Double RNA binding domain protein 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Double RNA binding domain protein 9

Species:

Leishmania donovani

UniProt:

A0A3Q8IPK7_LEIDO

TriTrypDb:

LdBPK_352590.1 , LdCL_350030800 , LDHU3_35.3350

Length:

456

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IPK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IPK7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.547
CLV_C14_Caspase3-7	384	388	PF00656	0.808
CLV_C14_Caspase3-7	67	71	PF00656	0.464
CLV_NRD_NRD_1	113	115	PF00675	0.487
CLV_NRD_NRD_1	138	140	PF00675	0.549
CLV_NRD_NRD_1	361	363	PF00675	0.509
CLV_NRD_NRD_1	365	367	PF00675	0.498
CLV_NRD_NRD_1	378	380	PF00675	0.574
CLV_NRD_NRD_1	421	423	PF00675	0.563
CLV_NRD_NRD_1	448	450	PF00675	0.552
CLV_NRD_NRD_1	45	47	PF00675	0.504
CLV_NRD_NRD_1	75	77	PF00675	0.765
CLV_PCSK_FUR_1	362	366	PF00082	0.515
CLV_PCSK_FUR_1	449	453	PF00082	0.486
CLV_PCSK_KEX2_1	138	140	PF00082	0.547
CLV_PCSK_KEX2_1	142	144	PF00082	0.538
CLV_PCSK_KEX2_1	175	177	PF00082	0.229
CLV_PCSK_KEX2_1	300	302	PF00082	0.221
CLV_PCSK_KEX2_1	361	363	PF00082	0.509
CLV_PCSK_KEX2_1	364	366	PF00082	0.499
CLV_PCSK_KEX2_1	380	382	PF00082	0.590
CLV_PCSK_KEX2_1	421	423	PF00082	0.649
CLV_PCSK_KEX2_1	448	450	PF00082	0.549
CLV_PCSK_KEX2_1	45	47	PF00082	0.542
CLV_PCSK_KEX2_1	451	453	PF00082	0.549
CLV_PCSK_KEX2_1	58	60	PF00082	0.517
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.563
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.229
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.262
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.513
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.590
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.549
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.549
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.644
CLV_PCSK_PC7_1	138	144	PF00082	0.480
CLV_PCSK_PC7_1	361	367	PF00082	0.562
CLV_PCSK_PC7_1	444	450	PF00082	0.539
CLV_PCSK_SKI1_1	116	120	PF00082	0.625
CLV_PCSK_SKI1_1	146	150	PF00082	0.577
CLV_PCSK_SKI1_1	162	166	PF00082	0.305
CLV_PCSK_SKI1_1	180	184	PF00082	0.221
CLV_PCSK_SKI1_1	221	225	PF00082	0.603
CLV_PCSK_SKI1_1	352	356	PF00082	0.575
CLV_PCSK_SKI1_1	41	45	PF00082	0.569
CLV_PCSK_SKI1_1	58	62	PF00082	0.523
CLV_PCSK_SKI1_1	94	98	PF00082	0.579
CLV_Separin_Metazoa	91	95	PF03568	0.575
DEG_SPOP_SBC_1	96	100	PF00917	0.656
DOC_ANK_TNKS_1	428	435	PF00023	0.551
DOC_CYCLIN_RxL_1	111	121	PF00134	0.514
DOC_MAPK_gen_1	48	57	PF00069	0.476
DOC_PP1_RVXF_1	433	439	PF00149	0.607
DOC_USP7_MATH_1	10	14	PF00917	0.679
