587
DOC_MAPK_MEF2A_6	80	88	PF00069	0.404
DOC_PP1_RVXF_1	182	189	PF00149	0.370
DOC_PP2B_LxvP_1	301	304	PF13499	0.577
DOC_PP2B_LxvP_1	411	414	PF13499	0.712
DOC_PP4_FxxP_1	473	476	PF00568	0.402
DOC_PP4_FxxP_1	724	727	PF00568	0.478
DOC_SPAK_OSR1_1	339	343	PF12202	0.599
DOC_USP7_MATH_1	110	114	PF00917	0.613
DOC_USP7_MATH_1	129	133	PF00917	0.740
DOC_USP7_MATH_1	146	150	PF00917	0.708
DOC_USP7_MATH_1	159	163	PF00917	0.617
DOC_USP7_MATH_1	254	258	PF00917	0.510
DOC_USP7_MATH_1	345	349	PF00917	0.620
DOC_USP7_MATH_1	365	369	PF00917	0.401
DOC_USP7_MATH_1	372	376	PF00917	0.744
DOC_USP7_MATH_1	382	386	PF00917	0.721
DOC_USP7_MATH_1	430	434	PF00917	0.689
DOC_USP7_MATH_1	462	466	PF00917	0.520
DOC_USP7_MATH_1	523	527	PF00917	0.576
DOC_USP7_MATH_1	623	627	PF00917	0.645
DOC_USP7_MATH_1	708	712	PF00917	0.605
DOC_USP7_MATH_1	793	797	PF00917	0.515
DOC_USP7_MATH_1	867	871	PF00917	0.463
DOC_USP7_UBL2_3	521	525	PF12436	0.554
DOC_WW_Pin1_4	124	129	PF00397	0.724
DOC_WW_Pin1_4	155	160	PF00397	0.763
DOC_WW_Pin1_4	391	396	PF00397	0.732
DOC_WW_Pin1_4	507	512	PF00397	0.646
DOC_WW_Pin1_4	55	60	PF00397	0.567
DOC_WW_Pin1_4	723	728	PF00397	0.406
DOC_WW_Pin1_4	744	749	PF00397	0.636
LIG_14-3-3_CanoR_1	195	205	PF00244	0.575
LIG_14-3-3_CanoR_1	260	264	PF00244	0.489
LIG_14-3-3_CanoR_1	266	276	PF00244	0.383
LIG_14-3-3_CanoR_1	279	283	PF00244	0.290
LIG_14-3-3_CanoR_1	29	38	PF00244	0.582
LIG_14-3-3_CanoR_1	318	322	PF00244	0.396
LIG_14-3-3_CanoR_1	339	345	PF00244	0.534
LIG_14-3-3_CanoR_1	388	395	PF00244	0.819
LIG_14-3-3_CanoR_1	446	451	PF00244	0.758
LIG_14-3-3_CanoR_1	48	56	PF00244	0.726
LIG_14-3-3_CanoR_1	501	509	PF00244	0.493
LIG_14-3-3_CanoR_1	556	561	PF00244	0.571
LIG_14-3-3_CanoR_1	57	63	PF00244	0.532
LIG_14-3-3_CanoR_1	6	14	PF00244	0.429
LIG_14-3-3_CanoR_1	612	619	PF00244	0.563
LIG_14-3-3_CanoR_1	624	629	PF00244	0.488
LIG_14-3-3_CanoR_1	710	719	PF00244	0.645
LIG_14-3-3_CanoR_1	81	87	PF00244	0.492
LIG_14-3-3_CanoR_1	843	852	PF00244	0.664
LIG_14-3-3_CanoR_1	862	869	PF00244	0.370
LIG_14-3-3_CanoR_1	964	970	PF00244	0.675
LIG_APCC_ABBA_1	685	690	PF00400	0.363
LIG_BIR_III_2	392	396	PF00653	0.589
LIG_deltaCOP1_diTrp_1	202	212	PF00928	0.582
LIG_FHA_1	149	155	PF00498	0.803
LIG_FHA_1	282	288	PF00498	0.449
LIG_FHA_1	305	311	PF00498	0.446
LIG_FHA_1	455	461	PF00498	0.539
LIG_FHA_1	465	471	PF00498	0.231
LIG_FHA_1	512	518	PF00498	0.640
LIG_FHA_1	545	551	PF00498	0.513
LIG_FHA_1	583	589	PF00498	0.571
LIG_FHA_1	613	619	PF00498	0.622
LIG_FHA_1	727	733	PF00498	0.391
LIG_FHA_1	751	757	PF00498	0.602
LIG_FHA_1	854	860	PF00498	0.618
LIG_FHA_1	954	960	PF00498	0.499
