Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IP33_LEIDO

TriTrypDb:

LdBPK_350750.1 , LdCL_350012200 , LDHU3_35.0900

Length:

921

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IP33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IP33

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	249	253	PF00656	0.643
CLV_C14_Caspase3-7	827	831	PF00656	0.820
CLV_NRD_NRD_1	3	5	PF00675	0.721
CLV_NRD_NRD_1	309	311	PF00675	0.666
CLV_NRD_NRD_1	409	411	PF00675	0.733
CLV_NRD_NRD_1	427	429	PF00675	0.580
CLV_NRD_NRD_1	480	482	PF00675	0.605
CLV_NRD_NRD_1	640	642	PF00675	0.634
CLV_NRD_NRD_1	7	9	PF00675	0.706
CLV_NRD_NRD_1	707	709	PF00675	0.712
CLV_NRD_NRD_1	793	795	PF00675	0.716
CLV_NRD_NRD_1	856	858	PF00675	0.756
CLV_NRD_NRD_1	859	861	PF00675	0.719
CLV_NRD_NRD_1	868	870	PF00675	0.716
CLV_NRD_NRD_1	871	873	PF00675	0.683
CLV_PCSK_FUR_1	857	861	PF00082	0.824
CLV_PCSK_FUR_1	869	873	PF00082	0.629
CLV_PCSK_KEX2_1	3	5	PF00082	0.696
CLV_PCSK_KEX2_1	309	311	PF00082	0.666
CLV_PCSK_KEX2_1	409	411	PF00082	0.733
CLV_PCSK_KEX2_1	427	429	PF00082	0.580
CLV_PCSK_KEX2_1	480	482	PF00082	0.606
CLV_PCSK_KEX2_1	528	530	PF00082	0.808
CLV_PCSK_KEX2_1	640	642	PF00082	0.634
CLV_PCSK_KEX2_1	675	677	PF00082	0.743
CLV_PCSK_KEX2_1	707	709	PF00082	0.712
CLV_PCSK_KEX2_1	858	860	PF00082	0.768
CLV_PCSK_KEX2_1	870	872	PF00082	0.815
CLV_PCSK_PC1ET2_1	528	530	PF00082	0.808
CLV_PCSK_PC1ET2_1	675	677	PF00082	0.743
CLV_PCSK_PC1ET2_1	858	860	PF00082	0.768
CLV_PCSK_PC1ET2_1	870	872	PF00082	0.815
CLV_PCSK_SKI1_1	467	471	PF00082	0.652
CLV_PCSK_SKI1_1	499	503	PF00082	0.660
CLV_PCSK_SKI1_1	910	914	PF00082	0.748
DEG_APCC_DBOX_1	471	479	PF00400	0.575
DEG_SPOP_SBC_1	278	282	PF00917	0.665
DEG_SPOP_SBC_1	491	495	PF00917	0.636
DEG_SPOP_SBC_1	501	505	PF00917	0.585
DEG_SPOP_SBC_1	547	551	PF00917	0.586
DEG_SPOP_SBC_1	579	583	PF00917	0.611
DOC_CDC14_PxL_1	131	139	PF14671	0.569
DOC_CKS1_1	434	439	PF01111	0.712
DOC_CKS1_1	486	491	PF01111	0.648
DOC_CKS1_1	52	57	PF01111	0.670
DOC_CKS1_1	899	904	PF01111	0.728
DOC_CYCLIN_RxL_1	461	471	PF00134	0.622
DOC_CYCLIN_RxL_1	638	648	PF00134	0.700
DOC_CYCLIN_yCln2_LP_2	434	440	PF00134	0.602
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.663
DOC_CYCLIN_yCln2_LP_2	617	620	PF00134	0.800
DOC_MAPK_gen_1	694	702	PF00069	0.756
DOC_MAPK_JIP1_4	696	702	PF00069	0.768
DOC_MAPK_MEF2A_6	675	684	PF00069	0.632
DOC_MAPK_MEF2A_6	696	704	PF00069	0.776
DOC_MAPK_RevD_3	693	708	PF00069	0.772
DOC_PP2B_LxvP_1	617	620	PF13499	0.800
DOC_PP2B_LxvP_1	728	731	PF13499	0.597
