Transporter, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IPN7_LEIDO

TriTrypDb:

LdBPK_352860.1 , LdCL_350033500 , LDHU3_35.3690

Length:

705

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3Q8IPN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IPN7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0022857	transmembrane transporter activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.352
CLV_NRD_NRD_1	212	214	PF00675	0.572
CLV_NRD_NRD_1	22	24	PF00675	0.460
CLV_NRD_NRD_1	27	29	PF00675	0.478
CLV_NRD_NRD_1	31	33	PF00675	0.453
CLV_PCSK_KEX2_1	109	111	PF00082	0.313
CLV_PCSK_KEX2_1	22	24	PF00082	0.477
CLV_PCSK_KEX2_1	31	33	PF00082	0.520
CLV_PCSK_KEX2_1	381	383	PF00082	0.456
CLV_PCSK_KEX2_1	461	463	PF00082	0.387
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.478
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.429
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.387
CLV_PCSK_SKI1_1	214	218	PF00082	0.520
CLV_PCSK_SKI1_1	32	36	PF00082	0.404
CLV_PCSK_SKI1_1	421	425	PF00082	0.496
CLV_PCSK_SKI1_1	466	470	PF00082	0.378
CLV_PCSK_SKI1_1	471	475	PF00082	0.368
CLV_PCSK_SKI1_1	584	588	PF00082	0.352
DEG_MDM2_SWIB_1	586	594	PF02201	0.360
DOC_CKS1_1	629	634	PF01111	0.360
DOC_MAPK_DCC_7	213	223	PF00069	0.312
DOC_MAPK_FxFP_2	572	575	PF00069	0.294
DOC_MAPK_gen_1	511	520	PF00069	0.335
DOC_MAPK_gen_1	682	690	PF00069	0.549
DOC_MAPK_MEF2A_6	214	223	PF00069	0.312
DOC_MAPK_MEF2A_6	475	484	PF00069	0.562
DOC_MAPK_MEF2A_6	8	16	PF00069	0.668
DOC_MAPK_NFAT4_5	475	483	PF00069	0.476
DOC_PP4_FxxP_1	266	269	PF00568	0.613
DOC_PP4_FxxP_1	385	388	PF00568	0.673
DOC_PP4_FxxP_1	469	472	PF00568	0.616
DOC_PP4_FxxP_1	572	575	PF00568	0.330
DOC_USP7_MATH_1	171	175	PF00917	0.340
DOC_USP7_MATH_1	194	198	PF00917	0.319
DOC_USP7_MATH_1	309	313	PF00917	0.595
DOC_USP7_MATH_1	436	440	PF00917	0.752
DOC_USP7_MATH_1	441	445	PF00917	0.719
DOC_USP7_MATH_1	562	566	PF00917	0.380
DOC_USP7_UBL2_3	29	33	PF12436	0.723
DOC_WW_Pin1_4	32	37	PF00397	0.636
DOC_WW_Pin1_4	324	329	PF00397	0.728
DOC_WW_Pin1_4	359	364	PF00397	0.738
DOC_WW_Pin1_4	384	389	PF00397	0.637
DOC_WW_Pin1_4	628	633	PF00397	0.360
LIG_14-3-3_CanoR_1	382	388	PF00244	0.733
LIG_14-3-3_CanoR_1	548	553	PF00244	0.469
LIG_14-3-3_CanoR_1	584	594	PF00244	0.280
LIG_14-3-3_CterR_2	702	705	PF00244	0.608
LIG_Actin_WH2_2	58	73	PF00022	0.360
LIG_BRCT_BRCA1_1	114	118	PF00533	0.399
LIG_BRCT_BRCA1_1	361	365	PF00533	0.665
LIG_BRCT_BRCA1_1	568	572	PF00533	0.460
LIG_deltaCOP1_diTrp_1	681	686	PF00928	0.614
LIG_DLG_GKlike_1	548	556	PF00625	0.469
LIG_EH1_1	176	184	PF00400	0.340
LIG_eIF4E_1	177	183	PF01652	0.340
LIG_eIF4E_1	80	86	PF01652	0.354
LIG_FHA_1	117	123	PF00498	0.352
LIG_FHA_1	233	239	PF00498	0.462
LIG_FHA_1	272	278	PF00498	0.678
LIG_FHA_1	315	321	PF00498	0.673
LIG_FHA_1	324	330	PF00498	0.631
LIG_FHA_1	397	403	PF00498	0.655
LIG_FHA_1	420	426	PF00498	0.832
LIG_FHA_1	44	50	PF00498	0.373
LIG_FHA_1	472	478	PF00498	0.626
LIG_FHA_1	519	525	PF00498	0.320
LIG_FHA_1	55	61	PF00498	0.340
