Glutathione S-transferase, C-terminal domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Glutathione S-transferase, C-terminal domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IPN5_LEIDO

TriTrypDb:

LdBPK_365550.1 , LdCL_360062800 , LDHU3_36.7380

Length:

646

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IPN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IPN5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	98	102	PF00656	0.733
CLV_NRD_NRD_1	126	128	PF00675	0.442
CLV_NRD_NRD_1	371	373	PF00675	0.453
CLV_NRD_NRD_1	433	435	PF00675	0.572
CLV_NRD_NRD_1	508	510	PF00675	0.574
CLV_NRD_NRD_1	606	608	PF00675	0.416
CLV_NRD_NRD_1	621	623	PF00675	0.384
CLV_PCSK_KEX2_1	371	373	PF00082	0.390
CLV_PCSK_KEX2_1	433	435	PF00082	0.572
CLV_PCSK_KEX2_1	507	509	PF00082	0.597
CLV_PCSK_KEX2_1	606	608	PF00082	0.431
CLV_PCSK_PC1ET2_1	507	509	PF00082	0.543
CLV_PCSK_SKI1_1	172	176	PF00082	0.369
CLV_PCSK_SKI1_1	284	288	PF00082	0.525
CLV_PCSK_SKI1_1	40	44	PF00082	0.468
CLV_PCSK_SKI1_1	421	425	PF00082	0.450
CLV_PCSK_SKI1_1	55	59	PF00082	0.482
CLV_PCSK_SKI1_1	89	93	PF00082	0.568
DEG_SCF_FBW7_1	235	242	PF00400	0.490
DEG_SPOP_SBC_1	318	322	PF00917	0.653
DOC_CKS1_1	236	241	PF01111	0.490
DOC_MAPK_DCC_7	172	182	PF00069	0.444
DOC_MAPK_gen_1	157	166	PF00069	0.420
DOC_MAPK_gen_1	606	612	PF00069	0.544
DOC_MAPK_HePTP_8	124	136	PF00069	0.655
DOC_MAPK_MEF2A_6	127	136	PF00069	0.551
DOC_MAPK_MEF2A_6	409	417	PF00069	0.546
DOC_PP4_FxxP_1	13	16	PF00568	0.646
DOC_PP4_FxxP_1	175	178	PF00568	0.444
DOC_USP7_MATH_1	251	255	PF00917	0.487
DOC_USP7_MATH_1	456	460	PF00917	0.760
DOC_USP7_MATH_1	461	465	PF00917	0.732
DOC_USP7_MATH_1	478	482	PF00917	0.643
DOC_USP7_MATH_1	590	594	PF00917	0.652
DOC_USP7_MATH_1	629	633	PF00917	0.662
DOC_WW_Pin1_4	12	17	PF00397	0.587
DOC_WW_Pin1_4	235	240	PF00397	0.496
DOC_WW_Pin1_4	439	444	PF00397	0.775
DOC_WW_Pin1_4	5	10	PF00397	0.678
DOC_WW_Pin1_4	59	64	PF00397	0.607
LIG_14-3-3_CanoR_1	284	289	PF00244	0.692
LIG_14-3-3_CanoR_1	325	333	PF00244	0.720
LIG_14-3-3_CanoR_1	40	50	PF00244	0.637
LIG_14-3-3_CanoR_1	53	58	PF00244	0.634
LIG_14-3-3_CanoR_1	562	572	PF00244	0.723
LIG_BRCT_BRCA1_1	252	256	PF00533	0.487
LIG_BRCT_BRCA1_1	48	52	PF00533	0.640
LIG_Clathr_ClatBox_1	255	259	PF01394	0.536
LIG_Clathr_ClatBox_1	396	400	PF01394	0.565
LIG_CtBP_PxDLS_1	334	338	PF00389	0.587
LIG_FHA_1	119	125	PF00498	0.688
LIG_FHA_1	16	22	PF00498	0.652
LIG_FHA_1	272	278	PF00498	0.591
LIG_FHA_1	381	387	PF00498	0.644
LIG_FHA_1	41	47	PF00498	0.635
LIG_FHA_1	568	574	PF00498	0.759
LIG_FHA_2	240	246	PF00498	0.490
LIG_FHA_2	289	295	PF00498	0.740
LIG_FHA_2	296	302	PF00498	0.754