DOC_PP4_FxxP_1	196	199	PF00568	0.650
DOC_PP4_FxxP_1	377	380	PF00568	0.579
DOC_PP4_FxxP_1	895	898	PF00568	0.702
DOC_SPAK_OSR1_1	557	561	PF12202	0.815
DOC_USP7_MATH_1	15	19	PF00917	0.742
DOC_USP7_MATH_1	22	26	PF00917	0.742
DOC_USP7_MATH_1	270	274	PF00917	0.647
DOC_USP7_MATH_1	286	290	PF00917	0.706
DOC_USP7_MATH_1	404	408	PF00917	0.761
DOC_USP7_MATH_1	491	495	PF00917	0.714
DOC_USP7_MATH_1	501	505	PF00917	0.590
DOC_USP7_MATH_1	547	551	PF00917	0.586
DOC_USP7_MATH_1	680	684	PF00917	0.768
DOC_USP7_MATH_1	70	74	PF00917	0.713
DOC_USP7_MATH_1	79	83	PF00917	0.501
DOC_USP7_MATH_1	824	828	PF00917	0.777
DOC_USP7_MATH_1	829	833	PF00917	0.711
DOC_USP7_MATH_1	851	855	PF00917	0.645
DOC_USP7_UBL2_3	5	9	PF12436	0.720
DOC_USP7_UBL2_3	507	511	PF12436	0.737
DOC_WW_Pin1_4	18	23	PF00397	0.661
DOC_WW_Pin1_4	342	347	PF00397	0.725
DOC_WW_Pin1_4	398	403	PF00397	0.808
DOC_WW_Pin1_4	411	416	PF00397	0.666
DOC_WW_Pin1_4	433	438	PF00397	0.718
DOC_WW_Pin1_4	459	464	PF00397	0.678
DOC_WW_Pin1_4	485	490	PF00397	0.780
DOC_WW_Pin1_4	492	497	PF00397	0.764
DOC_WW_Pin1_4	51	56	PF00397	0.565
DOC_WW_Pin1_4	541	546	PF00397	0.813
DOC_WW_Pin1_4	580	585	PF00397	0.680
DOC_WW_Pin1_4	604	609	PF00397	0.734
DOC_WW_Pin1_4	676	681	PF00397	0.731
DOC_WW_Pin1_4	706	711	PF00397	0.716
DOC_WW_Pin1_4	75	80	PF00397	0.602
DOC_WW_Pin1_4	803	808	PF00397	0.803
DOC_WW_Pin1_4	811	816	PF00397	0.700
DOC_WW_Pin1_4	898	903	PF00397	0.721
DOC_WW_Pin1_4	912	917	PF00397	0.581
LIG_14-3-3_CanoR_1	139	147	PF00244	0.601
LIG_14-3-3_CanoR_1	288	294	PF00244	0.814
LIG_14-3-3_CanoR_1	327	333	PF00244	0.649
LIG_14-3-3_CanoR_1	427	434	PF00244	0.685
LIG_14-3-3_CanoR_1	557	563	PF00244	0.682
LIG_14-3-3_CanoR_1	586	591	PF00244	0.711
LIG_14-3-3_CanoR_1	640	644	PF00244	0.629
LIG_14-3-3_CanoR_1	676	680	PF00244	0.732
LIG_14-3-3_CanoR_1	726	731	PF00244	0.825
LIG_14-3-3_CanoR_1	75	79	PF00244	0.615
LIG_14-3-3_CanoR_1	871	879	PF00244	0.714
LIG_14-3-3_CanoR_1	910	916	PF00244	0.778
LIG_14-3-3_CanoR_1	96	104	PF00244	0.574
LIG_14-3-3_CterR_2	917	921	PF00244	0.749
LIG_BIR_III_2	646	650	PF00653	0.796
LIG_BRCT_BRCA1_1	290	294	PF00533	0.723
LIG_BRCT_BRCA1_1	891	895	PF00533	0.703
LIG_deltaCOP1_diTrp_1	471	476	PF00928	0.672
LIG_EVH1_1	134	138	PF00568	0.644
LIG_EVH1_2	176	180	PF00568	0.657
LIG_FHA_1	327	333	PF00498	0.662
LIG_FHA_1	434	440	PF00498	0.704
LIG_FHA_1	455	461	PF00498	0.587
LIG_FHA_1	515	521	PF00498	0.818
LIG_FHA_1	52	58	PF00498	0.561
LIG_FHA_1	640	646	PF00498	0.725
LIG_FHA_1	744	750	PF00498	0.782
LIG_FHA_1	817	823	PF00498	0.607
LIG_FHA_1	913	919	PF00498	0.744