LIG_FHA_2	197	203	PF00498	0.504
LIG_FHA_2	372	378	PF00498	0.743
LIG_FHA_2	744	750	PF00498	0.678
LIG_FHA_2	801	807	PF00498	0.501
LIG_IRF3_LxIS_1	45	50	PF10401	0.535
LIG_IRF3_LxIS_1	734	741	PF10401	0.548
LIG_LIR_Apic_2	449	455	PF02991	0.663
LIG_LIR_Apic_2	472	476	PF02991	0.400
LIG_LIR_Apic_2	722	727	PF02991	0.508
LIG_LIR_Gen_1	202	213	PF02991	0.577
LIG_LIR_Gen_1	401	411	PF02991	0.659
LIG_LIR_Nem_3	202	208	PF02991	0.570
LIG_LIR_Nem_3	401	407	PF02991	0.660
LIG_LIR_Nem_3	606	611	PF02991	0.453
LIG_LIR_Nem_3	767	773	PF02991	0.474
LIG_LIR_Nem_3	90	96	PF02991	0.520
LIG_LYPXL_S_1	769	773	PF13949	0.456
LIG_LYPXL_yS_3	770	773	PF13949	0.459
LIG_NRBOX	171	177	PF00104	0.509
LIG_NRBOX	272	278	PF00104	0.491
LIG_NRBOX	599	605	PF00104	0.513
LIG_NRBOX	907	913	PF00104	0.476
LIG_PDZ_Class_2	965	970	PF00595	0.688
LIG_Pex14_2	208	212	PF04695	0.582
LIG_Rb_LxCxE_1	526	547	PF01857	0.508
LIG_RPA_C_Fungi	833	845	PF08784	0.704
LIG_RPA_C_Fungi	857	869	PF08784	0.513
LIG_SH2_SRC	327	330	PF00017	0.611
LIG_SH2_SRC	878	881	PF00017	0.515
LIG_SH2_STAT5	327	330	PF00017	0.569
LIG_SH2_STAT5	641	644	PF00017	0.645
LIG_SH2_STAT5	652	655	PF00017	0.525
LIG_SH3_3	140	146	PF00018	0.673
LIG_SH3_3	339	345	PF00018	0.591
LIG_SH3_3	505	511	PF00018	0.606
LIG_SH3_3	53	59	PF00018	0.719
LIG_SH3_3	745	751	PF00018	0.692
LIG_Sin3_3	865	872	PF02671	0.515
LIG_SUMO_SIM_anti_2	151	156	PF11976	0.804
LIG_SUMO_SIM_anti_2	167	173	PF11976	0.462
LIG_SUMO_SIM_anti_2	232	241	PF11976	0.541
LIG_SUMO_SIM_anti_2	307	313	PF11976	0.449
LIG_SUMO_SIM_anti_2	504	510	PF11976	0.509
LIG_SUMO_SIM_anti_2	758	764	PF11976	0.447
LIG_SUMO_SIM_anti_2	806	812	PF11976	0.468
LIG_SUMO_SIM_anti_2	85	90	PF11976	0.452
LIG_SUMO_SIM_par_1	465	472	PF11976	0.457
LIG_SUMO_SIM_par_1	504	510	PF11976	0.500
LIG_SUMO_SIM_par_1	752	758	PF11976	0.540
LIG_SUMO_SIM_par_1	82	87	PF11976	0.385
LIG_TRAF2_1	178	181	PF00917	0.552
LIG_TRAF2_1	397	400	PF00917	0.662
LIG_TRAF2_1	755	758	PF00917	0.583
LIG_TYR_ITIM	768	773	PF00017	0.459
LIG_UBA3_1	607	614	PF00899	0.616
LIG_WRC_WIRS_1	470	475	PF05994	0.383
MOD_CK1_1	124	130	PF00069	0.695
MOD_CK1_1	131	137	PF00069	0.645
MOD_CK1_1	267	273	PF00069	0.401
MOD_CK1_1	281	287	PF00069	0.495
MOD_CK1_1	33	39	PF00069	0.642
MOD_CK1_1	343	349	PF00069	0.547
MOD_CK1_1	435	441	PF00069	0.670
MOD_CK1_1	58	64	PF00069	0.670
MOD_CK1_1	711	717	PF00069	0.580
MOD_CK1_1	752	758	PF00069	0.590
MOD_CK1_1	861	867	PF00069	0.616
MOD_CK1_1	886	892	PF00069	0.706
MOD_CK1_1	893	899	PF00069	0.555
MOD_CK1_1	963	969	PF00069	0.665
MOD_CK2_1	175	181	PF00069	0.544
MOD_CK2_1	371	377	PF00069	0.712
