Choline/ethanolamine_kinase_putative/GeneDB:LmjF. 35.1470

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

choline/ethanolamine kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IPA3_LEIDO

TriTrypDb:

LdBPK_351480.1 , LdCL_350019700 , LDHU3_35.1940

Length:

668

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IPA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IPA3

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	13
GO:0006796	phosphate-containing compound metabolic process	4	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0016310	phosphorylation	5	13
GO:0044237	cellular metabolic process	2	13
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006646	phosphatidylethanolamine biosynthetic process	6	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0008610	lipid biosynthetic process	4	1
GO:0008654	phospholipid biosynthetic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0019637	organophosphate metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046337	phosphatidylethanolamine metabolic process	6	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0016301	kinase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	13
GO:0004305	ethanolamine kinase activity	5	3
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	3
GO:0004103	choline kinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	585	589	PF00656	0.590
CLV_C14_Caspase3-7	67	71	PF00656	0.675
CLV_NRD_NRD_1	415	417	PF00675	0.304
CLV_NRD_NRD_1	423	425	PF00675	0.304
CLV_NRD_NRD_1	448	450	PF00675	0.302
CLV_PCSK_KEX2_1	323	325	PF00082	0.381
CLV_PCSK_KEX2_1	394	396	PF00082	0.324
CLV_PCSK_KEX2_1	423	425	PF00082	0.326
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.374
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.362
CLV_PCSK_SKI1_1	203	207	PF00082	0.271
CLV_PCSK_SKI1_1	29	33	PF00082	0.558
CLV_PCSK_SKI1_1	299	303	PF00082	0.344
CLV_PCSK_SKI1_1	323	327	PF00082	0.365
CLV_PCSK_SKI1_1	37	41	PF00082	0.571
CLV_PCSK_SKI1_1	389	393	PF00082	0.348
CLV_PCSK_SKI1_1	449	453	PF00082	0.307
CLV_Separin_Metazoa	26	30	PF03568	0.606
DEG_APCC_DBOX_1	594	602	PF00400	0.520
DOC_AGCK_PIF_2	469	474	PF00069	0.480
DOC_ANK_TNKS_1	496	503	PF00023	0.645
DOC_CKS1_1	311	316	PF01111	0.548
DOC_CKS1_1	45	50	PF01111	0.712
DOC_CYCLIN_RxL_1	356	366	PF00134	0.539
DOC_CYCLIN_yCln2_LP_2	301	307	PF00134	0.577
DOC_MAPK_gen_1	107	116	PF00069	0.745
DOC_MAPK_gen_1	323	330	PF00069	0.581
DOC_MAPK_gen_1	360	370	PF00069	0.562
DOC_MAPK_gen_1	394	401	PF00069	0.539
DOC_MAPK_JIP1_4	158	164	PF00069	0.673
DOC_MAPK_MEF2A_6	110	118	PF00069	0.564
DOC_MAPK_MEF2A_6	394	401	PF00069	0.520
DOC_MAPK_MEF2A_6	465	472	PF00069	0.480
DOC_PP1_RVXF_1	463	470	PF00149	0.556
DOC_USP7_MATH_1	256	260	PF00917	0.535
DOC_USP7_MATH_1	284	288	PF00917	0.577
DOC_USP7_MATH_1	349	353	PF00917	0.469
DOC_USP7_MATH_1	438	442	PF00917	0.513
DOC_USP7_MATH_1	558	562	PF00917	0.627
DOC_USP7_MATH_1	636	640	PF00917	0.549
DOC_USP7_UBL2_3	323	327	PF12436	0.494
DOC_USP7_UBL2_3	450	454	PF12436	0.511
DOC_WW_Pin1_4	145	150	PF00397	0.693
DOC_WW_Pin1_4	233	238	PF00397	0.482
DOC_WW_Pin1_4	263	268	PF00397	0.480