LIG_FHA_2	144	150	PF00498	0.731
LIG_FHA_2	161	167	PF00498	0.734
LIG_FHA_2	247	253	PF00498	0.755
LIG_FHA_2	259	265	PF00498	0.619
LIG_FHA_2	633	639	PF00498	0.671
LIG_GBD_Chelix_1	439	447	PF00786	0.590
LIG_GSK3_LRP6_1	898	903	PF00069	0.585
LIG_Integrin_isoDGR_2	339	341	PF01839	0.654
LIG_Integrin_RGD_1	164	166	PF01839	0.737
LIG_LIR_Apic_2	892	898	PF02991	0.700
LIG_LIR_Gen_1	183	192	PF02991	0.508
LIG_LIR_Gen_1	354	359	PF02991	0.659
LIG_LIR_Gen_1	835	845	PF02991	0.793
LIG_LIR_Nem_3	183	188	PF02991	0.500
LIG_LIR_Nem_3	272	278	PF02991	0.768
LIG_LIR_Nem_3	308	314	PF02991	0.691
LIG_LIR_Nem_3	59	65	PF02991	0.552
LIG_LIR_Nem_3	835	841	PF02991	0.798
LIG_LYPXL_yS_3	134	137	PF13949	0.625
LIG_Pex14_1	80	84	PF04695	0.532
LIG_PTB_Apo_2	190	197	PF02174	0.638
LIG_SH2_GRB2like	653	656	PF00017	0.654
LIG_SH2_SRC	389	392	PF00017	0.592
LIG_SH2_SRC	653	656	PF00017	0.693
LIG_SH2_STAP1	389	393	PF00017	0.595
LIG_SH2_STAP1	65	69	PF00017	0.628
LIG_SH2_STAT5	120	123	PF00017	0.503
LIG_SH2_STAT5	185	188	PF00017	0.479
LIG_SH2_STAT5	703	706	PF00017	0.703
LIG_SH2_STAT5	715	718	PF00017	0.734
LIG_SH3_1	132	138	PF00018	0.649
LIG_SH3_3	132	138	PF00018	0.649
LIG_SH3_3	165	171	PF00018	0.738
LIG_SH3_3	24	30	PF00018	0.793
LIG_SH3_3	296	302	PF00018	0.720
LIG_SH3_3	362	368	PF00018	0.625
LIG_SH3_3	44	50	PF00018	0.573
LIG_SH3_3	457	463	PF00018	0.791
LIG_SH3_3	528	534	PF00018	0.604
LIG_SH3_3	681	687	PF00018	0.700
LIG_SH3_3	809	815	PF00018	0.737
LIG_SH3_3	896	902	PF00018	0.677
LIG_SH3_CIN85_PxpxPR_1	415	420	PF14604	0.729
LIG_Sin3_3	466	473	PF02671	0.707
LIG_SUMO_SIM_anti_2	152	160	PF11976	0.712
LIG_SUMO_SIM_par_1	152	160	PF11976	0.712
LIG_WRC_WIRS_1	215	220	PF05994	0.548
LIG_WW_2	135	138	PF00397	0.656
MOD_CDC14_SPxK_1	78	81	PF00782	0.645
MOD_CDK_SPK_2	912	917	PF00069	0.744
MOD_CDK_SPxK_1	580	586	PF00069	0.653
MOD_CDK_SPxK_1	75	81	PF00069	0.574
MOD_CDK_SPxxK_3	413	420	PF00069	0.731
MOD_CDK_SPxxK_3	492	499	PF00069	0.765
MOD_CDK_SPxxK_3	898	905	PF00069	0.731
MOD_CK1_1	18	24	PF00069	0.700
MOD_CK1_1	287	293	PF00069	0.744
MOD_CK1_1	392	398	PF00069	0.740
MOD_CK1_1	546	552	PF00069	0.769
MOD_CK1_1	561	567	PF00069	0.631
MOD_CK1_1	607	613	PF00069	0.769
MOD_CK1_1	720	726	PF00069	0.749
MOD_CK1_1	729	735	PF00069	0.684
MOD_CK1_1	73	79	PF00069	0.685
MOD_CK1_1	743	749	PF00069	0.617
MOD_CK1_1	803	809	PF00069	0.736
MOD_CK1_1	906	912	PF00069	0.720
MOD_CK2_1	143	149	PF00069	0.696
MOD_CK2_1	214	220	PF00069	0.544
MOD_CK2_1	258	264	PF00069	0.669
MOD_CK2_1	829	835	PF00069	0.730
MOD_Cter_Amidation	602	605	PF01082	0.712
