Nuclear transmembrane protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear transmembrane protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IP51_LEIDO

TriTrypDb:

LdBPK_350860.1 , LdCL_350013400 , LDHU3_35.1050

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0031090	organelle membrane	3	1
GO:0031965	nuclear membrane	4	1

Expansion

Sequence features

A0A3Q8IP51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IP51

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	340	342	PF00675	0.613
CLV_PCSK_KEX2_1	339	341	PF00082	0.620
CLV_PCSK_SKI1_1	14	18	PF00082	0.313
CLV_PCSK_SKI1_1	156	160	PF00082	0.434
CLV_PCSK_SKI1_1	186	190	PF00082	0.430
CLV_PCSK_SKI1_1	234	238	PF00082	0.369
CLV_PCSK_SKI1_1	255	259	PF00082	0.471
CLV_PCSK_SKI1_1	328	332	PF00082	0.668
CLV_PCSK_SKI1_1	49	53	PF00082	0.478
CLV_PCSK_SKI1_1	57	61	PF00082	0.441
CLV_PCSK_SKI1_1	81	85	PF00082	0.453
DEG_Nend_UBRbox_2	1	3	PF02207	0.451
DEG_SPOP_SBC_1	330	334	PF00917	0.473
DOC_CYCLIN_yCln2_LP_2	26	32	PF00134	0.347
DOC_CYCLIN_yCln2_LP_2	276	282	PF00134	0.304
DOC_MAPK_MEF2A_6	400	409	PF00069	0.230
DOC_PP2B_LxvP_1	202	205	PF13499	0.650
DOC_PP2B_LxvP_1	26	29	PF13499	0.347
DOC_PP2B_LxvP_1	275	278	PF13499	0.369
DOC_PP2B_LxvP_1	60	63	PF13499	0.626
DOC_PP4_FxxP_1	83	86	PF00568	0.631
DOC_USP7_MATH_1	127	131	PF00917	0.699
DOC_USP7_MATH_1	188	192	PF00917	0.619
DOC_USP7_MATH_1	294	298	PF00917	0.494
DOC_USP7_MATH_1	374	378	PF00917	0.646
DOC_USP7_MATH_1	384	388	PF00917	0.307
DOC_USP7_MATH_1	51	55	PF00917	0.623
DOC_USP7_MATH_1	63	67	PF00917	0.647
DOC_USP7_MATH_1	77	81	PF00917	0.620
DOC_USP7_UBL2_3	400	404	PF12436	0.230
DOC_WW_Pin1_4	104	109	PF00397	0.672
DOC_WW_Pin1_4	128	133	PF00397	0.729
DOC_WW_Pin1_4	290	295	PF00397	0.426
DOC_WW_Pin1_4	68	73	PF00397	0.656
DOC_WW_Pin1_4	82	87	PF00397	0.769
LIG_14-3-3_CanoR_1	113	122	PF00244	0.656
LIG_14-3-3_CanoR_1	156	163	PF00244	0.631
LIG_14-3-3_CanoR_1	198	203	PF00244	0.616
LIG_14-3-3_CanoR_1	328	335	PF00244	0.477
LIG_Actin_WH2_2	305	320	PF00022	0.349
LIG_BRCT_BRCA1_1	174	178	PF00533	0.638
LIG_BRCT_BRCA1_1	79	83	PF00533	0.636
LIG_Clathr_ClatBox_1	390	394	PF01394	0.369
LIG_FHA_1	136	142	PF00498	0.697
LIG_FHA_1	2	8	PF00498	0.433
LIG_FHA_1	347	353	PF00498	0.449
LIG_FHA_1	378	384	PF00498	0.304
LIG_FHA_2	147	153	PF00498	0.699
LIG_GBD_Chelix_1	309	317	PF00786	0.630
LIG_GBD_Chelix_1	385	393	PF00786	0.294
LIG_LIR_Apic_2	229	235	PF02991	0.614
LIG_LIR_Apic_2	80	86	PF02991	0.673
LIG_LIR_Gen_1	216	226	PF02991	0.697
LIG_LIR_Gen_1	266	276	PF02991	0.369
LIG_LIR_Gen_1	356	364	PF02991	0.269
LIG_LIR_Gen_1	387	396	PF02991	0.433
LIG_LIR_Nem_3	216	221	PF02991	0.704
LIG_LIR_Nem_3	266	271	PF02991	0.411
LIG_LIR_Nem_3	356	360	PF02991	0.269
LIG_LIR_Nem_3	387	391	PF02991	0.433
LIG_LIR_Nem_3	95	99	PF02991	0.646
LIG_NRBOX	270	276	PF00104	0.248
LIG_Pex14_2	409	413	PF04695	0.347
LIG_Pex14_2	96	100	PF04695	0.697
LIG_REV1ctd_RIR_1	9	18	PF16727	0.415
LIG_RPA_C_Fungi	334	346	PF08784	0.477
