Tubulin/FtsZ family, GTPase domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin delta chain

Species:

Leishmania donovani

UniProt:

A0A3Q8IPL1_LEIDO

TriTrypDb:

LdBPK_365220.1 , LdCL_360059400 , LDHU3_36.6990

Length:

562

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	9
GO:0099080	supramolecular complex	2	9
GO:0099081	supramolecular polymer	3	9
GO:0099512	supramolecular fiber	4	9
GO:0099513	polymeric cytoskeletal fiber	5	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1
GO:0005634	nucleus	5	2
GO:0005814	centriole	5	2
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

A0A3Q8IPL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IPL1

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	9
GO:0009987	cellular process	1	9
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0000278	mitotic cell cycle	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007049	cell cycle	2	1
GO:0016043	cellular component organization	3	3
GO:0071840	cellular component organization or biogenesis	2	3
GO:0030030	cell projection organization	4	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0005488	binding	1	9
GO:0005525	GTP binding	5	9
GO:0017076	purine nucleotide binding	4	9
GO:0019001	guanyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032561	guanyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9
GO:0005198	structural molecule activity	1	3
GO:0005200	structural constituent of cytoskeleton	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.539
CLV_C14_Caspase3-7	515	519	PF00656	0.524
CLV_C14_Caspase3-7	545	549	PF00656	0.410
CLV_NRD_NRD_1	148	150	PF00675	0.305
CLV_NRD_NRD_1	180	182	PF00675	0.302
CLV_NRD_NRD_1	189	191	PF00675	0.255
CLV_NRD_NRD_1	78	80	PF00675	0.334
CLV_PCSK_KEX2_1	148	150	PF00082	0.303
CLV_PCSK_KEX2_1	180	182	PF00082	0.288
CLV_PCSK_KEX2_1	189	191	PF00082	0.233
CLV_PCSK_KEX2_1	78	80	PF00082	0.334
CLV_PCSK_SKI1_1	108	112	PF00082	0.324
CLV_PCSK_SKI1_1	225	229	PF00082	0.281
CLV_PCSK_SKI1_1	230	234	PF00082	0.264
CLV_PCSK_SKI1_1	286	290	PF00082	0.610
CLV_PCSK_SKI1_1	359	363	PF00082	0.401
CLV_PCSK_SKI1_1	377	381	PF00082	0.427
CLV_PCSK_SKI1_1	45	49	PF00082	0.362
DEG_APCC_DBOX_1	107	115	PF00400	0.503
DEG_APCC_DBOX_1	445	453	PF00400	0.392
DEG_SPOP_SBC_1	137	141	PF00917	0.576
DOC_MAPK_DCC_7	302	312	PF00069	0.443
DOC_MAPK_gen_1	286	296	PF00069	0.575
DOC_PIKK_1	272	279	PF02985	0.528
DOC_PP2B_LxvP_1	310	313	PF13499	0.372
DOC_PP2B_LxvP_1	48	51	PF13499	0.545
DOC_PP4_FxxP_1	409	412	PF00568	0.624
DOC_PP4_FxxP_1	483	486	PF00568	0.472
DOC_USP7_MATH_1	137	141	PF00917	0.545
DOC_USP7_MATH_1	27	31	PF00917	0.478
DOC_USP7_MATH_1	361	365	PF00917	0.487
DOC_USP7_MATH_1	405	409	PF00917	0.481
DOC_USP7_MATH_1	414	418	PF00917	0.543
DOC_USP7_MATH_1	436	440	PF00917	0.677
DOC_USP7_MATH_1	478	482	PF00917	0.461