DOC_WW_Pin1_4	310	315	PF00397	0.528
DOC_WW_Pin1_4	44	49	PF00397	0.637
DOC_WW_Pin1_4	588	593	PF00397	0.607
LIG_14-3-3_CanoR_1	110	115	PF00244	0.793
LIG_14-3-3_CanoR_1	158	163	PF00244	0.648
LIG_14-3-3_CanoR_1	363	370	PF00244	0.480
LIG_14-3-3_CanoR_1	374	378	PF00244	0.480
LIG_APCC_ABBAyCdc20_2	465	471	PF00400	0.504
LIG_BIR_III_2	348	352	PF00653	0.522
LIG_BRCT_BRCA1_1	443	447	PF00533	0.562
LIG_CtBP_PxDLS_1	48	52	PF00389	0.728
LIG_deltaCOP1_diTrp_1	129	137	PF00928	0.467
LIG_FHA_1	202	208	PF00498	0.385
LIG_FHA_1	258	264	PF00498	0.471
LIG_FHA_1	363	369	PF00498	0.528
LIG_FHA_1	82	88	PF00498	0.634
LIG_FHA_2	311	317	PF00498	0.528
LIG_FHA_2	485	491	PF00498	0.480
LIG_FHA_2	583	589	PF00498	0.628
LIG_FHA_2	592	598	PF00498	0.501
LIG_FXI_DFP_1	197	201	PF00024	0.575
LIG_KLC1_Yacidic_2	335	339	PF13176	0.522
LIG_LIR_Apic_2	310	314	PF02991	0.561
LIG_LIR_Gen_1	272	280	PF02991	0.560
LIG_LIR_Gen_1	282	293	PF02991	0.537
LIG_LIR_Gen_1	30	39	PF02991	0.553
LIG_LIR_Gen_1	315	325	PF02991	0.522
LIG_LIR_Gen_1	376	385	PF02991	0.561
LIG_LIR_Gen_1	471	482	PF02991	0.562
LIG_LIR_Gen_1	613	623	PF02991	0.408
LIG_LIR_Gen_1	63	72	PF02991	0.734
LIG_LIR_Gen_1	654	662	PF02991	0.349
LIG_LIR_Nem_3	129	133	PF02991	0.494
LIG_LIR_Nem_3	141	145	PF02991	0.464
LIG_LIR_Nem_3	219	224	PF02991	0.575
LIG_LIR_Nem_3	242	248	PF02991	0.463
LIG_LIR_Nem_3	272	277	PF02991	0.480
LIG_LIR_Nem_3	282	288	PF02991	0.470
LIG_LIR_Nem_3	30	36	PF02991	0.543
LIG_LIR_Nem_3	315	320	PF02991	0.522
LIG_LIR_Nem_3	357	362	PF02991	0.501
LIG_LIR_Nem_3	376	380	PF02991	0.555
LIG_LIR_Nem_3	471	477	PF02991	0.502
LIG_LIR_Nem_3	503	509	PF02991	0.477
LIG_LIR_Nem_3	613	618	PF02991	0.364
LIG_LIR_Nem_3	643	647	PF02991	0.361
LIG_LIR_Nem_3	654	658	PF02991	0.347
LIG_LIR_Nem_3	8	14	PF02991	0.622
LIG_NRBOX	387	393	PF00104	0.562
LIG_PCNA_yPIPBox_3	12	20	PF02747	0.596
LIG_PCNA_yPIPBox_3	649	663	PF02747	0.479
LIG_Pex14_2	447	451	PF04695	0.562
LIG_Rb_pABgroove_1	131	139	PF01858	0.453
LIG_SH2_CRK	511	515	PF00017	0.567
LIG_SH2_NCK_1	311	315	PF00017	0.577
LIG_SH2_NCK_1	474	478	PF00017	0.480
LIG_SH2_PTP2	655	658	PF00017	0.395
LIG_SH2_SRC	33	36	PF00017	0.575
LIG_SH2_STAP1	285	289	PF00017	0.562
LIG_SH2_STAT3	518	521	PF00017	0.582
LIG_SH2_STAT5	317	320	PF00017	0.562
LIG_SH2_STAT5	337	340	PF00017	0.574
LIG_SH2_STAT5	35	38	PF00017	0.588
LIG_SH2_STAT5	474	477	PF00017	0.505
LIG_SH2_STAT5	495	498	PF00017	0.480
LIG_SH2_STAT5	511	514	PF00017	0.476
LIG_SH2_STAT5	537	540	PF00017	0.532
LIG_SH2_STAT5	576	579	PF00017	0.384
LIG_SH2_STAT5	644	647	PF00017	0.399
LIG_SH2_STAT5	655	658	PF00017	0.320
LIG_SH3_2	198	203	PF14604	0.588
LIG_SH3_3	195	201	PF00018	0.567
LIG_SH3_3	552	558	PF00018	0.573
LIG_SUMO_SIM_anti_2	384	390	PF11976	0.562
LIG_SUMO_SIM_par_1	46	56	PF11976	0.733
LIG_TRAF2_1	313	316	PF00917	0.536
LIG_TRAF2_1	514	517	PF00917	0.557
LIG_UBA3_1	175	183	PF00899	0.597
LIG_UBA3_1	387	394	PF00899	0.562
LIG_WRC_WIRS_1	240	245	PF05994	0.480
LIG_WRC_WIRS_1	285	290	PF05994	0.573
LIG_WRC_WIRS_1	377	382	PF05994	0.558
LIG_WW_3	26	30	PF00397	0.606
MOD_CDK_SPxxK_3	588	595	PF00069	0.615
MOD_CK1_1	212	218	PF00069	0.553
