Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IPM4_LEIDO

TriTrypDb:

LdBPK_365360.1 , LdCL_360060800 , LDHU3_36.7160

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IPM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IPM4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.407
CLV_C14_Caspase3-7	272	276	PF00656	0.462
CLV_MEL_PAP_1	133	139	PF00089	0.377
CLV_NRD_NRD_1	207	209	PF00675	0.517
CLV_PCSK_KEX2_1	152	154	PF00082	0.580
CLV_PCSK_KEX2_1	206	208	PF00082	0.542
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.580
CLV_PCSK_SKI1_1	157	161	PF00082	0.495
CLV_PCSK_SKI1_1	222	226	PF00082	0.497
DEG_APCC_DBOX_1	77	85	PF00400	0.510
DOC_MAPK_MEF2A_6	183	192	PF00069	0.467
DOC_PP4_FxxP_1	45	48	PF00568	0.428
DOC_USP7_MATH_1	102	106	PF00917	0.414
DOC_USP7_MATH_1	143	147	PF00917	0.407
DOC_USP7_MATH_1	151	155	PF00917	0.382
DOC_USP7_MATH_1	227	231	PF00917	0.540
DOC_USP7_MATH_1	255	259	PF00917	0.528
DOC_USP7_MATH_1	73	77	PF00917	0.512
DOC_USP7_UBL2_3	107	111	PF12436	0.519
DOC_WW_Pin1_4	119	124	PF00397	0.551
DOC_WW_Pin1_4	214	219	PF00397	0.413
DOC_WW_Pin1_4	44	49	PF00397	0.552
LIG_14-3-3_CanoR_1	136	142	PF00244	0.357
LIG_14-3-3_CanoR_1	183	189	PF00244	0.412
LIG_BIR_II_1	1	5	PF00653	0.463
LIG_BIR_III_4	23	27	PF00653	0.361
LIG_BRCT_BRCA1_1	70	74	PF00533	0.537
LIG_FHA_1	132	138	PF00498	0.425
LIG_FHA_2	194	200	PF00498	0.527
LIG_FHA_2	270	276	PF00498	0.455
LIG_FHA_2	91	97	PF00498	0.545
LIG_HCF-1_HBM_1	139	142	PF13415	0.322
LIG_LIR_Apic_2	56	60	PF02991	0.417
LIG_LIR_Gen_1	158	167	PF02991	0.406
LIG_LIR_Gen_1	38	48	PF02991	0.425
LIG_LIR_Gen_1	6	14	PF02991	0.379
LIG_LIR_Nem_3	158	162	PF02991	0.432
LIG_LIR_Nem_3	38	43	PF02991	0.443
LIG_LIR_Nem_3	6	10	PF02991	0.388
LIG_LIR_Nem_3	75	80	PF02991	0.400
LIG_SH2_CRK	166	170	PF00017	0.471
LIG_SH2_CRK	7	11	PF00017	0.406
LIG_SH2_GRB2like	7	10	PF00017	0.311
LIG_SH2_NCK_1	57	61	PF00017	0.490
LIG_SH2_SRC	197	200	PF00017	0.456
LIG_SH2_STAP1	234	238	PF00017	0.553
LIG_SH2_STAP1	7	11	PF00017	0.470
LIG_SH2_STAT5	17	20	PF00017	0.451
LIG_SH2_STAT5	197	200	PF00017	0.400
LIG_SH2_STAT5	234	237	PF00017	0.487
LIG_SH2_STAT5	7	10	PF00017	0.453
LIG_SH2_STAT5	80	83	PF00017	0.498
LIG_WW_1	4	7	PF00397	0.497
MOD_CDK_SPK_2	44	49	PF00069	0.363
MOD_CK1_1	118	124	PF00069	0.406
MOD_CK1_1	230	236	PF00069	0.468
MOD_CK1_1	61	67	PF00069	0.541
MOD_CK1_1	68	74	PF00069	0.512
MOD_CK2_1	73	79	PF00069	0.538
MOD_CK2_1	90	96	PF00069	0.456
MOD_GlcNHglycan	1	4	PF01048	0.572
MOD_GlcNHglycan	153	156	PF01048	0.440
MOD_GlcNHglycan	257	260	PF01048	0.515
MOD_GlcNHglycan	70	73	PF01048	0.463
MOD_GSK3_1	102	109	PF00069	0.432
MOD_GSK3_1	115	122	PF00069	0.440
MOD_GSK3_1	131	138	PF00069	0.302
MOD_GSK3_1	230	237	PF00069	0.444
MOD_GSK3_1	246	253	PF00069	0.288
MOD_GSK3_1	58	65	PF00069	0.415
MOD_GSK3_1	68	75	PF00069	0.378
MOD_N-GLC_1	115	120	PF02516	0.491
MOD_N-GLC_1	131	136	PF02516	0.397
MOD_N-GLC_1	227	232	PF02516	0.496
MOD_N-GLC_1	90	95	PF02516	0.441
MOD_NEK2_1	115	120	PF00069	0.448
MOD_NEK2_1	248	253	PF00069	0.419
MOD_NEK2_1	269	274	PF00069	0.502
MOD_NEK2_2	102	107	PF00069	0.512
MOD_NEK2_2	178	183	PF00069	0.506
MOD_NEK2_2	62	67	PF00069	0.523
MOD_OFUCOSY	113	119	PF10250	0.300
MOD_PKA_2	135	141	PF00069	0.408
MOD_Plk_1	157	163	PF00069	0.387
MOD_Plk_4	193	199	PF00069	0.524
MOD_Plk_4	80	86	PF00069	0.448
MOD_ProDKin_1	119	125	PF00069	0.558
MOD_ProDKin_1	214	220	PF00069	0.415
MOD_ProDKin_1	44	50	PF00069	0.547
MOD_SUMO_rev_2	146	154	PF00179	0.530
TRG_DiLeu_BaEn_2	204	210	PF01217	0.468
TRG_ENDOCYTIC_2	7	10	PF00928	0.428
TRG_ER_diArg_1	206	208	PF00400	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P495	Leptomonas seymouri	62%	100%
A0A0S4JKK5	Bodo saltans	24%	98%
A0A1X0P327	Trypanosomatidae	35%	96%
A0A422NMF9	Trypanosoma rangeli	35%	100%
A4HQ29	Leishmania braziliensis	77%	100%
A4IDT5	Leishmania infantum	99%	100%
D0A8T8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ATU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q0P9	Leishmania major	91%	100%
V5BWK1	Trypanosoma cruzi	34%	100%