Alpha/beta hydrolase family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IPH9_LEIDO

TriTrypDb:

LdBPK_364930.1 , LdCL_360056400 , LDHU3_36.6630

Length:

992

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IPH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IPH9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	584	588	PF00656	0.560
CLV_C14_Caspase3-7	770	774	PF00656	0.531
CLV_NRD_NRD_1	188	190	PF00675	0.483
CLV_NRD_NRD_1	342	344	PF00675	0.484
CLV_NRD_NRD_1	383	385	PF00675	0.473
CLV_NRD_NRD_1	394	396	PF00675	0.407
CLV_NRD_NRD_1	566	568	PF00675	0.737
CLV_NRD_NRD_1	59	61	PF00675	0.483
CLV_NRD_NRD_1	741	743	PF00675	0.659
CLV_NRD_NRD_1	789	791	PF00675	0.689
CLV_NRD_NRD_1	876	878	PF00675	0.471
CLV_PCSK_FUR_1	381	385	PF00082	0.491
CLV_PCSK_KEX2_1	188	190	PF00082	0.483
CLV_PCSK_KEX2_1	342	344	PF00082	0.484
CLV_PCSK_KEX2_1	371	373	PF00082	0.474
CLV_PCSK_KEX2_1	381	383	PF00082	0.466
CLV_PCSK_KEX2_1	396	398	PF00082	0.391
CLV_PCSK_KEX2_1	552	554	PF00082	0.647
CLV_PCSK_KEX2_1	61	63	PF00082	0.478
CLV_PCSK_KEX2_1	740	742	PF00082	0.692
CLV_PCSK_KEX2_1	876	878	PF00082	0.471
CLV_PCSK_KEX2_1	928	930	PF00082	0.435
CLV_PCSK_PC1ET2_1	371	373	PF00082	0.474
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.395
CLV_PCSK_PC1ET2_1	552	554	PF00082	0.647
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.478
CLV_PCSK_PC1ET2_1	740	742	PF00082	0.692
CLV_PCSK_PC1ET2_1	928	930	PF00082	0.435
CLV_PCSK_PC7_1	548	554	PF00082	0.646
CLV_PCSK_SKI1_1	100	104	PF00082	0.545
CLV_PCSK_SKI1_1	216	220	PF00082	0.300
CLV_PCSK_SKI1_1	396	400	PF00082	0.333
CLV_PCSK_SKI1_1	469	473	PF00082	0.671
CLV_PCSK_SKI1_1	516	520	PF00082	0.648
CLV_PCSK_SKI1_1	741	745	PF00082	0.675
CLV_PCSK_SKI1_1	929	933	PF00082	0.361
DEG_APCC_DBOX_1	394	402	PF00400	0.526
DEG_Nend_UBRbox_3	1	3	PF02207	0.572
DEG_SCF_FBW7_2	441	448	PF00400	0.458
DEG_SPOP_SBC_1	311	315	PF00917	0.644
DEG_SPOP_SBC_1	727	731	PF00917	0.492
DOC_ANK_TNKS_1	61	68	PF00023	0.589
DOC_CDC14_PxL_1	349	357	PF14671	0.689
DOC_CDC14_PxL_1	517	525	PF14671	0.468
DOC_CKS1_1	365	370	PF01111	0.666
DOC_CKS1_1	442	447	PF01111	0.456
DOC_CKS1_1	879	884	PF01111	0.673
DOC_CKS1_1	986	991	PF01111	0.628
DOC_CYCLIN_yCln2_LP_2	472	478	PF00134	0.538
DOC_CYCLIN_yCln2_LP_2	916	922	PF00134	0.562
DOC_MAPK_gen_1	395	402	PF00069	0.490
DOC_MAPK_MEF2A_6	395	402	PF00069	0.477
DOC_MAPK_MEF2A_6	469	476	PF00069	0.474
DOC_MAPK_NFAT4_5	469	477	PF00069	0.496
DOC_PIKK_1	51	59	PF02985	0.647
DOC_PP1_RVXF_1	701	708	PF00149	0.480
DOC_PP1_RVXF_1	926	933	PF00149	0.614
DOC_PP2B_LxvP_1	412	415	PF13499	0.466
DOC_PP2B_LxvP_1	472	475	PF13499	0.535
DOC_PP2B_LxvP_1	916	919	PF13499	0.574