MOD_CK1_1	376	382	PF00069	0.513
MOD_CK1_1	38	44	PF00069	0.636
MOD_CK1_1	441	447	PF00069	0.534
MOD_CK1_1	50	56	PF00069	0.555
MOD_CK1_1	608	614	PF00069	0.453
MOD_CK2_1	310	316	PF00069	0.505
MOD_CK2_1	349	355	PF00069	0.480
MOD_CK2_1	484	490	PF00069	0.480
MOD_CK2_1	591	597	PF00069	0.541
MOD_CMANNOS	612	615	PF00535	0.341
MOD_GlcNHglycan	184	187	PF01048	0.519
MOD_GlcNHglycan	211	214	PF01048	0.354
MOD_GlcNHglycan	29	32	PF01048	0.532
MOD_GlcNHglycan	381	384	PF01048	0.374
MOD_GlcNHglycan	639	642	PF01048	0.415
MOD_GSK3_1	148	155	PF00069	0.683
MOD_GSK3_1	182	189	PF00069	0.493
MOD_GSK3_1	350	357	PF00069	0.489
MOD_GSK3_1	369	376	PF00069	0.438
MOD_GSK3_1	43	50	PF00069	0.681
MOD_GSK3_1	437	444	PF00069	0.501
MOD_GSK3_1	53	60	PF00069	0.668
MOD_LATS_1	120	126	PF00433	0.698
MOD_N-GLC_1	122	127	PF02516	0.654
MOD_N-GLC_1	339	344	PF02516	0.349
MOD_N-GLC_1	70	75	PF02516	0.656
MOD_NEK2_1	338	343	PF00069	0.561
MOD_NEK2_1	354	359	PF00069	0.413
MOD_NEK2_1	362	367	PF00069	0.475
MOD_NEK2_1	399	404	PF00069	0.545
MOD_NEK2_1	484	489	PF00069	0.471
MOD_NEK2_1	535	540	PF00069	0.525
MOD_NEK2_1	602	607	PF00069	0.357
MOD_NEK2_1	610	615	PF00069	0.311
MOD_NEK2_1	91	96	PF00069	0.494
MOD_NEK2_2	35	40	PF00069	0.576
MOD_PIKK_1	169	175	PF00454	0.509
MOD_PIKK_1	339	345	PF00454	0.571
MOD_PIKK_1	41	47	PF00454	0.692
MOD_PK_1	110	116	PF00069	0.704
MOD_PKA_2	362	368	PF00069	0.495
MOD_PKA_2	373	379	PF00069	0.480
MOD_PKA_2	496	502	PF00069	0.464
MOD_Plk_1	122	128	PF00069	0.649
MOD_Plk_1	169	175	PF00069	0.541
MOD_Plk_1	354	360	PF00069	0.543
MOD_Plk_1	53	59	PF00069	0.742
MOD_Plk_4	138	144	PF00069	0.545
MOD_Plk_4	201	207	PF00069	0.418
MOD_Plk_4	265	271	PF00069	0.520
MOD_Plk_4	284	290	PF00069	0.566
MOD_Plk_4	373	379	PF00069	0.490
MOD_ProDKin_1	145	151	PF00069	0.700
MOD_ProDKin_1	233	239	PF00069	0.482
MOD_ProDKin_1	263	269	PF00069	0.480
MOD_ProDKin_1	310	316	PF00069	0.528
MOD_ProDKin_1	44	50	PF00069	0.630
MOD_ProDKin_1	588	594	PF00069	0.602
MOD_SUMO_for_1	39	42	PF00179	0.610
TRG_DiLeu_BaEn_1	170	175	PF01217	0.602
TRG_DiLeu_BaEn_1	272	277	PF01217	0.540
TRG_DiLeu_BaEn_1	83	88	PF01217	0.530
TRG_DiLeu_BaLyEn_6	129	134	PF01217	0.562
TRG_ENDOCYTIC_2	285	288	PF00928	0.510
TRG_ENDOCYTIC_2	317	320	PF00928	0.589
TRG_ENDOCYTIC_2	33	36	PF00928	0.575
TRG_ENDOCYTIC_2	474	477	PF00928	0.498
TRG_ENDOCYTIC_2	479	482	PF00928	0.488
TRG_ENDOCYTIC_2	65	68	PF00928	0.757
TRG_ENDOCYTIC_2	655	658	PF00928	0.348
TRG_ER_diArg_1	232	235	PF00400	0.585
TRG_ER_diArg_1	422	424	PF00400	0.558
TRG_NES_CRM1_1	216	229	PF08389	0.577
TRG_NLS_MonoExtC_3	322	327	PF00514	0.494
TRG_Pf-PMV_PEXEL_1	459	463	PF00026	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZI3	Leptomonas seymouri	69%	100%
A0A0S4JCZ4	Bodo saltans	23%	100%
A0A1X0NH78	Trypanosomatidae	41%	100%
A0A1X0NIW4	Trypanosomatidae	42%	100%
A0A422N9U8	Trypanosoma rangeli	43%	100%
A4HMG9	Leishmania braziliensis	88%	99%
A4IB50	Leishmania infantum	100%	100%
C9ZNP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AEX0	Leishmania major	96%	100%
E9B626	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BC85	Trypanosoma cruzi	45%	100%