MOD_Cter_Amidation	861	864	PF01082	0.822
MOD_DYRK1A_RPxSP_1	413	417	PF00069	0.769
MOD_DYRK1A_RPxSP_1	708	712	PF00069	0.707
MOD_GlcNHglycan	224	229	PF01048	0.751
MOD_GlcNHglycan	284	287	PF01048	0.734
MOD_GlcNHglycan	359	362	PF01048	0.703
MOD_GlcNHglycan	372	375	PF01048	0.704
MOD_GlcNHglycan	390	394	PF01048	0.749
MOD_GlcNHglycan	659	662	PF01048	0.815
MOD_GlcNHglycan	665	668	PF01048	0.765
MOD_GlcNHglycan	728	731	PF01048	0.624
MOD_GlcNHglycan	742	745	PF01048	0.712
MOD_GlcNHglycan	746	749	PF01048	0.695
MOD_GlcNHglycan	830	834	PF01048	0.652
MOD_GlcNHglycan	865	868	PF01048	0.781
MOD_GlcNHglycan	97	100	PF01048	0.563
MOD_GSK3_1	139	146	PF00069	0.645
MOD_GSK3_1	18	25	PF00069	0.700
MOD_GSK3_1	278	285	PF00069	0.745
MOD_GSK3_1	286	293	PF00069	0.698
MOD_GSK3_1	353	360	PF00069	0.656
MOD_GSK3_1	366	373	PF00069	0.598
MOD_GSK3_1	409	416	PF00069	0.762
MOD_GSK3_1	509	516	PF00069	0.696
MOD_GSK3_1	543	550	PF00069	0.765
MOD_GSK3_1	574	581	PF00069	0.782
MOD_GSK3_1	582	589	PF00069	0.779
MOD_GSK3_1	653	660	PF00069	0.743
MOD_GSK3_1	663	670	PF00069	0.677
MOD_GSK3_1	676	683	PF00069	0.783
MOD_GSK3_1	70	77	PF00069	0.708
MOD_GSK3_1	713	720	PF00069	0.826
MOD_GSK3_1	739	746	PF00069	0.693
MOD_GSK3_1	774	781	PF00069	0.723
MOD_GSK3_1	811	818	PF00069	0.764
MOD_GSK3_1	824	831	PF00069	0.611
MOD_GSK3_1	912	919	PF00069	0.662
MOD_LATS_1	245	251	PF00433	0.736
MOD_LATS_1	724	730	PF00433	0.604
MOD_N-GLC_1	188	193	PF02516	0.516
MOD_N-GLC_2	39	41	PF02516	0.564
MOD_NEK2_1	180	185	PF00069	0.648
MOD_NEK2_1	351	356	PF00069	0.750
MOD_NEK2_1	502	507	PF00069	0.612
MOD_NEK2_1	558	563	PF00069	0.641
MOD_NEK2_1	578	583	PF00069	0.528
MOD_NEK2_1	598	603	PF00069	0.682
MOD_NEK2_1	74	79	PF00069	0.591
MOD_NEK2_2	522	527	PF00069	0.739
MOD_NEK2_2	70	75	PF00069	0.714
MOD_PIKK_1	327	333	PF00454	0.747
MOD_PIKK_1	404	410	PF00454	0.842
MOD_PIKK_1	441	447	PF00454	0.485
MOD_PIKK_1	667	673	PF00454	0.816
MOD_PK_1	247	253	PF00069	0.729
MOD_PK_1	586	592	PF00069	0.663
MOD_PKA_1	4	10	PF00069	0.811
MOD_PKA_1	409	415	PF00069	0.732
MOD_PKA_1	427	433	PF00069	0.545
MOD_PKA_1	675	681	PF00069	0.733
MOD_PKA_1	794	800	PF00069	0.707
MOD_PKA_1	863	869	PF00069	0.797
MOD_PKA_1	871	877	PF00069	0.723
MOD_PKA_2	287	293	PF00069	0.811
MOD_PKA_2	326	332	PF00069	0.740
MOD_PKA_2	340	346	PF00069	0.582
MOD_PKA_2	409	415	PF00069	0.771
MOD_PKA_2	427	433	PF00069	0.682
MOD_PKA_2	558	564	PF00069	0.667
MOD_PKA_2	598	604	PF00069	0.681
MOD_PKA_2	639	645	PF00069	0.628
MOD_PKA_2	675	681	PF00069	0.807
MOD_PKA_2	74	80	PF00069	0.601
MOD_PKA_2	793	799	PF00069	0.676