DOC_PP4_FxxP_1	130	133	PF00568	0.702
DOC_USP7_MATH_1	111	115	PF00917	0.754
DOC_USP7_MATH_1	183	187	PF00917	0.689
DOC_USP7_MATH_1	265	269	PF00917	0.701
DOC_USP7_MATH_1	297	301	PF00917	0.643
DOC_USP7_MATH_1	427	431	PF00917	0.441
DOC_USP7_MATH_1	485	489	PF00917	0.532
DOC_USP7_MATH_1	605	609	PF00917	0.566
DOC_USP7_MATH_1	665	669	PF00917	0.527
DOC_USP7_MATH_1	752	756	PF00917	0.483
DOC_USP7_MATH_1	757	761	PF00917	0.511
DOC_USP7_MATH_1	808	812	PF00917	0.463
DOC_USP7_MATH_1	828	832	PF00917	0.236
DOC_USP7_MATH_1	851	855	PF00917	0.694
DOC_USP7_MATH_1	87	91	PF00917	0.768
DOC_USP7_MATH_1	880	884	PF00917	0.674
DOC_USP7_MATH_1	886	890	PF00917	0.672
DOC_USP7_UBL2_3	968	972	PF12436	0.548
DOC_WW_Pin1_4	122	127	PF00397	0.733
DOC_WW_Pin1_4	174	179	PF00397	0.664
DOC_WW_Pin1_4	271	276	PF00397	0.744
DOC_WW_Pin1_4	278	283	PF00397	0.692
DOC_WW_Pin1_4	344	349	PF00397	0.666
DOC_WW_Pin1_4	364	369	PF00397	0.687
DOC_WW_Pin1_4	441	446	PF00397	0.463
DOC_WW_Pin1_4	483	488	PF00397	0.597
DOC_WW_Pin1_4	793	798	PF00397	0.524
DOC_WW_Pin1_4	804	809	PF00397	0.424
DOC_WW_Pin1_4	878	883	PF00397	0.671
DOC_WW_Pin1_4	94	99	PF00397	0.709
DOC_WW_Pin1_4	985	990	PF00397	0.580
LIG_14-3-3_CanoR_1	100	109	PF00244	0.749
LIG_14-3-3_CanoR_1	143	147	PF00244	0.631
LIG_14-3-3_CanoR_1	342	348	PF00244	0.690
LIG_14-3-3_CanoR_1	432	438	PF00244	0.519
LIG_14-3-3_CanoR_1	607	613	PF00244	0.476
LIG_14-3-3_CanoR_1	776	780	PF00244	0.492
LIG_14-3-3_CanoR_1	782	786	PF00244	0.490
LIG_14-3-3_CanoR_1	861	867	PF00244	0.686
LIG_Actin_WH2_2	812	827	PF00022	0.299
LIG_APCC_ABBA_1	519	524	PF00400	0.441
LIG_APCC_ABBAyCdc20_2	577	583	PF00400	0.498
LIG_BIR_III_2	350	354	PF00653	0.684
LIG_BIR_III_4	64	68	PF00653	0.594
LIG_BRCT_BRCA1_1	761	765	PF00533	0.538
LIG_eIF4E_1	214	220	PF01652	0.523
LIG_FHA_1	21	27	PF00498	0.536
LIG_FHA_1	213	219	PF00498	0.618
LIG_FHA_1	335	341	PF00498	0.707
LIG_FHA_1	344	350	PF00498	0.648
LIG_FHA_1	444	450	PF00498	0.447
LIG_FHA_1	722	728	PF00498	0.531
LIG_FHA_1	793	799	PF00498	0.467
LIG_FHA_1	819	825	PF00498	0.345
LIG_FHA_1	879	885	PF00498	0.673
LIG_FHA_2	154	160	PF00498	0.552
LIG_FHA_2	162	168	PF00498	0.555
LIG_FHA_2	272	278	PF00498	0.636
LIG_FHA_2	608	614	PF00498	0.560
LIG_FHA_2	647	653	PF00498	0.450
LIG_FHA_2	986	992	PF00498	0.635
LIG_GBD_Chelix_1	974	982	PF00786	0.322
LIG_Integrin_isoDGR_2	546	548	PF01839	0.713
LIG_Integrin_RGD_1	62	64	PF01839	0.427
LIG_LIR_Apic_2	213	217	PF02991	0.568
LIG_LIR_Apic_2	909	915	PF02991	0.603
LIG_LIR_Gen_1	150	158	PF02991	0.566
LIG_LIR_Gen_1	664	674	PF02991	0.523
LIG_LIR_Gen_1	811	822	PF02991	0.330
LIG_LIR_Nem_3	150	154	PF02991	0.577
LIG_LIR_Nem_3	223	227	PF02991	0.519