LIG_FHA_2	330	336	PF00498	0.653
LIG_FHA_2	497	503	PF00498	0.766
LIG_FHA_2	96	102	PF00498	0.661
LIG_Integrin_RGD_1	160	162	PF01839	0.659
LIG_LIR_Apic_2	383	388	PF02991	0.585
LIG_LIR_Gen_1	138	144	PF02991	0.369
LIG_LIR_Gen_1	212	222	PF02991	0.510
LIG_LIR_Gen_1	26	35	PF02991	0.656
LIG_LIR_Gen_1	357	363	PF02991	0.603
LIG_LIR_Gen_1	56	66	PF02991	0.633
LIG_LIR_Gen_1	584	592	PF02991	0.626
LIG_LIR_Nem_3	138	142	PF02991	0.369
LIG_LIR_Nem_3	168	173	PF02991	0.290
LIG_LIR_Nem_3	212	218	PF02991	0.493
LIG_LIR_Nem_3	26	30	PF02991	0.555
LIG_LIR_Nem_3	268	273	PF02991	0.547
LIG_LIR_Nem_3	357	361	PF02991	0.571
LIG_LIR_Nem_3	45	51	PF02991	0.490
LIG_LIR_Nem_3	534	539	PF02991	0.623
LIG_LIR_Nem_3	56	61	PF02991	0.585
LIG_LIR_Nem_3	584	589	PF02991	0.624
LIG_LIR_Nem_3	8	13	PF02991	0.651
LIG_MLH1_MIPbox_1	48	52	PF16413	0.622
LIG_Pex14_2	252	256	PF04695	0.494
LIG_SH2_CRK	586	590	PF00017	0.562
LIG_SH2_NCK_1	539	543	PF00017	0.655
LIG_SH2_PTP2	609	612	PF00017	0.591
LIG_SH2_STAP1	144	148	PF00017	0.369
LIG_SH2_STAP1	17	21	PF00017	0.596
LIG_SH2_STAP1	48	52	PF00017	0.622
LIG_SH2_STAP1	586	590	PF00017	0.659
LIG_SH2_STAT5	144	147	PF00017	0.480
LIG_SH2_STAT5	158	161	PF00017	0.323
LIG_SH2_STAT5	17	20	PF00017	0.608
LIG_SH2_STAT5	170	173	PF00017	0.284
LIG_SH2_STAT5	27	30	PF00017	0.557
LIG_SH2_STAT5	276	279	PF00017	0.490
LIG_SH2_STAT5	38	41	PF00017	0.612
LIG_SH2_STAT5	385	388	PF00017	0.561
LIG_SH2_STAT5	51	54	PF00017	0.611
LIG_SH2_STAT5	539	542	PF00017	0.685
LIG_SH2_STAT5	597	600	PF00017	0.557
LIG_SH2_STAT5	609	612	PF00017	0.525
LIG_SH2_STAT5	97	100	PF00017	0.611
LIG_SH3_3	203	209	PF00018	0.590
LIG_SH3_3	448	454	PF00018	0.793
LIG_SH3_3	554	560	PF00018	0.687
LIG_SUMO_SIM_anti_2	162	168	PF11976	0.402
LIG_SUMO_SIM_anti_2	395	401	PF11976	0.555
LIG_TRAF2_1	510	513	PF00917	0.671
LIG_TRAF2_1	624	627	PF00917	0.677
LIG_TYR_ITIM	25	30	PF00017	0.587
MOD_CDK_SPxK_1	5	11	PF00069	0.730
MOD_CK1_1	15	21	PF00069	0.625
MOD_CK1_1	204	210	PF00069	0.543
MOD_CK1_1	303	309	PF00069	0.721
MOD_CK1_1	317	323	PF00069	0.763
MOD_CK1_1	41	47	PF00069	0.699
MOD_CK1_1	566	572	PF00069	0.744
MOD_CK1_1	64	70	PF00069	0.669
MOD_CK2_1	329	335	PF00069	0.683
MOD_CK2_1	496	502	PF00069	0.771
MOD_CK2_1	574	580	PF00069	0.665
MOD_Cter_Amidation	431	434	PF01082	0.556
MOD_Cter_Amidation	604	607	PF01082	0.430
MOD_GlcNHglycan	111	114	PF01048	0.560
MOD_GlcNHglycan	198	201	PF01048	0.451
MOD_GlcNHglycan	305	308	PF01048	0.585
MOD_GlcNHglycan	458	461	PF01048	0.544
MOD_GlcNHglycan	472	475	PF01048	0.429
MOD_GlcNHglycan	512	517	PF01048	0.565
MOD_GlcNHglycan	565	568	PF01048	0.503
MOD_GlcNHglycan	63	66	PF01048	0.489
MOD_GSK3_1	109	116	PF00069	0.750
MOD_GSK3_1	235	242	PF00069	0.498