MOD_PKA_2	871	877	PF00069	0.816
MOD_PKA_2	95	101	PF00069	0.562
MOD_PKB_1	776	784	PF00069	0.772
MOD_PKB_1	869	877	PF00069	0.818
MOD_Plk_1	667	673	PF00069	0.719
MOD_Plk_1	717	723	PF00069	0.830
MOD_Plk_1	834	840	PF00069	0.724
MOD_Plk_2-3	214	220	PF00069	0.544
MOD_Plk_2-3	454	460	PF00069	0.589
MOD_Plk_4	180	186	PF00069	0.609
MOD_Plk_4	214	220	PF00069	0.646
MOD_Plk_4	270	276	PF00069	0.717
MOD_Plk_4	561	567	PF00069	0.696
MOD_Plk_4	586	592	PF00069	0.716
MOD_Plk_4	729	735	PF00069	0.682
MOD_Plk_4	834	840	PF00069	0.724
MOD_ProDKin_1	18	24	PF00069	0.658
MOD_ProDKin_1	342	348	PF00069	0.724
MOD_ProDKin_1	398	404	PF00069	0.812
MOD_ProDKin_1	411	417	PF00069	0.664
MOD_ProDKin_1	433	439	PF00069	0.712
MOD_ProDKin_1	459	465	PF00069	0.672
MOD_ProDKin_1	485	491	PF00069	0.784
MOD_ProDKin_1	492	498	PF00069	0.761
MOD_ProDKin_1	51	57	PF00069	0.566
MOD_ProDKin_1	541	547	PF00069	0.808
MOD_ProDKin_1	580	586	PF00069	0.679
MOD_ProDKin_1	604	610	PF00069	0.731
MOD_ProDKin_1	676	682	PF00069	0.730
MOD_ProDKin_1	706	712	PF00069	0.717
MOD_ProDKin_1	75	81	PF00069	0.600
MOD_ProDKin_1	803	809	PF00069	0.805
MOD_ProDKin_1	811	817	PF00069	0.700
MOD_ProDKin_1	898	904	PF00069	0.727
MOD_ProDKin_1	912	918	PF00069	0.581
MOD_SUMO_for_1	383	386	PF00179	0.714
MOD_SUMO_for_1	506	509	PF00179	0.774
MOD_SUMO_rev_2	503	513	PF00179	0.727
TRG_DiLeu_BaEn_2	191	197	PF01217	0.644
TRG_DiLeu_BaLyEn_6	464	469	PF01217	0.616
TRG_ENDOCYTIC_2	134	137	PF00928	0.625
TRG_ENDOCYTIC_2	184	187	PF00928	0.492
TRG_ER_diArg_1	104	107	PF00400	0.674
TRG_ER_diArg_1	2	4	PF00400	0.630
TRG_ER_diArg_1	309	311	PF00400	0.670
TRG_ER_diArg_1	427	429	PF00400	0.584
TRG_ER_diArg_1	479	481	PF00400	0.593
TRG_ER_diArg_1	639	641	PF00400	0.635
TRG_ER_diArg_1	693	696	PF00400	0.636
TRG_ER_diArg_1	857	860	PF00400	0.780
TRG_ER_diArg_1	869	872	PF00400	0.675
TRG_NLS_Bipartite_1	857	874	PF00514	0.823
TRG_NLS_MonoCore_2	856	861	PF00514	0.825
TRG_NLS_MonoCore_2	868	873	PF00514	0.633
TRG_NLS_MonoExtC_3	603	608	PF00514	0.756
TRG_NLS_MonoExtC_3	856	861	PF00514	0.800
TRG_NLS_MonoExtC_3	869	875	PF00514	0.639
TRG_NLS_MonoExtN_4	857	862	PF00514	0.760
TRG_NLS_MonoExtN_4	869	874	PF00514	0.793
TRG_Pf-PMV_PEXEL_1	467	471	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	641	646	PF00026	0.699

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDY7	Leptomonas seymouri	36%	100%
A4HMA6	Leishmania braziliensis	66%	96%
A4IAX1	Leishmania infantum	100%	100%
E9AEP9	Leishmania major	87%	100%
E9B5V4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%