Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IP77_LEIDO

TriTrypDb:

LdBPK_363820.1 , LdCL_360045200 , LDHU3_36.5150

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IP77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IP77

PDB structure(s): 7aih_Z , 7am2_Z , 7ane_Z

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.537
CLV_NRD_NRD_1	162	164	PF00675	0.467
CLV_NRD_NRD_1	8	10	PF00675	0.495
CLV_NRD_NRD_1	80	82	PF00675	0.563
CLV_PCSK_KEX2_1	192	194	PF00082	0.437
CLV_PCSK_KEX2_1	8	10	PF00082	0.517
CLV_PCSK_KEX2_1	80	82	PF00082	0.479
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.437
CLV_PCSK_PC7_1	76	82	PF00082	0.448
CLV_PCSK_SKI1_1	192	196	PF00082	0.451
CLV_PCSK_SKI1_1	41	45	PF00082	0.625
CLV_PCSK_SKI1_1	9	13	PF00082	0.581
CLV_Separin_Metazoa	85	89	PF03568	0.513
DEG_Nend_Nbox_1	1	3	PF02207	0.550
DOC_CYCLIN_yClb1_LxF_4	102	107	PF00134	0.516
DOC_MAPK_gen_1	151	160	PF00069	0.422
DOC_MAPK_MEF2A_6	151	160	PF00069	0.442
DOC_PP1_RVXF_1	102	108	PF00149	0.412
DOC_PP1_RVXF_1	190	197	PF00149	0.410
DOC_PP4_FxxP_1	142	145	PF00568	0.441
DOC_PP4_FxxP_1	21	24	PF00568	0.473
DOC_USP7_MATH_1	113	117	PF00917	0.400
DOC_USP7_UBL2_3	100	104	PF12436	0.402
DOC_USP7_UBL2_3	151	155	PF12436	0.476
DOC_USP7_UBL2_3	188	192	PF12436	0.462
DOC_WW_Pin1_4	25	30	PF00397	0.441
LIG_deltaCOP1_diTrp_1	46	52	PF00928	0.450
LIG_FHA_1	67	73	PF00498	0.466
LIG_FHA_2	178	184	PF00498	0.666
LIG_FHA_2	26	32	PF00498	0.446
LIG_HP1_1	156	160	PF01393	0.429
LIG_LIR_Apic_2	141	145	PF02991	0.570
LIG_LIR_Nem_3	152	157	PF02991	0.468
LIG_MYND_3	144	148	PF01753	0.380
LIG_PCNA_yPIPBox_3	88	98	PF02747	0.507
LIG_Pex14_2	21	25	PF04695	0.478
LIG_REV1ctd_RIR_1	193	198	PF16727	0.487
LIG_SH2_PTP2	157	160	PF00017	0.425
LIG_SH2_STAT5	106	109	PF00017	0.424
LIG_SH2_STAT5	120	123	PF00017	0.368
LIG_SH2_STAT5	157	160	PF00017	0.425
LIG_SH3_3	109	115	PF00018	0.418
LIG_SH3_3	130	136	PF00018	0.462
LIG_SH3_4	188	195	PF00018	0.442
LIG_SxIP_EBH_1	79	88	PF03271	0.460
LIG_TRAF2_1	159	162	PF00917	0.459
LIG_UBA3_1	165	173	PF00899	0.581
LIG_UBA3_1	190	198	PF00899	0.545
LIG_WRPW_2	154	157	PF00400	0.441
MOD_CK1_1	181	187	PF00069	0.598
MOD_CK2_1	177	183	PF00069	0.585
MOD_CMANNOS	49	52	PF00535	0.371
MOD_GlcNHglycan	100	103	PF01048	0.408
MOD_GlcNHglycan	174	178	PF01048	0.687
MOD_GlcNHglycan	180	183	PF01048	0.710
MOD_GSK3_1	173	180	PF00069	0.646
MOD_GSK3_1	66	73	PF00069	0.463
MOD_N-GLC_1	149	154	PF02516	0.380
MOD_N-GLC_1	66	71	PF02516	0.506
MOD_NEK2_1	2	7	PF00069	0.543
MOD_NEK2_1	66	71	PF00069	0.445
MOD_PK_1	39	45	PF00069	0.554
MOD_Plk_1	149	155	PF00069	0.462
MOD_Plk_1	173	179	PF00069	0.635
MOD_Plk_4	14	20	PF00069	0.509
MOD_Plk_4	39	45	PF00069	0.434
MOD_ProDKin_1	25	31	PF00069	0.436
MOD_SUMO_rev_2	181	190	PF00179	0.561
MOD_SUMO_rev_2	42	50	PF00179	0.387
TRG_ENDOCYTIC_2	157	160	PF00928	0.425
TRG_ER_diArg_1	34	37	PF00400	0.617
TRG_ER_diArg_1	7	9	PF00400	0.523
TRG_ER_diArg_1	79	81	PF00400	0.554
TRG_NES_CRM1_1	85	95	PF08389	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4T5	Leptomonas seymouri	84%	100%
A0A0S4J3L6	Bodo saltans	68%	97%
A0A1X0P3A9	Trypanosomatidae	71%	100%
A0A422MY87	Trypanosoma rangeli	69%	98%
A4ID33	Leishmania infantum	99%	100%
D0A8I6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9AIX9	Leishmania braziliensis	92%	100%
E9ATE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q152	Leishmania major	95%	99%