Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IPF2_LEIDO

TriTrypDb:

LdBPK_364550.1 , LdCL_360052700 , LDHU3_36.6170

Length:

551

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IPF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IPF2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	62	66	PF00656	0.551
CLV_NRD_NRD_1	119	121	PF00675	0.732
CLV_NRD_NRD_1	242	244	PF00675	0.720
CLV_NRD_NRD_1	253	255	PF00675	0.656
CLV_NRD_NRD_1	330	332	PF00675	0.514
CLV_NRD_NRD_1	346	348	PF00675	0.665
CLV_NRD_NRD_1	362	364	PF00675	0.409
CLV_NRD_NRD_1	502	504	PF00675	0.766
CLV_NRD_NRD_1	513	515	PF00675	0.768
CLV_NRD_NRD_1	516	518	PF00675	0.810
CLV_PCSK_KEX2_1	119	121	PF00082	0.732
CLV_PCSK_KEX2_1	242	244	PF00082	0.720
CLV_PCSK_KEX2_1	253	255	PF00082	0.656
CLV_PCSK_KEX2_1	330	332	PF00082	0.636
CLV_PCSK_KEX2_1	346	348	PF00082	0.528
CLV_PCSK_KEX2_1	361	363	PF00082	0.509
CLV_PCSK_KEX2_1	494	496	PF00082	0.764
CLV_PCSK_KEX2_1	502	504	PF00082	0.686
CLV_PCSK_PC1ET2_1	494	496	PF00082	0.733
CLV_PCSK_PC7_1	249	255	PF00082	0.622
CLV_PCSK_SKI1_1	25	29	PF00082	0.631
CLV_PCSK_SKI1_1	283	287	PF00082	0.580
CLV_PCSK_SKI1_1	350	354	PF00082	0.667
CLV_PCSK_SKI1_1	538	542	PF00082	0.690
CLV_PCSK_SKI1_1	99	103	PF00082	0.709
DEG_COP1_1	317	328	PF00400	0.672
DOC_CYCLIN_RxL_1	535	542	PF00134	0.596
DOC_CYCLIN_yClb5_NLxxxL_5	17	26	PF00134	0.681
DOC_PP1_RVXF_1	536	542	PF00149	0.595
DOC_PP2B_LxvP_1	286	289	PF13499	0.556
DOC_PP4_FxxP_1	113	116	PF00568	0.707
DOC_USP7_MATH_1	154	158	PF00917	0.764
DOC_USP7_MATH_1	163	167	PF00917	0.646
DOC_USP7_MATH_1	311	315	PF00917	0.646
DOC_USP7_MATH_1	409	413	PF00917	0.696
DOC_USP7_MATH_1	415	419	PF00917	0.788
DOC_USP7_MATH_1	44	48	PF00917	0.678
DOC_USP7_MATH_1	546	550	PF00917	0.656
DOC_USP7_MATH_1	9	13	PF00917	0.668
DOC_USP7_UBL2_3	457	461	PF12436	0.634
DOC_WW_Pin1_4	122	127	PF00397	0.662
DOC_WW_Pin1_4	168	173	PF00397	0.653
DOC_WW_Pin1_4	225	230	PF00397	0.851
DOC_WW_Pin1_4	263	268	PF00397	0.665
DOC_WW_Pin1_4	40	45	PF00397	0.635
DOC_WW_Pin1_4	450	455	PF00397	0.679
DOC_WW_Pin1_4	495	500	PF00397	0.601
DOC_WW_Pin1_4	516	521	PF00397	0.708
LIG_14-3-3_CanoR_1	140	147	PF00244	0.738
LIG_14-3-3_CanoR_1	162	172	PF00244	0.795
LIG_14-3-3_CanoR_1	196	204	PF00244	0.644
LIG_14-3-3_CanoR_1	205	215	PF00244	0.692
LIG_14-3-3_CanoR_1	222	229	PF00244	0.741
LIG_14-3-3_CanoR_1	235	244	PF00244	0.666
LIG_14-3-3_CanoR_1	25	30	PF00244	0.584
LIG_14-3-3_CanoR_1	487	493	PF00244	0.730
LIG_14-3-3_CanoR_1	99	107	PF00244	0.705
LIG_Actin_WH2_2	265	280	PF00022	0.691
LIG_BIR_II_1	1	5	PF00653	0.593
LIG_BRCT_BRCA1_1	440	444	PF00533	0.679
LIG_deltaCOP1_diTrp_1	358	365	PF00928	0.480
LIG_FHA_1	137	143	PF00498	0.736
LIG_FHA_1	150	156	PF00498	0.515
LIG_FHA_1	169	175	PF00498	0.689
LIG_FHA_1	184	190	PF00498	0.561
LIG_FHA_1	320	326	PF00498	0.600
LIG_FHA_1	545	551	PF00498	0.563
LIG_FHA_2	123	129	PF00498	0.817
