Meiotic cell cortex C-terminal pleckstrin homology, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Meiotic cell cortex C-terminal pleckstrin homology, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IP29_LEIDO

TriTrypDb:

LdBPK_260920.1 , LdCL_260014800 , LDHU3_26.1180

Length:

613

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0005938	cell cortex	3	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3Q8IP29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IP29

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	6
GO:0032065	maintenance of protein location in cell cortex	4	6
GO:0032507	maintenance of protein location in cell	3	6
GO:0045185	maintenance of protein location	3	6
GO:0051179	localization	1	6
GO:0051235	maintenance of location	2	6
GO:0051651	maintenance of location in cell	2	6

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0005543	phospholipid binding	3	6
GO:0008289	lipid binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	197	199	PF00675	0.748
CLV_NRD_NRD_1	331	333	PF00675	0.681
CLV_NRD_NRD_1	353	355	PF00675	0.667
CLV_NRD_NRD_1	376	378	PF00675	0.550
CLV_NRD_NRD_1	50	52	PF00675	0.741
CLV_NRD_NRD_1	7	9	PF00675	0.672
CLV_PCSK_KEX2_1	197	199	PF00082	0.844
CLV_PCSK_KEX2_1	298	300	PF00082	0.696
CLV_PCSK_KEX2_1	331	333	PF00082	0.681
CLV_PCSK_KEX2_1	353	355	PF00082	0.667
CLV_PCSK_KEX2_1	376	378	PF00082	0.550
CLV_PCSK_KEX2_1	49	51	PF00082	0.742
CLV_PCSK_KEX2_1	6	8	PF00082	0.666
CLV_PCSK_KEX2_1	71	73	PF00082	0.759
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.672
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.674
CLV_PCSK_PC7_1	372	378	PF00082	0.573
DEG_SCF_FBW7_1	73	78	PF00400	0.653
DEG_SCF_TRCP1_1	11	16	PF00400	0.663
DEG_SCF_TRCP1_1	27	33	PF00400	0.550
DEG_SPOP_SBC_1	275	279	PF00917	0.665
DEG_SPOP_SBC_1	282	286	PF00917	0.614
DEG_SPOP_SBC_1	608	612	PF00917	0.674
DEG_SPOP_SBC_1	83	87	PF00917	0.636
DOC_CKS1_1	522	527	PF01111	0.342
DOC_CKS1_1	76	81	PF01111	0.682
DOC_CYCLIN_yCln2_LP_2	510	516	PF00134	0.356
DOC_MAPK_MEF2A_6	436	443	PF00069	0.537
DOC_PP2B_LxvP_1	177	180	PF13499	0.703
DOC_PP2B_LxvP_1	390	393	PF13499	0.518
DOC_PP2B_LxvP_1	510	513	PF13499	0.332
DOC_PP2B_LxvP_1	549	552	PF13499	0.458
DOC_USP7_MATH_1	129	133	PF00917	0.724
DOC_USP7_MATH_1	134	138	PF00917	0.694
DOC_USP7_MATH_1	149	153	PF00917	0.582
DOC_USP7_MATH_1	180	184	PF00917	0.734
DOC_USP7_MATH_1	228	232	PF00917	0.680
