JmjC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IP13_LEIDO

TriTrypDb:

LdBPK_260740.1 , LdCL_260013100 , LDHU3_26.0970

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IP13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IP13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	382	386	PF00656	0.667
CLV_NRD_NRD_1	272	274	PF00675	0.766
CLV_NRD_NRD_1	305	307	PF00675	0.664
CLV_NRD_NRD_1	348	350	PF00675	0.677
CLV_NRD_NRD_1	466	468	PF00675	0.698
CLV_NRD_NRD_1	54	56	PF00675	0.735
CLV_PCSK_FUR_1	170	174	PF00082	0.655
CLV_PCSK_KEX2_1	172	174	PF00082	0.661
CLV_PCSK_KEX2_1	272	274	PF00082	0.766
CLV_PCSK_KEX2_1	305	307	PF00082	0.643
CLV_PCSK_KEX2_1	347	349	PF00082	0.675
CLV_PCSK_KEX2_1	418	420	PF00082	0.598
CLV_PCSK_KEX2_1	466	468	PF00082	0.676
CLV_PCSK_KEX2_1	500	502	PF00082	0.649
CLV_PCSK_KEX2_1	511	513	PF00082	0.507
CLV_PCSK_KEX2_1	54	56	PF00082	0.735
CLV_PCSK_KEX2_1	7	9	PF00082	0.694
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.661
CLV_PCSK_PC1ET2_1	347	349	PF00082	0.752
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.697
CLV_PCSK_PC1ET2_1	500	502	PF00082	0.649
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.507
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.694
CLV_PCSK_SKI1_1	173	177	PF00082	0.655
CLV_PCSK_SKI1_1	391	395	PF00082	0.604
CLV_PCSK_SKI1_1	43	47	PF00082	0.592
CLV_PCSK_SKI1_1	454	458	PF00082	0.765
CLV_PCSK_SKI1_1	473	477	PF00082	0.534
CLV_PCSK_SKI1_1	528	532	PF00082	0.600
CLV_PCSK_SKI1_1	95	99	PF00082	0.732
CLV_Separin_Metazoa	51	55	PF03568	0.732
DEG_Nend_UBRbox_2	1	3	PF02207	0.766
DOC_CKS1_1	33	38	PF01111	0.684
DOC_MAPK_gen_1	478	487	PF00069	0.605
DOC_MAPK_MEF2A_6	481	489	PF00069	0.654
DOC_PP4_FxxP_1	376	379	PF00568	0.804
DOC_USP7_MATH_1	141	145	PF00917	0.738
DOC_USP7_MATH_1	147	151	PF00917	0.747
DOC_USP7_MATH_1	183	187	PF00917	0.765
DOC_USP7_MATH_1	379	383	PF00917	0.704
DOC_USP7_MATH_1	460	464	PF00917	0.778
DOC_USP7_MATH_1	510	514	PF00917	0.677
DOC_USP7_MATH_1	526	530	PF00917	0.436
DOC_USP7_MATH_2	241	247	PF00917	0.751
DOC_WW_Pin1_4	207	212	PF00397	0.687
DOC_WW_Pin1_4	24	29	PF00397	0.656
DOC_WW_Pin1_4	32	37	PF00397	0.632
LIG_14-3-3_CanoR_1	121	127	PF00244	0.772
LIG_14-3-3_CanoR_1	272	280	PF00244	0.704
LIG_14-3-3_CanoR_1	320	325	PF00244	0.738
LIG_14-3-3_CanoR_1	373	377	PF00244	0.789
LIG_14-3-3_CanoR_1	481	486	PF00244	0.613
LIG_14-3-3_CanoR_1	54	61	PF00244	0.737
LIG_APCC_ABBA_1	395	400	PF00400	0.561
LIG_BRCT_BRCA1_1	526	530	PF00533	0.567