LIG_FHA_2	340	346	PF00498	0.672
LIG_FHA_2	50	56	PF00498	0.558
LIG_FHA_2	60	66	PF00498	0.558
LIG_LIR_Apic_2	176	181	PF02991	0.549
LIG_LIR_Gen_1	180	189	PF02991	0.699
LIG_LIR_Gen_1	2	10	PF02991	0.644
LIG_LIR_Gen_1	484	492	PF02991	0.598
LIG_LIR_Nem_3	180	185	PF02991	0.573
LIG_LIR_Nem_3	201	207	PF02991	0.520
LIG_LIR_Nem_3	334	339	PF02991	0.577
LIG_LIR_Nem_3	484	488	PF02991	0.599
LIG_LIR_Nem_3	55	61	PF02991	0.608
LIG_PDZ_Class_1	546	551	PF00595	0.657
LIG_SH2_CRK	204	208	PF00017	0.577
LIG_SH2_CRK	58	62	PF00017	0.612
LIG_SH2_NCK_1	178	182	PF00017	0.697
LIG_SH2_PTP2	338	341	PF00017	0.554
LIG_SH2_SRC	182	185	PF00017	0.728
LIG_SH2_SRC	293	296	PF00017	0.541
LIG_SH2_SRC	338	341	PF00017	0.561
LIG_SH2_STAP1	293	297	PF00017	0.535
LIG_SH2_STAP1	303	307	PF00017	0.642
LIG_SH2_STAP1	36	40	PF00017	0.649
LIG_SH2_STAT5	276	279	PF00017	0.587
LIG_SH2_STAT5	324	327	PF00017	0.675
LIG_SH2_STAT5	338	341	PF00017	0.554
LIG_SH2_STAT5	36	39	PF00017	0.736
LIG_SH3_2	160	165	PF14604	0.668
LIG_SH3_2	172	177	PF14604	0.646
LIG_SH3_3	157	163	PF00018	0.672
LIG_SH3_3	169	175	PF00018	0.662
LIG_SH3_CIN85_PxpxPR_1	244	249	PF14604	0.618
LIG_TRAF2_1	271	274	PF00917	0.685
LIG_TRAF2_1	341	344	PF00917	0.616
LIG_TRAF2_1	356	359	PF00917	0.444
LIG_TYR_ITIM	56	61	PF00017	0.606
LIG_WRC_WIRS_1	532	537	PF05994	0.662
MOD_CDK_SPK_2	122	127	PF00069	0.656
MOD_CDK_SPK_2	168	173	PF00069	0.738
MOD_CDK_SPK_2	225	230	PF00069	0.851
MOD_CDK_SPK_2	40	45	PF00069	0.687
MOD_CDK_SPxK_1	450	456	PF00069	0.724
MOD_CDK_SPxxK_3	263	270	PF00069	0.628
MOD_CDK_SPxxK_3	450	457	PF00069	0.784
MOD_CDK_SPxxK_3	495	502	PF00069	0.644
MOD_CK1_1	136	142	PF00069	0.758
MOD_CK1_1	166	172	PF00069	0.824
MOD_CK1_1	195	201	PF00069	0.542
MOD_CK1_1	211	217	PF00069	0.663
MOD_CK1_1	228	234	PF00069	0.822
MOD_CK1_1	256	262	PF00069	0.844
MOD_CK1_1	314	320	PF00069	0.657
MOD_CK1_1	35	41	PF00069	0.821
MOD_CK1_1	445	451	PF00069	0.706
MOD_CK1_1	509	515	PF00069	0.710
MOD_CK1_1	72	78	PF00069	0.723
MOD_CK1_1	8	14	PF00069	0.697
MOD_CK1_1	88	94	PF00069	0.531
MOD_CK2_1	122	128	PF00069	0.815
MOD_CK2_1	153	159	PF00069	0.769
MOD_CK2_1	195	201	PF00069	0.487
MOD_CK2_1	339	345	PF00069	0.539
MOD_CK2_1	368	374	PF00069	0.543
MOD_CK2_1	474	480	PF00069	0.676
MOD_CK2_1	49	55	PF00069	0.577
MOD_CK2_1	516	522	PF00069	0.724
MOD_CK2_1	70	76	PF00069	0.627
MOD_Cter_Amidation	492	495	PF01082	0.713
MOD_Cter_Amidation	515	518	PF01082	0.638
MOD_DYRK1A_RPxSP_1	168	172	PF00069	0.650
MOD_DYRK1A_RPxSP_1	495	499	PF00069	0.640
MOD_GlcNHglycan	197	200	PF01048	0.464
MOD_GlcNHglycan	225	228	PF01048	0.814
MOD_GlcNHglycan	230	233	PF01048	0.767
MOD_GlcNHglycan	238	241	PF01048	0.635
MOD_GlcNHglycan	244	247	PF01048	0.549
MOD_GlcNHglycan	256	259	PF01048	0.615
MOD_GlcNHglycan	305	308	PF01048	0.678
MOD_GlcNHglycan	38	41	PF01048	0.804
MOD_GlcNHglycan	409	412	PF01048	0.649
MOD_GlcNHglycan	444	447	PF01048	0.797
MOD_GlcNHglycan	458	461	PF01048	0.785