DOC_USP7_MATH_1	152	156	PF00917	0.610
DOC_USP7_MATH_1	2	6	PF00917	0.628
DOC_USP7_MATH_1	269	273	PF00917	0.338
DOC_USP7_MATH_1	357	361	PF00917	0.634
DOC_USP7_MATH_1	80	84	PF00917	0.621
DOC_USP7_MATH_1	96	100	PF00917	0.507
DOC_USP7_UBL2_3	111	115	PF12436	0.669
DOC_USP7_UBL2_3	142	146	PF12436	0.513
DOC_USP7_UBL2_3	220	224	PF12436	0.503
DOC_USP7_UBL2_3	355	359	PF12436	0.654
DOC_USP7_UBL2_3	435	439	PF12436	0.646
DOC_WW_Pin1_4	392	397	PF00397	0.717
LIG_14-3-3_CanoR_1	81	89	PF00244	0.698
LIG_BIR_II_1	1	5	PF00653	0.611
LIG_BIR_III_4	387	391	PF00653	0.512
LIG_deltaCOP1_diTrp_1	284	291	PF00928	0.421
LIG_FHA_1	123	129	PF00498	0.483
LIG_FHA_1	161	167	PF00498	0.253
LIG_FHA_1	226	232	PF00498	0.405
LIG_FHA_1	257	263	PF00498	0.597
LIG_FHA_2	119	125	PF00498	0.572
LIG_FHA_2	256	262	PF00498	0.379
LIG_FHA_2	280	286	PF00498	0.431
LIG_FHA_2	331	337	PF00498	0.525
LIG_FHA_2	404	410	PF00498	0.515
LIG_FHA_2	42	48	PF00498	0.476
LIG_Integrin_isoDGR_2	339	341	PF01839	0.231
LIG_Integrin_RGD_1	334	336	PF01839	0.325
LIG_LIR_Gen_1	228	236	PF02991	0.347
LIG_LIR_Gen_1	285	296	PF02991	0.421
LIG_LIR_Gen_1	395	404	PF02991	0.719
LIG_LIR_Nem_3	22	26	PF02991	0.659
LIG_LIR_Nem_3	228	233	PF02991	0.312
LIG_LIR_Nem_3	285	291	PF02991	0.421
LIG_LIR_Nem_3	395	401	PF02991	0.698
LIG_LIR_Nem_3	412	416	PF02991	0.504
LIG_Pex14_2	119	123	PF04695	0.647
LIG_PTB_Apo_2	274	281	PF02174	0.421
LIG_PTB_Phospho_1	274	280	PF10480	0.421
LIG_SH2_STAP1	225	229	PF00017	0.320
LIG_SH2_STAT5	230	233	PF00017	0.310
LIG_SH2_STAT5	318	321	PF00017	0.421
LIG_SH3_2	443	448	PF14604	0.602
LIG_SH3_3	398	404	PF00018	0.536
LIG_SH3_3	437	443	PF00018	0.596
LIG_TRAF2_1	133	136	PF00917	0.600
LIG_TRAF2_1	155	158	PF00917	0.590
LIG_TRAF2_1	197	200	PF00917	0.437
LIG_TRAF2_1	282	285	PF00917	0.421
LIG_UBA3_1	51	58	PF00899	0.654
LIG_WRC_WIRS_1	287	292	PF05994	0.426
MOD_CK1_1	13	19	PF00069	0.680
MOD_CK1_1	184	190	PF00069	0.525
MOD_CK1_1	235	241	PF00069	0.494
MOD_CK1_1	392	398	PF00069	0.589
MOD_CK1_1	4	10	PF00069	0.606
MOD_CK1_1	83	89	PF00069	0.765
MOD_CK1_1	95	101	PF00069	0.641
MOD_CK2_1	152	158	PF00069	0.595
MOD_CK2_1	238	244	PF00069	0.505
MOD_CK2_1	279	285	PF00069	0.423
MOD_CK2_1	357	363	PF00069	0.534
MOD_CK2_1	41	47	PF00069	0.477
MOD_Cter_Amidation	74	77	PF01082	0.785
MOD_GlcNHglycan	101	104	PF01048	0.628
MOD_GlcNHglycan	12	15	PF01048	0.452
MOD_GlcNHglycan	225	228	PF01048	0.348
MOD_GlcNHglycan	234	237	PF01048	0.438
MOD_GlcNHglycan	240	243	PF01048	0.440
MOD_GlcNHglycan	383	386	PF01048	0.757
MOD_GlcNHglycan	7	10	PF01048	0.568
MOD_GlcNHglycan	84	88	PF01048	0.699