DOC_USP7_MATH_1	492	496	PF00917	0.636
DOC_USP7_MATH_1	499	503	PF00917	0.443
DOC_USP7_UBL2_3	324	328	PF12436	0.612
DOC_WW_Pin1_4	133	138	PF00397	0.545
DOC_WW_Pin1_4	139	144	PF00397	0.480
DOC_WW_Pin1_4	318	323	PF00397	0.524
DOC_WW_Pin1_4	472	477	PF00397	0.517
DOC_WW_Pin1_4	482	487	PF00397	0.450
DOC_WW_Pin1_4	490	495	PF00397	0.527
DOC_WW_Pin1_4	506	511	PF00397	0.440
LIG_14-3-3_CanoR_1	148	154	PF00244	0.534
LIG_14-3-3_CanoR_1	359	367	PF00244	0.458
LIG_14-3-3_CanoR_1	38	46	PF00244	0.534
LIG_BIR_II_1	1	5	PF00653	0.358
LIG_BIR_III_4	518	522	PF00653	0.470
LIG_BRCT_BRCA1_1	473	477	PF00533	0.596
LIG_Clathr_ClatBox_1	111	115	PF01394	0.503
LIG_FHA_1	1	7	PF00498	0.338
LIG_FHA_1	15	21	PF00498	0.434
LIG_FHA_1	199	205	PF00498	0.534
LIG_FHA_1	378	384	PF00498	0.507
LIG_FHA_1	430	436	PF00498	0.697
LIG_FHA_1	457	463	PF00498	0.489
LIG_FHA_1	507	513	PF00498	0.406
LIG_FHA_2	158	164	PF00498	0.480
LIG_FHA_2	360	366	PF00498	0.495
LIG_FHA_2	495	501	PF00498	0.607
LIG_LIR_Apic_2	408	412	PF02991	0.612
LIG_LIR_Apic_2	480	486	PF02991	0.458
LIG_LIR_Apic_2	493	499	PF02991	0.578
LIG_LIR_Gen_1	200	209	PF02991	0.481
LIG_LIR_Gen_1	248	257	PF02991	0.457
LIG_LIR_Gen_1	293	303	PF02991	0.452
LIG_LIR_Gen_1	391	402	PF02991	0.437
LIG_LIR_Nem_3	200	205	PF02991	0.466
LIG_LIR_Nem_3	248	254	PF02991	0.457
LIG_LIR_Nem_3	265	271	PF02991	0.463
LIG_LIR_Nem_3	293	299	PF02991	0.407
LIG_LIR_Nem_3	391	397	PF02991	0.411
LIG_MYND_1	46	50	PF01753	0.545
LIG_PDZ_Class_2	557	562	PF00595	0.539
LIG_Pex14_1	169	173	PF04695	0.463
LIG_Pex14_2	532	536	PF04695	0.476
LIG_SH2_CRK	251	255	PF00017	0.463
LIG_SH2_CRK	317	321	PF00017	0.521
LIG_SH2_NCK_1	151	155	PF00017	0.534
LIG_SH2_NCK_1	317	321	PF00017	0.521
LIG_SH2_NCK_1	360	364	PF00017	0.543
LIG_SH2_NCK_1	496	500	PF00017	0.570
LIG_SH2_NCK_1	554	558	PF00017	0.525
LIG_SH2_STAP1	554	558	PF00017	0.525
LIG_SH2_STAP1	86	90	PF00017	0.557
LIG_SH2_STAT3	173	176	PF00017	0.463
LIG_SH2_STAT3	90	93	PF00017	0.545
LIG_SH2_STAT5	317	320	PF00017	0.547
LIG_SH2_STAT5	496	499	PF00017	0.572
LIG_SH3_1	49	55	PF00018	0.428
LIG_SH3_3	234	240	PF00018	0.472
LIG_SH3_3	303	309	PF00018	0.481
LIG_SH3_3	49	55	PF00018	0.428
LIG_TRAF2_1	486	489	PF00917	0.528
LIG_TRFH_1	151	155	PF08558	0.534
LIG_UBA3_1	315	324	PF00899	0.551
LIG_WRC_WIRS_1	199	204	PF05994	0.534
MOD_CDC14_SPxK_1	321	324	PF00782	0.570
MOD_CDK_SPxK_1	318	324	PF00069	0.550
MOD_CK1_1	135	141	PF00069	0.563
MOD_CK1_1	142	148	PF00069	0.461
MOD_CK1_1	214	220	PF00069	0.534
MOD_CK1_1	345	351	PF00069	0.623
MOD_CK1_1	418	424	PF00069	0.719
MOD_CK2_1	157	163	PF00069	0.463
MOD_CK2_1	22	28	PF00069	0.534
MOD_CK2_1	421	427	PF00069	0.722
MOD_CK2_1	482	488	PF00069	0.486
MOD_CK2_1	539	545	PF00069	0.488
MOD_GlcNHglycan	144	147	PF01048	0.329
MOD_GlcNHglycan	163	167	PF01048	0.160