LIG_FHA_2	282	288	PF00498	0.721
LIG_FHA_2	365	371	PF00498	0.722
LIG_FHA_2	488	494	PF00498	0.320
LIG_FHA_2	669	675	PF00498	0.586
LIG_LIR_Apic_2	569	575	PF02991	0.342
LIG_LIR_Gen_1	321	330	PF02991	0.667
LIG_LIR_Gen_1	46	54	PF02991	0.437
LIG_LIR_Nem_3	321	325	PF02991	0.666
LIG_LIR_Nem_3	46	50	PF02991	0.408
LIG_LIR_Nem_3	551	556	PF02991	0.517
LIG_LIR_Nem_3	569	574	PF02991	0.296
LIG_LIR_Nem_3	696	701	PF02991	0.528
LIG_LYPXL_S_1	255	259	PF13949	0.389
LIG_MLH1_MIPbox_1	568	572	PF16413	0.363
LIG_MYND_1	215	219	PF01753	0.400
LIG_NRBOX	479	485	PF00104	0.270
LIG_NRBOX	649	655	PF00104	0.320
LIG_PCNA_yPIPBox_3	308	320	PF02747	0.643
LIG_Pex14_1	134	138	PF04695	0.283
LIG_Pex14_2	586	590	PF04695	0.381
LIG_REV1ctd_RIR_1	136	144	PF16727	0.320
LIG_SH2_CRK	226	230	PF00017	0.363
LIG_SH2_GRB2like	226	229	PF00017	0.363
LIG_SH2_GRB2like	540	543	PF00017	0.578
LIG_SH2_NCK_1	192	196	PF00017	0.297
LIG_SH2_PTP2	254	257	PF00017	0.571
LIG_SH2_PTP2	481	484	PF00017	0.270
LIG_SH2_PTP2	517	520	PF00017	0.352
LIG_SH2_SRC	192	195	PF00017	0.297
LIG_SH2_SRC	254	257	PF00017	0.571
LIG_SH2_SRC	663	666	PF00017	0.372
LIG_SH2_STAP1	419	423	PF00017	0.623
LIG_SH2_STAP1	665	669	PF00017	0.517
LIG_SH2_STAT5	226	229	PF00017	0.363
LIG_SH2_STAT5	254	257	PF00017	0.641
LIG_SH2_STAT5	481	484	PF00017	0.268
LIG_SH2_STAT5	517	520	PF00017	0.391
LIG_SH2_STAT5	540	543	PF00017	0.603
LIG_SH2_STAT5	566	569	PF00017	0.412
LIG_SH2_STAT5	571	574	PF00017	0.399
LIG_SH2_STAT5	663	666	PF00017	0.412
LIG_SH3_3	322	328	PF00018	0.651
LIG_SH3_3	6	12	PF00018	0.784
LIG_SH3_3	626	632	PF00018	0.377
LIG_SUMO_SIM_anti_2	352	357	PF11976	0.656
LIG_SUMO_SIM_anti_2	391	401	PF11976	0.647
LIG_SUMO_SIM_anti_2	476	481	PF11976	0.340
LIG_SUMO_SIM_anti_2	557	562	PF11976	0.359
LIG_SUMO_SIM_par_1	391	401	PF11976	0.647
LIG_TRAF2_1	490	493	PF00917	0.413
LIG_TRFH_1	571	575	PF08558	0.339
LIG_TYR_ITIM	479	484	PF00017	0.520
LIG_TYR_ITIM	515	520	PF00017	0.352
LIG_UBA3_1	156	163	PF00899	0.481
LIG_WRC_WIRS_1	233	238	PF05994	0.441
MOD_CDK_SPxxK_3	324	331	PF00069	0.618
MOD_CK1_1	206	212	PF00069	0.391
MOD_CK1_1	270	276	PF00069	0.637
MOD_CK1_1	283	289	PF00069	0.644
MOD_CK1_1	346	352	PF00069	0.804
MOD_CK1_1	53	59	PF00069	0.360
MOD_CK1_1	655	661	PF00069	0.235
MOD_CK1_1	693	699	PF00069	0.517
MOD_CK2_1	281	287	PF00069	0.745
MOD_CK2_1	289	295	PF00069	0.763
MOD_CK2_1	368	374	PF00069	0.665
MOD_CK2_1	487	493	PF00069	0.320
MOD_CK2_1	71	77	PF00069	0.312
MOD_Cter_Amidation	107	110	PF01082	0.354
MOD_GlcNHglycan	114	117	PF01048	0.304
MOD_GlcNHglycan	119	122	PF01048	0.363
MOD_GlcNHglycan	197	200	PF01048	0.593
MOD_GlcNHglycan	438	441	PF01048	0.500
MOD_GlcNHglycan	484	487	PF01048	0.399
MOD_GlcNHglycan	601	604	PF01048	0.390
MOD_GlcNHglycan	654	657	PF01048	0.466
MOD_GlcNHglycan	660	663	PF01048	0.363
MOD_GlcNHglycan	81	84	PF01048	0.419
MOD_GlcNHglycan	95	98	PF01048	0.419
MOD_GSK3_1	112	119	PF00069	0.352
MOD_GSK3_1	267	274	PF00069	0.661
MOD_GSK3_1	277	284	PF00069	0.687
MOD_GSK3_1	364	371	PF00069	0.719