LIG_CtBP_PxDLS_1	217	221	PF00389	0.630
LIG_FHA_1	470	476	PF00498	0.667
LIG_FHA_1	482	488	PF00498	0.530
LIG_FHA_1	513	519	PF00498	0.611
LIG_FHA_2	312	318	PF00498	0.815
LIG_FHA_2	529	535	PF00498	0.608
LIG_LIR_Apic_2	189	193	PF02991	0.670
LIG_LIR_Apic_2	374	379	PF02991	0.800
LIG_LIR_Apic_2	520	526	PF02991	0.633
LIG_LIR_Gen_1	104	111	PF02991	0.628
LIG_LIR_Gen_1	334	343	PF02991	0.679
LIG_LIR_Gen_1	392	401	PF02991	0.564
LIG_LIR_Gen_1	474	482	PF02991	0.604
LIG_LIR_Gen_1	529	540	PF02991	0.554
LIG_LIR_Nem_3	104	109	PF02991	0.728
LIG_LIR_Nem_3	392	397	PF02991	0.571
LIG_LIR_Nem_3	474	479	PF02991	0.607
LIG_LIR_Nem_3	529	535	PF02991	0.551
LIG_LIR_Nem_3	78	83	PF02991	0.593
LIG_Rb_pABgroove_1	35	43	PF01858	0.634
LIG_RPA_C_Fungi	344	356	PF08784	0.666
LIG_SH2_CRK	11	15	PF00017	0.635
LIG_SH2_NCK_1	11	15	PF00017	0.635
LIG_SH2_NCK_1	398	402	PF00017	0.550
LIG_SH2_NCK_1	41	45	PF00017	0.709
LIG_SH2_SRC	398	401	PF00017	0.552
LIG_SH2_STAP1	322	326	PF00017	0.646
LIG_SH2_STAP1	41	45	PF00017	0.593
LIG_SH2_STAP1	521	525	PF00017	0.571
LIG_SH2_STAT3	247	250	PF00017	0.805
LIG_SH2_STAT3	83	86	PF00017	0.641
LIG_SH2_STAT5	20	23	PF00017	0.646
LIG_SH2_STAT5	269	272	PF00017	0.721
LIG_SH2_STAT5	5	8	PF00017	0.586
LIG_SH2_STAT5	83	86	PF00017	0.725
LIG_SH3_1	146	152	PF00018	0.555
LIG_SH3_2	149	154	PF14604	0.549
LIG_SH3_2	33	38	PF14604	0.657
LIG_SH3_3	146	152	PF00018	0.648
LIG_SH3_3	30	36	PF00018	0.669
LIG_TRAF2_1	409	412	PF00917	0.579
LIG_TRAF2_1	496	499	PF00917	0.691
LIG_UBA3_1	414	418	PF00899	0.693
LIG_WW_3	151	155	PF00397	0.547
MOD_CDK_SPxK_1	32	38	PF00069	0.656
MOD_CDK_SPxxK_3	207	214	PF00069	0.717
MOD_CK1_1	101	107	PF00069	0.754
MOD_CK1_1	133	139	PF00069	0.765
MOD_CK1_1	202	208	PF00069	0.792
MOD_CK1_1	223	229	PF00069	0.744
MOD_CK1_1	369	375	PF00069	0.716
MOD_CK2_1	223	229	PF00069	0.718
MOD_CK2_1	311	317	PF00069	0.818
MOD_CK2_1	447	453	PF00069	0.791
MOD_CK2_1	510	516	PF00069	0.608
MOD_CK2_1	530	536	PF00069	0.636
MOD_CK2_1	72	78	PF00069	0.665
MOD_DYRK1A_RPxSP_1	24	28	PF00069	0.617
MOD_GlcNHglycan	100	103	PF01048	0.718
MOD_GlcNHglycan	204	207	PF01048	0.781
MOD_GlcNHglycan	222	225	PF01048	0.571
MOD_GlcNHglycan	349	352	PF01048	0.603
MOD_GlcNHglycan	381	384	PF01048	0.687
MOD_GlcNHglycan	469	472	PF01048	0.668
MOD_GSK3_1	115	122	PF00069	0.674
MOD_GSK3_1	126	133	PF00069	0.667
MOD_GSK3_1	20	27	PF00069	0.651
MOD_GSK3_1	219	226	PF00069	0.724
MOD_GSK3_1	311	318	PF00069	0.783
MOD_GSK3_1	320	327	PF00069	0.639