DOC_USP7_MATH_1	247	251	PF00917	0.532
DOC_USP7_MATH_1	25	29	PF00917	0.725
DOC_USP7_MATH_1	275	279	PF00917	0.824
DOC_USP7_MATH_1	282	286	PF00917	0.697
DOC_USP7_MATH_1	428	432	PF00917	0.622
DOC_USP7_MATH_1	565	569	PF00917	0.665
DOC_USP7_MATH_1	608	612	PF00917	0.647
DOC_USP7_MATH_1	79	83	PF00917	0.692
DOC_USP7_UBL2_3	77	81	PF12436	0.683
DOC_WW_Pin1_4	107	112	PF00397	0.821
DOC_WW_Pin1_4	139	144	PF00397	0.808
DOC_WW_Pin1_4	158	163	PF00397	0.548
DOC_WW_Pin1_4	166	171	PF00397	0.657
DOC_WW_Pin1_4	205	210	PF00397	0.851
DOC_WW_Pin1_4	252	257	PF00397	0.688
DOC_WW_Pin1_4	269	274	PF00397	0.681
DOC_WW_Pin1_4	278	283	PF00397	0.621
DOC_WW_Pin1_4	303	308	PF00397	0.821
DOC_WW_Pin1_4	501	506	PF00397	0.405
DOC_WW_Pin1_4	521	526	PF00397	0.199
DOC_WW_Pin1_4	582	587	PF00397	0.658
DOC_WW_Pin1_4	64	69	PF00397	0.678
DOC_WW_Pin1_4	71	76	PF00397	0.618
LIG_14-3-3_CanoR_1	158	162	PF00244	0.684
LIG_14-3-3_CanoR_1	186	195	PF00244	0.686
LIG_14-3-3_CanoR_1	202	206	PF00244	0.636
LIG_14-3-3_CanoR_1	276	282	PF00244	0.722
LIG_14-3-3_CanoR_1	283	292	PF00244	0.682
LIG_14-3-3_CanoR_1	315	321	PF00244	0.730
LIG_14-3-3_CanoR_1	326	334	PF00244	0.611
LIG_14-3-3_CanoR_1	413	421	PF00244	0.613
LIG_14-3-3_CanoR_1	527	532	PF00244	0.403
LIG_14-3-3_CanoR_1	564	570	PF00244	0.668
LIG_BIR_II_1	1	5	PF00653	0.669
LIG_deltaCOP1_diTrp_1	454	459	PF00928	0.405
LIG_EH_1	372	376	PF12763	0.631
LIG_EVH1_2	391	395	PF00568	0.617
LIG_FHA_1	31	37	PF00498	0.612
LIG_FHA_1	553	559	PF00498	0.539
LIG_FHA_1	86	92	PF00498	0.765
LIG_FHA_2	206	212	PF00498	0.694
LIG_FHA_2	232	238	PF00498	0.785
LIG_FHA_2	430	436	PF00498	0.616
LIG_LIR_Apic_2	16	20	PF02991	0.654
LIG_LIR_Apic_2	554	559	PF02991	0.565
LIG_LIR_Gen_1	379	387	PF02991	0.596
LIG_LIR_Gen_1	540	551	PF02991	0.405
LIG_LIR_Nem_3	11	17	PF02991	0.661
LIG_LIR_Nem_3	379	383	PF02991	0.594
LIG_LIR_Nem_3	540	546	PF02991	0.405
LIG_LIR_Nem_3	582	587	PF02991	0.655
LIG_Pex14_1	580	584	PF04695	0.660
LIG_PTB_Apo_2	383	390	PF02174	0.600
LIG_PTB_Phospho_1	383	389	PF10480	0.597
LIG_REV1ctd_RIR_1	514	523	PF16727	0.405
LIG_SH2_CRK	17	21	PF00017	0.656
LIG_SH2_CRK	543	547	PF00017	0.405
LIG_SH2_CRK	556	560	PF00017	0.495
LIG_SH2_CRK	584	588	PF00017	0.655
LIG_SH2_NCK_1	600	604	PF00017	0.642
LIG_SH2_PTP2	469	472	PF00017	0.405
LIG_SH2_SRC	389	392	PF00017	0.551
LIG_SH2_SRC	604	607	PF00017	0.687
LIG_SH2_SRC	9	12	PF00017	0.671
LIG_SH2_STAT3	363	366	PF00017	0.680
LIG_SH2_STAT5	363	366	PF00017	0.782
