TLC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IP15_LEIDO

TriTrypDb:

LdBPK_363110.1 , LdCL_360037500 , LDHU3_36.4300

Length:

132

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3Q8IP15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IP15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	71	75	PF00082	0.523
CLV_PCSK_SKI1_1	84	88	PF00082	0.506
DEG_APCC_DBOX_1	83	91	PF00400	0.357
DEG_Nend_Nbox_1	1	3	PF02207	0.667
DOC_CYCLIN_RxL_1	68	78	PF00134	0.402
LIG_Actin_WH2_2	9	25	PF00022	0.528
LIG_BRCT_BRCA1_1	59	63	PF00533	0.379
LIG_BRCT_BRCA1_1	88	92	PF00533	0.325
LIG_EH1_1	120	128	PF00400	0.483
LIG_FHA_1	101	107	PF00498	0.318
LIG_FHA_1	6	12	PF00498	0.581
LIG_FHA_2	76	82	PF00498	0.367
LIG_GBD_Chelix_1	45	53	PF00786	0.445
LIG_LIR_Gen_1	109	116	PF02991	0.427
LIG_LIR_Gen_1	15	25	PF02991	0.611
LIG_LIR_Gen_1	60	69	PF02991	0.398
LIG_LIR_Nem_3	109	114	PF02991	0.449
LIG_LIR_Nem_3	15	20	PF02991	0.580
LIG_LIR_Nem_3	60	66	PF02991	0.439
LIG_NRBOX	61	67	PF00104	0.295
LIG_NRBOX	86	92	PF00104	0.363
LIG_Pex14_2	2	6	PF04695	0.559
LIG_SH2_CRK	50	54	PF00017	0.445
LIG_SH2_CRK	88	92	PF00017	0.379
LIG_SH2_STAP1	7	11	PF00017	0.528
LIG_SH2_STAP1	88	92	PF00017	0.368
LIG_SH2_STAT3	116	119	PF00017	0.494
LIG_SH2_STAT5	121	124	PF00017	0.542
LIG_SH2_STAT5	7	10	PF00017	0.571
LIG_SUMO_SIM_par_1	102	107	PF11976	0.354
LIG_SUMO_SIM_par_1	72	78	PF11976	0.371
LIG_TYR_ITIM	86	91	PF00017	0.384
LIG_UBA3_1	123	132	PF00899	0.551
LIG_WRC_WIRS_1	105	110	PF05994	0.417
MOD_CK1_1	96	102	PF00069	0.424
MOD_CK2_1	75	81	PF00069	0.394
MOD_GlcNHglycan	95	98	PF01048	0.659
MOD_GSK3_1	106	113	PF00069	0.318
MOD_GSK3_1	86	93	PF00069	0.341
MOD_GSK3_1	96	103	PF00069	0.337
MOD_NEK2_1	106	111	PF00069	0.312
MOD_NEK2_1	57	62	PF00069	0.387
MOD_NEK2_1	75	80	PF00069	0.288
MOD_NEK2_1	90	95	PF00069	0.445
MOD_PIKK_1	90	96	PF00454	0.382
MOD_Plk_4	100	106	PF00069	0.278
MOD_Plk_4	110	116	PF00069	0.308
MOD_Plk_4	31	37	PF00069	0.555
MOD_Plk_4	86	92	PF00069	0.363
TRG_DiLeu_BaEn_1	81	86	PF01217	0.395
TRG_ENDOCYTIC_2	120	123	PF00928	0.529
TRG_ENDOCYTIC_2	17	20	PF00928	0.615
TRG_ENDOCYTIC_2	50	53	PF00928	0.384
TRG_ENDOCYTIC_2	88	91	PF00928	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Z5	Leptomonas seymouri	55%	100%
A0A1X0NKL9	Trypanosomatidae	38%	99%
A0A3R7KH99	Trypanosoma rangeli	39%	100%
A4HPG2	Leishmania braziliensis	80%	100%
A4ID84	Leishmania infantum	99%	100%
E9AT74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q1C3	Leishmania major	95%	100%