LIG_LIR_Nem_3	37	42	PF02991	0.532
LIG_LIR_Nem_3	637	642	PF02991	0.598
LIG_LIR_Nem_3	664	669	PF02991	0.565
LIG_LIR_Nem_3	763	769	PF02991	0.464
LIG_LIR_Nem_3	811	817	PF02991	0.330
LIG_LIR_Nem_3	872	878	PF02991	0.720
LIG_LIR_Nem_3	911	916	PF02991	0.514
LIG_LIR_Nem_3	935	940	PF02991	0.548
LIG_NRBOX	153	159	PF00104	0.611
LIG_PDZ_Class_2	987	992	PF00595	0.620
LIG_Pex14_1	818	822	PF04695	0.308
LIG_Pex14_2	142	146	PF04695	0.639
LIG_Pex14_2	16	20	PF04695	0.530
LIG_REV1ctd_RIR_1	456	462	PF16727	0.474
LIG_REV1ctd_RIR_1	962	973	PF16727	0.540
LIG_SH2_CRK	214	218	PF00017	0.613
LIG_SH2_CRK	39	43	PF00017	0.516
LIG_SH2_CRK	666	670	PF00017	0.542
LIG_SH2_CRK	745	749	PF00017	0.451
LIG_SH2_CRK	875	879	PF00017	0.727
LIG_SH2_CRK	944	948	PF00017	0.540
LIG_SH2_NCK_1	666	670	PF00017	0.506
LIG_SH2_STAP1	230	234	PF00017	0.521
LIG_SH2_STAT3	437	440	PF00017	0.454
LIG_SH2_STAT3	940	943	PF00017	0.533
LIG_SH2_STAT5	171	174	PF00017	0.658
LIG_SH2_STAT5	214	217	PF00017	0.567
LIG_SH2_STAT5	251	254	PF00017	0.603
LIG_SH2_STAT5	501	504	PF00017	0.485
LIG_SH2_STAT5	522	525	PF00017	0.448
LIG_SH2_STAT5	666	669	PF00017	0.477
LIG_SH2_STAT5	814	817	PF00017	0.315
LIG_SH2_STAT5	912	915	PF00017	0.589
LIG_SH2_STAT5	940	943	PF00017	0.548
LIG_SH3_1	362	368	PF00018	0.677
LIG_SH3_1	794	800	PF00018	0.494
LIG_SH3_1	876	882	PF00018	0.671
LIG_SH3_3	172	178	PF00018	0.715
LIG_SH3_3	362	368	PF00018	0.677
LIG_SH3_3	41	47	PF00018	0.581
LIG_SH3_3	439	445	PF00018	0.466
LIG_SH3_3	745	751	PF00018	0.438
LIG_SH3_3	794	800	PF00018	0.490
LIG_SH3_3	876	882	PF00018	0.671
LIG_SH3_3	895	901	PF00018	0.684
LIG_SH3_3	911	917	PF00018	0.555
LIG_SH3_3	983	989	PF00018	0.601
LIG_SH3_4	837	844	PF00018	0.638
LIG_SUMO_SIM_anti_2	153	159	PF11976	0.609
LIG_SUMO_SIM_anti_2	337	342	PF11976	0.725
LIG_SUMO_SIM_par_1	153	159	PF11976	0.609
LIG_SUMO_SIM_par_1	241	247	PF11976	0.500
LIG_SUMO_SIM_par_1	462	467	PF11976	0.448
LIG_SUMO_SIM_par_1	679	686	PF11976	0.482
LIG_SUMO_SIM_par_1	825	831	PF11976	0.345
LIG_TYR_ITIM	228	233	PF00017	0.367
LIG_TYR_ITIM	743	748	PF00017	0.519
LIG_TYR_ITSM	35	42	PF00017	0.355
LIG_UBA3_1	517	525	PF00899	0.632
LIG_UBA3_1	920	928	PF00899	0.362
LIG_WRC_WIRS_1	819	824	PF05994	0.258
LIG_WW_1	211	214	PF00397	0.544
MOD_CDC14_SPxK_1	796	799	PF00782	0.619
MOD_CDC14_SPxK_1	97	100	PF00782	0.558
MOD_CDK_SPxK_1	793	799	PF00069	0.619
MOD_CDK_SPxK_1	94	100	PF00069	0.555
MOD_CDK_SPxxK_3	364	371	PF00069	0.580
MOD_CK1_1	10	16	PF00069	0.381
MOD_CK1_1	177	183	PF00069	0.534
MOD_CK1_1	195	201	PF00069	0.634
MOD_CK1_1	300	306	PF00069	0.619
MOD_CK1_1	363	369	PF00069	0.673
MOD_CK1_1	486	492	PF00069	0.704
MOD_CK1_1	534	540	PF00069	0.633
MOD_CK1_1	569	575	PF00069	0.690