LIG_SH2_CRK	218	222	PF00017	0.637
LIG_SH2_PTP2	232	235	PF00017	0.456
LIG_SH2_PTP2	357	360	PF00017	0.347
LIG_SH2_STAP1	19	23	PF00017	0.294
LIG_SH2_STAP1	280	284	PF00017	0.531
LIG_SH2_STAP1	31	35	PF00017	0.294
LIG_SH2_STAT5	195	198	PF00017	0.563
LIG_SH2_STAT5	209	212	PF00017	0.540
LIG_SH2_STAT5	232	235	PF00017	0.500
LIG_SH2_STAT5	319	322	PF00017	0.445
LIG_SH2_STAT5	357	360	PF00017	0.489
LIG_SH3_3	121	127	PF00018	0.671
LIG_SUMO_SIM_anti_2	356	362	PF11976	0.294
LIG_SUMO_SIM_anti_2	382	387	PF11976	0.304
LIG_SUMO_SIM_par_1	387	395	PF11976	0.308
LIG_TRAF2_1	149	152	PF00917	0.648
LIG_TRAF2_1	213	216	PF00917	0.531
LIG_TRAF2_1	236	239	PF00917	0.486
LIG_TRFH_1	33	37	PF08558	0.527
LIG_WRC_WIRS_1	385	390	PF05994	0.369
MOD_CDK_SPxK_1	68	74	PF00069	0.535
MOD_CK1_1	114	120	PF00069	0.592
MOD_CK1_1	137	143	PF00069	0.684
MOD_CK1_1	180	186	PF00069	0.716
MOD_CK1_1	283	289	PF00069	0.509
MOD_CK1_1	377	383	PF00069	0.372
MOD_CK1_1	85	91	PF00069	0.702
MOD_CK2_1	146	152	PF00069	0.630
MOD_CK2_1	210	216	PF00069	0.542
MOD_GlcNHglycan	163	166	PF01048	0.647
MOD_GlcNHglycan	174	177	PF01048	0.569
MOD_GlcNHglycan	190	193	PF01048	0.547
MOD_GlcNHglycan	394	397	PF01048	0.304
MOD_GlcNHglycan	53	56	PF01048	0.548
MOD_GlcNHglycan	75	78	PF01048	0.626
MOD_GSK3_1	102	109	PF00069	0.650
MOD_GSK3_1	137	144	PF00069	0.646
MOD_GSK3_1	177	184	PF00069	0.595
MOD_GSK3_1	220	227	PF00069	0.519
MOD_GSK3_1	290	297	PF00069	0.535
MOD_GSK3_1	329	336	PF00069	0.623
MOD_GSK3_1	51	58	PF00069	0.515
MOD_GSK3_1	73	80	PF00069	0.560
MOD_GSK3_1	85	92	PF00069	0.543
MOD_N-GLC_1	221	226	PF02516	0.565
MOD_NEK2_1	1	6	PF00069	0.522
MOD_NEK2_1	141	146	PF00069	0.632
MOD_NEK2_1	210	215	PF00069	0.685
MOD_NEK2_1	312	317	PF00069	0.518
MOD_NEK2_1	335	340	PF00069	0.618
MOD_NEK2_1	367	372	PF00069	0.369
MOD_OFUCOSY	365	371	PF10250	0.304
MOD_PIKK_1	156	162	PF00454	0.597
MOD_PIKK_1	203	209	PF00454	0.534
MOD_PIKK_1	89	95	PF00454	0.558
MOD_PKA_2	114	120	PF00069	0.613
MOD_PKA_2	172	178	PF00069	0.537
MOD_PKA_2	180	186	PF00069	0.620
MOD_PKA_2	197	203	PF00069	0.460
MOD_PKA_2	374	380	PF00069	0.304
MOD_PKA_2	73	79	PF00069	0.589
MOD_Plk_1	1	7	PF00069	0.519
MOD_Plk_1	181	187	PF00069	0.539
MOD_Plk_1	224	230	PF00069	0.469
MOD_Plk_1	55	61	PF00069	0.507
MOD_Plk_4	356	362	PF00069	0.364
MOD_Plk_4	384	390	PF00069	0.369
MOD_Plk_4	92	98	PF00069	0.576
MOD_ProDKin_1	104	110	PF00069	0.590
MOD_ProDKin_1	128	134	PF00069	0.667
MOD_ProDKin_1	290	296	PF00069	0.524
MOD_ProDKin_1	68	74	PF00069	0.566
MOD_ProDKin_1	82	88	PF00069	0.724
TRG_ENDOCYTIC_2	218	221	PF00928	0.634
TRG_ENDOCYTIC_2	357	360	PF00928	0.369
TRG_ER_diArg_1	170	173	PF00400	0.549
TRG_ER_diArg_1	316	319	PF00400	0.401
TRG_ER_diArg_1	339	341	PF00400	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHG2	Leptomonas seymouri	45%	99%
A4HMB5	Leishmania braziliensis	70%	96%
A4IAY1	Leishmania infantum	99%	100%
E9AEQ9	Leishmania major	88%	100%
E9B5W4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%