Leucine Rich repeat/Leucine Rich Repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IPA0_LEIDO

TriTrypDb:

LdBPK_261650.1 , LdCL_260022100 , LDHU3_26.2060

Length:

603

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8IPA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IPA0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.413
CLV_NRD_NRD_1	145	147	PF00675	0.392
CLV_NRD_NRD_1	353	355	PF00675	0.425
CLV_NRD_NRD_1	548	550	PF00675	0.435
CLV_NRD_NRD_1	58	60	PF00675	0.497
CLV_NRD_NRD_1	87	89	PF00675	0.408
CLV_PCSK_FUR_1	143	147	PF00082	0.401
CLV_PCSK_KEX2_1	145	147	PF00082	0.392
CLV_PCSK_KEX2_1	353	355	PF00082	0.436
CLV_PCSK_KEX2_1	373	375	PF00082	0.444
CLV_PCSK_KEX2_1	392	394	PF00082	0.250
CLV_PCSK_KEX2_1	548	550	PF00082	0.399
CLV_PCSK_KEX2_1	58	60	PF00082	0.608
CLV_PCSK_KEX2_1	86	88	PF00082	0.540
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.430
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.231
CLV_PCSK_SKI1_1	136	140	PF00082	0.341
CLV_PCSK_SKI1_1	18	22	PF00082	0.549
CLV_PCSK_SKI1_1	291	295	PF00082	0.456
CLV_PCSK_SKI1_1	354	358	PF00082	0.427
CLV_PCSK_SKI1_1	367	371	PF00082	0.381
CLV_PCSK_SKI1_1	46	50	PF00082	0.518
CLV_PCSK_SKI1_1	541	545	PF00082	0.468
CLV_PCSK_SKI1_1	576	580	PF00082	0.501
CLV_PCSK_SKI1_1	589	593	PF00082	0.391
DEG_APCC_DBOX_1	45	53	PF00400	0.559
DEG_Nend_UBRbox_3	1	3	PF02207	0.580
DEG_SPOP_SBC_1	104	108	PF00917	0.364
DEG_SPOP_SBC_1	401	405	PF00917	0.309
DOC_CYCLIN_RxL_1	13	23	PF00134	0.526
DOC_MAPK_DCC_7	505	514	PF00069	0.461
DOC_MAPK_DCC_7	551	560	PF00069	0.324
DOC_MAPK_gen_1	175	184	PF00069	0.479
DOC_MAPK_gen_1	289	298	PF00069	0.382
DOC_MAPK_gen_1	372	381	PF00069	0.375
DOC_MAPK_MEF2A_6	289	298	PF00069	0.292
DOC_MAPK_MEF2A_6	505	514	PF00069	0.416
DOC_MAPK_MEF2A_6	551	560	PF00069	0.590
DOC_MAPK_NFAT4_5	291	299	PF00069	0.281
DOC_MAPK_RevD_3	73	88	PF00069	0.455
DOC_PP1_RVXF_1	143	150	PF00149	0.405
DOC_PP1_RVXF_1	521	528	PF00149	0.454
DOC_USP7_MATH_1	256	260	PF00917	0.440
DOC_USP7_MATH_1	401	405	PF00917	0.381
DOC_USP7_MATH_1	487	491	PF00917	0.400
DOC_USP7_MATH_1	533	537	PF00917	0.431
DOC_USP7_MATH_1	597	601	PF00917	0.517
DOC_USP7_UBL2_3	471	475	PF12436	0.608
DOC_WW_Pin1_4	69	74	PF00397	0.581
LIG_14-3-3_CanoR_1	175	180	PF00244	0.460
LIG_14-3-3_CanoR_1	232	238	PF00244	0.354
LIG_14-3-3_CanoR_1	239	244	PF00244	0.370
LIG_14-3-3_CanoR_1	317	325	PF00244	0.407
LIG_14-3-3_CanoR_1	353	357	PF00244	0.403
LIG_14-3-3_CanoR_1	367	376	PF00244	0.327
LIG_14-3-3_CanoR_1	489	494	PF00244	0.367
LIG_14-3-3_CanoR_1	541	547	PF00244	0.547
LIG_14-3-3_CanoR_1	589	596	PF00244	0.463
LIG_Actin_WH2_2	561	578	PF00022	0.548