LIG_SH2_STAT5	369	372	PF00017	0.668
LIG_SH2_STAT5	389	392	PF00017	0.551
LIG_SH2_STAT5	469	472	PF00017	0.405
LIG_SH2_STAT5	9	12	PF00017	0.671
LIG_SH3_3	137	143	PF00018	0.708
LIG_SH3_3	188	194	PF00018	0.693
LIG_SH3_3	217	223	PF00018	0.647
LIG_SH3_3	289	295	PF00018	0.665
LIG_SH3_3	318	324	PF00018	0.676
LIG_SH3_3	331	337	PF00018	0.724
LIG_SH3_3	52	58	PF00018	0.693
LIG_SH3_3	73	79	PF00018	0.691
LIG_TRAF2_1	432	435	PF00917	0.617
LIG_TYR_ITIM	541	546	PF00017	0.405
LIG_UBA3_1	479	487	PF00899	0.272
LIG_WW_3	218	222	PF00397	0.628
MOD_CDC14_SPxK_1	255	258	PF00782	0.689
MOD_CDK_SPK_2	278	283	PF00069	0.694
MOD_CDK_SPxK_1	252	258	PF00069	0.690
MOD_CDK_SPxK_1	521	527	PF00069	0.342
MOD_CDK_SPxK_1	71	77	PF00069	0.675
MOD_CDK_SPxxK_3	269	276	PF00069	0.666
MOD_CDK_SPxxK_3	308	315	PF00069	0.718
MOD_CDK_SPxxK_3	64	71	PF00069	0.673
MOD_CK1_1	100	106	PF00069	0.586
MOD_CK1_1	130	136	PF00069	0.706
MOD_CK1_1	139	145	PF00069	0.617
MOD_CK1_1	169	175	PF00069	0.628
MOD_CK1_1	184	190	PF00069	0.624
MOD_CK1_1	203	209	PF00069	0.615
MOD_CK1_1	231	237	PF00069	0.688
MOD_CK1_1	250	256	PF00069	0.533
MOD_CK1_1	278	284	PF00069	0.822
MOD_CK1_1	311	317	PF00069	0.700
MOD_CK1_1	412	418	PF00069	0.630
MOD_CK1_1	482	488	PF00069	0.299
MOD_CK1_1	498	504	PF00069	0.265
MOD_CK1_1	530	536	PF00069	0.383
MOD_CK1_1	582	588	PF00069	0.645
MOD_CK1_1	63	69	PF00069	0.730
MOD_CK1_1	82	88	PF00069	0.690
MOD_CK2_1	205	211	PF00069	0.716
MOD_CK2_1	428	434	PF00069	0.623
MOD_CK2_1	87	93	PF00069	0.640
MOD_GlcNHglycan	100	103	PF01048	0.627
MOD_GlcNHglycan	11	14	PF01048	0.747
MOD_GlcNHglycan	129	132	PF01048	0.802
MOD_GlcNHglycan	136	139	PF01048	0.800
MOD_GlcNHglycan	185	189	PF01048	0.841
MOD_GlcNHglycan	27	30	PF01048	0.538
MOD_GlcNHglycan	443	446	PF01048	0.356
MOD_GlcNHglycan	487	490	PF01048	0.387
MOD_GlcNHglycan	62	65	PF01048	0.701
MOD_GlcNHglycan	81	84	PF01048	0.687
MOD_GSK3_1	103	110	PF00069	0.641
MOD_GSK3_1	129	136	PF00069	0.720
MOD_GSK3_1	180	187	PF00069	0.691
MOD_GSK3_1	200	207	PF00069	0.588
MOD_GSK3_1	237	244	PF00069	0.687
MOD_GSK3_1	274	281	PF00069	0.772
MOD_GSK3_1	282	289	PF00069	0.644
MOD_GSK3_1	310	317	PF00069	0.701
MOD_GSK3_1	475	482	PF00069	0.405
MOD_GSK3_1	485	492	PF00069	0.302
MOD_GSK3_1	495	502	PF00069	0.302
MOD_GSK3_1	530	537	PF00069	0.279
MOD_GSK3_1	547	554	PF00069	0.375
MOD_GSK3_1	575	582	PF00069	0.654
MOD_GSK3_1	591	598	PF00069	0.501
MOD_GSK3_1	60	67	PF00069	0.734
