Rdx family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rdx family, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IP70_LEIDO

TriTrypDb:

LdBPK_351120.1 , LdCL_350016000 , LDHU3_35.1430

Length:

331

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IP70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IP70

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0019725	cellular homeostasis	2	1
GO:0042592	homeostatic process	3	1
GO:0045454	cell redox homeostasis	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004791	thioredoxin-disulfide reductase activity	2	1
GO:0015035	protein-disulfide reductase activity	3	1
GO:0015036	disulfide oxidoreductase activity	4	1
GO:0016209	antioxidant activity	1	1
GO:0016491	oxidoreductase activity	2	1
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	1
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	4	1
GO:0047134	protein-disulfide reductase (NAD(P)) activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.691
CLV_C14_Caspase3-7	19	23	PF00656	0.687
CLV_C14_Caspase3-7	50	54	PF00656	0.654
CLV_C14_Caspase3-7	61	65	PF00656	0.707
CLV_NRD_NRD_1	191	193	PF00675	0.504
CLV_NRD_NRD_1	221	223	PF00675	0.504
CLV_NRD_NRD_1	260	262	PF00675	0.388
CLV_PCSK_FUR_1	258	262	PF00082	0.407
CLV_PCSK_KEX2_1	221	223	PF00082	0.504
CLV_PCSK_KEX2_1	260	262	PF00082	0.388
CLV_PCSK_SKI1_1	102	106	PF00082	0.599
CLV_PCSK_SKI1_1	221	225	PF00082	0.504
CLV_PCSK_SKI1_1	276	280	PF00082	0.504
CLV_PCSK_SKI1_1	316	320	PF00082	0.444
CLV_Separin_Metazoa	189	193	PF03568	0.454
DOC_CYCLIN_RxL_1	313	321	PF00134	0.516
DOC_MAPK_gen_1	89	96	PF00069	0.545
DOC_MAPK_RevD_3	77	91	PF00069	0.617
DOC_USP7_MATH_1	147	151	PF00917	0.718
DOC_USP7_MATH_1	162	166	PF00917	0.793
DOC_USP7_MATH_1	4	8	PF00917	0.686
DOC_USP7_MATH_1	63	67	PF00917	0.784
DOC_USP7_MATH_2	6	12	PF00917	0.811
DOC_WW_Pin1_4	216	221	PF00397	0.504
DOC_WW_Pin1_4	6	11	PF00397	0.544
DOC_WW_Pin1_4	66	71	PF00397	0.726
LIG_14-3-3_CanoR_1	261	271	PF00244	0.504
LIG_Actin_WH2_2	234	249	PF00022	0.504
LIG_APCC_ABBA_1	284	289	PF00400	0.407
LIG_BIR_II_1	1	5	PF00653	0.803
LIG_BIR_III_3	1	5	PF00653	0.746
LIG_BRCT_BRCA1_1	265	269	PF00533	0.407
LIG_FHA_1	234	240	PF00498	0.504
LIG_FHA_1	303	309	PF00498	0.467
LIG_FHA_1	69	75	PF00498	0.661
LIG_FHA_1	81	87	PF00498	0.338
LIG_FHA_2	150	156	PF00498	0.689
LIG_FHA_2	59	65	PF00498	0.785
LIG_Integrin_RGD_1	153	155	PF01839	0.644
LIG_LIR_Gen_1	185	195	PF02991	0.496
LIG_LIR_Gen_1	291	299	PF02991	0.399
LIG_LIR_Nem_3	185	191	PF02991	0.496
LIG_LIR_Nem_3	208	212	PF02991	0.371
LIG_LIR_Nem_3	291	297	PF02991	0.407
LIG_NRBOX	308	314	PF00104	0.504
LIG_NRBOX	81	87	PF00104	0.464
LIG_PTB_Apo_2	278	285	PF02174	0.504
LIG_SH2_CRK	294	298	PF00017	0.504
LIG_SH2_NCK_1	178	182	PF00017	0.407
LIG_SH2_SRC	133	136	PF00017	0.631
LIG_SH2_STAP1	184	188	PF00017	0.329
LIG_SH3_2	217	222	PF14604	0.504
LIG_SH3_3	198	204	PF00018	0.348
LIG_SH3_3	214	220	PF00018	0.348
LIG_SUMO_SIM_anti_2	173	178	PF11976	0.504
LIG_SUMO_SIM_anti_2	251	258	PF11976	0.504
LIG_TRAF2_1	78	81	PF00917	0.495
LIG_TYR_ITIM	292	297	PF00017	0.504
LIG_UBA3_1	109	115	PF00899	0.601
MOD_CDC14_SPxK_1	219	222	PF00782	0.504
MOD_CDK_SPK_2	216	221	PF00069	0.504
MOD_CDK_SPxK_1	216	222	PF00069	0.504
MOD_CK1_1	66	72	PF00069	0.708
MOD_CK2_1	183	189	PF00069	0.424
MOD_CK2_1	75	81	PF00069	0.502
MOD_GlcNHglycan	10	13	PF01048	0.804
MOD_GlcNHglycan	155	158	PF01048	0.778
MOD_GlcNHglycan	294	297	PF01048	0.454
MOD_GlcNHglycan	299	302	PF01048	0.412
MOD_GlcNHglycan	64	68	PF01048	0.604
MOD_GSK3_1	149	156	PF00069	0.732
MOD_GSK3_1	195	202	PF00069	0.422
MOD_GSK3_1	4	11	PF00069	0.684
MOD_N-GLC_1	297	302	PF02516	0.504
MOD_NEK2_1	233	238	PF00069	0.379
MOD_NEK2_1	263	268	PF00069	0.439
MOD_NEK2_1	292	297	PF00069	0.396
MOD_NEK2_1	314	319	PF00069	0.405
MOD_PIKK_1	135	141	PF00454	0.670
MOD_PKB_1	151	159	PF00069	0.765
MOD_Plk_1	314	320	PF00069	0.470
MOD_Plk_1	80	86	PF00069	0.430
MOD_Plk_2-3	75	81	PF00069	0.502
MOD_Plk_4	249	255	PF00069	0.504
MOD_ProDKin_1	216	222	PF00069	0.504
MOD_ProDKin_1	6	12	PF00069	0.545
MOD_ProDKin_1	66	72	PF00069	0.717
MOD_SUMO_rev_2	202	212	PF00179	0.379
TRG_DiLeu_BaEn_1	81	86	PF01217	0.500
TRG_ENDOCYTIC_2	294	297	PF00928	0.407
TRG_ER_diArg_1	220	222	PF00400	0.504
TRG_ER_diArg_1	257	260	PF00400	0.370
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	316	321	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUE3	Leptomonas seymouri	47%	83%
A4IB07	Leishmania infantum	100%	100%
E9AET5	Leishmania major	90%	99%
E9B5Z0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%