LIG_BRCT_BRCA1_1	302	306	PF00533	0.372
LIG_BRCT_BRCA1_1	312	316	PF00533	0.379
LIG_BRCT_BRCA1_1	41	45	PF00533	0.574
LIG_BRCT_BRCA1_1	479	483	PF00533	0.457
LIG_CtBP_PxDLS_1	456	460	PF00389	0.421
LIG_FHA_1	20	26	PF00498	0.468
LIG_FHA_1	347	353	PF00498	0.452
LIG_FHA_1	401	407	PF00498	0.398
LIG_FHA_1	577	583	PF00498	0.455
LIG_FHA_1	70	76	PF00498	0.547
LIG_FHA_2	122	128	PF00498	0.473
LIG_FHA_2	329	335	PF00498	0.455
LIG_GBD_Chelix_1	161	169	PF00786	0.336
LIG_HP1_1	510	514	PF01393	0.378
LIG_IRF3_LxIS_1	260	266	PF10401	0.360
LIG_LIR_Gen_1	176	185	PF02991	0.393
LIG_LIR_Gen_1	193	201	PF02991	0.224
LIG_LIR_Gen_1	203	212	PF02991	0.306
LIG_LIR_Gen_1	245	255	PF02991	0.449
LIG_LIR_Gen_1	267	276	PF02991	0.391
LIG_LIR_Gen_1	295	306	PF02991	0.345
LIG_LIR_Gen_1	478	488	PF02991	0.533
LIG_LIR_Gen_1	521	532	PF02991	0.406
LIG_LIR_LC3C_4	115	118	PF02991	0.445
LIG_LIR_Nem_3	130	135	PF02991	0.379
LIG_LIR_Nem_3	15	20	PF02991	0.400
LIG_LIR_Nem_3	176	182	PF02991	0.480
LIG_LIR_Nem_3	193	197	PF02991	0.301
LIG_LIR_Nem_3	203	207	PF02991	0.397
LIG_LIR_Nem_3	245	250	PF02991	0.476
LIG_LIR_Nem_3	267	273	PF02991	0.395
LIG_LIR_Nem_3	295	301	PF02991	0.342
LIG_LIR_Nem_3	303	309	PF02991	0.284
LIG_LIR_Nem_3	478	484	PF02991	0.551
LIG_LIR_Nem_3	521	527	PF02991	0.378
LIG_LIR_Nem_3	569	575	PF02991	0.590
LIG_NRBOX	134	140	PF00104	0.464
LIG_PTB_Apo_2	385	392	PF02174	0.300
LIG_REV1ctd_RIR_1	388	397	PF16727	0.358
LIG_SH2_CRK	132	136	PF00017	0.429
LIG_SH2_CRK	204	208	PF00017	0.453
LIG_SH2_SRC	495	498	PF00017	0.397
LIG_SH2_STAP1	204	208	PF00017	0.384
LIG_SH2_STAT3	167	170	PF00017	0.414
LIG_SH2_STAT5	167	170	PF00017	0.556
LIG_SH2_STAT5	226	229	PF00017	0.352
LIG_SH2_STAT5	495	498	PF00017	0.397
LIG_SH3_3	44	50	PF00018	0.557
LIG_SH3_3	504	510	PF00018	0.503
LIG_SH3_3	565	571	PF00018	0.488
LIG_SH3_3	57	63	PF00018	0.612
LIG_SH3_3	70	76	PF00018	0.573
LIG_SUMO_SIM_anti_2	257	262	PF11976	0.355
LIG_SUMO_SIM_par_1	510	516	PF11976	0.335
MOD_CK1_1	173	179	PF00069	0.562
MOD_CK1_1	193	199	PF00069	0.277
MOD_CK1_1	355	361	PF00069	0.482
MOD_CK1_1	39	45	PF00069	0.444
MOD_CK1_1	427	433	PF00069	0.430
MOD_CK1_1	435	441	PF00069	0.436
MOD_CK1_1	528	534	PF00069	0.372
MOD_CK2_1	175	181	PF00069	0.379
MOD_CK2_1	328	334	PF00069	0.467
MOD_CK2_1	446	452	PF00069	0.426
MOD_CK2_1	564	570	PF00069	0.446
MOD_Cter_Amidation	84	87	PF01082	0.453
MOD_GlcNHglycan	228	231	PF01048	0.487
MOD_GlcNHglycan	408	411	PF01048	0.429
MOD_GlcNHglycan	41	44	PF01048	0.482
MOD_GlcNHglycan	448	451	PF01048	0.448
MOD_GlcNHglycan	491	494	PF01048	0.466
MOD_GlcNHglycan	500	504	PF01048	0.398
MOD_GlcNHglycan	534	538	PF01048	0.412