MOD_CK2_1	394	400	PF00069	0.699
MOD_CK2_1	752	758	PF00069	0.536
MOD_CK2_1	800	806	PF00069	0.497
MOD_CK2_1	84	90	PF00069	0.385
MOD_CK2_1	932	938	PF00069	0.498
MOD_CK2_1	963	969	PF00069	0.655
MOD_DYRK1A_RPxSP_1	55	59	PF00069	0.573
MOD_GlcNHglycan	112	115	PF01048	0.648
MOD_GlcNHglycan	123	126	PF01048	0.725
MOD_GlcNHglycan	131	134	PF01048	0.596
MOD_GlcNHglycan	135	138	PF01048	0.591
MOD_GlcNHglycan	222	225	PF01048	0.683
MOD_GlcNHglycan	269	272	PF01048	0.385
MOD_GlcNHglycan	32	35	PF01048	0.606
MOD_GlcNHglycan	367	370	PF01048	0.674
MOD_GlcNHglycan	415	418	PF01048	0.663
MOD_GlcNHglycan	425	428	PF01048	0.627
MOD_GlcNHglycan	432	435	PF01048	0.739
MOD_GlcNHglycan	49	52	PF01048	0.734
MOD_GlcNHglycan	67	70	PF01048	0.571
MOD_GlcNHglycan	719	722	PF01048	0.709
MOD_GlcNHglycan	740	743	PF01048	0.578
MOD_GlcNHglycan	885	888	PF01048	0.680
MOD_GlcNHglycan	934	937	PF01048	0.369
MOD_GSK3_1	117	124	PF00069	0.628
MOD_GSK3_1	129	136	PF00069	0.670
MOD_GSK3_1	146	153	PF00069	0.752
MOD_GSK3_1	155	162	PF00069	0.652
MOD_GSK3_1	382	389	PF00069	0.780
MOD_GSK3_1	430	437	PF00069	0.681
MOD_GSK3_1	507	514	PF00069	0.625
MOD_GSK3_1	523	530	PF00069	0.390
MOD_GSK3_1	688	695	PF00069	0.507
MOD_GSK3_1	886	893	PF00069	0.640
MOD_N-GLC_1	708	713	PF02516	0.544
MOD_NEK2_1	238	243	PF00069	0.553
MOD_NEK2_1	259	264	PF00069	0.448
MOD_NEK2_1	278	283	PF00069	0.479
MOD_NEK2_1	30	35	PF00069	0.610
MOD_NEK2_1	314	319	PF00069	0.398
MOD_NEK2_1	340	345	PF00069	0.535
MOD_NEK2_1	423	428	PF00069	0.712
MOD_NEK2_1	47	52	PF00069	0.713
MOD_NEK2_1	495	500	PF00069	0.424
MOD_NEK2_1	527	532	PF00069	0.438
MOD_NEK2_1	598	603	PF00069	0.557
MOD_NEK2_1	688	693	PF00069	0.519
MOD_NEK2_1	703	708	PF00069	0.368
MOD_NEK2_1	738	743	PF00069	0.521
MOD_NEK2_1	788	793	PF00069	0.544
MOD_NEK2_1	84	89	PF00069	0.494
MOD_NEK2_1	858	863	PF00069	0.634
MOD_NEK2_1	922	927	PF00069	0.561
MOD_NEK2_1	951	956	PF00069	0.530
MOD_PIKK_1	556	562	PF00454	0.643
MOD_PIKK_1	598	604	PF00454	0.426
MOD_PIKK_1	711	717	PF00454	0.648
MOD_PIKK_1	929	935	PF00454	0.616
MOD_PK_1	150	156	PF00069	0.716
MOD_PK_1	231	237	PF00069	0.450
MOD_PKA_1	15	21	PF00069	0.518
MOD_PKA_1	196	202	PF00069	0.504
MOD_PKA_1	5	11	PF00069	0.557
MOD_PKA_2	15	21	PF00069	0.449
MOD_PKA_2	196	202	PF00069	0.572
MOD_PKA_2	238	244	PF00069	0.498
MOD_PKA_2	259	265	PF00069	0.579
MOD_PKA_2	278	284	PF00069	0.303
MOD_PKA_2	317	323	PF00069	0.391
MOD_PKA_2	382	388	PF00069	0.775
MOD_PKA_2	430	436	PF00069	0.610
MOD_PKA_2	47	53	PF00069	0.694
MOD_PKA_2	5	11	PF00069	0.429
MOD_PKA_2	555	561	PF00069	0.658
MOD_PKA_2	623	629	PF00069	0.598
MOD_PKA_2	788	794	PF00069	0.595