MOD_CK1_1	585	591	PF00069	0.606
MOD_CK1_1	608	614	PF00069	0.709
MOD_CK1_1	728	734	PF00069	0.604
MOD_CK1_1	755	761	PF00069	0.587
MOD_CK1_1	774	780	PF00069	0.786
MOD_CK1_1	792	798	PF00069	0.548
MOD_CK1_1	853	859	PF00069	0.618
MOD_CK1_1	860	866	PF00069	0.609
MOD_CK1_1	94	100	PF00069	0.571
MOD_CK2_1	153	159	PF00069	0.421
MOD_CK2_1	161	167	PF00069	0.408
MOD_CK2_1	300	306	PF00069	0.685
MOD_CK2_1	646	652	PF00069	0.619
MOD_CK2_1	656	662	PF00069	0.780
MOD_CK2_1	687	693	PF00069	0.625
MOD_CK2_1	985	991	PF00069	0.523
MOD_CMANNOS	809	812	PF00535	0.514
MOD_GlcNHglycan	103	106	PF01048	0.731
MOD_GlcNHglycan	179	182	PF01048	0.564
MOD_GlcNHglycan	185	188	PF01048	0.608
MOD_GlcNHglycan	189	192	PF01048	0.637
MOD_GlcNHglycan	267	270	PF01048	0.662
MOD_GlcNHglycan	300	303	PF01048	0.672
MOD_GlcNHglycan	362	365	PF01048	0.626
MOD_GlcNHglycan	429	432	PF01048	0.507
MOD_GlcNHglycan	489	492	PF01048	0.683
MOD_GlcNHglycan	5	8	PF01048	0.444
MOD_GlcNHglycan	533	536	PF01048	0.626
MOD_GlcNHglycan	571	574	PF01048	0.676
MOD_GlcNHglycan	607	610	PF01048	0.738
MOD_GlcNHglycan	654	657	PF01048	0.640
MOD_GlcNHglycan	659	662	PF01048	0.621
MOD_GlcNHglycan	853	856	PF01048	0.683
MOD_GSK3_1	161	168	PF00069	0.418
MOD_GSK3_1	183	190	PF00069	0.676
MOD_GSK3_1	195	202	PF00069	0.702
MOD_GSK3_1	3	10	PF00069	0.440
MOD_GSK3_1	310	317	PF00069	0.605
MOD_GSK3_1	360	367	PF00069	0.719
MOD_GSK3_1	427	434	PF00069	0.480
MOD_GSK3_1	483	490	PF00069	0.663
MOD_GSK3_1	562	569	PF00069	0.748
MOD_GSK3_1	581	588	PF00069	0.570
MOD_GSK3_1	652	659	PF00069	0.620
MOD_GSK3_1	683	690	PF00069	0.630
MOD_GSK3_1	691	698	PF00069	0.653
MOD_GSK3_1	699	706	PF00069	0.682
MOD_GSK3_1	717	724	PF00069	0.527
MOD_GSK3_1	755	762	PF00069	0.566
MOD_GSK3_1	771	778	PF00069	0.529
MOD_GSK3_1	780	787	PF00069	0.603
MOD_GSK3_1	789	796	PF00069	0.567
MOD_GSK3_1	79	86	PF00069	0.563
MOD_GSK3_1	804	811	PF00069	0.498
MOD_GSK3_1	836	843	PF00069	0.668
MOD_GSK3_1	853	860	PF00069	0.530
MOD_GSK3_1	861	868	PF00069	0.628
MOD_GSK3_1	87	94	PF00069	0.616
MOD_N-GLC_1	111	116	PF02516	0.595
MOD_N-GLC_1	298	303	PF02516	0.686
MOD_N-GLC_1	450	455	PF02516	0.526
MOD_N-GLC_1	7	12	PF02516	0.437
MOD_N-GLC_1	792	797	PF02516	0.642
MOD_N-GLC_2	170	172	PF02516	0.546
MOD_NEK2_1	101	106	PF00069	0.631
MOD_NEK2_1	142	147	PF00069	0.612
MOD_NEK2_1	450	455	PF00069	0.526
MOD_NEK2_1	526	531	PF00069	0.604
MOD_NEK2_1	683	688	PF00069	0.607
MOD_NEK2_1	691	696	PF00069	0.620
MOD_NEK2_1	725	730	PF00069	0.655
MOD_NEK2_1	789	794	PF00069	0.601
MOD_NEK2_1	850	855	PF00069	0.624
MOD_NEK2_2	870	875	PF00069	0.567
MOD_PIKK_1	906	912	PF00454	0.596
MOD_PKA_1	342	348	PF00069	0.593
MOD_PKA_1	567	573	PF00069	0.650