MOD_GSK3_1	379	386	PF00069	0.747
MOD_GSK3_1	477	484	PF00069	0.639
MOD_GSK3_1	512	519	PF00069	0.646
MOD_GSK3_1	524	531	PF00069	0.535
MOD_GSK3_1	68	75	PF00069	0.655
MOD_N-GLC_1	291	296	PF02516	0.695
MOD_N-GLC_1	300	305	PF02516	0.703
MOD_N-GLC_1	366	371	PF02516	0.656
MOD_N-GLC_1	431	436	PF02516	0.740
MOD_N-GLC_1	98	103	PF02516	0.608
MOD_NEK2_1	1	6	PF00069	0.763
MOD_NEK2_1	204	209	PF00069	0.824
MOD_NEK2_1	220	225	PF00069	0.659
MOD_NEK2_1	310	315	PF00069	0.746
MOD_NEK2_1	324	329	PF00069	0.528
MOD_PIKK_1	109	115	PF00454	0.823
MOD_PIKK_1	223	229	PF00454	0.760
MOD_PIKK_1	273	279	PF00454	0.814
MOD_PIKK_1	383	389	PF00454	0.638
MOD_PIKK_1	437	443	PF00454	0.751
MOD_PIKK_1	53	59	PF00454	0.768
MOD_PIKK_1	534	540	PF00454	0.588
MOD_PIKK_1	68	74	PF00454	0.475
MOD_PKA_1	272	278	PF00069	0.637
MOD_PKA_1	347	353	PF00069	0.668
MOD_PKA_1	467	473	PF00069	0.644
MOD_PKA_2	120	126	PF00069	0.746
MOD_PKA_2	176	182	PF00069	0.815
MOD_PKA_2	272	278	PF00069	0.690
MOD_PKA_2	315	321	PF00069	0.756
MOD_PKA_2	324	330	PF00069	0.652
MOD_PKA_2	347	353	PF00069	0.658
MOD_PKA_2	372	378	PF00069	0.772
MOD_PKA_2	460	466	PF00069	0.703
MOD_PKA_2	477	483	PF00069	0.644
MOD_PKA_2	53	59	PF00069	0.737
MOD_Plk_1	1	7	PF00069	0.695
MOD_Plk_1	291	297	PF00069	0.693
MOD_Plk_1	300	306	PF00069	0.706
MOD_Plk_1	452	458	PF00069	0.731
MOD_Plk_1	98	104	PF00069	0.629
MOD_Plk_4	1	7	PF00069	0.578
MOD_Plk_4	163	169	PF00069	0.713
MOD_Plk_4	243	249	PF00069	0.830
MOD_Plk_4	372	378	PF00069	0.730
MOD_ProDKin_1	207	213	PF00069	0.687
MOD_ProDKin_1	24	30	PF00069	0.659
MOD_ProDKin_1	32	38	PF00069	0.632
MOD_SUMO_for_1	487	490	PF00179	0.729
MOD_SUMO_for_1	63	66	PF00179	0.721
MOD_SUMO_rev_2	385	393	PF00179	0.582
MOD_SUMO_rev_2	450	456	PF00179	0.700
MOD_SUMO_rev_2	504	513	PF00179	0.638
TRG_DiLeu_BaEn_1	410	415	PF01217	0.588
TRG_DiLeu_LyEn_5	410	415	PF01217	0.588
TRG_ENDOCYTIC_2	336	339	PF00928	0.688
TRG_ER_diArg_1	272	274	PF00400	0.766
TRG_ER_diArg_1	304	306	PF00400	0.703
TRG_ER_diArg_1	53	55	PF00400	0.734
TRG_NLS_MonoExtN_4	305	310	PF00514	0.749
TRG_Pf-PMV_PEXEL_1	214	219	PF00026	0.679
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.590
TRG_Pf-PMV_PEXEL_1	473	477	PF00026	0.655
TRG_Pf-PMV_PEXEL_1	95	100	PF00026	0.763

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2U8	Leptomonas seymouri	35%	95%
A4HET2	Leishmania braziliensis	50%	100%
A4I208	Leishmania infantum	99%	100%
E9AY56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	96%
Q4Q9B7	Leishmania major	85%	100%