MOD_GlcNHglycan	94	97	PF01048	0.716
MOD_GSK3_1	1	8	PF00069	0.522
MOD_GSK3_1	118	125	PF00069	0.533
MOD_GSK3_1	392	399	PF00069	0.704
MOD_GSK3_1	405	412	PF00069	0.565
MOD_GSK3_1	92	99	PF00069	0.668
MOD_N-GLC_1	280	285	PF02516	0.330
MOD_N-GLC_1	348	353	PF02516	0.605
MOD_NEK2_1	1	6	PF00069	0.645
MOD_NEK2_1	118	123	PF00069	0.650
MOD_NEK2_1	232	237	PF00069	0.507
MOD_NEK2_1	255	260	PF00069	0.393
MOD_NEK2_1	26	31	PF00069	0.644
MOD_NEK2_1	322	327	PF00069	0.483
MOD_NEK2_1	33	38	PF00069	0.654
MOD_NEK2_2	269	274	PF00069	0.338
MOD_PKA_1	141	147	PF00069	0.638
MOD_PKA_1	364	370	PF00069	0.495
MOD_PKA_1	379	385	PF00069	0.514
MOD_PKA_1	41	47	PF00069	0.487
MOD_PKA_2	307	313	PF00069	0.431
MOD_PKA_2	364	370	PF00069	0.489
MOD_PKA_2	80	86	PF00069	0.742
MOD_PKB_1	139	147	PF00069	0.631
MOD_PKB_1	379	387	PF00069	0.576
MOD_Plk_1	2	8	PF00069	0.451
MOD_Plk_1	269	275	PF00069	0.344
MOD_Plk_1	396	402	PF00069	0.686
MOD_Plk_4	118	124	PF00069	0.520
MOD_Plk_4	269	275	PF00069	0.347
MOD_ProDKin_1	392	398	PF00069	0.718
MOD_SUMO_rev_2	120	128	PF00179	0.601
MOD_SUMO_rev_2	218	226	PF00179	0.500
MOD_SUMO_rev_2	293	302	PF00179	0.487
MOD_SUMO_rev_2	307	316	PF00179	0.487
MOD_SUMO_rev_2	351	357	PF00179	0.660
MOD_SUMO_rev_2	377	382	PF00179	0.688
MOD_SUMO_rev_2	427	436	PF00179	0.571
MOD_SUMO_rev_2	54	60	PF00179	0.509
TRG_DiLeu_BaEn_1	244	249	PF01217	0.405
TRG_DiLeu_BaEn_2	269	275	PF01217	0.367
TRG_ENDOCYTIC_2	230	233	PF00928	0.329
TRG_ENDOCYTIC_2	318	321	PF00928	0.421
TRG_ENDOCYTIC_2	398	401	PF00928	0.583
TRG_ER_diArg_1	138	141	PF00400	0.613
TRG_ER_diArg_1	191	194	PF00400	0.439
TRG_ER_diArg_1	301	304	PF00400	0.424
TRG_ER_diArg_1	420	422	PF00400	0.635
TRG_NLS_Bipartite_1	364	384	PF00514	0.652
TRG_NLS_Bipartite_1	41	62	PF00514	0.445
TRG_NLS_MonoCore_2	401	406	PF00514	0.702
TRG_NLS_MonoCore_2	447	452	PF00514	0.483
TRG_NLS_MonoExtC_3	140	145	PF00514	0.485
TRG_NLS_MonoExtC_3	401	407	PF00514	0.620
TRG_NLS_MonoExtC_3	447	452	PF00514	0.548
TRG_NLS_MonoExtN_4	138	145	PF00514	0.536
TRG_NLS_MonoExtN_4	379	384	PF00514	0.624
TRG_NLS_MonoExtN_4	446	453	PF00514	0.546
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	213	218	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8R8	Leptomonas seymouri	72%	100%
A0A0S4KJJ6	Bodo saltans	49%	100%
A0A1X0P6L1	Trypanosomatidae	46%	100%
A0A3R7LUT6	Trypanosoma rangeli	46%	100%
A4HMS6	Leishmania braziliensis	84%	100%
C9ZZA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AF78	Leishmania major	93%	100%
E9B6D4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BNV3	Trypanosoma cruzi	49%	100%