MOD_GlcNHglycan	495	498	PF01048	0.682
MOD_GlcNHglycan	522	525	PF01048	0.793
MOD_GlcNHglycan	7	10	PF01048	0.625
MOD_GlcNHglycan	86	90	PF01048	0.763
MOD_GlcNHglycan	92	95	PF01048	0.646
MOD_GSK3_1	136	143	PF00069	0.817
MOD_GSK3_1	145	152	PF00069	0.660
MOD_GSK3_1	163	170	PF00069	0.765
MOD_GSK3_1	206	213	PF00069	0.647
MOD_GSK3_1	221	228	PF00069	0.741
MOD_GSK3_1	249	256	PF00069	0.815
MOD_GSK3_1	259	266	PF00069	0.681
MOD_GSK3_1	30	37	PF00069	0.661
MOD_GSK3_1	311	318	PF00069	0.654
MOD_GSK3_1	40	47	PF00069	0.738
MOD_GSK3_1	438	445	PF00069	0.744
MOD_GSK3_1	448	455	PF00069	0.638
MOD_GSK3_1	5	12	PF00069	0.648
MOD_GSK3_1	506	513	PF00069	0.720
MOD_GSK3_1	516	523	PF00069	0.612
MOD_LATS_1	23	29	PF00433	0.619
MOD_LATS_1	348	354	PF00433	0.453
MOD_N-GLC_1	140	145	PF02516	0.625
MOD_N-GLC_1	211	216	PF02516	0.758
MOD_N-GLC_1	236	241	PF02516	0.742
MOD_N-GLC_1	301	306	PF02516	0.648
MOD_N-GLC_1	318	323	PF02516	0.550
MOD_N-GLC_1	368	373	PF02516	0.572
MOD_N-GLC_1	438	443	PF02516	0.710
MOD_NEK2_1	111	116	PF00069	0.663
MOD_NEK2_1	488	493	PF00069	0.595
MOD_PIKK_1	111	117	PF00454	0.605
MOD_PIKK_1	133	139	PF00454	0.797
MOD_PIKK_1	213	219	PF00454	0.752
MOD_PIKK_1	221	227	PF00454	0.740
MOD_PIKK_1	396	402	PF00454	0.669
MOD_PIKK_1	415	421	PF00454	0.653
MOD_PKA_1	242	248	PF00069	0.657
MOD_PKA_1	253	259	PF00069	0.628
MOD_PKA_1	456	462	PF00069	0.724
MOD_PKA_2	164	170	PF00069	0.790
MOD_PKA_2	192	198	PF00069	0.653
MOD_PKA_2	221	227	PF00069	0.747
MOD_PKA_2	242	248	PF00069	0.725
MOD_PKA_2	253	259	PF00069	0.738
MOD_PKA_2	415	421	PF00069	0.600
MOD_PKA_2	44	50	PF00069	0.697
MOD_PKA_2	448	454	PF00069	0.794
MOD_PKA_2	509	515	PF00069	0.681
MOD_PKA_2	77	83	PF00069	0.777
MOD_PKB_1	247	255	PF00069	0.812
MOD_Plk_1	211	217	PF00069	0.745
MOD_Plk_1	350	356	PF00069	0.503
MOD_Plk_4	184	190	PF00069	0.569
MOD_ProDKin_1	122	128	PF00069	0.661
MOD_ProDKin_1	168	174	PF00069	0.650
MOD_ProDKin_1	225	231	PF00069	0.851
MOD_ProDKin_1	263	269	PF00069	0.660
MOD_ProDKin_1	40	46	PF00069	0.634
MOD_ProDKin_1	450	456	PF00069	0.680
MOD_ProDKin_1	495	501	PF00069	0.602
MOD_ProDKin_1	516	522	PF00069	0.709
MOD_SUMO_rev_2	124	131	PF00179	0.620
TRG_DiLeu_BaEn_4	76	82	PF01217	0.711
TRG_ENDOCYTIC_2	182	185	PF00928	0.574
TRG_ENDOCYTIC_2	204	207	PF00928	0.570
TRG_ENDOCYTIC_2	4	7	PF00928	0.657
TRG_ENDOCYTIC_2	58	61	PF00928	0.613
TRG_ER_diArg_1	242	244	PF00400	0.639
TRG_ER_diArg_1	253	255	PF00400	0.700
TRG_ER_diArg_1	330	332	PF00400	0.514
TRG_ER_diArg_1	360	363	PF00400	0.501
TRG_ER_diArg_1	385	388	PF00400	0.687
TRG_NLS_Bipartite_1	502	518	PF00514	0.672
TRG_NLS_MonoExtC_3	513	518	PF00514	0.622
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0U4	Leptomonas seymouri	38%	100%
A4HPV1	Leishmania braziliensis	57%	99%
A4IE40	Leishmania infantum	99%	100%
E9ATL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	97%
Q4Q0Y0	Leishmania major	84%	97%