MOD_PKA_2	837	843	PF00069	0.673
MOD_PKA_2	853	859	PF00069	0.706
MOD_PKA_2	861	867	PF00069	0.468
MOD_PKA_2	963	969	PF00069	0.628
MOD_PKB_1	836	844	PF00069	0.652
MOD_Plk_1	231	237	PF00069	0.551
MOD_Plk_1	254	260	PF00069	0.530
MOD_Plk_1	296	302	PF00069	0.660
MOD_Plk_1	372	378	PF00069	0.609
MOD_Plk_1	829	835	PF00069	0.602
MOD_Plk_1	881	887	PF00069	0.624
MOD_Plk_1	89	95	PF00069	0.402
MOD_Plk_2-3	357	363	PF00069	0.634
MOD_Plk_4	150	156	PF00069	0.804
MOD_Plk_4	254	260	PF00069	0.469
MOD_Plk_4	278	284	PF00069	0.518
MOD_Plk_4	469	475	PF00069	0.499
MOD_Plk_4	479	485	PF00069	0.460
MOD_Plk_4	624	630	PF00069	0.561
MOD_Plk_4	653	659	PF00069	0.552
MOD_Plk_4	764	770	PF00069	0.429
MOD_Plk_4	84	90	PF00069	0.385
MOD_ProDKin_1	124	130	PF00069	0.723
MOD_ProDKin_1	155	161	PF00069	0.746
MOD_ProDKin_1	391	397	PF00069	0.723
MOD_ProDKin_1	507	513	PF00069	0.658
MOD_ProDKin_1	55	61	PF00069	0.555
MOD_ProDKin_1	723	729	PF00069	0.403
MOD_ProDKin_1	744	750	PF00069	0.639
MOD_SUMO_for_1	794	797	PF00179	0.459
MOD_SUMO_rev_2	516	523	PF00179	0.583
MOD_SUMO_rev_2	841	846	PF00179	0.595
TRG_DiLeu_BaEn_1	696	701	PF01217	0.548
TRG_DiLeu_BaEn_1	9	14	PF01217	0.445
TRG_DiLeu_BaLyEn_6	26	31	PF01217	0.573
TRG_DiLeu_BaLyEn_6	305	310	PF01217	0.522
TRG_DiLeu_BaLyEn_6	584	589	PF01217	0.471
TRG_DiLeu_BaLyEn_6	768	773	PF01217	0.535
TRG_DiLeu_BaLyEn_6	907	912	PF01217	0.399
TRG_DiLeu_LyEn_5	696	701	PF01217	0.548
TRG_ENDOCYTIC_2	770	773	PF00928	0.481
TRG_ER_diArg_1	14	16	PF00400	0.451
TRG_ER_diArg_1	195	197	PF00400	0.636
TRG_ER_diArg_1	216	219	PF00400	0.698
TRG_ER_diArg_1	26	29	PF00400	0.484
TRG_ER_diArg_1	439	442	PF00400	0.781
TRG_ER_diArg_1	787	790	PF00400	0.666
TRG_ER_diArg_1	79	81	PF00400	0.477
TRG_ER_diArg_1	834	836	PF00400	0.650
TRG_NES_CRM1_1	582	595	PF08389	0.510
TRG_NES_CRM1_1	940	953	PF08389	0.555
TRG_NLS_MonoCore_2	439	444	PF00514	0.785
TRG_NLS_MonoExtC_3	351	357	PF00514	0.618
TRG_NLS_MonoExtC_3	439	444	PF00514	0.785
TRG_NLS_MonoExtN_4	439	445	PF00514	0.764
TRG_Pf-PMV_PEXEL_1	359	364	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	617	621	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	717	722	PF00026	0.633
TRG_Pf-PMV_PEXEL_1	910	914	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9D8	Leptomonas seymouri	47%	94%
A0A1X0P0U5	Trypanosomatidae	28%	100%
A0A3R7KDM9	Trypanosoma rangeli	30%	100%
A4HQ62	Leishmania braziliensis	75%	100%
A4IDW1	Leishmania infantum	99%	100%
D0A455	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ATY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4Q0L4	Leishmania major	90%	100%