MOD_PKA_2	142	148	PF00069	0.534
MOD_PKA_2	187	193	PF00069	0.700
MOD_PKA_2	342	348	PF00069	0.618
MOD_PKA_2	431	437	PF00069	0.540
MOD_PKA_2	531	537	PF00069	0.657
MOD_PKA_2	566	572	PF00069	0.634
MOD_PKA_2	646	652	PF00069	0.524
MOD_PKA_2	695	701	PF00069	0.632
MOD_PKA_2	775	781	PF00069	0.620
MOD_PKA_2	789	795	PF00069	0.590
MOD_PKA_2	860	866	PF00069	0.611
MOD_PKB_1	236	244	PF00069	0.352
MOD_Plk_1	450	456	PF00069	0.529
MOD_Plk_1	703	709	PF00069	0.626
MOD_Plk_1	774	780	PF00069	0.610
MOD_Plk_1	886	892	PF00069	0.672
MOD_Plk_2-3	153	159	PF00069	0.421
MOD_Plk_4	10	16	PF00069	0.472
MOD_Plk_4	153	159	PF00069	0.421
MOD_Plk_4	336	342	PF00069	0.632
MOD_Plk_4	687	693	PF00069	0.705
MOD_Plk_4	703	709	PF00069	0.563
MOD_Plk_4	761	767	PF00069	0.570
MOD_Plk_4	781	787	PF00069	0.597
MOD_Plk_4	808	814	PF00069	0.579
MOD_Plk_4	818	824	PF00069	0.315
MOD_Plk_4	828	834	PF00069	0.183
MOD_Plk_4	870	876	PF00069	0.570
MOD_Plk_4	88	94	PF00069	0.553
MOD_Plk_4	908	914	PF00069	0.376
MOD_Plk_4	936	942	PF00069	0.484
MOD_ProDKin_1	122	128	PF00069	0.672
MOD_ProDKin_1	174	180	PF00069	0.573
MOD_ProDKin_1	271	277	PF00069	0.689
MOD_ProDKin_1	278	284	PF00069	0.609
MOD_ProDKin_1	344	350	PF00069	0.580
MOD_ProDKin_1	364	370	PF00069	0.606
MOD_ProDKin_1	441	447	PF00069	0.571
MOD_ProDKin_1	483	489	PF00069	0.763
MOD_ProDKin_1	793	799	PF00069	0.663
MOD_ProDKin_1	804	810	PF00069	0.513
MOD_ProDKin_1	878	884	PF00069	0.589
MOD_ProDKin_1	94	100	PF00069	0.642
MOD_ProDKin_1	985	991	PF00069	0.471
MOD_SUMO_rev_2	481	486	PF00179	0.573
MOD_SUMO_rev_2	608	617	PF00179	0.684
MOD_SUMO_rev_2	633	642	PF00179	0.535
TRG_ENDOCYTIC_2	230	233	PF00928	0.373
TRG_ENDOCYTIC_2	39	42	PF00928	0.370
TRG_ENDOCYTIC_2	403	406	PF00928	0.315
TRG_ENDOCYTIC_2	666	669	PF00928	0.685
TRG_ENDOCYTIC_2	745	748	PF00928	0.573
TRG_ENDOCYTIC_2	766	769	PF00928	0.577
TRG_ENDOCYTIC_2	814	817	PF00928	0.395
TRG_ENDOCYTIC_2	875	878	PF00928	0.665
TRG_ER_diArg_1	236	239	PF00400	0.395
TRG_ER_diArg_1	325	328	PF00400	0.569
TRG_ER_diArg_1	341	343	PF00400	0.534
TRG_ER_diArg_1	380	383	PF00400	0.576
TRG_ER_diArg_1	395	398	PF00400	0.482
TRG_ER_diArg_1	577	580	PF00400	0.756
TRG_ER_diArg_1	59	62	PF00400	0.604
TRG_ER_diArg_1	741	743	PF00400	0.646
TRG_ER_diArg_1	875	877	PF00400	0.586
TRG_NLS_Bipartite_1	381	399	PF00514	0.523
TRG_Pf-PMV_PEXEL_1	372	377	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	741	746	PF00026	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8A1	Leptomonas seymouri	46%	92%
A4HPY7	Leishmania braziliensis	68%	100%
A4IDP8	Leishmania infantum	99%	100%
E9ATQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4Q0U4	Leishmania major	89%	100%