MOD_GSK3_1	284	291	PF00069	0.694
MOD_GSK3_1	296	303	PF00069	0.710
MOD_GSK3_1	310	317	PF00069	0.648
MOD_GSK3_1	329	336	PF00069	0.648
MOD_GSK3_1	350	357	PF00069	0.579
MOD_GSK3_1	38	45	PF00069	0.605
MOD_GSK3_1	435	442	PF00069	0.727
MOD_GSK3_1	53	60	PF00069	0.611
MOD_GSK3_1	562	569	PF00069	0.714
MOD_GSK3_1	629	636	PF00069	0.644
MOD_N-GLC_1	401	406	PF02516	0.466
MOD_NEK2_1	109	114	PF00069	0.733
MOD_NEK2_1	149	154	PF00069	0.376
MOD_NEK2_1	350	355	PF00069	0.536
MOD_NEK2_1	42	47	PF00069	0.595
MOD_NEK2_1	424	429	PF00069	0.654
MOD_NEK2_2	17	22	PF00069	0.678
MOD_NEK2_2	251	256	PF00069	0.522
MOD_NEK2_2	366	371	PF00069	0.652
MOD_NMyristoyl	1	7	PF02799	0.635
MOD_OFUCOSY	140	146	PF10250	0.429
MOD_PIKK_1	118	124	PF00454	0.704
MOD_PIKK_1	350	356	PF00454	0.541
MOD_PIKK_1	407	413	PF00454	0.611
MOD_PIKK_1	478	484	PF00454	0.752
MOD_PIKK_1	640	646	PF00454	0.601
MOD_PK_1	53	59	PF00069	0.676
MOD_PKA_1	127	133	PF00069	0.636
MOD_PKA_1	630	636	PF00069	0.700
MOD_PKA_2	278	284	PF00069	0.624
MOD_PKA_2	3	9	PF00069	0.774
MOD_PKA_2	324	330	PF00069	0.748
MOD_PKA_2	574	580	PF00069	0.598
MOD_Plk_1	244	250	PF00069	0.531
MOD_Plk_1	300	306	PF00069	0.752
MOD_Plk_1	401	407	PF00069	0.628
MOD_Plk_1	424	430	PF00069	0.698
MOD_Plk_1	93	99	PF00069	0.757
MOD_Plk_4	23	29	PF00069	0.670
MOD_Plk_4	251	257	PF00069	0.516
MOD_Plk_4	261	267	PF00069	0.510
MOD_Plk_4	284	290	PF00069	0.708
MOD_Plk_4	42	48	PF00069	0.481
MOD_Plk_4	424	430	PF00069	0.705
MOD_Plk_4	461	467	PF00069	0.628
MOD_Plk_4	581	587	PF00069	0.587
MOD_ProDKin_1	12	18	PF00069	0.584
MOD_ProDKin_1	235	241	PF00069	0.496
MOD_ProDKin_1	439	445	PF00069	0.771
MOD_ProDKin_1	5	11	PF00069	0.677
MOD_ProDKin_1	59	65	PF00069	0.606
MOD_SUMO_for_1	91	94	PF00179	0.734
TRG_DiLeu_BaEn_2	345	351	PF01217	0.585
TRG_ENDOCYTIC_2	27	30	PF00928	0.652
TRG_ENDOCYTIC_2	586	589	PF00928	0.627
TRG_ENDOCYTIC_2	609	612	PF00928	0.591
TRG_ER_diArg_1	370	372	PF00400	0.686
TRG_ER_diArg_1	52	55	PF00400	0.616
TRG_ER_diArg_1	606	608	PF00400	0.641
TRG_NES_CRM1_1	389	401	PF08389	0.594
TRG_NLS_Bipartite_1	606	626	PF00514	0.576
TRG_NLS_MonoExtC_3	506	512	PF00514	0.675
TRG_NLS_MonoExtC_3	621	627	PF00514	0.630
TRG_NLS_MonoExtN_4	506	511	PF00514	0.676
TRG_NLS_MonoExtN_4	620	626	PF00514	0.627
TRG_Pf-PMV_PEXEL_1	368	373	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3U3	Leptomonas seymouri	59%	100%
A0A0S4ITV1	Bodo saltans	33%	100%
A4HQ46	Leishmania braziliensis	80%	100%
A4IC82	Leishmania infantum	99%	100%
D0A8R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ATW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q0N0	Leishmania major	94%	100%
V5B6S7	Trypanosoma cruzi	44%	100%