MOD_GlcNHglycan	213	216	PF01048	0.267
MOD_GlcNHglycan	303	306	PF01048	0.442
MOD_GlcNHglycan	335	338	PF01048	0.650
MOD_GlcNHglycan	344	347	PF01048	0.604
MOD_GlcNHglycan	39	42	PF01048	0.287
MOD_GlcNHglycan	412	415	PF01048	0.604
MOD_GlcNHglycan	417	420	PF01048	0.619
MOD_GlcNHglycan	59	62	PF01048	0.128
MOD_GlcNHglycan	64	67	PF01048	0.307
MOD_GSK3_1	132	139	PF00069	0.576
MOD_GSK3_1	194	201	PF00069	0.521
MOD_GSK3_1	386	393	PF00069	0.521
MOD_GSK3_1	401	408	PF00069	0.518
MOD_GSK3_1	410	417	PF00069	0.624
MOD_GSK3_1	478	485	PF00069	0.487
MOD_GSK3_1	490	497	PF00069	0.303
MOD_GSK3_1	67	74	PF00069	0.531
MOD_N-GLC_1	444	449	PF02516	0.513
MOD_NEK2_1	19	24	PF00069	0.476
MOD_NEK2_1	233	238	PF00069	0.480
MOD_NEK2_1	255	260	PF00069	0.463
MOD_NEK2_1	315	320	PF00069	0.524
MOD_NEK2_1	37	42	PF00069	0.534
MOD_NEK2_1	379	384	PF00069	0.436
MOD_NEK2_1	469	474	PF00069	0.444
MOD_NEK2_1	553	558	PF00069	0.404
MOD_NEK2_2	436	441	PF00069	0.573
MOD_NEK2_2	478	483	PF00069	0.491
MOD_PIKK_1	245	251	PF00454	0.463
MOD_PKA_1	189	195	PF00069	0.534
MOD_PKA_2	189	195	PF00069	0.516
MOD_PKA_2	301	307	PF00069	0.503
MOD_PKA_2	37	43	PF00069	0.531
MOD_Plk_1	100	106	PF00069	0.562
MOD_Plk_1	27	33	PF00069	0.562
MOD_Plk_1	292	298	PF00069	0.441
MOD_Plk_1	436	442	PF00069	0.625
MOD_Plk_1	444	450	PF00069	0.493
MOD_Plk_1	499	505	PF00069	0.521
MOD_Plk_2-3	368	374	PF00069	0.510
MOD_Plk_4	194	200	PF00069	0.562
MOD_Plk_4	223	229	PF00069	0.493
MOD_Plk_4	233	239	PF00069	0.428
MOD_Plk_4	436	442	PF00069	0.383
MOD_Plk_4	478	484	PF00069	0.440
MOD_Plk_4	501	507	PF00069	0.391
MOD_Plk_4	86	92	PF00069	0.543
MOD_ProDKin_1	133	139	PF00069	0.545
MOD_ProDKin_1	318	324	PF00069	0.531
MOD_ProDKin_1	472	478	PF00069	0.508
MOD_ProDKin_1	482	488	PF00069	0.463
MOD_ProDKin_1	490	496	PF00069	0.525
MOD_ProDKin_1	506	512	PF00069	0.437
MOD_SUMO_rev_2	113	119	PF00179	0.461
MOD_SUMO_rev_2	217	227	PF00179	0.513
MOD_SUMO_rev_2	273	282	PF00179	0.589
MOD_SUMO_rev_2	424	431	PF00179	0.720
TRG_DiLeu_BaEn_1	464	469	PF01217	0.499
TRG_ENDOCYTIC_2	251	254	PF00928	0.463
TRG_ENDOCYTIC_2	85	88	PF00928	0.534
TRG_ER_diArg_1	148	150	PF00400	0.527
TRG_ER_diArg_1	188	190	PF00400	0.480
TRG_ER_diArg_1	78	80	PF00400	0.562
TRG_Pf-PMV_PEXEL_1	466	471	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4R4	Leptomonas seymouri	66%	99%
A0A0S4JK93	Bodo saltans	35%	97%
A0A422NC27	Trypanosoma rangeli	38%	100%
A4IDS2	Leishmania infantum	99%	100%
D0A8V4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ATT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q0R3	Leishmania major	95%	99%
Q4R7T7	Macaca fascicularis	21%	100%
Q6FNU9	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	24%	100%
Q8HZV4	Canis lupus familiaris	22%	100%
Q8WZE0	Microbotryum violaceum	22%	100%
Q9R1K7	Mus musculus	22%	100%
Q9UJT1	Homo sapiens	21%	100%