MOD_GlcNHglycan	66	69	PF01048	0.504
MOD_GSK3_1	169	176	PF00069	0.441
MOD_GSK3_1	196	203	PF00069	0.349
MOD_GSK3_1	234	241	PF00069	0.483
MOD_GSK3_1	348	355	PF00069	0.465
MOD_GSK3_1	402	409	PF00069	0.469
MOD_GSK3_1	495	502	PF00069	0.454
MOD_GSK3_1	576	583	PF00069	0.526
MOD_GSK3_1	64	71	PF00069	0.531
MOD_N-GLC_1	170	175	PF02516	0.400
MOD_N-GLC_1	263	268	PF02516	0.414
MOD_N-GLC_1	435	440	PF02516	0.519
MOD_N-GLC_1	471	476	PF02516	0.550
MOD_N-GLC_1	525	530	PF02516	0.450
MOD_NEK2_1	103	108	PF00069	0.479
MOD_NEK2_1	139	144	PF00069	0.479
MOD_NEK2_1	169	174	PF00069	0.399
MOD_NEK2_1	238	243	PF00069	0.413
MOD_NEK2_1	263	268	PF00069	0.400
MOD_NEK2_1	279	284	PF00069	0.297
MOD_NEK2_1	294	299	PF00069	0.239
MOD_NEK2_1	300	305	PF00069	0.335
MOD_NEK2_1	346	351	PF00069	0.408
MOD_NEK2_1	406	411	PF00069	0.364
MOD_NEK2_1	432	437	PF00069	0.352
MOD_NEK2_1	462	467	PF00069	0.428
MOD_NEK2_1	499	504	PF00069	0.381
MOD_NEK2_1	527	532	PF00069	0.332
MOD_NEK2_2	518	523	PF00069	0.463
MOD_OFUCOSY	102	109	PF10250	0.368
MOD_PIKK_1	581	587	PF00454	0.520
MOD_PKA_2	231	237	PF00069	0.367
MOD_PKA_2	238	244	PF00069	0.368
MOD_PKA_2	352	358	PF00069	0.401
MOD_PKB_1	175	183	PF00069	0.396
MOD_PKB_1	539	547	PF00069	0.464
MOD_PKB_1	86	94	PF00069	0.517
MOD_Plk_1	170	176	PF00069	0.397
MOD_Plk_1	294	300	PF00069	0.385
MOD_Plk_1	335	341	PF00069	0.435
MOD_Plk_1	435	441	PF00069	0.352
MOD_Plk_1	528	534	PF00069	0.473
MOD_Plk_4	256	262	PF00069	0.360
MOD_Plk_4	402	408	PF00069	0.537
MOD_Plk_4	424	430	PF00069	0.256
MOD_Plk_4	477	483	PF00069	0.489
MOD_Plk_4	542	548	PF00069	0.413
MOD_ProDKin_1	69	75	PF00069	0.574
MOD_SUMO_for_1	12	15	PF00179	0.454
TRG_DiLeu_BaEn_1	164	169	PF01217	0.451
TRG_DiLeu_BaLyEn_6	504	509	PF01217	0.368
TRG_DiLeu_BaLyEn_6	586	591	PF01217	0.421
TRG_ENDOCYTIC_2	132	135	PF00928	0.367
TRG_ENDOCYTIC_2	204	207	PF00928	0.429
TRG_ENDOCYTIC_2	344	347	PF00928	0.465
TRG_ER_diArg_1	143	146	PF00400	0.544
TRG_ER_diArg_1	174	177	PF00400	0.420
TRG_ER_diArg_1	288	291	PF00400	0.411
TRG_ER_diArg_1	352	354	PF00400	0.435
TRG_ER_diArg_1	539	542	PF00400	0.435
TRG_ER_diArg_1	547	549	PF00400	0.404
TRG_ER_diArg_1	57	59	PF00400	0.580
TRG_ER_diArg_1	86	88	PF00400	0.534
TRG_Pf-PMV_PEXEL_1	589	593	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P389	Leptomonas seymouri	68%	100%
A0A1X0NSQ4	Trypanosomatidae	32%	100%
A0A422N1Z7	Trypanosoma rangeli	34%	100%
A4HF21	Leishmania braziliensis	92%	100%
A4I2A0	Leishmania infantum	100%	100%
C9ZRP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	93%
E9AYE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q928	Leishmania major	96%	100%
V5B197	Trypanosoma cruzi	33%	100%