MOD_GSK3_1	413	420	PF00069	0.659
MOD_GSK3_1	436	443	PF00069	0.685
MOD_GSK3_1	50	57	PF00069	0.455
MOD_GSK3_1	562	569	PF00069	0.460
MOD_GSK3_1	599	606	PF00069	0.624
MOD_GSK3_1	636	643	PF00069	0.360
MOD_LATS_1	69	75	PF00433	0.312
MOD_N-GLC_1	16	21	PF02516	0.461
MOD_N-GLC_1	195	200	PF02516	0.578
MOD_N-GLC_1	289	294	PF02516	0.503
MOD_N-GLC_1	346	351	PF02516	0.486
MOD_N-GLC_1	50	55	PF02516	0.363
MOD_NEK2_1	117	122	PF00069	0.371
MOD_NEK2_1	127	132	PF00069	0.363
MOD_NEK2_1	224	229	PF00069	0.425
MOD_NEK2_1	232	237	PF00069	0.429
MOD_NEK2_1	277	282	PF00069	0.702
MOD_NEK2_1	341	346	PF00069	0.710
MOD_NEK2_1	364	369	PF00069	0.731
MOD_NEK2_1	50	55	PF00069	0.360
MOD_NEK2_1	520	525	PF00069	0.465
MOD_NEK2_1	578	583	PF00069	0.428
MOD_NEK2_1	586	591	PF00069	0.513
MOD_NEK2_1	612	617	PF00069	0.527
MOD_NEK2_1	634	639	PF00069	0.384
MOD_NEK2_1	652	657	PF00069	0.417
MOD_NEK2_2	419	424	PF00069	0.653
MOD_OFUCOSY	301	307	PF10250	0.421
MOD_PIKK_1	314	320	PF00454	0.672
MOD_PIKK_1	612	618	PF00454	0.498
MOD_PK_1	71	77	PF00069	0.312
MOD_PKA_2	403	409	PF00069	0.748
MOD_Plk_1	195	201	PF00069	0.384
MOD_Plk_1	277	283	PF00069	0.647
MOD_Plk_1	351	357	PF00069	0.635
MOD_Plk_1	487	493	PF00069	0.320
MOD_Plk_1	50	56	PF00069	0.363
MOD_Plk_1	680	686	PF00069	0.604
MOD_Plk_2-3	374	380	PF00069	0.641
MOD_Plk_4	129	135	PF00069	0.425
MOD_Plk_4	152	158	PF00069	0.523
MOD_Plk_4	206	212	PF00069	0.435
MOD_Plk_4	217	223	PF00069	0.297
MOD_Plk_4	232	238	PF00069	0.421
MOD_Plk_4	351	357	PF00069	0.714
MOD_Plk_4	43	49	PF00069	0.346
MOD_Plk_4	54	60	PF00069	0.419
MOD_Plk_4	542	548	PF00069	0.607
MOD_Plk_4	562	568	PF00069	0.505
MOD_Plk_4	593	599	PF00069	0.418
MOD_Plk_4	607	613	PF00069	0.553
MOD_ProDKin_1	32	38	PF00069	0.627
MOD_ProDKin_1	324	330	PF00069	0.728
MOD_ProDKin_1	359	365	PF00069	0.739
MOD_ProDKin_1	384	390	PF00069	0.638
MOD_ProDKin_1	628	634	PF00069	0.360
MOD_SUMO_rev_2	373	383	PF00179	0.728
MOD_SUMO_rev_2	439	448	PF00179	0.689
MOD_SUMO_rev_2	457	463	PF00179	0.621
TRG_DiLeu_BaEn_2	261	267	PF01217	0.580
TRG_DiLeu_BaLyEn_6	325	330	PF01217	0.685
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.675
TRG_ENDOCYTIC_2	226	229	PF00928	0.347
TRG_ENDOCYTIC_2	256	259	PF00928	0.586
TRG_ENDOCYTIC_2	481	484	PF00928	0.456
TRG_ENDOCYTIC_2	517	520	PF00928	0.389
TRG_ENDOCYTIC_2	571	574	PF00928	0.362
TRG_ENDOCYTIC_2	592	595	PF00928	0.517
TRG_ENDOCYTIC_2	698	701	PF00928	0.600
TRG_ER_diArg_1	109	111	PF00400	0.513
TRG_NES_CRM1_1	41	52	PF08389	0.512
TRG_NLS_MonoExtC_3	27	32	PF00514	0.694
TRG_NLS_MonoExtN_4	28	35	PF00514	0.666

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM8	Leptomonas seymouri	46%	100%
A0A3Q8II42	Leishmania donovani	31%	99%
A4HMU7	Leishmania braziliensis	64%	100%
A4HMU9	Leishmania braziliensis	30%	97%
A4IBH0	Leishmania infantum	100%	100%
A4IBH1	Leishmania infantum	31%	99%
E8NHI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9AFA5	Leishmania major	89%	100%
E9AFA6	Leishmania major	31%	98%
E9B6G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%