MOD_GSK3_1	71	78	PF00069	0.695
MOD_GSK3_1	79	86	PF00069	0.614
MOD_GSK3_1	87	94	PF00069	0.609
MOD_GSK3_1	9	16	PF00069	0.665
MOD_N-GLC_1	120	125	PF02516	0.699
MOD_N-GLC_1	552	557	PF02516	0.525
MOD_N-GLC_1	592	597	PF02516	0.660
MOD_N-GLC_1	98	103	PF02516	0.688
MOD_NEK2_1	127	132	PF00069	0.677
MOD_NEK2_1	409	414	PF00069	0.658
MOD_NEK2_1	479	484	PF00069	0.483
MOD_NEK2_1	60	65	PF00069	0.713
MOD_NEK2_1	91	96	PF00069	0.674
MOD_NEK2_2	247	252	PF00069	0.682
MOD_PIKK_1	115	121	PF00454	0.718
MOD_PIKK_1	169	175	PF00454	0.647
MOD_PIKK_1	367	373	PF00454	0.677
MOD_PIKK_1	412	418	PF00454	0.601
MOD_PKA_2	103	109	PF00069	0.685
MOD_PKA_2	127	133	PF00069	0.614
MOD_PKA_2	149	155	PF00069	0.652
MOD_PKA_2	157	163	PF00069	0.655
MOD_PKA_2	181	187	PF00069	0.670
MOD_PKA_2	201	207	PF00069	0.734
MOD_PKA_2	275	281	PF00069	0.712
MOD_PKA_2	282	288	PF00069	0.686
MOD_PKA_2	30	36	PF00069	0.612
MOD_PKA_2	314	320	PF00069	0.729
MOD_PKA_2	325	331	PF00069	0.633
MOD_PKA_2	412	418	PF00069	0.640
MOD_PKA_2	475	481	PF00069	0.380
MOD_PKA_2	563	569	PF00069	0.666
MOD_Plk_1	552	558	PF00069	0.484
MOD_Plk_4	136	142	PF00069	0.687
MOD_Plk_4	172	178	PF00069	0.629
MOD_Plk_4	228	234	PF00069	0.743
MOD_Plk_4	316	322	PF00069	0.692
MOD_Plk_4	475	481	PF00069	0.477
MOD_Plk_4	87	93	PF00069	0.663
MOD_ProDKin_1	107	113	PF00069	0.831
MOD_ProDKin_1	139	145	PF00069	0.809
MOD_ProDKin_1	158	164	PF00069	0.548
MOD_ProDKin_1	166	172	PF00069	0.656
MOD_ProDKin_1	205	211	PF00069	0.853
MOD_ProDKin_1	252	258	PF00069	0.690
MOD_ProDKin_1	269	275	PF00069	0.674
MOD_ProDKin_1	278	284	PF00069	0.622
MOD_ProDKin_1	303	309	PF00069	0.820
MOD_ProDKin_1	501	507	PF00069	0.405
MOD_ProDKin_1	521	527	PF00069	0.199
MOD_ProDKin_1	582	588	PF00069	0.655
MOD_ProDKin_1	64	70	PF00069	0.677
MOD_ProDKin_1	71	77	PF00069	0.622
MOD_SUMO_rev_2	488	498	PF00179	0.405
TRG_DiLeu_BaEn_1	438	443	PF01217	0.547
TRG_DiLeu_BaLyEn_6	420	425	PF01217	0.520
TRG_ENDOCYTIC_2	469	472	PF00928	0.405
TRG_ENDOCYTIC_2	543	546	PF00928	0.405
TRG_ENDOCYTIC_2	584	587	PF00928	0.659
TRG_ER_diArg_1	331	333	PF00400	0.719
TRG_ER_diArg_1	352	354	PF00400	0.684
TRG_ER_diArg_1	375	377	PF00400	0.572
TRG_ER_diArg_1	48	51	PF00400	0.718
TRG_ER_diArg_1	5	8	PF00400	0.659

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HEV0	Leishmania braziliensis	58%	92%
A4I224	Leishmania infantum	99%	100%
E9AY73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q999	Leishmania major	90%	100%